Open Archive: Publications from Karolinska Institutet
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Oxidative stress in cell and tissue damage and selenium-based therapeutics in cancer
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-25)Redox homeostasis is the balance between cellular prooxidants and antioxidants, maintained by the interplay of electrons. Reactive oxygen species (ROS) is a term for molecules with unpaired valence electrons or unstable ... -
Biased signalling at the IGF-1R : pitfalls and potential of the GRK/β-arrestin system in cancer therapeutics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-25)Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors ... -
Genetic epidemiology of cardiometabolic biomarkers : twin studies in the genomic era
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-05-25)Following the Human Genome Project, many genomic approaches have been developed in genetic epidemiology to investigate the genetic influences on human complex traits. This thesis aims to answer four genetic epidemiological ... -
Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-05-25)Protecting genome integrity is a vital task that is constantly challenged by various genotoxic stresses. Among different types of DNA damage, double-strand breaks (DSBs) constitute a particular threat since they result ... -
Pulmonary hypertension : the role and place of PDGF
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)Pulmonary hypertension is a severe condition, leading to right heart dysfunction and preterm death. For pulmonary arterial hypertension (PAH), a disease group in which the primary pathology resides within the pulmonary ...