Karolinska Institutet Open Archive
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Conformational dynamics in microRNAs : the example of miR-34a targeting Sirt1 mRNA
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-06-17)In biology, regulatory mechanisms are essential to achieve complex tasks, as virtually every process can be positively or negatively modulated in its outcome, upon different cues. In humans, microRNAs (miRNAs) ... -
Lipids, apolipoproteins, and prognosis of amyotrophic lateral sclerosis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-06-08)Objective: To determine whether lipids and apolipoproteins predict prognosis of patients with amyo- trophic lateral sclerosis in a cohort study of 99 patients with amyotrophic lateral sclerosis who were diagnosed during ... -
Fibrinogen-binding proteins from Staphylococcus aureus
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-06-08)Staphylococcus aureus produces a large number of proteins that specifically bind to molecules from plasma or from the human extracellular matrix where they are involved in processes associated with the colonization of the ... -
Exploring chromatin organization and transcription in S.pombe and hematopoietic development
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-05-28)DNA in the eukaryotic nucleus is organized into histone-DNA complex, so-called chromatin, through forming an array of nucleosomes. Each nucleosome consists of a 147bp DNA wrapped around a histone octamer harboring two ... -
Extensive tooth wear in adults : classification and prosthetic treatment
(Inst för odontologi / Dept of Dental Medicine, 2020-05-27)Background: Tooth wear (TW) is an insidious and cumulative mul- tifactorial process that may comprise erosion, abrasion or attrition, and combinations thereof. These different processes are of chemical or physical origin ...