Avhandlingar / Theses
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Radiation-induced vascular inflammation : translational studies
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-04-18)Radiotherapy has been shown to increase the risk for localized cardiovascular disease in a growing population of cancer survivors. However, irradiation, as a risk factor for vascular complications in free flap surgery, has ... -
Clinical aspects of chronic graft-versus-host disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-18)Chronic graft-versus-host disease (cGVHD) remains one of the most severe complications after allogeneic hematopoietic stem cell transplantation (HSCT), affecting both the quality of life and mortality of long-term survivors. ... -
Microsimulation modelling of prostate cancer screening in Sweden
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-04-18)Evidence-based health policy may require modelling of different interventions. The choice of model complexity is a trade-off, where simpler models may be easier to describe and calibrate, while complex models may better ... -
Impact of cardiovascular and neuropsychiatric multimorbidity on older adults' health
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-04-17)Multimorbidity, the presence of two or more chronic diseases in one person, is common in older people, and associates with a number of negative outcomes. In this thesis, we propose a methodology to assess and measure ... -
Predictors of arrhythmias, cardiac arrest, and mortality in Acute coronary syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-17)Background. Patients with acute coronary syndrome (ACS) face a high risk of lethal complications, both during the hospital course and after discharge. The aim of this thesis was to assess patient characteristics and ... -
Quality of life, physical activity and bone health in idiopathic scoliosis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-04-16)Idiopathic scoliosis is a deformation of the spine affecting 1-3% of children and adolescents during growth. Severe deformities may lead to pulmonary dysfunction, pain and decreased quality of life. The etiology of the ... -
The reactive stroma in pancreatic diseases
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-04-16)Stroma, or activated connective tissue, is a key component in both pancreatitis and pancreatic tumors. Acute pancreatitis (AP) is an inflammation of the pancreas which ranges from mild and local to systemic with severe ... -
Person-centered care supported by an interactive app for patients with pancreatic cancer following surgery
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-04-16)Background: Patients with pancreatic or periampullary cancer experience severe symptoms and have poor prognosis even after intentionally curative surgery. To meet patients’ needs healthcare professionals are required to ... -
Invariant T cell subsets in immune defense of oral mucosa and skin
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-12)Innate-like T lymphocytes such as mucosa-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells recognize antigens presented by MR1 and CD1d molecules, respectively. As MR1 presents microbial ... -
Role of cholesterol metabolism in hepatic steatosis and glucose tolerance
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-04-12)The liver is the central organ for lipid, lipoprotein and glucose homeostasis, thus hepatic metabolic disturbances can predispose individuals to develop cardiometabolic disorders (CMD) such as atherosclerotic cardiovascular ... -
Genetic and morphological studies of tumor heterogeneity, multifocality and outcome in locally advanced prostate cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-04-12)Prostate cancer is a leading cause of mortality worldwide. Patients with locally advanced disease have a higher risk of relapse after treatment with curative intent. Examples of risk factors are seminal vesicle invasion ... -
Structural genomic variation in human disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-04-12)Structural variants (SVs) are physical changes in the structure of chromosomes and include both unbalanced copy number variants (CNVs) and balanced events (translocations, inversions and insertions). Many SVs constitute ... -
Physical function, physical activity and quality of life in systemic sclerosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-11)Background and aims. Systemic sclerosis (SSc) is a multisystem rheumatic disease characterized by fibrosis, vasculopathy and immune system activation. There is a dearth of knowledge how different subphenotypes such as ... -
Natural killer cells, multiple myeloma, and daratumumab : a love-hate relationship
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-04-11)Multiple myeloma is a treatable, but not yet curable, malignant plasma cell disease. Over the last decades, the overall survival time of multiple myeloma patients has constantly increased thanks to improvements in ... -
Molecular mechanisms of cell death and cell clearance
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-04-10)Programmed cell death (PCD) is a naturally occurring event in multicellular organisms. It is part of the development as well as ensuring tissue homeostasis and cellular turnover. The cell death process and the removal ... -
Chlamydia among youth in Stockholm : testing habits and evaluation of a mobile phone intervention to promote safe sexual practices
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-04-10)Background. The World Health Organization (WHO) estimates that 350 million new cases of curable sexually transmitted infections (STIs) occur each year. Prevention of STIs include both primary and secondary prevention ... -
Myeloid cells in experimental neuropathologies
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-04-05)The first innate immune cells, most importantly for this thesis macrophages, microglia and eosinophils, were described more than 100 years ago and only now do we begin to understand more about their development, functions ... -
Diet and the risk of latent autoimmune diabetes in adults (LADA) : studies on the association with fish and sweetened beverages
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-04-05)Diabetes is an increasing public health problem affecting a breathtaking number of people worldwide. The knowledge about modifiable lifestyle factors influencing diabetes risk is extensive for type 2 diabetes, but limited ... -
The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-05)Background: The rotavirus causes the most severe cases of viral gastroenteritis in small children worldwide, resulting in both high morbidity and mortality. The World Health Organization has recommended vaccination against ... -
Contact allergy in Swedish adolescents : results from the BAMSE cohort study
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-04-02)Background: Contact allergy affects about 20-25% of adults in the general population, but it is not completely clear how common it is among children and adolescents. Contact allergy is caused by skin contact to sensitizing ...