Avhandlingar / Theses
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Pharmacoepidemiological studies of rheumatoid arthritis : methodological considerations and applications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-08-04)Study I – Biological disease-modifying anti-rheumatic drugs (DMARDs) and the risk of gastrointestinal perforations: Study I was motivated by previous signals of an increased risk of lower gastro-intestinal perforations ... -
Register-based studies of infertility and the use of assisted reproductive techniques : possibilities and challenges
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-08-04)The implementation of assisted reproductive techniques (ART) has enabled over 10 million births in the past 45 years. Concern for excess risks of adverse birth outcomes has largely, but not entirely, been mitigated by ... -
Development of immunomodulatory RNA therapeutics for immune disorders
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-08-03)Autoimmune diseases such as Rheumatoid Arthritis (RA) are complex and involve many different cell types. Of these cell types, T cells are thought to be key drivers of the inflammation. The current treatment options available ... -
Novel markers for smooth muscle cell modulation in vascular injury and disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-08-02)Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during ... -
The role of innate immunity in obesity-induced tissue inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-08-02)The prevalence of obesity is rapidly increasing globally, which causes an increase in associated diseases such as type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). In addition to the ... -
Exploring inter- and intra-heterogeneity in childhood neuroblastoma and pheochromocytoma
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-08-01)Neuroblastoma is the most common extra-cranial solid tumor of the sympathoadrenal cell lineage, which is a unique pediatric malignancy with remarkable inter- and intra-tumoral heterogeneity. In infants, neuroblastoma can ... -
Real-world outcomes in oncology : assessing the value of rewardable innovation
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-07-29)Recent years have seen a remarkable expansion of therapeutic options available for many forms of cancer. Evidence for the efficacy of these treatments have mainly come from randomized controlled trials, however questions ... -
Aspects of medical knowledge sources among junior doctors and general practitioners : needs, use, values and effects
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-07-29)INTRODUCTION Physicians are facing increasing demands to keep up with the accelerated expansion of medical knowledge. There is a rapid development and adoption of information technology in today’s health care, ... -
Elucidating the principles of gene regulation in the human genome
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-07-28)Gene regulation is largely controlled by two groups of cis-regulatory elements: (i) promoters that initiate stable mRNAs and (ii) enhancers that generate bidirectionally transcribed unstable enhancer RNAs (eRNAs). While ... -
The effect of spinal manipulative therapy on heart rate variability and pain in patients with persistent or recurrent neck pain
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-07-26)OBJECTIVE: Persistent or recurrent neck pain is a common reason to seek healthcare. Manual therapy in combination with exercises is recommended by clinical guidelines for this patient group. Autonomic dysregulation ... -
Machine learning methods for precision medicine
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-06-17)In precision medicine, predicting the risk of an event during a specific period may help, for example, to identify patients that need early preventive treatment. Modern machine learning (ML) techniques are therefore ideal ... -
A clinical epidemiological study on end-stage liver disease in Ghana
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-06-01)End-stage liver disease (ESLD), including advanced liver cirrhosis and hepatocellular carcinoma (HCC), is the final stage of long-standing injury to the liver due to risk factors such as chronic viral hepatitis and alcoholic ... -
Investigation of tumour/stroma crosstalk in pancreatic cancer by an advanced 3D co-culture model
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2022-06-01)Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies all over the world. This dire situation is mainly attributable to the dense desmoplasia in the tumour microenvironment (TME) and almost complete ... -
Towards a cohesive understanding of the DNA damage response as a therapeutic target
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-06-01)At the basis of the complexity that forms a human being is a highly regulated interplay of factors found at a molecular, cellular, and macroscopic level. Ever since we evolved to work this way, even the slightest dysregulation ... -
HealthyMoms : a smartphone application to promote healthy weight gain, diet and physical activity during pregnancy : a randomized controlled trial
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-06-01)Background: The prevalence of overweight and obesity is a major public health concern, also among pregnant women. Alarmingly, around half of pregnant women in high income countries exceed the recommendations for an optimal ... -
Evaluation of genetic cancer predisposition and potential cancer genes
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-05-30)Germline pathogenic TP53 variants are associated with a broad spectrum of hereditary cancers characterized from Li-Fraumeni syndrome (LFS) to hereditary breast cancer (HBC) outcomes, known as heritable TP53-related cancer ... -
A modular mRNA approach to study and treat phospholamban mediated cardiomyopathies
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-05-30)In the heart, phospholamban (PLN) is a key regulator of calcium cycling through its inhibitory effect on the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump. For more than two decades, modulating calcium channels ... -
Neural stem cell therapy and inflammation status of post-traumatic syringomyelia
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-05-30)Post-traumatic syringomyelia (PTS) is a severe complication of chronic spinal cord injury (SCI) with intraspinal expanding cysts as the major pathology. PTS occurs in up to 30 % of SCI patients, and time of diagnosis is ... -
Estrogen regulation of non-Hodgkin lymphomas and its underlying mechanisms
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2022-05-30)Most non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL), show a higher male to female incidence ratio. The reason for this is not clear, but epidemiological and ... -
Effects of lifestyle intervention in overweight women with polycystic ovary syndrome : aspects on reproduction, metabolism, psychological well-being and sleep
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2022-05-30)Lifestyle intervention is the first line treatment for many symptoms in women with polycystic ovary syndrome (PCOS). However, the efficacy of this treatment in comparison to minimal intervention for improving aspects ...