Open Archive: Publications from Karolinska Institutet
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T cell signatures and modulation by regulatory T cells
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-03-22)CD4 T cells are crucial coordinators of protective immune responses against microbes and tumors. However, immune responses misdirected towards self-antigens are the hallmarks of autoimmune diseases. Regulatory T cells ... -
The interplay between mitochondria-endoplasmic reticulum contacts and Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-03-22)Even though Alzheimer’s disease (AD) was first described more than 100 years ago, we still have no treatment preventing the ongoing neurodegenerative process. Two major pathological hallmarks have been connected to AD: ... -
Maternal antibody transfer in HIV-1 infected women and impact on infant health : the role of antiretroviral prophylaxis and breastfeeding practices
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-03-22)Children born to human immunodeficiency virus type 1 (HIV-1) infected women are more vulnerable to infections and are more likely to die even when they are not HIV-1 infected. These adverse outcomes may blunt any gains ... -
Cognitive development and educational attainment across the life span
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-03-22)In this thesis I explore two strands of research: in the first half I explore the effects of language learning on brain structure and cognitive function. In the second half I study to what extent educational attainment ... -
Feeling the force : role of AmotL2 in normal development and cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-03-21)Cells that fabricate the body, dwell in a very heterogeneous environment. Self-organization of individual cells into complex tissues and organs at the time of growth and revival is brought about by the combinatory action ...