Avhandlingar / Theses
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A fishing expedition for antidiabetic drugs : identifying new avenues to stimulate beta-cell regeneration
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-10-15)All types of diabetes are characterized by loss of the insulin-producing β-cells that reside in the pancreas. While current treatments can manage the disease, there is still no cure available. Understanding and promoting ... -
Physical capacity, physical activity and skeletal muscle in heart failure : studies of pathophysiology
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-10-15)The overall aim of the present thesis was to provide a better understanding of the pathophysiology of heart failure (HF), especially to explore possible mechanistic links between the failing heart and the periphery, as ... -
Analysis of antibodies to cartilage oligomeric matrix protein in rheumatoid arthritis and in mouse models
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-10-13)Rheumatoid arthritis (RA), a common autoimmune disease, affects 0.5-1% of the world’s population. It is not only an important health problem but also a socioeconomic problem considering that it can lead to joint destruction ... -
Gene regulation in normal and malignant B-lineage cells
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-10-13)B-cells are the central players of humoral immunity. It is known that their development is orchestrated by a small group of transcription factors including the E-proteins and the FOXO proteins, yet this process is far ... -
Biological ages: correlations, genetic determinants, and health outcomes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-10-08)Population aging is a global trend and requires better evidence-based guidance. This thesis studied population aging from a molecular epidemiological angle. The overall work is centered on the “biological age (BA)”, which, ... -
Bridging the gap : patients and professionals perspective on risk and recovery in forensic psychiatry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-08)Background: The aim of forensic psychiatry is to protect society and care for offenders with severe mental illness (SMI). People with severe mental illness show a certain increased risk of committing violent crimes, which ... -
Promoter mutations/methylation in thyroid and urothelial carcinomas : biological and clinical implications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-10-06)Genetic and epigenetic aberrations are well established to drive cancer development and progression. However, the underlying mechanisms are incompletely understood, and the translational applications of aberrant alterations ... -
Modulating the activity of OGG1 using small molecules to target the oxidative DNA damage response in cancer and inflammation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-10-05)The production of reactive oxygen species (ROS) is increased in several pathological conditions including cancer and inflammation. Multiple lines of evidence suggest that ROS are involved in signaling events that promote ... -
The Chiranjeevi Yojana (CY) : a public-private-partnership to promote institutional births in Gujarat, India : studies of providers and users
(Inst för global folkhälsa / Dept of Global Public Health, 2021-10-05)Introduction: National, regional and local governments, particularly in lower middleincome countries, are encouraged to pursue partnerships with the pool of private providers available to them, in order to achieve the ... -
Do-Not-Attempt-Cardiopulmonary-Resuscitation decisions in the hospital setting
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-10-01)Background: A Do-Not-Attempt-Cardiopulmonary-Resuscitation (DNACPR) order can be placed when CPR is not in accordance with the patient’s will, when CPR is considered not to benefit the patient, or when CPR is very unlikely ... -
Antisecretory factor in the perinatal period
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-10-01)Preterm birth is the major cause of neonatal morbidity and mortality. Human milk, especially mothers’ own milk, has many health benefits for infants, especially infants born preterm. The causes of preterm birth are not yet ... -
Effects of insulin on the decidualization of human endometrial stromal cells : in vitro studies
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2021-10-01)Hyperinsulinemia is a known characteristic of obesity and polycystic ovary syndrome, two common clinical conditions associated with reproductive problems. However, the underlying mechanisms to reduced fertility are not ... -
Defining the role of CAAX protein proteolysis and methylation in the pathogenesis and treatment of progeria
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-10-01)Hutchinson-Gilford progeria syndrome (HGPS) is a rare childhood disease characterized by failure to thrive, bone abnormalities, hair loss, and a shortened life span due to cardiovascular disease, and nuclear shape abnormalities ... -
Deciphering the complexity of biological systems using machine learning applied to big data
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-10-01)With the rising of the omics era and the recent technological advancements in biology and medicine, the generated data is growing exponentially. Increasing the volume of the data in parallel to complexity and heterogeneity ... -
Anti-gene oligonucleotides : DNA binding and therapeutic application
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-10-01)The field of nucleic acid therapeutics has in the last decade experienced substantial growth. This is evident from a multitude of new publications, an increasing number of clinical trials and several approved therapeutics ... -
Dynamic changes in chemotactic and metabolic properties in tumor cells undergoing TGFb1-induced Epithelial-Mesenchymal Transition (EMT)
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-09-30)Epithelial-Mesenchymal Transition (EMT) is a process linked to several hallmarks of cancer including metabolic switching, inflammation, and chemotactic properties. Tumor cells that undergo EMT lose epithelial characteristics ... -
Platelet-regulated CD4+ t effector cell responses in atherosclerosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-09-30)Atherosclerosis (AS) is a thrombotic and inflammatory disease of the medium- and largesized arteries. Platelets participate in all stages of its formation, forming thrombus at the ruptured plaque; meanwhile, CD4+ T cells ... -
A view from the top : the local politico-administrative leadership in implementing evidence-based practice in social services
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-09-30)Background: Evidence-based practice is a way to integrate three knowledge sources into decision-making: research evidence, professional expertise, and client preferences and experience. It is argued that evidence-based ... -
Primary hyperparathyroidism : nonclassical symptoms and benefits from parathyroidectomy
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-09-28)Primary hyperparathyroidism (PHPT) is characterized by an inadequate increase in calcium and parathyroid hormone levels in blood. The cause is usually a benign tumor, parathyroid adenoma, and the only curative treatment ... -
Analysis of extracellular vesicles and their application in immunotherapy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-09-28)Extracellular Vesicles (EVs) are nano-sized particles secreted by most, if not all, cell types. They are important mediators in intercellular communication and carry a broad array of biomolecules such as lipids, nucleic ...