Avhandlingar / Theses
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Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-01-17)The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. ... -
Mantle cell lymphoma : studies of predictive markers, the role of the microenvironment in disease development and identification of new potential targets for therapy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-01-16)Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma and accounts for 5-10 % of all non-Hodgkin lymphomas (NHL). In Sweden, the incidence of NHL is 21.6 and 15.3 per 100 000 persons for men and women, respectively, ... -
Cognitive behavioral therapy for stress-related disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-01-16)Background: Stress-related disorders in the form of adjustment disorder (AD) and exhaustion disorder (ED) are prevalent and associated with significant suffering, functional impairment and high societal costs. Cognitive ... -
Exploring paths to youth suicide and sudden violent death : a multimethod case-control investigation
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-01-16)Suicide and other forms of sudden violent death are the most common causes of death among young people worldwide. Both suicide and other forms of sudden violent death are more frequent among males than females. Risk ... -
Evaluation of prostheses in shoulder arthroplasty : methods for assessment of outcome
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-01-15)Today, the shoulder joint is the third most commonly replaced joint after the hip and knee joints and the incidence is increasing. In Sweden, 1863 primary Shoulder Arthroplasties and 195 revisions were performed in 2017. ... -
Demyelinating conditions regulated by ROS pathways outside and inside the brain
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-01-14)Multiple sclerosis (MS) is a chronic inflammatory condition of the central nervous system with immune-mediated damage on myelinated nerve tracts. Accumulating evidence support a role for autoreactive T-lymphocytes ... -
Ultrasound assessment and risk prediction in women with endometrial cancer
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-01-09)Background: Endometrial cancer is the most common gynecological cancer in the industrialized world, constituting 4.5% of all cancer in Swedish women. Standard surgery is hysterectomy and bilateral salpingo-oophorectomy, ... -
DNA methylation and aging : a longitudinal study of old Swedish twins
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-01-09)DNA methylation is a well-known biomarker of aging. Many previous studies have reported the change of DNA methylation patterns with age, and analyzed DNA methylation in association with aging outcomes. However, most ... -
Major lower limb amputation in peripheral arterial disease : treatment outcome, risk factors, and health-related quality of life
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-01-09)Critical limb ischemia is the end stage of peripheral arterial disease. These patients have a high risk of amputation and death regardless of revascularization. One of the most important questions for the patient and the ... -
Family-based prevention of childhood obesity : long-term outcomes, challenges and implications for future research
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-01-03)Background: Childhood obesity is considered to be one of the most serious health challenges of the 21st century. There have been indications that the prevalence has reached a plateau in high-income countries, yet the ... -
Retinal tumorigenesis and neurodegeneration : strategies to promote tumor cell death and support retinal cell survival to preserve vision
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-27)Our vision is central to our quality of life enabling us to interact with our environment and lead productive lives. The ability to see begins in the retina, one of the paramount features of the eye, as it takes on the ... -
The papilla of Vater : issues relevant to transpapillary cannulation and clinical management.
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-12-20)Background: Many endoscopists have since the beginning of endoscopic retrograde cholangiopancreatography (ERCP) commented on the variation in the macroscopic appearance of the papilla of Vater. How the macroscopic appearance ... -
Clinical, microbiological and immunological effects of antiseptics in periodontal treatment
(Inst för odontologi / Dept of Dental Medicine, 2019-12-19)Periodontal diseases are characterized by high prevalence in many populations and the chronic and progressive course of the disease. A fundamental stage of treatment is mechanical debridement of the tooth surface. During ... -
Brain immune mechanisms in schizophrenia : experimental and clinical characterization
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-12-19)The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine ... -
Microglia in the juvenile brain after cranial irradiation
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-12-19)Radiotherapy is used to treat pediatric brain tumors and is often accompanied with debilitating late effects, such as cognitive decline. However, the mechanisms are poorly understood, and consequently there is still no ... -
Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-18)The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, ... -
Clinical epidemiological studies of the association between chronic inflammation, immune-modulatory therapies, and cancer
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-12-18)Rheumatic diseases are chronic conditions that affect a substantial proportion of the adult population. Likewise, cancer is a major threat to public health, and the leading cause of death worldwide. Chronic inflammation ... -
Life after intensive care-post-intensive care syndrome, inflammation, and HMGB1
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-12-17)Survival rates of intensive care unit (ICU) patients are consistently increasing. This new patient population has recently gained increased recognition as they suffer from psychological, physical, and cognitive impairments ... -
Ready to pull : force transmission during vascular development
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-12-17)The transmission of mechanical forces controls a multitude of cellular processes such as migration, the formation of new organs, muscle contraction, and resistance to the continuous stress that blood flow exerts on the ... -
On the neuronal basis of cognition : cell-type specific circuitry and functions of the prefrontal cortex
(Inst för neurovetenskap / Dept of Neuroscience, 2019-12-13)This thesis recapitulates the history of research, and current knowledge, of the prefrontal cortex (PFC) in order to provide a context for the included scientific articles. The evident, but ill-defined, symptoms of a ...