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  • Skin cell heterogeneity and dynamics during morphogenesis, tissue homeostasis, and regeneration 

    Jacob, Tina (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-03-31)
    Skin is our protective barrier against various environmental harms. For the skin to fulfill its crucial function, it relies on multiple cell types working in concert; but most importantly it relies on skin-resident ...
  • Role of GPS2 in the regulation of adipocyte fate and function : a multi-omics approach 

    Barilla, Serena (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-10-09)
    The escalating prevalence of obesity and its association with comorbidities like insulin resistance and type 2 diabetes have raised the interest in adipose tissue biology and its therapeutic potential. Adipose tissue ...
  • Estrogen signaling in colon inflammation and colorectal cancer 

    Hases, Linnea (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-10-09)
    Colorectal cancer (CRC) is the third most deadly form of cancer in the Western world. Although screening efforts have reduced the overall mortality, the incidence is increasing among young adults. The frequency of ...
  • Mechanisms acting on Hedgehog-GLI pathway and their therapeutic potential 

    Azatyan, Ani (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-08-13)
    Hedgehog signaling is crucial for diverse aspects of animal development, essential in regulating many cellular processes and is largely implicated in various forms of human cancer. However, many aspects of Hedgehog ...
  • Exploring chromatin organization and transcription in S. pombe and hematopoietic development 

    Dong, Wenbo (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-05-28)
    DNA in the eukaryotic nucleus is organized into histone-DNA complex, so-called chromatin, through forming an array of nucleosomes. Each nucleosome consists of a 147bp DNA wrapped around a histone octamer harboring two ...
  • Epigenetic regulation of transcription and cellular development 

    Shahin Varnoosfaderani, Farzaneh (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-03-11)
    Epigenetic machinery can regulate different biological processes via different mechanisms. In this thesis, we explore the effects of the epigenetic system on transcription and how it can differ during cellular development ...
  • PAK4 signaling in development and cancer 

    Costa, Tânia (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-10-17)
    Our understanding of cancer biology has been evolving rapidly shaped by groundbreaking discoveries. We now understand that cancer is not one disease but many, and that tumors are not foreign objects in the human body but ...
  • A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer 

    He, Huan (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-09-27)
    Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy ...
  • Somatic mutations in healthy cells and age-associated diseases 

    Helgadottir, Hafdis Thorunn (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-09-05)
    Aging is a complex process that affects all living organisms. As we age, the biological functions are affected, resulting in a decline of the tissue and possibly age-related diseases. Several environmental and genetic ...
  • Molecular insights into Hutchinson-Gilford progeria syndrome and age-associated disease : from mechanisms to treatment strategy 

    Revêchon, Gwladys (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-08-30)
    Aging is a complex process that occurs as we grow old and is associated with a gradual decline of tissue functions. Scientists have been trying to understand the mechanisms that drive such phenomenon by studying premature ...
  • Discovering and targeting the mechanisms that govern age-related decline 

    Lin, Xin-Xuan (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-05-10)
    Aging is recognized as a major risk factor for many diseases. Thus, the identification of a means to target aging would bear great potential to improve human health and quality of life. This thesis tries to help this ...
  • Transcriptional control of liver metabolism and disease by nuclear receptor-corepressor networks 

    Liang, Ning (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-05-03)
    Liver lipid metabolism is coordinated via transcriptional networks composed of transcription factors and coregulators. Disturbance of such networks leads to metabolic dysregulation and is linked to the progression of ...
  • Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis 

    Lock, John G; Jones, Mattew C.; Askari, Janet A.; Gong, Xiaowei; Oddone, Anna; Olofsson, Helene; Göransson, Sara; Lakadamyali, Melike; Humphries, Martin J.; Strömblad, Staffan (Inst för biovetenskaper och näringslära / Dept of Biosciences and NutritionStrömblad laboratory of Clinical molecular biology, 2019-02-11)
    Adhesion to the extracellular matrix persists during mitosis in most cell types. However, while classical adhesion complexes, such as focal adhesions, do and must disassemble to enable mitotic rounding, the mechanisms of ...
  • Decoding the heterogeneity of skin in homeostasis and regeneration at single-cell resolution 

    Joost, Simon (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-12-20)
    The skin plays a critical role in securing homeostasis in the mammalian body. Its epidermis forms a tight barrier, which separates the internal from the external environment, thereby shielding the body from physical and ...
  • Role of GPS2 in epigenome alterations linked to metaflammation 

    Huang, Zhiqiang (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-10-18)
    Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein ...
  • Objective quantification and analysis of eating behaviour associated with obesity development - from lab to real-life 

    Langlet, Billy (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-10-18)
    Introduction: The last four decades have seen a marked increase in childhood and adult obesity prevalence, attributed to an “obesogenic” environment. Several genetical, environmental and behavioural factors have been ...
  • Regulation and function of ciliary dyslexia candidate genes 

    Bieder, Andrea (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-09-20)
    Dyslexia is defined as an unexpected difficulty in reading despite normal intelligence, senses and instruction. It is the most common learning disability with estimated 5-10% of the population affected. Its heredity is ...
  • Structural studies of proteins essential for fertilization 

    Dioguardi, Elisa (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-08-24)
    Where do babies come from? Even though it sounds like a fairly obvious question, it took more than 200 years to discover that sperm, whose first observation dates back to the 17th century, can penetrate into the oocyte ...
  • The role of RFX transcription factors in neurons and in the human brain 

    Sugiaman-Trapman, Debora. (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-08-15)
    RFX transcription factors (TFs) are conserved in animals, fungi and some amoebae, but not in algae, plants and protozoan species. The conservation is based on the protein sequence of the DNA binding domain (DBD). The RFX ...
  • Genetics of irritable bowel syndrome and associated gastrointestinal symptoms 

    Henström, Maria (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-05-07)
    Irritable bowel syndrome (IBS) affects more than one in ten individuals worldwide and is the most common cause of gut illness. It is classified according to the symptom-based Rome criteria as a functional gastrointestinal ...

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