Karolinska Institutet Open Archive
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Cell lineage analysis in humans
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-07-29)Delineating a cell’s history, where it came from and what has happened to it, can provide clues as to how tissues and organs are formed and function in the healthy state and in disease. The gold standard for tracing the ... -
Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-07-29)Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic ... -
Executive functions and successful behavior
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-07-28)Executive functions are the underlying mechanisms that drive top-down regulation of information processing. While suboptimal executive functions have been investigated in various groups of patients, their impact and ... -
Improved statistical methodology for high-throughput omics data analysis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-07-19)Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ... -
Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, HuddingeStem Cell and Regenerative Medicine Consortium, LKS Faculty of Medicine, The University of HongKong, Hong Kong, ChinaDr. Li Dak-Sum Research Centre, University of Hong Kong-Karolinska Institutet Collaborations in Regenerative Medicine, The Universityof Hong Kong, Hong Kong, ChinaInstitute for Experimental MedicalResearch, Oslo University Hospital and University of Oslo, Oslo, Norway, 2021-07-01)The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ...