Avhandlingar / Theses
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Hips don't lie : the use of benchmarking and register data to assess the performance of orthopaedic care
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-05-05)Background: Today’s healthcare systems face challenges involving rising need and demand for healthcare as well as concerns about cost containment, misuse of medical services and unwarranted variations in medical practices. ... -
Plurifaceted proteomics in studying cellular dynamics and action mechanisms of anticancer drugs
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-05-05)Mass spectrometry (MS)-based proteomics has developed tremendously in recent years and was the leading technology for many novel methods to study protein chemistry. Contrary to classical approaches based on Western blot, ... -
Pattern recognition and iNKT cell regulation of B cell activation
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-05)The immune system protects individuals against infections but can cause disease if the response is unbalanced. Immune responses include both innate and adaptive response, and these systems are connected. As the first line ... -
Bariatric surgery: predictors of outcome : results from a national database (SOREG) with particular emphasis on patients’ age.
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2021-05-04)A global pandemic of obesity and its health-related concerns, in form of comorbidities, increased risk of mortality, and reduced health-related quality of life, is ongoing. At the same time, conservative treatment for ... -
Unequal tracks? Studies on work, retirement and health
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-03)Background. In Sweden, the proportion of people aged 65 and older has doubled since 1950, and is projected to continue to increase. The increased longevity and proportion of older people in the population pose a challenge ... -
Translational studies of syndecan-1 as angiogenesis inhibitor : from basic research to clinical applications
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-03)Malignant mesothelioma (MM) is a highly aggressive primary tumor of the pleura, associated with poor prognosis. MM is mainly related to exposure to mineral fibers such as asbestos. The diagnosis of MM, despite multiple ... -
Nutrient-regulated skeletal muscle metabolism and circadian clock
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-04-30)The prevalence of obesity has tripled in the last four decades, becoming a major risk for the development of cardiometabolic diseases such as type 2 diabetes. Obesity is associated with pathological storage of lipids in ... -
On the role of parvalbumin interneurons in neuronal network activity in the prefrontal cortex
(Inst för neurovetenskap / Dept of Neuroscience, 2021-04-30)The prefrontal cortex (PFC) is an area important for executive functions, the initiation and temporal organization of goal-directed behavior, as well as social behaviors. Inhibitory interneurons expressing parvalbumin ... -
Participation in everyday occupations and situations outside home for older adults living with and without dementia : places, familiarity and risks.
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-04-29)Participation in occupations and places outside the home has been related to health and social benefits as well as offering challenging and risks for older adults living with and without dementia, yet little is known ... -
The role of oestrogens and antibiotics on the development of cancer
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-04-29)Despite advances in cancer treatment and surgery, cancer-related mortality remains the leading cause of death globally, harvesting over ten million lives annually. While the risk factors are both hormonal and non-hormonal, ... -
The kynurenine pathway in body and brain : relation with physical exercise and mental health
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2021-04-29)The kynurenine pathway of tryptophan degradation is the focus in a variety of research fields and several of the metabolites produced along the pathway are suggested as future biomarkers. Growing interest in a better ... -
Communication, coping and social networking regarding infertility
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-04-29)Infertility is a worldwide problem and is experienced as psychologically stressful. Communication about infertility varies depending on clinical aspects, personal relationships, and culture. The aim of this thesis was ... -
Chronic kidney disease : a clinical model of premature vascular aging
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-27)Patients with chronic kidney disease (CKD) are prone to develop an accelerated vascular aging phenotype characterized by vascular calcification (VC), a major culprit of cardiovascular complications and premature death. ... -
Mapping the immune landscape in solid tumors : implications for immunotherapy
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-04-27)Our cells are programmed with various safety mechanisms to avoid transformation into tumor cells. In case these fail, we have a guarding immune system ready to recognize and eliminate these cells. Despite these safety ... -
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(Inst för global folkhälsa / Dept of Global Public Health, 2021-04-27)Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ... -
Life course determinants of women’s health : from reproductive age to menopause
(Inst för global folkhälsa / Dept of Global Public Health, 2021-04-26)Over the past four decades, growing evidence has indicated that characteristics such as birth weight and length of gestation are not only key indicators for infant’s health, but also predictors of adult health and disease ... -
Alzheimer’s disease heterogeneity assessment with MRI biomarkers and unsupervised statistical learning
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-04-23)Alzheimer’s disease (AD) is the most common cause of dementia. It is characterized by loss of memory and other cognitive functions. Although it is a heterogeneous condition, it has been studied as one disease for many ... -
A neuroimaging perspective on regulation of emotion, reward, and attention
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-04-22)Emotional symptoms and non-emotional symptoms such as inattention often co-occur. Each of these symptom domains covers symptoms that are distributed along a continuum across the population; from non-clinical levels to ... -
Advancing antiviral strategies against emerging RNA viruses by phenotypic drug discovery
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-21)Pathogenic RNA viruses can emerge from unexpected sources at unexpected times and cause severe disease in humans, as exemplified by the ongoing coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory ... -
The molecular basis of the development and diversity of proprioceptive neurons : a story of surviving and thriving
(Inst för neurovetenskap / Dept of Neuroscience, 2021-04-21)Proprioception, also known as the sixth sense, describes the sensation of our body position and movement. Its proper function is essential for our daily activities from coarse movements, e.g. locomotion, to precise movements, ...