Karolinska Institutet Open Archive
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The trident of the pancreatic duct : stemness, morphogenesis and endocrinogenesis
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-29)Different subtypes of diabetes are all featured by the deterioration and loss of functional β-cell. Currently, there is still lack of therapeutic strategies to cure diabetes. However, harnessing the innate stem cell ... -
Discovering circulating protein biomarkers through in-depth plasma proteomics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-29)Plasma, i.e., the liquid component of blood, is one of the most clinically used samples for biomarker measurement. Despite that plasma proteins and metabolites are the most frequently analysed biomarkers in practice, ... -
Mitigating neuroinflammation : new potential therapeutics and targets
(Inst för neurovetenskap / Dept of Neuroscience, 2023-05-29)Neurodegenerative disorders, from chronic diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) to more acute injuries such traumatic brain injury (TBI), present a particular challenge to public health ... -
Clonal structures and cell interactions in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-29)Despite sharing an identical genome, cells of higher order multicellular organisms display a large degree of phenotypic diversity. This diversity is maintained by a sophisticated regulatory machinery that integrates ... -
Prognosis of nasopharyngeal carcinoma : body mass index, plasma Epstein-Barr virus DNA and oral microbiome
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-05-29)Nasopharyngeal carcinoma (NPC) has a geographically skewed distribution worldwide, with high incidence rates in East and Southeast Asia. Although hospital-based studies suggest that the development of new radiotherapy ...