Avhandlingar / Theses
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Exploring B cell responses in Plasmodium falciparum malaria
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-10-18)Plasmodium falciparum malaria remains one of the most devastating infectious diseases today. Small children in sub-Saharan Africa carry the heaviest burden of morbidity and mortality. Immunity to malaria is not well ... -
A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-10-18)Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is ... -
Involving concerned significant others in the treatment of problem gambling
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-10-18)Background: Problem gambling (PG) is a worldwide phenomenon that affects both gamblers and their concerned significant others (CSOs). Apart from financial difficulties, problem gambling is associated with disrupted ... -
Clinical decision support in emergency medicine : exploring the prerequisites
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2019-10-18)A clinical decision support system is a technical system that combines individual patient data and evidence-based clinical knowledge to give advice and support to clinicians. For quite a long time, the emergence of such ... -
Perinatal mental health among young women in urban China
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-10-18)In order to reach the WHO’s Sustainable Development Goals relating to maternal and infant health, maternal mental health preconditional needs to be addressed. The purpose of the thesis project was to explore how Shanghai ... -
PAK4 signaling in development and cancer
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-10-17)Our understanding of cancer biology has been evolving rapidly shaped by groundbreaking discoveries. We now understand that cancer is not one disease but many, and that tumors are not foreign objects in the human body but ... -
Internet-delivered cognitive behaviour therapy for paediatric anxiety disorders in clinical settings : increasing access to evidence-based treatments
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-10-17)Background: Paediatric anxiety disorders are common, impairing and associated with a societal and economic burden. Even though there are efficacious treatments to treat these disorders, access to them are limited. ... -
Exposure to air pollution in the work and residential environment during pregnancy and adverse birth effects
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-10-17)Air pollution is an environmental health risk that causes millions of premature deaths every year around the world. Air pollution exposure has been associated with respiratory and cardiovascular morbidity and an increased ... -
Molecular adaptations of skeletal muscle in health and disease
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-10-17)Appropriate function of skeletal muscle is essential for locomotion, everyday activities and athletic performance. In addition to its mechanic tasks, skeletal muscle communicates with other organs via metabolic pathways ... -
Trial of labour after caesarean
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-10-15)Background: Induction of labour and caesarean delivery are common interventions in obstetric care and over the last decades both have been steadily increasing in frequency worldwide. The two interventions are concatenated, ... -
PET/CT with 18F-FDG and 68Ga-DOTATOC in pulmonary carcinoid imaging
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-10-11)Background: PET/CT, positron emission tomography combined with computed tomography, with 18F-FDG (2-deoxy-2-[18F]fluoro-D-glucose) is well established in oncological imaging. Pulmonary carcinoid tumours may have metabolic ... -
Studies on the role of NGF in arthritis-induced pain transmission using gait and weight bearing as outcome measures
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-10-11)Pain is one of the most common reasons for seeking healthcare, with approximately forty percent of those suffering from chronic pain having joint pain. Osteoarthritis is the most common cause of joint pain, but currently ... -
Characterization of structural chromosomal variants by massively parallel sequencing
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-10-10)Chromosomal Structural Variation (SV) such as translocations, inversions, deletions, and duplications are rearrangements of one or several DNA molecules. SVs are widespread across the human genome, and each individual ... -
Generation and investigation of neural microenvironment in health and disease
(Inst för neurovetenskap / Dept of Neuroscience, 2019-10-09)Cells in our body are under the constant influence of intrinsic and extrinsic factors that modulate their behavior. Early on, starting during the development of the organism, growth factors, nutrients, oxygen, the extracellular ... -
Mobile teleconsultations in acute burn care : acceptance and user-experience among emergency care providers in resource-poor settings
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2019-10-08)Background: Burn injuries are a global health problem with severe consequences for those affected and nearly 95% of all burns occur in low- and middle-income countries (LMICs). While minor burns can be treated locally ... -
Predictors and consequences of injurious falls among older adults : a holistic approach
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-10-04)The field of research on falls among older adults is well studied. Despite this, there are some knowledge gaps that need to be addressed: 1) research studying injurious falls, as opposed to any falls; 2) knowledge on sex ... -
Epidemiological perspective of chronic immune thrombocytopenia
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-10-04)This thesis deals with different aspects of immune thrombocytopenia disease (ITP), what happens before diagnosis, characteristics of patients at treatment start and outcomes potentially related to the disease and treatment, ... -
Tobacco Cessation on Prescription : a primary healthcare intervention targeting socioeconomically disadvantaged areas in Stockholm
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2019-10-04)Background: In Sweden, the prevalence of tobacco use is higher among socioeconomically disadvantaged groups. Primary healthcare (PHC) has the main responsibility for tobacco cessation treatment in the Swedish healthcare ... -
Shoulder injuries in adolescent elit handball players
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-10-04)Background: Handball is a physically demanding sport that includes jumping, running, side-cutting movements and frequent throwing. A high prevalence of shoulder problems and pain has been reported in adult handball players ... -
Human amnion epithelial stem cells as a therapy for liver disease
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-10-04)Placenta-derived stem cells have been proposed as potential new treatments for acute and congenital liver diseases. Of all the different perinatal tissues, amnion membrane and isolated amnion epithelial cells have been ...