Avhandlingar / Theses
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The role of RFX transcription factors in neurons and in the human brain
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-08-15)RFX transcription factors (TFs) are conserved in animals, fungi and some amoebae, but not in algae, plants and protozoan species. The conservation is based on the protein sequence of the DNA binding domain (DBD). The RFX ... -
Improving surgical therapy for oesophageal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-14)Despite advances in multimodality treatment, surgery remains the mainstay of curative treatment for oesophageal cancer. However short- and long-term mortality from oesophagectomy for oesophageal cancer still shows large ... -
Redox alterations in inflammatory diseases : diabetes, kidney failure and cancer
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-10)In order to combat oxidative stress and maintain the intracellular redox homeostasis, cells are equipped with antioxidant systems. The thioredoxin and glutaredoxin systems are the major thiol reducing systems and central ... -
Immune mechanisms in chronic rheumatic muscle inflammation, myositis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-08-10)The idiopathic inflammatory myopathies (IIM), shortly named myositis, is a group of heterogeneous and rare autoimmune diseases with the target tissue of skeletal muscle. It is not curable and affects the daily life of ... -
Renal dysfunction in heart failure : insights on prevalence and prognosis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-08-10)Background Kidney disease is common in heart failure (HF) and has been found to be associated with worse outcomes. The impact of different degrees of chronic kidney disease (CKD) in HF, as well as the link to, and ... -
Evidence by interaction : a new role of caspase-2
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-08-10)Caspase-2 is the best conserved member of the caspase family. Although being known to mediate cell death following DNA damage, many studies have implicated that this protease regulates a variety of cellular processes. ... -
Recurrent abdominal pain in children : the concept, aetiology, diagnostics and prognosis
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2018-08-10)Background: Recurrent abdominal pain (RAP) due to an abdominal pain-related functional gastrointestinal disorder (ap-FGID) is one of the most common disorders of childhood and it accounts for much suffering and many ... -
Optic nerve hypoplasia in children - prevalence, associated disorders and genetic causes
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2018-08-10)Optic nerve hypoplasia (ONH) is a congenital ocular malformation with a thin optic nerve in one or both eyes. ONH has been associated with neurodevelopmental disorders and pituitary dysfunction, but the prevalence of ... -
Diversity and focus of CMV specific T-cell responses in patients post-HSCT and with solid tumor
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-08-09)Human Cytomegalovirus (CMV) is a beta-herpesvirus that commonly infects humans. Most symptoms in healthy individuals are very mild. The virus is never eliminated and remains in the individual life-long. Thus, CMV and the ... -
High-intensity interval training in combination with aerobic or resistance training for patients with breast cancer : a HIIT to counteract detrimental effects of chemotherapy
(2018-08-09)With the increasing number of individuals that enter cancer survivorship there is a growing need for interventions that can alleviate treatment-related adverse effects such as fatigue, and that can improve and restore ... -
Structure and function relationships in the PGC-1 family of transcriptional coactivators
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-08-08)PGC-1 coactivators are central regulators of several cellular processes, most notably the coupling between energy demands and supply. PGCs activate distinct biological processes in a tissue-specific manner. These include ... -
Predictive biomarkers in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-08-07)Being a very heterogeneous disease, rheumatoid arthritis (RA) is challenging for treatment. On a group level, some therapy options might be superior compared with others, however, this does not mutually exclude the less ... -
Antiretroviral treatment outcome and molecular epidemiology of HIV-1 subtype C drug resistance in Ethiopia
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-08-06)Over the last decade, antiretroviral therapy (ART) has been rolled out in Ethiopia at a large scale. However, the outcome and aspects of drug resistance have been poorly studied at the national level. Also, the epidemic ... -
Making or breaking organizational interventions : the role of leadership
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2018-08-03)Introduction: In the occupational health literature, organizational interventions have been recommended as an effective way to improve employee health and well-being. However, meta-analyses and literature reviews have shown ... -
Leading implementation in health and social care : the line manager in the spotlight
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2018-08-03)Background: Health and social care organizations are frequently undergoing changes intended to improve quality of care and are expected to implement practices based on the best available evidence. However, about two-thirds ... -
Critical illness myopathy : mechanisms and pharmacological interventions
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-08-02)The human body typically contains over 600 skeletal muscles that make up about 40% of total body weight. These muscles work together to perform functions such as locomotion, breathing, mastication, heat regulation and ... -
Novel culture systems to model testicular function and organization
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2018-08-02)In vitro systems to model the testicular microenvironment are required to study physiology and pathology of the testis, the gonadotoxic effect of environmental and pharmaceutical chemicals, as well as to explore the ... -
Investigating the pathological heart and its regenerative potential
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-07-31)Cardiovascular disease is a leading contributor to mortality the world over, affecting millions of people each year. This, combined with its associated monetary and societal costs, has made the investigation of the ... -
Molecular characteristics of HIV-1 subtype C and its impact on therapeutic outcome in Ethiopia
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-07-26)HIV-1 is characterized by a high genetic diversity which poses several challenges and implications with regard to disease progression, drug resistance and outcome of antiretroviral therapy (ART). HIV-1 subtype C (HIV-1C) ... -
Psychological aspects in differences/disorders of sex development
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2018-07-24)Background Sex differentiation depends on a complex set of molecular events. These are at one point initiated by SRY gene expression and involve gene transcription, which in turn can be affected by the prescence ...