Avhandlingar / Theses
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Structural and functional brain connectivity abnormalities associated with adolescent conduct disorder in females
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-22)Background: Antisocial behavior (ASB) in childhood and adolescence is indexed by the diagnosis of conduct disorder (CD) and is associated with high rates of comorbid mental disorders, such as anxiety, depression, alcohol ... -
Diverse effects of endocrine-disruptive chemicals on Leydig and adrenocortical cell steroidogenesis in rodents and humans
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2017-09-22)We are living in a man-made world and often exposed to different chemicals known as endocrine disrupting chemicals (EDCs) that negatively influence our hormonal system. These compounds have the potential to interrupt a ... -
Monitoring calls in telephone advice nursing : parents´and telenurses´experiences
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-09-22)Background: Approximately 2 million of the 4.5 million calls made in 2016 to the 1177 healthcare advice line resulted in the telenurse providing self-care advice to the care seeker. In some of these calls, the care seekers ... -
Smak- och luktförändringars betydelse för personer i olika skeden av utredning och behandling vid lungcancer
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2017-09-20)Bakgrund: Smak och lukt är två av våra sinnen som tillsammans med andra sinnesförnimmelser är centrala för smakupplevelsen av sådant som vi äter och dricker. Smakoch luktsinnena har också som funktion att uppmärksamma oss ... -
Violence among offenders with mental disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-20)Background Interpersonal violence is described as a global health problem by the World Health Organization. Even though individuals with severe mental disorders commit only a fraction of all violent acts, they appear ... -
Understanding chronic immunodeficiency disorders through assessment of cytotoxic lymphocyte function
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2017-09-20)Representing an evolving and diverse group of syndromes, immunodeficiencies can currently be viewed as a spectrum of disorders where a dysfunction of the immune system plays a significant etiologic role. Cytotoxic ... -
Epidemiological studies of medication use and effectiveness in bipolar disorder
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-09-19)In the last decades, new treatments for bipolar disorder (BD) have emerged, prompting a decrease in the use of lithium – the former “gold standard” for relapse prevention, and increasing the possibilities for individualized ... -
Brain networks in time : deriving and quantifying dynamic functional connectivity
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-18)Studying the brain’s structure and function as a network has provided insight about the brain’s activity in health and disease. Networks in the brain are often averaged over trials, frequency and time and this is called ... -
The role of telomerase reverse transcriptase in human malignancies : genetic polymorphisms and promoter mutations
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-09-15)Telomerase is a ribonucleoprotein with its catalytic subunit telomerase reverse transcriptase (TERT) as a key component, lengthening telomeres. In differentiated human cells, telomerase is silent due to the transcriptional ... -
The role of SOXC transcription factors in B-cell development and lymphoid malignancies
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-09-15)Mantle cell lymphoma (MCL) accounts for 5-10% out of all Non-Hodgkin lymphomas (NHLs) and is one of the most aggressive forms of lymphomas with a median survival of less than 5 years. Currently, MCL is considered to be an ... -
Aspects on interventions in complicated gallstone disease
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-09-15)Background: Laparoscopic cholecystectomy (LC) is the standard treatment for symptomatic gallstone disease. In 10-15% of these patients, common bile duct stones (CBDS) are encountered. These are managed commonly by ... -
Approaches to modulate vaccine-induced antibody responses
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-09-15)Most successful licensed vaccines mediate protection by inducing antibody responses capable of protecting the individual from infection or disease. Despite the availability of many effective vaccines, we lack knowledge ... -
Cutaneous malignant melanoma : body site, sun exposure, genetic factors and prognosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-09-14)Background: The interplay between tumor site, ultraviolet radiation (UVR) exposure, genetic factors and various epidemiological parameters of cutaneous melanoma is complex. In this thesis, we aimed to investigate the impact ... -
Molecular studies on the autoantibody-mediated bone destruction in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-09-14)Autoantibody-positive rheumatoid arthritis (RA), also called seropositive RA, is characterised by the presence of anti citrullinated proteins antibodies (ACPA) that can be detected in blood several years before disease ... -
Information processing and expectations in delusion-proneness
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-09-11)One of the most characteristic features of psychosis is delusional ideation. Delusions represent incorrect and inflexible beliefs that are not based on reality. It has been proposed that delusions may be secondary to ... -
Characterizing cancer cell signaling at the protein level : from targeted to proteome and phosphoproteome‐wide analyses
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-09-11)Proteins are the effectors of cellular functions and the constituting elements of cellular signaling cascades. The ability to analyze the abundances and the dynamics of proteins is central to dissect cellular signaling ... -
Astrocytes : a reservoir for new neurons
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-09-08)The goal of regenerative medicine is to be able to help the body to replace worn-out cells and tissues. To achieve this goal, one approach being pursued today is to recruit and boost the body’s own mechanisms for cell ... -
Transcriptomic and taxonomic profiling of periodontitis by massively parallel sequencing
(Inst för odontologi / Dept of Dental Medicine, 2017-09-08)Periodontitis is a microbial-induced, chronic inflammatory disease that affects tissue and bone anchoring the teeth, and can ultimately lead to tooth loss. In addition, periodontitis may contribute to systemic diseases, ... -
Human immunodeficiency virus and human papillomavirus infections in Mozambique : from epidemiological reports to clinical trials and vaccine implementation
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-09-08)Human immunodeficiency virus (HIV) and human papillomavirus (HPV) are sexually transmitted microorganisms responsible for two major infectious diseases and public health concerns, particularly in developing countries and ... -
Chronic kidney disease of unknown etiology in Central America and Sri Lanka : renal morphology and clinical characteristics
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-09-07)Background: Chronic kidney disease (CKD) is a global health problem. The most common etiologies of CKD are diabetes mellitus, hypertension, and glomerulonephritis, but over the last several decades a high prevalence of ...