Avhandlingar / Theses
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Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-07-29)Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic ... -
Executive functions and successful behavior
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-07-28)Executive functions are the underlying mechanisms that drive top-down regulation of information processing. While suboptimal executive functions have been investigated in various groups of patients, their impact and ... -
Improved statistical methodology for high-throughput omics data analysis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-07-19)Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ... -
Mechanisms of flavor perception : how odor and taste interact when we eat
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-06-02)Every time we eat, our brains are bombarded with sensory information from the olfactory and gustatory modalities. Through a binding process that is not fully understood, the odor and taste are then merged into flavor, a ... -
Sexual violence : epidemiology, treatment and health care access
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-06-01)Sexual violence is recognized by the World Health Organization as a “… global public health problem of epidemic proportions, requiring urgent action” [1]. In Sweden, the estimated incidence of penetrative sexual violence ... -
Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues ... -
Exploring mTOR-dependent regulation of mRNA translation in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation ... -
Atopic dermatitis in adults : epidemiological studies of comorbidity and studies of patients on systemic treatment
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-06-01)Background: Atopic dermatitis (AD) is one of the most common chronic skin disorders globally. It is an itchy inflammatory skin disease that can have a detrimental impact on health-related quality of life. In recent years, ... -
Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies ... -
Enterprise within the enterprise : a study of management and performance in a public health care delivery organisation
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-06-01)Background The challenges in healthcare are an everyday struggle for managers. Efficiency and responsiveness of public sector services have been of interest over the past decades. Different reforms have been launched. ... -
Neuroinflammation and its resolution in Alzheimer's disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)Alzheimer's disease (AD) is the most common dementia with high prevalence among an increasing aged population. Despite the existence of symptom-reliving drugs for AD, the clinical trials performed until now have failed ... -
Post-migration stress and mental health among refugees : a population-based survey among refugees from Syria recently resettled in Sweden
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-31)Refugees are exposed to several risk factors for mental ill health before, during, and after the migration. While the impact of traumatic experiences on the mental health of refugees is well-known, the effect of adverse ... -
Optimization of intermittent preventive therapy for malaria during pregnancy : effectiveness of dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-28)Malaria is a Tropical disease caused by different parasites species of genius Plasmodium. Because of pregnancy associated lowered immunity, women who are pregnant are at higher risk to malaria infection than non-pregnant ... -
Deciphering the role of genetics and circadian rhythm in cluster headache
(Inst för neurovetenskap / Dept of Neuroscience, 2021-05-28)Cluster headache (CH) is a complex neurovascular disorder with a distinct circadian attack pattern. Although many aspects of the disease’s pathophysiology remain to be elucidated, it is likely caused by a combination of ... -
Studies of inflammatory responses in hantavirus infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)Throughout the world, orthohantaviruses cause severe, acute infections in humans. Orthohantaviruses, commonly referred to as hantaviruses, are zoonotic viruses with a single stranded RNA genome of negative sense. Hantavirus ... -
Exposure-based cognitive behavior therapy for atrial fibrillation : a novel treatment paradigm
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-28)Background: Atrial fibrillation (AF) is a prevalent arrhythmia associated with symptoms such as irregular heartbeat, palpitations, dyspnea, chest pain and fatigue. In many patients, AF symptoms are not alleviated by ... -
Objectively measured eating behaviors and their relation to food intake in school and hospital settings
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-05-28)Introduction: The measurement of food intake (what and how much we eat and drink) is of great importance due to its involvement in three great challenges facing humanity: 1) obesity/overnutrition, 2) undernutrition and ... -
PAK4 in organ development and cancer initiation
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-05-28)Tumors are complex organs with a unique ecosystem containing tumor cells entangled with various infiltrating cells. Tumors have distinct signaling signatures, which confers upon it the ability to grow in the primary host ... -
An object's smell in the multisensory brain : how our senses interact during olfactory object processing
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-28)Object perception is a remarkable and fundamental cognitive ability that allows us to interpret and interact with the world we are living in. In our everyday life, we constantly perceive objects–mostly without being aware ... -
From fatty liver to end-stage liver disease through type 2 diabetes
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-05-28)The past decades have seen a marked increase in the incidence of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Epidemiological studies have clearly demonstrated that there is an association between type 2 ...