Avhandlingar / Theses
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Relation between nutritional status, the outcome of infection and immune responses
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-08-16)A causal interaction between nutrition and the outcome of different infections has been known since long time ago. Moreover, responses of human beings to infection are diverse and demarcated by immunity. A deficient and ... -
Self-management of type 2 diabetes : processes for setting up a diabetes and pre-diabetes support intervention in socioeconomically disadvantaged communities in Sweden
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2019-08-13)Background: Type 2 diabetes and pre-diabetes are major public health challenges, disproportionately affecting disadvantaged populations worldwide. The high burden of Type 2 diabetes (T2D) contributes significantly to ... -
Lineage stability and effector function of CD4+FOXP3+ regulatory T cells
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-08-12)This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated ... -
Role of new podocyte-associated proteins in the renal ultrafiltration barrier
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-08-09)Chronic kidney disease (CKD) is a major health problem and an economical burden affecting people worldwide. The main causes of CKD are diabetes and hypertension and patient numbers keep increasing. In many cases, CKD is ... -
Borderline and locally advanced pancreatic cancer : redefining the biological and technical profile of the disease
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-08-09)Surgery is the only treatment modality that provides a chance for long-term survival in pancreatic cancer (PC). Thus, the current classification systems for PC are technically skewed to predicted the probability for surgical ... -
Connecting viral oncoproteins to microRNA, autophagy and metabolism in Merkel cell carcinoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-08-08)Merkel cell carcinoma (MCC) is an aggressive type of skin cancer. Around 80% of MCCs harbor an integrated Merkel cell polyomavirus (MCPyV) genome with a mutation in the large T antigen (LT) gene, leading to expression of ... -
Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-08-08)Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile ... -
Aspects of positive and negative mental health in young people, aged 16-29 years : measurements, determinants, and interventions
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2019-08-07)Background: Mental health problems in young people, i.e. those self-reported as well as registered diagnoses, have been of concern for decades. For Western societies, most studies indicate a rise in symptoms, but also ... -
Interplay between birthweight, family history, obesity, and genes in the development of latent autoimmune diabetes in adults (LADA) and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-08-07)Diabetes is a chronic and serious public health concern affecting millions of people around the globe. For effective prevention understanding of modifiable risk factors is fundamental. For type 2 diabetes these risk ... -
Exploration of large molecular datasets using global gene networks : computational methods and tools
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-08-02)Defining gene expression profiles and mapping complex interactions between molecular regulators and proteins is a key for understanding biological processes and the functional properties of cells, which is therefore, the ... -
The dependency of image quality on acquisition protocol and image processing in chest tomosynthesis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-08-02)The digital tomosynthesis (DTS) technique is a next generation of the old tomography technique, the use of which has been extended during the past decade. The interest in this technique has increased more and more in ... -
Interdisciplinary rehabilitation in patients with chronic pain : prognostic factors and effectiveness
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-08-01)Interdisciplinary multimodal pain rehabilitation (IMPR) is currently considered best practice for combatting chronic pain. However, it is believed that health-related outcomes could be improved with more adequately tailored ... -
Teamarbete och informationsöverföring inom perioperativ vård : operationssjuksköterskans perspektiv
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-06-12)Bakgrund: Ett säkert genomförande av en kirurgisk intervention fordrar professionell kompetens, med såväl tekniska som icke-tekniska färdigheter. En säker vård kräver adekvat information om patienten och planerade ... -
Tailoring and standardizing the assessment of ability and disability in ADHD and autism : the development of WHO ICF core sets
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-05-29)The concept of health has evolved over time and is today considered a multidimensional construct that involves not only absence of impairments or pathologies, but also quality of life and individual functioning. This ... -
Effects of DNA damage and vesicular exchange in P. falciparum
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-28)Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ... -
Post abortion care in Uganda : improving access and quality of care through task sharing and exploring the perspectives of young women and healthcare providers
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-05-28)BACKGROUND. Unsafe abortions in Uganda continue to cause significant harm to women’s health and lives and pose a heavy burden on the health system. The consistent shortage and maldistribution of healthcare providers impede ... -
Roles of SNAP-25 isoforms in activity-dependent long-term synaptic plasticity
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-28)SNARE proteins, SNAP-25, syntaxin 1A and VAMP2 constitute the functional units which join together to form the core SNARE complex. The SNARE complex carries out the vital function of membrane fusion of intracellular vesicles ... -
Regulation of calcium flux by activating and inhibitory receptor crosstalk in NK cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-27)The birth of a new born child kicks off the immune system to be on call and to respond promptly to threats from the environment. Natural Killer cells, classified as a member of the innate lymphoid cell family, express ... -
Endocrine and paracrine factors related to pregnancy and infertility
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-05-24)Unexplained infertility, one of the common gynecological disorders, affecting 10 to 15 % of women worldwide. Recurrent pregnancy loss affects approximately 1 to 3 % of pregnant women with an unknown etiology in 50 % of ... -
The development of the human immune system during the first five years of life
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-05-24)Systems immunology is a scientific field combining high-throughput analytic technologies and integrative data analysis to study the immune system from a holistic perspective. As the immune system is a complex integrated ...