Open Archive: Publications from Karolinska Institutet
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Repertoire diversity and maturation of HIV-1 vaccine-induced B cell responses
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-06-04)In the work presented in this thesis, I characterized B cell responses in rhesus macaques inoculated with HIV-1 envelope glycoprotein (Env)-based vaccines to define genetic and functional properties of the elicited ... -
HCMV-induced epigenetic alterations : a novel pathway to CNS tumor?
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-06-01)Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ... -
Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-30)The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, ... -
Achilles tendon loading and deformation during rehabilitation and use of ankle foot orthoses
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-30)Achilles tendon rupture is a common injury which most often affects otherwise healthy individuals and which causes long periods of rehabilitation with absence from work and sport activities and frequently sequele with ... -
Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-30)A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows ...