RSS submission
 

Collections

Recent Submissions

  • Role of GPS2 in epigenome alterations linked to metaflammation 

    Huang, Zhiqiang (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-10-18)
    Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein ...
  • Objective quantification and analysis of eating behaviour associated with obesity development - from lab to real-life 

    Langlet, Billy (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-10-18)
    Introduction: The last four decades have seen a marked increase in childhood and adult obesity prevalence, attributed to an “obesogenic” environment. Several genetical, environmental and behavioural factors have been ...
  • Regulation and function of ciliary dyslexia candidate genes 

    Bieder, Andrea (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-09-20)
    Dyslexia is defined as an unexpected difficulty in reading despite normal intelligence, senses and instruction. It is the most common learning disability with estimated 5-10% of the population affected. Its heredity is ...
  • Structural studies of proteins essential for fertilization 

    Dioguardi, Elisa (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-08-24)
    Where do babies come from? Even though it sounds like a fairly obvious question, it took more than 200 years to discover that sperm, whose first observation dates back to the 17th century, can penetrate into the oocyte ...
  • The role of RFX transcription factors in neurons and in the human brain 

    Sugiaman-Trapman, Debora. (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-08-15)
    RFX transcription factors (TFs) are conserved in animals, fungi and some amoebae, but not in algae, plants and protozoan species. The conservation is based on the protein sequence of the DNA binding domain (DBD). The RFX ...
  • Genetics of irritable bowel syndrome and associated gastrointestinal symptoms 

    Henström, Maria (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-05-07)
    Irritable bowel syndrome (IBS) affects more than one in ten individuals worldwide and is the most common cause of gut illness. It is classified according to the symptom-based Rome criteria as a functional gastrointestinal ...
  • Understanding the interplay between gut microbiota, gut function and host genes in the generation of gastrointestinal symptoms and disease 

    Hadizadeh, Fatemeh (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-11-27)
    Irritable bowel syndrome (IBS) is a multifactorial and complex disease categorized in the functional gastrointestinal disorders (FGIDs) with an intricate pathogenesis yet far from understood. The prevalence and burden ...
  • Role of PAK4 in pancreas development and breast cancer 

    Zhao, Miao (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-10-31)
    PAK4 is a Rho GTPase-regulated serine/threonine kinase that possesses critical functions in embryonic, neuronal and vascular development, immune defense and cancer. Constitutive PAK4 depletion causes embryonic lethality ...
  • A web- and mobile phone-based obesity prevention intervention in 4-year-olds : a population-based randomized controlled trial 

    Delisle Nyström, Christine (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-10-27)
    Background: Childhood overweight and obesity has increased significantly over the past two decades. Many well-conducted obesity prevention trials have been conducted in pre-school aged children but the majority have not ...
  • Understanding structural features of biomolecular interactions : from classical simulations to ab initio calculations 

    Hartono, Yossa Dwi (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-10-17)
    The structures of biomolecules and their interactions dictate their functions. In this thesis, five papers are presented to illustrate how the dynamics of biomolecules can be investigated and derivation of desired ...
  • Insight into 5-lipoxygenase biocatalysis and interaction with membrane components 

    Kumar, Ramakrishnan B. (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-05-12)
    Inflammation is one of the innate defence mechanisms exerted by the human body for protection and to initiate the healing process. Chronic inflammatory reactions can lead to several disease conditions like asthma, allergic ...
  • Analysis of phenotype reversibility in Hutchinson-Gilford progeria syndrome in mice 

    Strandgren, Charlotte (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-04-12)
    Aging affects all people and is a complex process involving both genetic and environmental factors in a way that is not yet completely understood. Studies of premature aging syndromes might be helpful to acquire further ...
  • The role of estrogens and the microenvironment in lymphoma progression and drug sensitivity 

    Guan, Jiyu (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-03-08)
    Lymphomas are a group of cancers which originate from lymphatic cells. More than 90% of the lymphomas belong to the group of Non-Hodgkin lymphoma (NHL), which in itself is a non-homogeneous group consisting of different ...
  • Stem cells and development : studies on SUFU and LGR5 

    Hölzl, Maria (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-12-16)
    Embryonic development and cancer formation appear quite different from each other at first glance, yet they share common characteristics such as the reliance on certain signalling pathways. The Hedgehog (HH) and WNT ...
  • GLI1 modulation of the output of hedgehog signaling in human cancer 

    Diao, Yumei (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-11-11)
    The Hedgehog (HH) signaling pathway has critical roles in embryonic development and tumorigenesis. Aberrant activation of HH signaling has been known to be involved in several types of malignant tumors. GLI1 is a transcription ...
  • Molecular modeling and thermodynamics simulation of nucleic acids 

    Xu, You (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-11-04)
    Nucleic acids participate in many cellular processes. DNA is responsible for gene heredity and its structure is mainly in double helix, whereas RNA has wide functions in gene transcription and regulation so its structures ...
  • Identification and functional characterization of gastrointestinal disease genes 

    Assadi, Ghazaleh (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-09-21)
    The inflammatory bowel diseases (IBD) Crohn’s disease (CD) and ulcerative colitis (UC) are conditions characterized by chronic and relapsing inflammation of the gastrointestinal tract. IBD affects around 2.5 million ...
  • Potential novel molecular targets for breast cancer diagnosis and treatment 

    Kharman Biz, Amirhossein (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-09-09)
    Breast cancer possesses the highest incidence among cancers in women worldwide, accounting for approximately 26% of all cancers in women. Due to the discovery of specific predictive and prognostic biomarkers, breast ...
  • A crystallographic view of egg-sperm interaction 

    Sadat, Hamed (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-08-12)
    Animal reproduction is a heavily studied biological event, however our knowledge regarding the molecular basis of the recognition between gametes – egg and sperm – still remains very incomplete. In particular, it is currently ...
  • Application of next generation sequencing in genetic and genomic studies 

    Wang, Jingwen (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-07-07)
    Genetic variants that spread along the human genome play vital roles in determining our traits, affecting development and potentially causing disorders. Most common disorders have complex underlying mechanisms involving ...

View more