Karolinska Institutet Open Archive
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Recruitment to multicentre randomised controlled trials in stroke : lessons learnt from the effects trial
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-26)Randomised controlled trials are the gold standard for evaluation treatments. Nevertheless, recruitment into trials is still challenging and many trials fail to meet their recruitment goals within the predetermined time. ... -
Immunopathogenesis in pulmonary tuberculosis : impact of immunomodulation and diabetes co-morbidity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-26)Even in the 21st century, tuberculosis (TB) remains a major global health threat, primarily due to the emergence of antibiotic resistance. Presence of co-morbidities such as diabetes mellitus (DM) has worsened the current ... -
Clinical aspects of device-detected arrhythmias
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2021-02-25)INTRODUCTION Cardiac implantable electronic devices (CIEDs) enable continuous monitoring of the heart rhythm. CIEDs constitute a unique opportunity for detecting arrhythmias, as the duration of cardiac monitoring is of ... -
Selenium compounds as a novel class of experimental cancer chemotherapeutics
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-02-25)Selenium is an essential micronutrient for humans, it has a narrow margin between antioxidant and pro-oxidant effects. Redox-active selenium compounds have the potency to increase ROS levels in cancer cells, providing a ... -
Method Development for [11C]carbon monoxide radiochemistry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-25)Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found extensive utility in biomedical research and in drug development. A fundamental pre-requisite for PET is the tracer, which is ...