Karolinska Institutet Open Archive
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Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-07-29)Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic ... -
Executive functions and successful behavior
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-07-28)Executive functions are the underlying mechanisms that drive top-down regulation of information processing. While suboptimal executive functions have been investigated in various groups of patients, their impact and ... -
Improved statistical methodology for high-throughput omics data analysis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-07-19)Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ... -
Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, HuddingeStem Cell and Regenerative Medicine Consortium, LKS Faculty of Medicine, The University of HongKong, Hong Kong, ChinaDr. Li Dak-Sum Research Centre, University of Hong Kong-Karolinska Institutet Collaborations in Regenerative Medicine, The Universityof Hong Kong, Hong Kong, ChinaInstitute for Experimental MedicalResearch, Oslo University Hospital and University of Oslo, Oslo, Norway, 2021-07-01)The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ... -
Mechanisms of flavor perception : how odor and taste interact when we eat
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-06-02)Every time we eat, our brains are bombarded with sensory information from the olfactory and gustatory modalities. Through a binding process that is not fully understood, the odor and taste are then merged into flavor, a ...