Avhandlingar / Theses
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Cripto-1: potential target for cancer immunotherapy?!
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-02-20)Cancer immunotherapy refers to the stimulation of the immune system to eliminate cancer cells and can be applied by several different means. One form of cancer immunotherapy is therapeutic vaccination with the goal to ... -
Children and adolescents with chronic pain: parental factors, functioning, and neurodevelopmental comorbidity
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-02-19)Background: Pediatric chronic pain affects between 11 and 38% of all children. Although pain may result from injury or disease, the cause of chronic pain is commonly unclear. The interaction between biological, psychological, ... -
The importance of thyroid function for female reproduction
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-02-18)Background: Thyroid dysfunction is one of the most common endocrine disorder. Thyroid dysfunction affects the female reproductive system and can be manifested by menstrual irregularities, pregnancy loss and infertility. ... -
Developing new models of childhood malignancies using human induced pluripotent stem cells
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-02-15)Early onset diseases such as childhood malignancies and neurodevelopmental disorders have been intricate to study. For many years, research has relied and dependent upon different animal systems. Despite the usefulness of ... -
Long-term effects of pre-and postnatal glucocorticoid treatment in congenital adrenal hyperplasia
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-02-15)Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder mostly caused by mutations in the CYP21A2 gene leading to impaired production of cortisol and aldosterone. Precursors in the steroidogenic pathway are ... -
Studies of effector functions in mycobacterium tuberculosis infected macrophages with implications for host-directed therapies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-02-15)Tuberculosis infection remains a global health problem and the emergence of multidrugresistant TB (MDR-TB) adds further challenges in the battle to stop the spread of infection. Macrophages are the primary host cells to ... -
Pancreatic βeta-cell insulin signaling in genetic and dietary models of obesity and insulin resistance
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-02-14)Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood glucose levels that has reached pandemic proportions. Genome-wide association studies have linked T2DM to the function ... -
The toxicological pharmacoepidemiology of suicide : population-based studies on psychotropic-mediation use in Sweden
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-02-14)The act of completed suicide is a complex phenomenon associated with numerous identified individual and combined risk factors. Mental illness and related disorders confer among the highest risks of completed suicide and ... -
Occupational exposure to chemicals and cancer
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-02-14)We spend a lot of our time at work and the exposures in our work environment have a great influence on our health. Certain occupational groups, like firefighters, are exposed to a large number of chemicals and an increased ... -
Working life in people with multiple sclerosis
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-02-14)Background: Multiple sclerosis (MS) is a chronic disease in the central nervous system, usually with an onset in early adulthood with many years of working age ahead. The employment rate in people with MS (PwMS) is low and ... -
Drug utilization in children with asthma : methodological approaches and practical implications
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-12)There is limited research on drug utilization among children, despite them representing 20% of the total population in Europe. In the Priority Medicines report, the World Health Organization suggested that drug utilization ... -
Diabetic foot care in Sweden
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-02-11)Diabetes mellitus (DM) is a growing global disorder associated with several complications that include micro- and macrovascular disturbances. Conditions affecting the foot make up one of the major complications of the ... -
Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-02-08)The existence of latent HIV-1 reservoir (LR) in all HIV-1 infected patients serves as a major obstacle to completely cure HIV-1 infection. However, up to now there is still no available assay that provides an accurate ... -
Molecular mechanisms and targets of new anticancer treatments
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-02-06)The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies ... -
Mechanisms of type I interferons in autoimmunity and cancer
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-01)Interferons (IFNs) were first described in the 1950’s and has since been characterized as potent inducers of pathogen defense mechanisms. Since then, researchers have uncovered a depth of mechanisms in the IFN system ... -
Patient experiences and the influence on health literacy and self-care using mHealth to manage symptoms during radiotherapy for prostate cancer
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-02-01)Introduction: Prostate cancer is a diagnosis that can affect the men’s quality of life both due to the symptoms related to the disease and the treatment the men receive. Treatment with radiotherapy for prostate cancer ... -
Sex differences in adverse drug events from cardiovascular medicines in routine care
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-31)In preventive drug treatment of cardiovascular disease, adverse drug effects often lead to suboptimal compliance with a risk of disability and shorter life expectancy. The overall aim of this thesis was to assess the nature ... -
Bronchoprovocation studies to define mechanisms in asthma and airway inflammation
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-01-31)Bronchial provocations with a variety of stimuli have been widely used over the past 70 years in both asthma research as well as in daily clinical praxis in order to aid the physician to establish the asthma diagnosis. In ... -
Fysisk miljö på strokeenheter : betydelse för vården
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-01-31)Bakgrund: Den fysiska miljön har betydelse för människors hälsa och välbefinnande. Rehabilitering som påbörjas på strokeenheter i ett tidigt skede, kan förbättra återhämtning och minska risken för funktionshinder. Hur den ... -
Understanding the role of bone marrow niche in myeloid malignancies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-01-31)Normal hematopoiesis is generated and maintained by rare hematopoietic stem cells (HSCs) through their capacity to self-renew and differentiate. This process is rigorously controlled, both by HSC-intrinsic molecular ...