• Does treating vascular risk factors prevent dementia and Alzheimer’s disease? A systematic review and meta-analysis 

  Larsson, Susanna; Markus, Hugh (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-07-05)

  Background: Epidemiological evidence has associated Alzheimer’s disease (AD) with vascular risk factors (VRFs), but whether treatment of VRFs reduces the incidence of dementia and AD is uncertain. Objective: To ...

• A study of two major challenges in prostate cancer : effective chemo-prevention and overcoming resistance to hormonal and chemotherapy 

  Ma, Yuanjun (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-06-29)

  For men, over the course of a lifetime the risk of developing prostate cancer is 1 in 9. Both the illness itself and treatment affect quality of life in multiple aspects, including urinary problems, pain, and sexual ...

• Repertoire diversity and maturation of HIV-1 vaccine-induced B cell responses 

  Phad, Ganesh Eknath (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-06-04)

  In the work presented in this thesis, I characterized B cell responses in rhesus macaques inoculated with HIV-1 envelope glycoprotein (Env)-based vaccines to define genetic and functional properties of the elicited ...

• HCMV-induced epigenetic alterations : a novel pathway to CNS tumor? 

  Estekizadeh, Atosa (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-06-01)

  Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...

• Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation 

  Nematollahi Mahani, Amir (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-30)

  The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, ...

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