Avhandlingar / Theses
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Antibody-associated inflammation in and outside the joint in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-08-17)Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by pain, chronic inflammation and joint destruction. Epidemiological investigations in large populationbased cohorts have identified both genetic ... -
Global regulation of gene expression in stem cells and regeneration
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-08-17)Rapid developments in genomics and transcriptomics fields have made it possible to ask new questions as well as solve various old problems in biology that were not achievable previously. Novel techniques such as RNA ... -
Exploring the impact of diabetes in Sudan : out-of-pocket expenditure and social consequences of diabetes on patients and their families
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2017-08-10)Diabetes mellitus in Sudan is a growing health problem in all socio-economic classes. The natural history of the disease is associated with poor of glycaemic control, a high prevalence of complications and a low quality ... -
The challenge of co-existence : from graft-versus-host disease to stable mixed chimerism after allogeneic hematopoietic stem cell transplantation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-08-08)The only curative treatment strategy for many hematologic and inborn immunodeficiency disorders is an allogeneic hematopoietic stem cell transplantation (HSCT). The treatment involves replacing the entire hematopoietic ... -
The matter of white and gray matter in cognitive impairment
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-08-03)Cognitive impairment spans from minor subjective cognitive impairment to disabling dementia. Many biomarkers have been developed to monitor different aspects of cognitive impairment. Magnetic resonance imaging is the ... -
Inter-individual differences in associative memory : structural and functional brain correlates and genetic modulators
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-08-03)Our memory for personal experiences (e.g., the first day at school) is termed episodic memory. This form of memory involves the recollection of single information as well as the connection between these pieces of information ... -
Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-07-25)The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its ... -
Psychosocial factors and preterm birth : national register-based studies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-06-29)Every year, approximately fifteen million infants are born preterm, defined as prior to 37 gestational weeks. Preterm birth is the number one cause of neonatal mortality, which kills more than one million babies every ... -
Between two lungs : proteomic and metabolomic approaches in inflammatory lung diseases
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-06-15)This doctoral thesis presents results on proteomic and metabolomic profiling of two distinct inflammatory lung diseases: sarcoidosis and chronic obstructive pulmonary disease (COPD). Chronic inflammatory lung diseases ... -
Touching cognition : somatosensory processing and plasticity deficits in mouse barrel cortex
(Inst för neurovetenskap / Dept of Neuroscience, 2017-06-07)Senses together with thoughts and experience are key factors that shape our cognition. Touch is an important source of sensory information. Disturbances to the development of the somatosensory system have serious consequences ... -
Orbital blow out fracture : to operate or not to operate - that is the question
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-06-02)When the eye socket is exposed to severe blunt trauma the pressure in the socket increases. As a protection mechanism to prevent the eye from disruption, the thin bony walls surrounding the eye fracture. Such a fracture ... -
Epidemiology and emergency cardiac care services for out-of-hospital cardiac arrest in Qatar
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2017-05-31)Background: Out-of-hospital cardiac arrest (OHCA) is a common cause of cardiac emergency and death. Worldwide, there is wide variation in epidemiology and survival of OHCA. Racial and ethnic disparities are important ... -
Studies on the relationship between periodontitis and rheumatoid arthritis
(Inst för odontologi / Dept of Dental Medicine, 2017-05-31)Periodontitis and rheumatoid arthritis (RA) are both widespread multifactorial diseases, characterized by chronic inflammation leading to tissue and bone destruction around teeth or joints, respectively. An association ... -
Tumour microenvironment in serous ovarian cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-30)Ovarian cancer is the seventh most common malignancy in women worldwide and the most lethal gynaecological malignancy in developed countries. The epithelial subtype is divided in five main histologic groups, of which the ... -
Evidence based care of the very preterm infant : studies on thermal care and breastfeeding in Europe
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-05-26)Very preterm birth occurs in approximately 1.5% of all births in Europe. Advances in neonatal intensive care has contributed to a decline in mortality and morbidity, nevertheless very preterm birth (birth before 32 weeks ... -
Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking
(Inst för neurovetenskap / Dept of Neuroscience, 2017-05-26)Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit ... -
Brain matter matters : renewal in the human brain
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-05-26)Many cells have a shorter life span than the organism itself and are continuously being replaced. However, for many cell types in the human body it is still largely unknown whether they turn over at all once development ... -
Studies on microglia in tumor biology and neurobiology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-24)Microglia are innate immune cells that reside in the central nervous system (CNS). Their activities are critical for ensuring the correct microenvironment for brain development and for maintaining homeostasis in the brain ... -
From movement to skill : neural and behavioral mechanisms of motor sequence learning
(Inst för neurovetenskap / Dept of Neuroscience, 2017-05-24)How do we learn new movements? The simple answer to this question is Through practice! Yet, a better response might be What aspect of motor learning are we talking about? Our capacity for learning new skills and for ... -
Hemorrhagic and thromboembolic complications following cholecystectomy
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-05-24)Laparoscopic cholecystectomy for gallstone disease is one of the most common procedures in the Western world. The overall complication rate is 10%. Whereas most complications are easily managed, bile duct injuries may ...