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  • Can Parkinson’s disease be prevented? : epidemiological evidence on lifestyle factors 

    Yang, Fei (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-03-24)
    The etiology of Parkinson’s disease (PD) is largely unknown, but epidemiological studies have provided robust evidence that environmental factors have a central role in PD pathogenesis and progression. The studies included ...
  • Gut microbes and the developing brain 

    Arentsen, Tim B. F. (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-17)
    The discovery that commensal gut microbiota can influence host development and physiology beyond the gastrointestinal (GI) tract has triggered a paradigm shift in our conceptualization of the origin of human diseases. A ...
  • Breast cancer in young women : aspects on mortality and local recurrence 

    Fredholm, Hanna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-17)
    The general aim of the thesis was to gain increased insight into the long-term prognosis for young women with breast cancer. In a population-based cohort of 22,017 women with breast cancer, we studied prognosis by ...
  • CNS tumours of childhood/adolescence : outcomes related to disability and identity in adult survivors 

    Hörnquist, Lina Olivia (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2017-03-16)
    Central nervous system (CNS) tumour survivors are at increased risk for adverse health and functional late effects. Results from previous studies from the Swedish LIFE project, of which this licentiate thesis is a part, ...
  • Thioredoxin and Glutaredoxin systems under oxidative and nitrosative stress 

    Ren, Xiaoyuan (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-03-16)
    Our knowledge about reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been changed from simple damaging molecules to redox signaling mediators. ROS/RNS mediated signaling is mainly based on the reversible ...
  • Complicated peptic ulcer disease : prevention and treatment 

    Sverdén, Emma (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-15)
    Peptic ulcer is a common disease worldwide and its complications can cause serious clinical problems. While the incidence of uncomplicated peptic ulcer disease is decreasing, the incidence of more complex ulcer disease is ...
  • The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast 

    Tran, Martin (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-03-15)
    The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, ...
  • Exploring disease biomarkers and mechanisms using metabolomics 

    Lindahl, Anna (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-03-14)
    A metabolome is the complete set of small molecules or metabolites present in a biological system. It is the result of internal, genetically determined processes, as well as external factors. The metabolome can consequently ...
  • On the role of bioactive sphingolipids and their metabolizing enzymes in cancer 

    Ahmed, Dilruba (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-03-13)
    Ceramide is a family of closely related molecules, which are presumed to be in the center of sphingolipid metabolism. Among sphingolipid metabolites, several ceramide subspecies and sphingosine induce apoptosis, cell ...
  • Persistence to antihypertensive drug treatment in Swedish primary care 

    Qvarnström, Miriam (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-03-10)
    Hypertension is The efficacy of antihypertensive drug therapy is undisputed, but large surveys report that one in four patients reach a target blood pressure of <140/90 mm Hg. Although there are several explanations to ...
  • Molecular determinants of endocannabinoid-mediated brain development 

    Calvigioni, Daniela (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-10)
    The enchanting process of brain development entails a fragile and finite time window, throughout which biochemical imbalances and external insults can potentially affect developing neuronal circuits. Within the numerous ...
  • Lactobacillus mediated delivery of therapeutic peptides in the gastrointestinal tract 

    Lin, Yin (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-03-10)
    Lactobacilli are normal residents of the human gastrointestinal (GI) tract. Many species belonging to the genera Lactobacillus with health beneficial properties have been introduced as probiotics. Genetic engineering of ...
  • Encounters for learning and participation in breast cancer care 

    Engqvist Boman, Lena (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2017-03-10)
    The overall aim of this thesis, is to increase the understanding of how women’s well-being, learning and participation during their breast cancer trajectory, especially in the context of short hospital stays, can be ...
  • On gender dysphoria 

    Dhejne, Cecilia (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-03-10)
    Gender identity refers to an innate and deeply felt psychological identification as a female, male, or some other non-binary gender. Gender identity may be congruent or incongruent with the sex assigned at birth. Gender ...
  • Identification of pathways of degeneration and protection in motor neuron diseases 

    Nichterwitz, Susanne (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-09)
    Motor neuron diseases preferentially affect specific neuronal populations with distinct clinical features even if disease-causing genes are expressed in many cell types. In spinal muscular atrophy (SMA), somatic motor ...
  • Cancer mortality and survival after cancer diagnosis by migration background and socioeconomic position in Sweden 

    Abdoli, Gholamreza (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-03-09)
    Aims: The overall aim of this thesis was to investigate the risk of cancer mortality and survival after cancer diagnosis based on migration background and socioeconomic position in Sweden. We studied the effects of country ...
  • Heart failure : studies of prognosis and advanced therapy 

    Thorvaldsen, Tonje (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-03-09)
    Background Heart failure (HF) is a major health problem affecting 2-3% of the Western population. The clinical syndrome of HF is associated with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Around 50% of ...
  • The role of estrogens and the microenvironment in lymphoma progression and drug sensitivity 

    Guan, Jiyu (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-03-08)
    Lymphomas are a group of cancers which originate from lymphatic cells. More than 90% of the lymphomas belong to the group of Non-Hodgkin lymphoma (NHL), which in itself is a non-homogeneous group consisting of different ...
  • Genotype-phenotype characterization of familial hyperkinetic movement disorders : emphasis on ataxia and brain calcifications 

    Paucar, Martin (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-03-08)
    Differential diagnosis of familial chorea encompasses Huntington’s disease along with a group of conditions referred to as Huntington’s disease-like (HDL). One such HDL is an inherited prion disorder (IPD) caused by ...
  • The role of autophagy in cartilage physiology and metabolism : implications for growth and ageing 

    Vuppalapati, Karuna Kumari (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-03-08)
    Cartilage is the main constituent of the embryonic skeleton. At the ends of long bones cartilage forms a growth plate consisting of chondrocytes in distinct stages of differentiation and arranged into three zones. These ...

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