Karolinska Institutet Open Archive
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The functional organisation of basal ganglia inputs.
(Inst för neurovetenskap / Dept of Neuroscience, 2020-04-07)The basal ganglia allow organisms to adjust their behaviour according to changes in their internal state or their environment. One essential prerequisite for the selection and execution of appropriate movements is the ... -
Pharmacoepidemiology and health economics of adherence to pharmaceutical fracture prevention
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2020-04-06)Background: Osteoporosis is a disease characterized by weak bone, affecting hundreds of millions of people worldwide, predominantly postmenopausal women. The main clinical consequence of the disease is bone fractures and ... -
The role of epigenetics in Multiple Sclerosis development, progression and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-03)The overall aim of this thesis was to determine epigenetic changes in peripheral immune cells from Multiple Sclerosis (MS) patients. MS is a chronic inflammatory neurodegenerative disease, which initially presents itself ... -
Current diagnostic aspects on acute and chronic pulmonary embolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-04-03)Background: Acute pulmonary embolism (APE) is a potentially severe medical condition with blood clots obstructing the pulmonary arterial vasculature. In most cases the APE resolves without any sequelae after anticoagulation ... -
Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer: biology and clinical implications
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-04-03)Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed ...