Avhandlingar / Theses
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Helicobacter pylori eradication treatment and the risk of gastric and oesophageal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-12-19)Helicobacter pylori is a strong and well-established risk factor for gastric cancer, but seems to decrease the risk of oesophageal adenocarcinoma. Thus, eradication treatment for Helicobacter pylori may decrease the risk ... -
Breast and prostate cancer : the impact of diagnosis and treatment on sick leave and work
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-12-17)Treatment for breast or prostate cancer can have negative consequences on working life. In addition to sick leave during treatment, women and men with breast or prostate cancer are at increased risk of permanent absence ... -
What is the function of B cells in experimental atherosclerosis?
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-12-14)Cardiovascular disease is one of the leading causes of death worldwide. A major cause is atherosclerosis, which is a chronic inflammatory disease of medium and large size arteries characterized by the accumulation of ... -
Mitochondria targeting and its consequences for cell death in neuroblastoma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-12-14)Mitochondria are one of the central regulators of several physiological and pathological processes. For instance, homeostatic glycolysis, citric acid cycle, and oxidative phosphorylation are all regulated by mitochondria. ... -
Activation mechanisms of Class F receptors
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-12-12)Our genetic makeup is composed of thousands of genes that code for the proteins involved in all aspects of cellular function. Proteins are molecular machines that dynamically and structurally respond to stimuli. Cells ... -
Human iPSC derived neural cells as models of brain development and as tools in pharmaceutical drug discovery
(Inst för neurovetenskap / Dept of Neuroscience, 2018-12-12)Human brain evolution has resulted in a cognitive superiority compared to all other animals. Unique cortical structures and expanding progenitor populations have been associated with the possibility for developing a ... -
Novel technologies for studies of structural and functional connections
(Inst för neurovetenskap / Dept of Neuroscience, 2018-11-30)To understand the mechanisms underlying the correct functioning of an organ it is important to study its architecture and how the interactions between cells are leading to a specific function. Specifically, the connections ... -
How can health care organizations create value? Business model explorations
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2018-11-30)Background: The Triple Aim posits that health care should strive to improve patient experience, improve population health, and maintain or lower costs. However, most organizations are not organized to achieve the Triple ... -
Challenges in the management of urothelial cancer : novel treatment, evaluation of biomarkers, and imaging techniques
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-29)Urothelial cancer (UC) is the most common malignancy found in the urinary tract. The global annual incidence is approximately 430 000 new cases (Sweden: 3 200 new cases). Approximately one in four new UC patients being ... -
The role of HIF-1alpha in epigenetic regulation of transcription
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-11-27)The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating ... -
Fishing for cures : the zebrafish as a powerful tool to identify novel therapies against glioblastoma by targeting MTH1 and beyond
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-27)Glioblastoma (GBM) is the most aggressive form of brain cancer. Despite today’s combinatory therapy consisting of surgery, radio- and chemotherapy, the prognosis remains dismal. Fostered by extensive tumor heterogeneity, ... -
Sinomenine as a novel analgesic : mechanisms and applications
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-11-26)Chronic pain of various origins is a major health care issue affecting a large patient population, also bring significant social and economic cost on the society. Work presented in this thesis concerns novel methods of ... -
Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland
(Inst för neurovetenskap / Dept of Neuroscience, 2018-11-23)The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome ... -
Oesophageal cancer surgery : nutritional determinants of survivorship
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-23)Oesophagectomy, the surgery offered as a curative treatment for cancer of the oesophagus is highly invasive with a radical change in anatomy and carries a risk for significant morbidity and mortality. The recovery is ... -
War and peace in the tumor microenvironment : tumor-associated cells as facilitators or adversaries during tumor development
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-23)The tumor microenvironment, including immune cells, fibroblasts and vasculature, profoundly affects tumor development by initially opposing, but eventually facilitating tumor growth, vascularization and spread. Though ... -
Patient safety at emergency departments : challenges with crowding, multitasking and interruptions
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-22)Several challenges with patient safety in the emergency department (ED) context have been previously identified, and some commonly mentioned are crowding, multitasking, and interruptions. The ED is a complex, high-risk ... -
Communication over language barriers in paediatric oncology care : a prerequisite for equity in care
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2018-11-22)Background: Out of Sweden's more than two million children under the age of eighteen, 23% have a foreign background, which means that every fourth child has a foreign background. We know that migration and the mixed ... -
Autologous fat transplantation to the female breast after surgery and radiotherapy assessment of patient-reported outcomes, radiology and gene expression patterns
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-22)Autologous fat transplantation (AFT) is commonly used as a complementary method to enhance breast appearance after breast surgery, radiotherapy and breast reconstruction. Some of the indications for AFT to the breast are ... -
Gene expression profiling in autoimmune diseases : a story of ups and downs
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-22)Autoimmune diseases are believed to arise from a combination of genetic and environmental factors that affect normal function of immune cells. In this thesis, we studied the functional role of genetic variants, in ... -
Modifiers of patients' emergency department care-seeking behavior
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2018-11-22)Background: Inflow of patients to the emergency departments (ED) is increasing in many parts of the world, including Sweden. At the same time the number of EDs are decreasing. In addition to this, ED inflow is volatile. ...