Avhandlingar / Theses
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Getting close with discomfort : exposure therapy for fibromyalgia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-13)Background: Fibromyalgia (FM) is a common and debilitating disorder for which there are currently no treatments available that are satisfyingly effective. Cognitive behavior therapy (CBT) might be a promising treatment ... -
Immune cells and stem cells in spinal cord injury : defining spinal cord injury associated microglia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-13)Traumatic spinal cord injury (SCI) commonly results from falls, sport activities or traffic accidents and most often results in lost sensory, motor and/or autonomic functions below the level of injury. The cellular- and ... -
Increasing uptake of long-acting reversible contraception — LARC
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-11-12)BACKGROUND: Unintended pregnancies are an inexhaustible source to life-changing decisions and events for individuals and result in enormous costs for societies having to deal with maternal health services, deliveries, ... -
Methodological issues in psychological treatment research : applications to gambling research and therapist effects
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-12)Over the last couple of decades evidence-based psychotherapies have flourished, and there are now therapies that are well-established for a wide range of problems. At the same time the mental-health burden is still enormous, ... -
Interactions between the opioid and serotonin systems in chronic pain : quantitative live cell study by Fluorescence Cross-Correlation Spectroscopy (FCCS)
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-11-11)Chronic pain is a major health issue worldwide. It enacts considerable suffering on the affected individuals and significantly increases the societal burden, as it is the most common reason why individuals seek sick leave ... -
Consequences of multiple sclerosis for patients in Sweden
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-11-11)This study aimed to consider consequences of multiple sclerosis for patients in Sweden throughout various stages of the life course. The thesis was separated into four constituent papers, which dealt with different aspects ... -
Adolescents’ future academic prospects : predictors and mental health outcomes
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2019-11-08)In the context of a changing labor market and increasing demand for higher education, young people may face challenges and uncertainty about their futures. Sweden has also faced many changes to the education system, as ... -
Phalangeal fractures: current treatment, complications and innovations
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-11-07)Phalangeal fractures are common and most of them heal well without surgical intervention. However, the comminuted and displaced unstable fractures sometimes require surgery. There are many different surgical options available ... -
Mesenchymal stromal cell crosstalk with the immune system
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-11-07)Cell therapy is a promising treatment for several diseases. One of the most commonly used cell types are mesenchymal stromal cells (MSCs). MSCs are found in most connective tissues but for clinical use they are commonly ... -
Unprovoked seizures in children : incidence, neurodevelopmental comorbidities and treatment
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-11-07)Epilepsy is considered to be the neurological disease that gives the largest burden of disease in children. It is a heterogeneous disease with very diverse consequences in the lives of the patient. Comorbidities with other ... -
Bacterial communities and antibiotic resistance in human-impacted water environments
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-07)From a One-Health concept the health of humans, animals and the environment is interconnected and what happens to one of the domains will affect the other two simultaneously. This concept can be applied not only to the ... -
Well begun is half done : preoperative physical performance & home-based exercise in older adults undergoing abdominal cancer surgery
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-11-07)The proportion of older adults continues to increase in Sweden and globally. Consequently, we are seeing an increase in diseases associated with aging, such as cancer. The primary treatment for abdominal cancer is surgery, ... -
Antibody activation of sensory neurons : exploring novel pain mechanisms in rheumatoid arthritis
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-11-07)Chronic pain is a worldwide major problem that presents several challenges due to lack of treatment efficacy and/or side effects associated with long-term usage of analgesics. Autoimmune diseases such as rheumatoid ... -
Anabolic response to amino acid supplementation in critical illness
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-11-07)Background: Critically ill patients suffer from protein catabolism with losses of skeletal muscle and whole-body proteins associated with morbidity and mortality. Catabolism is difficult to overcome, but nutritional ... -
On the evolutionary origin of the vertebrate cortex
(Inst för neurovetenskap / Dept of Neuroscience, 2019-11-07)The aim of this thesis is to dissect out the minimalistic ancestral neural hardware, which has been conserved in homologue structures of the cerebral cortex and in particular the neocortex, across vertebrates. For this ... -
Long non-coding RNAs and cellular interactions : investigating underlying mechanisms of oncogenesis
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-11-06)Cancer is a leading cause of death worldwide with one in 8 men and one in 11 women dying from the disease (World Health Organization, 2018). Despite vast improvements in cancer diagnosis and therapy, the global cancer ... -
Revealing the secrets of MARCO : a target for cancer immunotherapy
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-06)Our immune system protects us from infectious agents and sustains the homeostasis in our body. However, the immune system can also play a role in initiation and progression of diseases such as autoimmune diseases and cancer. ... -
Save the brain! Studies on GLP-1-mediated neuroprotection
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-11-06)Background: Patients with type 2 diabetes (T2D) suffer stroke more often and have worse recovery. Moreover, hyperglycemic stroke patients treated with thrombolytic therapy have more intracranial bleedings. Insulin is the ... -
Neutrophil subsets in airway inflammation and hyperreactivity
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-11-06)Neutrophils are part of the first lines of defence against invading microbes. They play an essential role in antimicrobial host defence by recognizing microorganisms through the various receptors that can be expressed on ... -
Antiapoptotic effect of ouabain in renal cells exposed to toxic glucose levels
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-11-06)Diabetes mellitus is a group of metabolic diseases that causes enormous social and economic burden. The kidney is the filtration organ that produces urine and is the primary target of diabetic complications, a condition ...