Avhandlingar / Theses
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Primary hyperparathyroidismc : nonclassical symptoms and benefits from parathyroidectomy
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-28)Primary hyperparathyroidism (PHPT) is characterized by an inadequate increase in calcium and parathyroid hormone levels in blood. The cause is usually a benign tumor, parathyroid adenoma, and the only curative treatment ... -
Analysis of extracellular vesicles and their application in immunotherapy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-09-28)Extracellular Vesicles (EVs) are nano-sized particles secreted by most, if not all, cell types. They are important mediators in intercellular communication and carry a broad array of biomolecules such as lipids, nucleic ... -
Mechanisms of inter-organ crosstalk mediated by tryptophan metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-09-28)Physical exercise and nutrition balance the “energy in-energy out” equilibrium that keeps the system at a dynamic homeostasis, energetically speaking. However, this is a simplistic vision of a dynamic system that is in ... -
Students’ workplace learning in primary health care : learning from patients
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-09-24)Background: Facilitation of patients’ participation in own care is considered key component to achieve a person-centered, high-quality care delivery. Person-centered care, including communication techniques and ... -
Prenatal metabolic risks for offspring neurodevelopmental and psychiatric disorders
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-24)Prenatal metabolic disturbances have been reported to increase the risk for offspring adverse outcomes. However, the joint (i.e. combined) effects of several prenatal metabolic exposures on offspring neurodevelopmental and ... -
Open tibial fractures in Sweden
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-23)Background Open tibial fractures are serious injuries, challenging both for patients and doctors. For the patients, personal, psychological and physical costs are enormous. For healthcare and society, open tibial ... -
Brief online interventions for concerned gamblers in a gambling helpline
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-09-23)Background: Problem gambling (PG) is common throughout the world and affects approximately 2% of the adult population in Sweden and most other western countries. Individuals who gamble in a problematic way experience ... -
Socio-economic differences in the healthcare utilisation of older persons in Sweden
(Inst för global folkhälsa / Dept of Global Public Health, 2021-09-22)The global population is ageing and this demographic change has important implications for the provision of healthcare and social care. Older people often have multiple and complex health problems and a range of different ... -
Bioinformatic methods in rare disease genomics
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-22)The larger goal of medical genetics is to map genotype to phenotype and to understand how genomic variation affects human health. In the field of rare disease genomics, there is a mendelian assumption that states: one ... -
Early life determinants of socioeconomic and health inequalities : life course studies within and across generations
(Inst för global folkhälsa / Dept of Global Public Health, 2021-09-20)The role of the early life social and maternal environments in the production of health inequalities was widely documented in the past few decades but the underlying mechanisms were often subject to suboptimal analytic ... -
Single-cell analysis of mammalian cardiogenesis elucidating an essential role of outflow tract progenitors
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-09-14)The heart is the first organ to form and start to function during mammalian embryogenesis. This complex organ system is constructed by a diverse set of cell types, involving mesodermal precursors and heart progenitors, ... -
Genetic predisposition to immune cell malfunction and inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds ... -
Gene regulation of acute insulin response in human adipose tissue in obesity and after weight-loss
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-09-10)The incidence and prevalence of obesity and type 2 diabetes is reaching epidemic proportions worldwide and insulin resistance, the pathophysiological link between the two conditions is consequently the focus of intense ... -
The epidemiology of varicella zoster virus disease in Sweden : before and after vaccination
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-09-10)Primary infection with the varicella zoster virus (VZV) presents as chickenpox, a highly contagious infection. Thereafter the virus establishes latency in nerve ganglia of the host. The virus may reactivate later in life ... -
Long-term follow-up after risk-reducing mastectomy and immediate breast reconstruction : from a patient, partner, and 3D perspective
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-10)BACKGROUND: Breast cancer is the most common type of cancer among women. Approximately 5–10% of all breast cancer cases have an inherited pattern, and ~20% of all hereditary cases have an identifiable mutation. Through ... -
Learning from primary immunodeficiencies to treat cancer
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-09)The immune system is a fine-tuned network of cells, tissues, organs and biological processes working together in order to protect our body. Immunodeficiency disorders occur when the body’s immune system is reduced or absent ... -
From in-situ simulation to beyond : improving paediatric trauma care
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-09-08)Background: In-situ-simulation (ISS) has been adopted across the globe as an educational tool to enhance the quality of care provided to severely injured children. As an intervention that trains individuals where they ... -
Cholestasis in infants at risk
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-09-03)Cholestasis is a condition when bile flow from the liver to the intestines is impaired. Unresolved, it may lead to liver transplantation or death. Overall, it affects 1 out of 2500 term infants, but is far more common ... -
Redox regulation of T cells in autoimmunity
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-09-03)Autoimmune disorders affect a significant part of the population and therefore present a serious health and economic burden. One of the most common autoimmune diseases is rheumatoid arthritis (RA), affecting 0.5-1% of the ... -
Hfq- and sRNA-mediated regulation in Neisseria meningitidis
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-03)Neisseria meningitidis, also known as the meningococcus, is a human-specific pathogen that commonly colonises the nasopharynx without causing disease. For reasons unknown, N. meningitidis can traverse the nasopharyngeal ...