Open Archive: Publications from Karolinska Institutet
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Expanding the genetic and phenotypic spectrum of skeletal dysplasias
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-17)Skeletal dysplasias constitute a large and heterogeneous group of disorders, many causing disabilities with profound effects on the quality of life of the affected individuals and their families. Each individual skeletal ... -
Early indicators for adverse development of cardiovascular, renal and metabolic function in children born with low birth weight
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2018-08-17)Prematurity affects more than 10% of infants worldwide and is the main reason for neonatal mortality. Improvements in neonatal care have led to higher survival rates into adulthood. Adverse events during organogenesis ... -
The role of RFX transcription factors in neurons and in the human brain
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-08-15)RFX transcription factors (TFs) are conserved in animals, fungi and some amoebae, but not in algae, plants and protozoan species. The conservation is based on the protein sequence of the DNA binding domain (DBD). The RFX ... -
Improving surgical therapy for oesophageal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-14)Despite advances in multimodality treatment, surgery remains the mainstay of curative treatment for oesophageal cancer. However short- and long-term mortality from oesophagectomy for oesophageal cancer still shows large ... -
Redox alterations in inflammatory diseases : diabetes, kidney failure and cancer
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-10)In order to combat oxidative stress and maintain the intracellular redox homeostasis, cells are equipped with antioxidant systems. The thioredoxin and glutaredoxin systems are the major thiol reducing systems and central ...