Avhandlingar / Theses
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Spinal cord stimulation in chronic pain : a study of health outcomes and costs
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-12-01)Background: The aetiology of chronic pain is complex and encompasses many different causes. Chronic pain commonly arises due to spinal disorders causing pain in the back and legs. Chronic pain is a substantial global public ... -
Human myeloid cells in cancer, inflammation, and infection
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2021-12-01)Myeloid cells are a part of innate immunity, playing a major role in orchestrating innate and adaptive immune responses. While work performed in experiment model systems has significantly increased our knowledge on ... -
Molecular biomarkers in melanoma susceptibility and therapy response
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-30)Melanoma accounts for the majority of the mortality from all types of skin cancers. Five to ten percent of the cases are familial melanoma, yet more than 50% of the melanoma families cannot be explained by established ... -
Comorbidity and mortality in Prader-Willi syndrome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-30)Background: Prader-Willi syndrome (PWS) is a multisymptomatic, rare, genetic, disorder, due to lack of the expression of paternal genes in the q11-q13 region of chromosome 15. The main characteristics of PWS are muscular ... -
Streptococcal and staphylococcal tissue infections: therapeutic challenges and opportunities
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-11-26)Streptococcus pyogenes and Staphylococcus aureus have been leading causes of human infections throughout history. S. pyogenes is of the top-ten pathogens responsible for most death globally, 0.5 million deaths per year. ... -
Measurement and valuation of health among children and adolescents using the EQ-5D-Y : Methodological considerations and implications
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-11-26)Introduction: Around the world, life expectancy is increasing but not all years are lived in full health. Hence it is important to look beyond survival rates and also measure healthrelated quality of life. Measurement ... -
Translational studies on Alzheimer's disease : a focus on cholesterol metabolism, Thioredoxin-80 and microglia function
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-11-26)Disturbances in cholesterol metabolism and inflammatory processes may have a negative impact on brain health. These two aspects are considered to be signs of early changes in Alzheimer’s Disease (AD). However, clear ... -
Alzheimer disease : a super-resolved picture of the amyloid β-peptide producing machinery
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-11-26)Alzheimer disease (AD) is the most common neurodegenerative disease, influencing 40 million patients in the world. Pathologically, AD is hallmarked by intracellular tau tangles and extracellular Amyloid-β peptide (Aβ) ... -
The DNA repair enzymes MTH1 and OGG1 as targets to treat inflammation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-25)Chronic and acute inflammatory diseases, such as multiple sclerosis (MS), psoriasis and sepsis, account for vast disability and morbidity in the world. Several new immunomodulating treatment alternatives have been developed ... -
Breast reconstruction with biological graft : clinical outcomes in the setting of breast cancer treatment
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-25)The overall aim of this thesis was to investigate the use of acellular dermal matrix (ADM) in implant-based breast reconstructions (IBBR) in the setting of breast cancer treatment. ADM refers to a surgical mesh developed ... -
Diagnostic and prognostic markers in thyroid carcinoma with focus on TERT activation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-25)Well-differentiated follicular cell-derived thyroid carcinomas are usually categorized into papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), which represent the most common and second most common ... -
The impact of social information on emotional learning
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-11-24)Our survival is contingent on our ability to observe and interact with conspecifics. For example, by observing the facial expressions of others, we can vicariously learn to avoid potentially dangerous events without ... -
Delayed babbling at 10 months : observation, detection and a two-year follow-up
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-11-24)Babbling variables that can predict later expressive language, such as presence and onset of canonical babbling (CB), presence of anterior stops and consonant inventory, are suitable targets for a CB screening and the ... -
Elucidation of the molecular mechanisms of action of anti-cancer compounds reveals possible combination strategies for anti-cancer therapy
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-11-24)Cancer develops due to accumulation of mutations or epigenetic changes within normal cells, usually over a considerable period of time. When cancer patients are diagnosed at late stage, the tumor cells are often more ... -
Comprehensive evaluation of spasticity and other sensorimotor dysfunctions after lesions to the central or peripheral nervous system
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2021-11-23)Background: Understanding how sensorimotor impairments may contribute to changes in body structure and function, and also to activity and participation limitations is an important challenge in neurorehabilitation research, ... -
Hereditary predisposition and prognostic prediction in cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-11-23)Cancer is a genetic disease. The cancer cells evolve clonally through changes of their genome, gaining malignant characteristics. In hereditary cancer syndromes, a genetic aberration which puts the cells one step closer ... -
Synthesis and studies of 2´-o-alkylated oligonucleotides with enhanced stability and cellpenetrating properties
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-11-23)Basic structures of natural oligonucleotides (ONs) are RNA and DNA are giving rise to conformations and secondary structures inside cells and are the fundamentals for life. Many chemically modified oligonucleotides have ... -
Beyond exhaustion and pain : the intertwinement of health and suffering among women and mothers
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-11-23)Aims The overall goal of the thesis was to understand and to conceptualize health and suffering among women living with exhaustion and long-lasting pain, with a particular focus on motherhood. Methods The ... -
Novel FISH methods to unveil genome architecture
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-11-22)The genome consists of incredibly long DNA strands that encode all the vital information for the cell to function. The DNA inclusion in the very tight nuclear space and, simultaneously, the establishment of a hierarchical ... -
The Stockholm Spinal Cord Uro Study
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-11-22)Aims: To evaluate urinary tract function and complications in a regional population with chronic traumatic spinal cord injury (SCI), to estimate risk profiles for recurring complications and improve follow-up for neurogenic ...