Open Archive: Publications from Karolinska Institutet
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Developing new models of childhood malignancies using human induced pluripotent stem cells
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-02-15)ABSTRACT Early onset diseases such as childhood malignancies and neurodevelopmental disorders have been intricate to study. For many years, research has relied and dependent upon different animal systems. Despite the ... -
Long-term effects of pre-and postnatal glucocorticoid treatment in congenital adrenal hyperplasia
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-02-15)Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder mostly caused by mutations in the CYP21A2 gene leading to impaired production of cortisol and aldosterone. Precursors in the steroidogenic pathway are ... -
Studies of effector functions in mycobacterium tuberculosis infected macrophages with implications for host-directed therapies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-02-15)Tuberculosis infection remains a global health problem and the emergence of multidrugresistant TB (MDR-TB) adds further challenges in the battle to stop the spread of infection. Macrophages are the primary host cells to ... -
Pancreatic βeta-cell insulin signaling in genetic and dietary models of obesity and insulin resistance
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-02-14)Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood glucose levels that has reached pandemic proportions. Genome-wide association studies have linked T2DM to the function ... -
The toxicological pharmacoepidemiology of suicide : population-based studies on psychotropic-mediation use in Sweden
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-02-14)The act of completed suicide is a complex phenomenon associated with numerous identified individual and combined risk factors. Mental illness and related disorders confer among the highest risks of completed suicide and ...