Karolinska Institutet Open Archive
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The role of epigenetics in Multiple Sclerosis development, progression and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-03)The overall aim of this thesis was to determine epigenetic changes in peripheral immune cells from Multiple Sclerosis (MS) patients. MS is a chronic inflammatory neurodegenerative disease, which initially presents itself ... -
Current diagnostic aspects on acute and chronic pulmonary embolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-04-03)Background: Acute pulmonary embolism (APE) is a potentially severe medical condition with blood clots obstructing the pulmonary arterial vasculature. In most cases the APE resolves without any sequelae after anticoagulation ... -
Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer: biology and clinical implications
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-04-03)Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed ... -
Drug discovery targeting non-amyloid pathways in Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-04-02)Alzheimer’s disease (AD) is the most common form of dementia with almost 50 million people affected and unfortunately, no cure or treatment to halt the disease progression is available. In the hereditary forms of AD, an ... -
Regulations of neuronal plasticity by the Nogo system
(Inst för neurovetenskap / Dept of Neuroscience, 2020-04-02)Our brain has a lifelong capacity to create new memories, to learn and to adapt. This is due to the ability of neurons to modify their signaling depending on the situation to which the nervous system is exposed. The neurons ...