Avhandlingar / Theses
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Will diabetes care move closer to rural patients in China? : assessing the impact of an educational intervention for type 2 diabetes among patients and health care professionals in rural China
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2020-09-22)Aim The overall aim of this PhD thesis was to increase knowledge on the feasibility and impact of an educational intervention to shift the management of type 2 diabetes mellitus from hospitals to primary health care ... -
Every bug counts : neonatal colonization and infection of Gram-negative bacilli - aspects on antibiotic resistance in Sweden and Ecuador
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-09-18)Neonatal infections caused by extended-spectrum beta-lactamase (ESBL)-producing Gramnegative bacilli are associated with high morbidity and mortality. In order to perform targeted preventive interventions against the ... -
Health effects of air pollution : innovative approaches for spatio-temporal evaluations
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-09-17)Air pollution is one of the major risk factors to human health, causing both short- and long-term effects and the global burden on mortality is estimated in more than 4 million deaths every year. Most of the evidence on ... -
Implantable cardioverter defibrillator treatment in patients with hypertrophic cardiomyopathy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-09-17)Background: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease with various clinical manifestations, including sudden cardiac death, which can be prevented by an implantable cardioverter defibrillator (ICD). Aims: ... -
Responsible antibiotic use and diagnostic challenges in infectious diseases : studies in a resource-limited setting and a high-income setting
(Inst för global folkhälsa / Dept of Global Public Health, 2020-09-17)Background Antibiotic resistance is a globally emerging health challenge. In resource-limited settings, the burdens of infectious diseases and of antibiotic resistance are the highest. The World Health Organization ... -
Understanding preclinical dementia : early detection of dementia through cognitive and biological markers
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-09-14)Dementia is becoming a growing healthcare crisis, therefore identifying individuals at risk or in the earliest stages of dementia is essential if prevention or disease modification is to be achieved. The objective of ... -
Malaria in travellers and migrants : disease severity and long term effects
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-09-11)Malaria is a potentially fatal infection, where prompt and correct management is crucial for the outcome. Despite international efforts to reduce transmission, there are over 200 million new malaria cases with approximately ... -
Molecular epidemiology studies on risk factors for breast cancer and disease aggressiveness
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-09-10)Breast cancer is a heterogeneous disease. Aggressive subtypes are characterized by faster growth rates, increased capability to invade and metastasize, leading to poorer clinical outcomes. In this thesis, we use a molecular ... -
In the right place and at the right time : cellular and functional neuroanatomy of endocannabinoids and neuropeptides
(Inst för neurovetenskap / Dept of Neuroscience, 2020-09-10)A plethora of chemical signals, including endocannabinoids and neuropeptides, enable neuronal communication beyond the classical neurotransmitters. Many of these molecules are also expressed during (early) brain development, ... -
MicroRNA and energy metabolism in gastrointestinal tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-09-09)MicroRNAs (miRNAs) contribute to cancer development and drug resistance via cellular biological processes, including metabolic pathways. Energy metabolism plays a significant role to maintain tumor proliferation in ... -
Fracture healing, functional outcome and health related quality of life in younger patients with a femoral neck fracture
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-09-08)Few prospective studies have investigated the patient-reported outcome measures (PROM) in patients less than 70 years that sustained a femoral neck fracture (FNF) treated with closed reduction and internal fixation (CRIF). ... -
Assessment and prognostic importance of nutritional status and body composition in liver transplantation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-09-08)Chronic liver disease and liver cirrhosis are progressive diseases closely linked to metabolism and nutritional status. Weight loss is a result of negative energy balance and is therefore a good measure of risk of malnutrition. ... -
Clinical quality and performance measurement in the prehospital emergency medical services in the low-to-middle-income setting : developing clinical quality and performance indicators as a measure of care in South Africa
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-09-08)BACKGROUND: Measuring quality and safety in any healthcare setting however is highly contextual, and depends on the manner in which quality is defined or viewed within that setting. It is this contextual nature that has ... -
Biomarkers and surgical predictors in temporomandibular joint disease
(Inst för odontologi / Dept of Dental Medicine, 2020-09-07)Background: Temporomandibular joint (TMJ) disc displacement (DD) is associated with pain and impaired function and has two main sub-diagnoses, DD with or without reduction (DDwR/DDwoR). DD synovial tissue has been sparsely ... -
Pregnancies complicated by obesity : focus on stillbirth and infants born large for gestational age
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-09-07)Background: The prevalence of obesity has increased globally and reached pandemic levels. Obesity is associated with increased risks of complications during conception, pregnancy and delivery as well as during the postpartum ... -
Short and long-term regulation of autophagy
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-09-04)Autophagy is a conserved catabolic pathway triggered by stress conditions in which portions of the cytoplasm, damage organelles, misfolded proteins and intracellular bacteria are delivered and degraded in the lysosome/vacuoles. ... -
Surgical treatment of obstructive sleep apnea : randomized controlled studies in children and adults
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-09-03)Obstructive sleep apnea (OSA) is a common disorder in both children and adults. In adults, OSA is a major health concern because it is highly prevalent and increases the risk for hypertension, cardiovascular disease, and ... -
Improving biomarker assessment in breast pathology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-09-02)The accuracy of prognostic and therapy-predictive biomarker assessment in breast tumours is crucial for management and therapy decision in patients with breast cancer. In this thesis, biomarkers used in clinical practice ... -
Studying the cell cycle using systems biology and high content characterization of the Ubiquitin Proteasome System
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-09-02)The cell cycle is the process through which our cells grow and divide in a carefully orchestrated and controlled manner. An uncontrolled cell cycle is a basic hallmark of cancer, in which excessive cell growth leads to ... -
Immunometabolic regulation of atherosclerosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-08-31)Ischaemic heart disease and stroke are the most common causes of death in the world, both diseases being manifestations of atherosclerotic cardiovascular disease. Atherosclerosis is a slow process initialized by the retention ...