Karolinska Institutet Open Archive
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Healthcare when the bets are off : symptoms, trajectories and treatment of individuals with gambling disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2023-03-28)Gambling Disorder is a debilitating condition associated with several adverse outcomes. Despite available treatment, most of those suffering never seek help and those that do often present a complex clinical picture with ... -
Early life exposures and lung function development
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-03-27)BACKGROUND: Lung development is a dynamic process, vulnerable to adverse environmental exposures. Starting in utero, development continues postnatally, and although lung structure is mainly set at around two years of age, ... -
Dysglycaemia and cardiovascular disease. Aspects on screening, management, and prognosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-03-24)Background: Dysglycaemia, in this thesis defined as impaired glucose tolerance (IGT) or type 2 diabetes (T2DM), is a major risk factor for cardiovascular disease (CVD). International guidelines recommend screening for ... -
Exploration of novel hepatic In-vitro systems for drug metabolism and pharmacokinetic studies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-03-24)The development of a novel drug is a highly cost-intensive and risky process and many drug candidates fail on the way to final approval. An important task during this development is to investigate the absorption, ... -
Prediction-driven decision rules, RCT design and survival analysis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-03-23)Predictions are becoming more and more a part of our lives, and they are becoming increasingly useful in medical science as the science evolves. Increased understanding of disease and its treatments allows us to use ...