Open Archive: Publications from Karolinska Institutet
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Children and adolescents with chronic pain: parental factors, functioning, and neurodevelopmental comorbidity
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-02-19)Background: Pediatric chronic pain affects between 11 and 38% of all children. Although pain may result from injury or disease, the cause of chronic pain is commonly unclear. The interaction between biological, psychological, ... -
The importance of thyroid function for female reproduction
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-02-18)Background: Thyroid dysfunction is one of the most common endocrine disorder. Thyroid dysfunction affects the female reproductive system and can be manifested by menstrual irregularities, pregnancy loss and infertility. ... -
Developing new models of childhood malignancies using human induced pluripotent stem cells
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-02-15)Early onset diseases such as childhood malignancies and neurodevelopmental disorders have been intricate to study. For many years, research has relied and dependent upon different animal systems. Despite the usefulness of ... -
Long-term effects of pre-and postnatal glucocorticoid treatment in congenital adrenal hyperplasia
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-02-15)Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder mostly caused by mutations in the CYP21A2 gene leading to impaired production of cortisol and aldosterone. Precursors in the steroidogenic pathway are ... -
Studies of effector functions in mycobacterium tuberculosis infected macrophages with implications for host-directed therapies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-02-15)Tuberculosis infection remains a global health problem and the emergence of multidrugresistant TB (MDR-TB) adds further challenges in the battle to stop the spread of infection. Macrophages are the primary host cells to ...