Avhandlingar / Theses
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The role of epigenetics in Multiple Sclerosis development, progression and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-03)The overall aim of this thesis was to determine epigenetic changes in peripheral immune cells from Multiple Sclerosis (MS) patients. MS is a chronic inflammatory neurodegenerative disease, which initially presents itself ... -
Current diagnostic aspects on acute and chronic pulmonary embolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-04-03)Background: Acute pulmonary embolism (APE) is a potentially severe medical condition with blood clots obstructing the pulmonary arterial vasculature. In most cases the APE resolves without any sequelae after anticoagulation ... -
Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer: biology and clinical implications
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-04-03)Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed ... -
Drug discovery targeting non-amyloid pathways in Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-04-02)Alzheimer’s disease (AD) is the most common form of dementia with almost 50 million people affected and unfortunately, no cure or treatment to halt the disease progression is available. In the hereditary forms of AD, an ... -
Regulations of neuronal plasticity by the Nogo system
(Inst för neurovetenskap / Dept of Neuroscience, 2020-04-02)Our brain has a lifelong capacity to create new memories, to learn and to adapt. This is due to the ability of neurons to modify their signaling depending on the situation to which the nervous system is exposed. The neurons ... -
Reduced working hours and stress in the Swedish social services
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-04-01)Background: Since a financial crisis in the 1990’s employees in the Swedish public sector have suffered from work stress and related consequences such as long-term sick leave. Reduced working hours has long been debated ... -
The new old normal : reassessing perioperative oxygen consumption and haemodynamics in the elderly
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-04-01)Perioperative haemodynamic instability and disturbances of global oxygen transport are associated with complications and organ injury after surgery. The continuously growing population of elderly in surgical care are at ... -
Inference of systems-level behaviors in the immune system from single-cell data
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-03-27)Understanding the systems-level behaviours of the immune system requires profiling many parameters of its constituents as well as identifying environmental factors influencing the time evolution of immune response. Recent ... -
External collaborations in multinational pharmaceutical companies
(2020-03-26)Traditionally, the internal research and development (R&D) departments of multinational companies (MNCs) have served as a main driver of MNCs innovative capacity. Today’s high pace of change and competitive landscape ... -
Differential microRNA and metabolic expressions in neuroendocrine and cervical carcinomas
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-03-26)MicroRNAs (miRNAs) are important regulators of many biological processes involved in cancer development and progression. However, the functional roles of miRNAs in some cancer types are still poorly understood. The aim of ... -
Immediate breast reconstruction : patient information, regional variations and effects of radiotherapy
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-03-26)The type of surgical treatment in breast cancer shows strong regional variation. The aim of studies I-III was to specifically investigate causes of the disparity in breast conservation and immediate breast reconstruction ... -
Molecular and functional neuroanatomy of mood disorder circuits
(Inst för neurovetenskap / Dept of Neuroscience, 2020-03-26)The ability to interpret and react to external stimuli is essential for survival. An organism has to be able to predict a favorable outcome, and, more importantly, a non-favorable one that could mean danger for ... -
Studies of side effects related to adjuvant breast cancer regimens with focus on chemotherapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-03-26)Radiotherapy, endocrine therapy, chemotherapy and targeted therapy adjunct to surgery have a critical role in the management of early breast cancer for outcome improvement. Anthracycline containing chemotherapy reduces ... -
Targeting polo-like kinase 1 in pediatric leukemia
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-03-24)Acute lymphoblastic leukemia (ALL) is one of the most common cancers among children in the world, with almost 90% complete remission rate after the primary treatment. However, some patients are resistant to treatment and ... -
Estrogen actions in the growth plate cartilage
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-03-24)Estrogens may influence bone growth locally or systemically via the estrogen receptors alpha (ERα), beta (ERβ) and G protein-coupled estrogen receptor 1 (GPER-1). In Paper I, our study showed that the treatment of ... -
On osmolality and sperm function during processing for assisted reproduction
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-03-24)Deep basic knowledge about sperm physiology is relevant and important to optimize the outcome of procedures used during Assisted Reproductive Technologies (ART) to select spermatozoa for fertilization. More specifically, ... -
Stress during cancer diagnostic workup
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-03-24)Receiving a cancer diagnosis is an extremely stressful life event. Cancer patients have been reported to experience an excessive risk of stress-related health outcomes including suicide. The time period between the first ... -
Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-17)The research focus of this thesis is polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, associated with reproductive, cardio-metabolic, and mental health complications. ... -
Machine learning and data-parallel processing for viral metagenomics
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-03-13)More than 2 million cancer cases around the world each year are caused by viruses. In addition, there are epidemiological indications that other cancer-associated viruses may also exist. However, the identification of ... -
The role of dietary nitrate in regulation of blood pressure and metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-03-12)A diet rich in vegetables is recommended for health in general and is also associated with lower blood pressure. Research suggests that inorganic nitrate present in leafy green vegetables could be a contributing factor ...