Avhandlingar / Theses
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Studies on myeloid cell functions in periodontitis
(Inst för odontologi / Dept of Dental Medicine, 2020-08-05)Periodontitis (PD) is a chronic inflammatory disease characterized by destruction of the tooth supporting tissues; gingiva, periodontal ligament, and alveolar bone. Myeloid cells, including monocytes and macrophages, play ... -
Limb ownership and voluntary action: human behavioral and neuroimaging studies
(Inst för neurovetenskap / Dept of Neuroscience, 2020-08-05)To be able to interact with our surroundings in a goal directed manner, we need to have sense what our body is made up of as well as a sense of being able to control our body. These two experiences, the sense of body ... -
Understanding the role of non-coding RNAs in skin homeostasis and cancer
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-04)The epidermis is a stratified epithelium with continuous self-renewing capacity. As the outermost layer of our body, it provides a protective barrier against external trauma, produces pigmentation, and keeps the skin ... -
Models of the lung tissue microenvironment for studies of human myeloid cell function
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-07-31)Studies of the immune system requires knowledge concerning not only the perturbating event itself, i.e. specific microorganisms, and how it interacts with immune cells but also how it functions in its natural environment ... -
Interleukin 15 throughout murine natural killer cell biology
(2020-07-31)Natural killer (NK) cells are innate immune cells that mount responses against virally infected, transformed and allogeneic transplanted cells. Equipped with cytolytic molecules and death receptors, NK cells mediate ... -
Oxygen sensing in myeloid cells : implications for physiology and cancer
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-07-31)All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O2) through inspiration. In the lungs, O2 is gathered by erythrocytes that consequently deliver it to all cells by the ... -
Genotoxic effects among Bolivian farmers exposed to mixtures of pesticides : population and in vitro based studies
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-07-31)Human exposure to pesticides has increased exponentially in recent decades, especially in low- and middle-income countries where regulations on the use of pesticides and personal protective equipment (PPE) are not fully ... -
Neuromodulation shapes interneuron communication in the mouse striatum
(Inst för neurovetenskap / Dept of Neuroscience, 2020-07-24)A proper understanding of cognition relies on detailed knowledge about the functional connectivity within and between brain areas. The striatum is generally regarded as the input structure to the basal ganglia, a group of ... -
Late-stage 11C-carbonylation of drug-like molecules for PET
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-07-23)Positron emission tomography (PET) is a non-invasive in vivo imaging technique used for translational biomedical research and clinical diagnosis. A fundamental pre-condition for PET is the radiolabelled tracer molecule ... -
Understanding the response to EGFR targeting therapy in non-small-cell lung cancer using -omics approach
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-07-21)NSCLC is the leading cause of cancer-related death worldwide. EGFR targeted therapy is used to inhibit the progress of NSCLC, but patients inevitably develop resistance to EGFRTKIs. The work presented in this thesis ... -
Conformational dynamics in microRNAs : the example of miR-34a targeting Sirt1 mRNA
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-06-17)In biology, regulatory mechanisms are essential to achieve complex tasks, as virtually every process can be positively or negatively modulated in its outcome, upon different cues. In humans, microRNAs (miRNAs) ... -
Fibrinogen-binding proteins from Staphylococcus aureus
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-06-08)Staphylococcus aureus produces a large number of proteins that specifically bind to molecules from plasma or from the human extracellular matrix where they are involved in processes associated with the colonization of the ... -
Exploring chromatin organization and transcription in S.pombe and hematopoietic development
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-05-28)DNA in the eukaryotic nucleus is organized into histone-DNA complex, so-called chromatin, through forming an array of nucleosomes. Each nucleosome consists of a 147bp DNA wrapped around a histone octamer harboring two ... -
Extensive tooth wear in adults : classification and prosthetic treatment
(Inst för odontologi / Dept of Dental Medicine, 2020-05-27)Background: Tooth wear (TW) is an insidious and cumulative mul- tifactorial process that may comprise erosion, abrasion or attrition, and combinations thereof. These different processes are of chemical or physical origin ... -
Common respiratory virus infections in cystic fibrosis : from immunity to vaccine
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-27)Cystic fibrosis is the most common lethal monogenetic disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator protein which is responsible for appropriate ion and water ... -
Endometrial regeneration : unraveling the mysteries of the stroma
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-05-27)The healthy endometrium has the unique capacity of shedding and regenerating its functional layer once every menstrual cycle, under the regulation of hormones, progenitor cell populations and inflammatory mediators. ... -
Immunometabolic network interactions of the kynurenine pathway in cutaneous malignant melanoma
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-26)Cancer is the second leading cause of mortality worldwide, and melanoma represents the most aggressive and deadliest form of skin cancer. Despite the various therapeutic approaches, metastatic melanoma is a disease with ... -
A study on the role of T helper cells in allergic inflammation
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-26)Asthma is a chronic inflammatory disease of the airways affecting hundreds of millions of people worldwide. Central to the development of asthma and allergic airway inflammation are CD4 T cells, which upon activation through ... -
Cerebral oedema after reperfusion therapy in patients with ischaemic stroke : predictors, outcomes and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-26)Introduction: Reperfusion therapy by intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT) are established treatments in ischaemic stroke. Cerebral oedema (COED), caused by dysfunction the blood brain ... -
Hygiene at CT and MRI
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-26)Background: Preventing the spread of infections is a constant battle against microorganisms. Hospital-acquired infections (HAIs) with multidrug-resistant (MDR) bacteria are a global problem today and causes suffering for ...