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  • Repertoire diversity and maturation of HIV-1 vaccine-induced B cell responses 

    Phad, Ganesh Eknath (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-06-04)
    In the work presented in this thesis, I characterized B cell responses in rhesus macaques inoculated with HIV-1 envelope glycoprotein (Env)-based vaccines to define genetic and functional properties of the elicited ...
  • HCMV-induced epigenetic alterations : a novel pathway to CNS tumor? 

    Estekizadeh, Atosa (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-06-01)
    Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
  • Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation 

    Nematollahi Mahani, Amir (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-30)
    The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, ...
  • Achilles tendon loading and deformation during rehabilitation and use of ankle foot orthoses 

    Fröberg, Åsa (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-30)
    Achilles tendon rupture is a common injury which most often affects otherwise healthy individuals and which causes long periods of rehabilitation with absence from work and sport activities and frequently sequele with ...
  • Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53 

    Zhang, Meiqiongzi (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-30)
    A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows ...

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