Avhandlingar / Theses
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Investigations of body mass, gastrointestinal, and dietary factors influencing the emergence and maintenance of eating disorders
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-10-20)Eating disorders are severe psychiatric illnesses, characterized by dysregulated eating and distorted attitudes toward weight and body shape, causing enormous suffering for patients and their families. Although great ... -
The claustrum is a highway not a hub : organizing principles of claustrocortical synaptic transmission
(Inst för neurovetenskap / Dept of Neuroscience, 2020-10-20)The claustrum (CLA) is a brain nucleus wedged between the cortex and striatum. The behaviors it has been implicated in include consciousness, attention, memory and salience detection; dysfunction of CLA circuits is associated ... -
Investigating the role of p73 proteins in controlling the tumor microenvironment
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-10-20)Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ... -
Pharmacological prevention of ischemic stroke and tia : epidemiological aspects and how to improve treatment
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-10-19)Background: Medications can prevent stroke but are not used optimally. The overarching aim of this thesis was to study medication use in patients with previous ischemic stroke or transient ischemic attack (TIA) and ... -
Viral gastrointestinal infections in allogeneic hematopoietic stem cell transplant patients
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-10-16)Gastrointestinal symptoms, and elevated liver enzymes, are common after HSCT, often due to drug toxicity, graft-versus-host disease (GVHD) or infections. It is essential to distinguish between GVHD and infection, since ... -
Oncologic and functional outcomes after robot-assisted radical hysterectomy for cervical cancer
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-10-16)Background: Cervical cancer is the fourth most common cancer in women worldwide, but the incidence has rapidly declined in developed countries after the introduction of structured screening programs. This disease is caused ... -
Transforming medical competency into medical management capability : developing physician leaders by finding management in medicine
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2020-10-16)Background: Management thinking has made inroads into health care, but the relationship between medicine and management is often described as one of competing logics. Given a recognized need for bridging the two logics, ... -
Uvulopalatopharyngoplasty : patient selection, long- term outcomes, and side effects
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-10-16)Uvulopalatopharyngoplasty (UPPP) is the most common surgical treatment for adult patients with obstructive sleep apnea (OSA). Its short-term efficacy, as measured through polysomnography, is well-established and has been ... -
The neurogenic potential of astrocytes : a story of transformation and renewal
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-10-15)To not simply repair an organ, but to regenerate and fully recover its function, like there was no injury at all, that is the goal of regenerative medicine. Of all the organs in the human body, the most delicate and ... -
Role of syndecan-1 in tumor cell proliferation and epithelial-mesenchymal plasticity
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-15)Syndecan-1 (SDC1) is a heparan sulfate proteoglycan (HSPG) intercalated in the cell membrane but also translocated to the cell nucleus in a regulated manner. SDC1 is involved in several malignancy-associated processes such ... -
Socioeconomic status and out-of-hospital cardiac arrest
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-10-15)Background: Out-of-hospital cardiac arrest (OHCA) is a common cause of death. Around 6000 people in Sweden suffer OHCA each year and only about 10% survive. Historically, the focus of OHCA research has been on different ... -
Interactions between innate immune effectors and multidrug resistant bacteria
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-14)Antibiotic resistance is an increasingly difficult problem in the clinic, where conventional antibiotics are failing, and new alternative solutions are in high demand. Infections caused by Gram-negative bacteria with multi ... -
Role of GPS2 in the regulation of adipocyte fate and function : a multi-omics approach
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-10-09)The escalating prevalence of obesity and its association with comorbidities like insulin resistance and type 2 diabetes have raised the interest in adipose tissue biology and its therapeutic potential. Adipose tissue ... -
Estrogen signaling in colon inflammation and colorectal cancer
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-10-09)Colorectal cancer (CRC) is the third most deadly form of cancer in the Western world. Although screening efforts have reduced the overall mortality, the incidence is increasing among young adults. The frequency of ... -
Biting and chewing behaviours in humans : development and age-related changes
(Inst för odontologi / Dept of Dental Medicine, 2020-10-09)Background: The central nervous system initiates chewing and biting behaviours, while the peripheral sensory receptors embedded in various orofacial structures (e.g. masticatory muscles, temporomandibular joint, and ... -
Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-08)The cellular degradation system actively participates in cell homeostasis. Despite ongoing efforts and much progress in recent years, the underlying mechanisms of these pathways are not entirely understood. This thesis ... -
The relation among aging, dopamine-regulating genes, and neurocognition
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-10-07)When people are getting old, they often feel increasingly harder to concentrate, and become slower and more inflexible during tasks that involve focused attention, information maintenance in the face of distractions, and ... -
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-07)In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also ... -
Oncological safety and health-related quality of life after reconstructive breast cancer surgery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-10-02)The main aim of this thesis was to gain knowledge about the oncological safety of nipple- sparing mastectomy (NSM) with immediate implant-based reconstruction and delayed Deep Inferior Epigastric Perforator (DIEP) flap ... -
Vaccine effectiveness against HPV infections
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-10-02)Infections with human papilloma viruses (HPV) are the most prevalent sexually transmitted diseases. The vast majority of the sexually active population acquires them during lifetime but almost all HPV infections become ...