Open Archive: Publications from Karolinska Institutet
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Novel technologies for studies of structural and functional connections
(Inst för neurovetenskap / Dept of Neuroscience, 2018-11-30)To understand the mechanisms underlying the correct functioning of an organ it is important to study its architecture and how the interactions between cells are leading to a specific function. Specifically, the connections ... -
How can health care organizations create value? Business model explorations
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2018-11-30)Background: The Triple Aim posits that health care should strive to improve patient experience, improve population health, and maintain or lower costs. However, most organizations are not organized to achieve the Triple ... -
Challenges in the management of urothelial cancer : novel treatment, evaluation of biomarkers, and imaging techniques
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-29)Urothelial cancer (UC) is the most common malignancy found in the urinary tract. The global annual incidence is approximately 430 000 new cases (Sweden: 3 200 new cases). Approximately one in four new UC patients being ... -
The role of HIF-1alpha in epigenetic regulation of transcription
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-11-27)The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating ... -
Fishing for cures : the zebrafish as a powerful tool to identify novel therapies against glioblastoma by targeting MTH1 and beyond
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-27)Glioblastoma (GBM) is the most aggressive form of brain cancer. Despite today’s combinatory therapy consisting of surgery, radio- and chemotherapy, the prognosis remains dismal. Fostered by extensive tumor heterogeneity, ...