Avhandlingar / Theses
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Repertoire diversity and maturation of HIV-1 vaccine-induced B cell responses
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-06-04)In the work presented in this thesis, I characterized B cell responses in rhesus macaques inoculated with HIV-1 envelope glycoprotein (Env)-based vaccines to define genetic and functional properties of the elicited ... -
HCMV-induced epigenetic alterations : a novel pathway to CNS tumor?
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-06-01)Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ... -
Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-30)The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, ... -
Achilles tendon loading and deformation during rehabilitation and use of ankle foot orthoses
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-30)Achilles tendon rupture is a common injury which most often affects otherwise healthy individuals and which causes long periods of rehabilitation with absence from work and sport activities and frequently sequele with ... -
Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-30)A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows ... -
p53 transcriptional activity as a tool to uncover novel and diverse druggable targets in cancer
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-05-28)The transcription factor p53 is one of the most studied tumour suppressors with over 90 000 publications in PubMed referring to the protein. It is also the most frequently mutated gene across all cancer types with around ... -
Oxidative stress in cell and tissue damage and selenium-based therapeutics in cancer
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-25)Redox homeostasis is the balance between cellular prooxidants and antioxidants, maintained by the interplay of electrons. Reactive oxygen species (ROS) is a term for molecules with unpaired valence electrons or unstable ... -
Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-25)Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors ... -
Genetic epidemiology of cardiometabolic biomarkers : twin studies in the genomic era
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-05-25)Following the Human Genome Project, many genomic approaches have been developed in genetic epidemiology to investigate the genetic influences on human complex traits. This thesis aims to answer four genetic epidemiological ... -
Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-05-25)Protecting genome integrity is a vital task that is constantly challenged by various genotoxic stresses. Among different types of DNA damage, double-strand breaks (DSBs) constitute a particular threat since they result ... -
Pulmonary hypertension : the role and place of PDGF
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)Pulmonary hypertension is a severe condition, leading to right heart dysfunction and preterm death. For pulmonary arterial hypertension (PAH), a disease group in which the primary pathology resides within the pulmonary ... -
Occupational skin exposure to cobalt : origin and fate
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-05-25)Exposure to cobalt is not without risk. Besides adverse health effects on the respiratory system, cobalt is one of the most important sensitising metals with a contact allergy prevalence of 2.2% in the general population. ... -
Role of inositol pyrophosphates in pancreatic beta cell function
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)Inositol pyrophosphates are high energy diphosphate containing molecules that are ubiquitous in eukaryotic cells. They have been implicated in diverse cellular processes ranging from DNA repair, telomere length regulation, ... -
Men with borderline personality disorder and antisocial behavior : clinical characteristics, developmental perspectives and interventions.
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-05-25)Background: Borderline personality disorder (BPD) is a mental disorder characterized by a pervasive pattern of emotional instability, impulsivity, relationship problems and identity disturbance. As the disorder has been ... -
Let's talk about SOX : diverse key players in the transcriptional regulation of neural stem cells
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-05-25)The development of the central nervous system relies on neural stem cells. How these stem cells either maintain their identity as self-renewing progenitors or differentiate into cells of the neuronal or glial lineage are ... -
Assessment and management of patients at risk for persisting disability after mild traumatic brain injury
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-25)There is a lack of evidence-based interventions for patients with persisting problems after mild traumatic brain injury (mTBI). The interventions needed should focus on patients at particular risk for persisting disability ... -
From genes to function in autoimmunity - a salty story
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-05-24)Autoimmunity is a condition in which the ability to tolerate self breaks down, resulting in immune responses against the body’s own healthy cells and tissues. Autoimmune diseases are complex and multifactorial, and both ... -
Understanding p53 structure and targeting mutant p53 for improved cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-24)The p53 gene family consists of p53, p63 and p73. The three proteins share a high degree of structural similarity in their DNA-binding domains but have rather different functions. The tumor suppressor p53 acts as the ... -
Guts over fear : internet therapy for abdominal pain in children
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-05-24)Background: Pediatric functional abdominal pain disorders (FAPDs) are prevalent and associated with painful symptoms, low quality of life, and functional impairments. The origin is likely multifactorial and includes ... -
Outcome after liver resection : epidemiological and clinical studies with special focus on the role of post-hepatectomy liver failure
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-24)Background: Liver surgery has undergone significant developments over the last three decades. However, population-based data are scarce, and there is limited knowledge of the impact on mortality and possible treatment ...