Karolinska Institutet Open Archive
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Regulation of vaccine immunity : from myeloid cell functions to antibody responses
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-12-05)The generation of vaccine-induced protection against infections relies on a well-coordinated network of innate immune responses, adaptive cellular responses, and humoral responses. Sufficient stimulation of the innate ... -
Regulation of chromatin transitions in the 3D architecture of the nucleus
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-11-27)The thesis explores the dynamic features and functions of chromatin crosstalk in the 3D nucleus space, with a focus on the regulation of chromatin transitions. In Paper I we employed the circular chromosome conformation ... -
Role of tartrate-resistant acid phosphatase in bone remodeling
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-11-27)Tartrate-resistant acid phosphatase is a metalloenzyme that exists as two isoforms: the monomeric TRAP 5a and the proteolytically cleaved TRAP 5b, responsible for phosphatase activity, which is highly expressed in osteoclasts ... -
Amyotrophic lateral sclerosis and multiple sclerosis associated neuroinflammation : nationwide epidemiological studies on etiology, comorbidities, and treatment
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-11-26)Amyotrophic lateral sclerosis (ALS) is a relatively rare but fatal neurodegenerative disease characterized by progressive muscle paralysis, due to loss of upper and lower motor neurons. Signs of neuroinflammation have been ... -
Periodontitis and invasive oral treatment in relation to myocardial infarction : epidemiological studies
(Inst för odontologi / Dept of Dental Medicine, 2019-11-25)Background: Cardiovascular disease and periodontitis are major global health problems that are a large burden for the individual and society. During the last 30 years, it has been discussed whether there is an association ...