Karolinska Institutet Open Archive
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Systems biology of mitochondrial dysfunction
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-04-12)The human body consumes vast amounts of metabolites that are transformed into one another, modified to useful building blocks and broken down to harvest their energy. Mitochondria are at the core of this metabolic turnover ... -
Prostate cancer : population-based screening and markers for long-term clinical outcome
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-12)In 1988 and 1989 a large screening study for prostate cancer was launched in Stockholm, Sweden. At the time approximately 27 000 men between 55 and 70 years of age resided within a defined area of southern Stockholm. 2400 ... -
Improving endometrial carcinoma diagnostics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-08)Endometrial carcinoma is the most common gynecological malignancy and greatly affects global disease burden. Despite it being among the most common cancers it is relatively understudied and until recently poorly understood. ... -
Epiphora : impact on vision, outcome of lacrimal surgery and investigations with ultra-high-frequency ultrasound
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-04-08)Epiphora is a common condition that often receives little attention. Excessive tear production creates an irregular and ever-changing ocular surface, affecting refraction and reducing vision. However, in a standard test ... -
Regulation of G2 phase and long-term consequences of DNA damage
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-04-08)Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated ...