Karolinska Institutet Open Archive
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The role of atrial fibrillation in cognitive aging : a population-based study
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-11-18)The role of atrial fibrillation (AF) in brain and cognitive aging (e.g., cognitive decline and dementia) is still unclear. In this doctoral thesis, we aimed to investigate the temporal trends and potential determinants ... -
Statistical models of breast cancer tumour growth and spread
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-11-18)In this thesis, we develop statistical methods for studying tumour growth and metastatic lymph node spread in breast cancer. The methods can be used for analysing breast cancer disease progression before diagnosis. They ... -
Ergonomic risk assessment and intervention through smart workwear systems
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-11-15)The rapid development of wearable technology has provided opportunities to ergonomics research and practice with new ways for workload measurements, data analytics, risk assessment and intervention. This thesis aims at ... -
Sex differences in cancer risk and survival
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-11-15)Aim: The objective of study I was to delineate and quantify sex differences in cancer risk and survival together with assessing the potential gain achieved by eliminating the excess cancer risk in men. Study II and III ... -
Novel methods to study genomic fragility and structural variation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-11-15)DNA double-strand breaks (DSBs) are major DNA lesions that when repaired unfaithfully can give rise to loss of genetic information, chromosomal rearrangements such as insertions/deletions (indels) and copy number alterations ...