Avhandlingar / Theses
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Between two lungs : proteomic and metabolomic approaches in inflammatory lung diseases
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-06-15)This doctoral thesis presents results on proteomic and metabolomic profiling of two distinct inflammatory lung diseases: sarcoidosis and chronic obstructive pulmonary disease (COPD). Chronic inflammatory lung diseases ... -
Touching cognition : somatosensory processing and plasticity deficits in mouse barrel cortex
(Inst för neurovetenskap / Dept of Neuroscience, 2017-06-07)Senses together with thoughts and experience are key factors that shape our cognition. Touch is an important source of sensory information. Disturbances to the development of the somatosensory system have serious consequences ... -
Orbital blow out fracture : to operate or not to operate - that is the question
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-06-02)When the eye socket is exposed to severe blunt trauma the pressure in the socket increases. As a protection mechanism to prevent the eye from disruption, the thin bony walls surrounding the eye fracture. Such a fracture ... -
Epidemiology and emergency cardiac care services for out-of-hospital cardiac arrest in Qatar
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2017-05-31)Background: Out-of-hospital cardiac arrest (OHCA) is a common cause of cardiac emergency and death. Worldwide, there is wide variation in epidemiology and survival of OHCA. Racial and ethnic disparities are important ... -
Studies on the relationship between periodontitis and rheumatoid arthritis
(Inst för odontologi / Dept of Dental Medicine, 2017-05-31)Periodontitis and rheumatoid arthritis (RA) are both widespread multifactorial diseases, characterized by chronic inflammation leading to tissue and bone destruction around teeth or joints, respectively. An association ... -
Tumour microenvironment in serous ovarian cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-30)Ovarian cancer is the seventh most common malignancy in women worldwide and the most lethal gynaecological malignancy in developed countries. The epithelial subtype is divided in five main histologic groups, of which the ... -
Evidence based care of the very preterm infant : studies on thermal care and breastfeeding in Europe
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-05-26)Very preterm birth occurs in approximately 1.5% of all births in Europe. Advances in neonatal intensive care has contributed to a decline in mortality and morbidity, nevertheless very preterm birth (birth before 32 weeks ... -
Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking
(Inst för neurovetenskap / Dept of Neuroscience, 2017-05-26)Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit ... -
Brain matter matters : renewal in the human brain
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-05-26)Many cells have a shorter life span than the organism itself and are continuously being replaced. However, for many cell types in the human body it is still largely unknown whether they turn over at all once development ... -
Studies on microglia in tumor biology and neurobiology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-24)Microglia are innate immune cells that reside in the central nervous system (CNS). Their activities are critical for ensuring the correct microenvironment for brain development and for maintaining homeostasis in the brain ... -
From movement to skill : neural and behavioral mechanisms of motor sequence learning
(Inst för neurovetenskap / Dept of Neuroscience, 2017-05-24)How do we learn new movements? The simple answer to this question is Through practice! Yet, a better response might be What aspect of motor learning are we talking about? Our capacity for learning new skills and for ... -
Hemorrhagic and thromboembolic complications following cholecystectomy
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-05-24)Laparoscopic cholecystectomy for gallstone disease is one of the most common procedures in the Western world. The overall complication rate is 10%. Whereas most complications are easily managed, bile duct injuries may ... -
Specification and potency of human neural stem cells for clinical transplantation
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-05-24)Neural stem cells hold promise for future treatment of spinal cord injury. Various aspects regarding cell fate specification, manufacturing and monitoring, with implications for clinical applications of these cells, are ... -
Development and testing of an m-Health platform to reduce post-operative penetrative sex in recipients of voluntary medical male circumcision
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2017-05-24)Background: The widespread roll-out of voluntary medical male circumcision (VMMC) has been accompanied by reports of VMMC recipients, particularly men who are married or cohabiting, resuming sexual intercourse before the ... -
The atypical Rho GTPase RhoD and its role in cellular dynamics
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-05-24)Despite its discovery 20 years ago, the accumulated knowledge about the Rho member RhoD is scarce. Instead, the vast majority of studies concerning Rho GTPases has focused on the three classical members RhoA, Cdc42 and ... -
Emotion recognition and expression in autism spectrum disorder : significance, complexity, and effect of training
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2017-05-23)The overall scientific aim of this thesis is to examine emotion recognition in children with Autism Spectrum Disorder (ASD), its specificity to ASD and connection to other cognitive functions, as well as to map the effects ... -
The role of psychological stress in cervical and prostate carcinogenesis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-05-23)Psychological stress is common in everyday life, and has been well recognized as one of the major contributors to many mental and physical illnesses, such as mental disorders and cardiovascular diseases. The association ... -
What we talk about when we talk about change : a study of change practice and change agency in higher education
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2017-05-22)This thesis is concerned with change practice, particularly in one specific higher education institution. The thesis examines theoretical perspectives of change practice and presents five empirical studies that, in ... -
Vessel occlusion and functional outcome after acute stroke : prediction and evaluation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-05-22)In the acute setting of ischaemic stroke, two proven treatments are available: intravenous thrombolysis (iv-tPA) with alteplase and endovascular thrombectomy. The main aim of this thesis was to investigate the ... -
Diagnosis, treatment and evaluation of chronic venous disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-19)BACKGROUND AND AIMS: Varicose veins (VVs) are the most common manifestation of chronic venous disease (CVD) in the Western hemisphere. Recent research shows that the disease encompasses the global population and with ...