Avhandlingar / Theses
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On the neuronal basis of cognition : cell-type specific circuitry and functions of the prefrontal cortex
(Inst för neurovetenskap / Dept of Neuroscience, 2019-12-13)This thesis recapitulates the history of research, and current knowledge, of the prefrontal cortex (PFC) in order to provide a context for the included scientific articles. The evident, but ill-defined, symptoms of a ... -
Optimization of pediatrics antiretroviral treatment outcomes among HIV infected children in Ethiopia
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-12-11)Ending the HIV/AIDS epidemic by 2030 is a global agenda. To meet this global goal, having safe and effective antiretroviral therapy is a key requirement. In Ethiopia, the safety and efficacy of combination antiretroviral ... -
Regulation of vaccine immunity : from myeloid cell functions to antibody responses
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-12-05)The generation of vaccine-induced protection against infections relies on a well-coordinated network of innate immune responses, adaptive cellular responses, and humoral responses. Sufficient stimulation of the innate ... -
Regulation of chromatin transitions in the 3D architecture of the nucleus
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-11-27)The thesis explores the dynamic features and functions of chromatin crosstalk in the 3D nucleus space, with a focus on the regulation of chromatin transitions. In Paper I we employed the circular chromosome conformation ... -
Role of tartrate-resistant acid phosphatase in bone remodeling
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-11-27)Tartrate-resistant acid phosphatase is a metalloenzyme that exists as two isoforms: the monomeric TRAP 5a and the proteolytically cleaved TRAP 5b, responsible for phosphatase activity, which is highly expressed in osteoclasts ... -
Amyotrophic lateral sclerosis and multiple sclerosis associated neuroinflammation : nationwide epidemiological studies on etiology, comorbidities, and treatment
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-11-26)Amyotrophic lateral sclerosis (ALS) is a relatively rare but fatal neurodegenerative disease characterized by progressive muscle paralysis, due to loss of upper and lower motor neurons. Signs of neuroinflammation have been ... -
Periodontitis and invasive oral treatment in relation to myocardial infarction : epidemiological studies
(Inst för odontologi / Dept of Dental Medicine, 2019-11-25)Background: Cardiovascular disease and periodontitis are major global health problems that are a large burden for the individual and society. During the last 30 years, it has been discussed whether there is an association ... -
Hormonal and metabolic effects of diet and physical exercise in overweight/obese women with polycystic ovary syndrome.
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-11-22)Background: Overweight/obese women with polycystic ovary syndrome (PCOS) often have hormonal problems characterized by irregular menses and decreased fertility. In addition, the overweight/obese women carry metabolic ... -
Health effects of road traffic noise in childhood and adolescence
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-11-22)Traffic noise is an increasing environmental exposure, primarily as a consequence of continuous urbanisation and growth of the transport sector. The burden of disease from noise is the second highest in Europe among all ... -
On the origin of ACPA : exploring the role of P.gingivalis in the development of rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-11-22)Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by chronic synovial inflammation, joint destruction, and the presence of anti-citrullinated protein autoantibodies (ACPA) in a majority of patients. ... -
Epidemiology, prevention and control of Legionnaires’ disease in Europe
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-11-22)Legionnaires’ disease (LD) is a water-borne infection cause by Gram-negative bacteria Legionella spp. with virtually no person-to-person transmission. The clinical presentation is a severe pneumonia with a case fatality ... -
Too tired to talk? Sleep, fatigue, and social functioning
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-21)Sleep has been shown to have many health promoting functions, and is vital for the maintenance of physiological, cognitive, and emotional well-being. Much of what we know about sleep derives from studies showing what happens ... -
Translational investigations of novel and current antitumoral therapies in gastrointestinal stromal tumors
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-11-21)Gastrointestinal stromal tumor (GIST) is the most common human sarcoma. Its incidence is around 10-15 per million person-years, translating into 150 new cases each year in Sweden. The molecular background for the absolute ... -
Definition of immunoglobulin germline genes by next generation sequencing for studies of antigen-specific b cell responses
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-21)Immunoglobulins play a critical role in the adaptive immune system, existing as cell surface-expressed B cell receptors and secreted antibodies. Circulating antibodies are the main correlate of protective immunity for most ... -
Single cell analysis of iPS derived neural stem cells and neurons
(Inst för neurovetenskap / Dept of Neuroscience, 2019-11-21)In vitro derived neural stem cells can be used to model events of neurogenesis and neurodevelopmental dysfunction. Formation of stable neural stem cell environments relies on cellular components to stabilize cell-to-cell ... -
Web-based ECG education : utility and usage in undergraduate medical education
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-11-20)Investigating the heart with an electrocardiogram (ECG) is an important, frequent and noninvasive investigation. Failure to correctly interpret the ECG may harm the patient. Learning to interpret ECGs is difficult for ... -
To scar or not to scar : origin and function of fibrotic tissue in the central nervous system
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-11-20)After injury, the adult mammalian central nervous system lacks long-distance axon regeneration, and insufficient repair results in the formation of a multicellular and compartmentalized scar. A great body of work has ... -
Influence of chronic kidney disease on presentation, treatment and outcome in patients with coronary artery disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-11-20)Background. About one third of patients with myocardial infarction (MI) have renal dysfunction (RD). Concomitant coronary artery disease (CAD) and RD is accompanied by a markedly higher risk of death and subsequent ... -
Evaluation of potential antidiabetic and antibacterial activities of Bolivian nutraceutical plants
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-11-19)Type 2 diabetes mellitus is a health problem worldwide that requires the search for novel therapeutic strategies. Natural products are a source of potential therapies due to their acceptation and traditional use or ... -
The role of atrial fibrillation in cognitive aging : a population-based study
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-11-18)The role of atrial fibrillation (AF) in brain and cognitive aging (e.g., cognitive decline and dementia) is still unclear. In this doctoral thesis, we aimed to investigate the temporal trends and potential determinants ...