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  • Molecular mechanisms of salamander limb regeneration 

    Brito, Gonçalo M. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-09-21)
    Salamanders, like newts and axolotls, stand out among adult vertebrates for their outstanding capacity to regenerate whole body parts and restore complex structures upon injury. One of the best-known examples is their ...
  • Identification of novel pathways of regulation of AHR and HIF-­1 function 

    Gralla, Michael (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-09-14)
    Mammalian bHLH-Pas (basic HLH (helix-loop-helix)-PER-ARNT-SIM) proteins belong to the bHLH superfamily of transcription factors. Members of the family have a broad spectrum of functions that among others sense and regulate ...
  • Investigating the pathological heart and its regenerative potential 

    Graham, Evan Lee (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-07-31)
    Cardiovascular disease is a leading contributor to mortality the world over, affecting millions of people each year. This, combined with its associated monetary and societal costs, has made the investigation of the ...
  • Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites 

    Pfeiffer, Annika (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-05-25)
    Protecting genome integrity is a vital task that is constantly challenged by various genotoxic stresses. Among different types of DNA damage, double-strand breaks (DSBs) constitute a particular threat since they result ...
  • Let's talk about SOX : diverse key players in the transcriptional regulation of neural stem cells 

    Klum, Susanne (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-05-25)
    The development of the central nervous system relies on neural stem cells. How these stem cells either maintain their identity as self-renewing progenitors or differentiate into cells of the neuronal or glial lineage are ...
  • SOX in development and disease 

    Kurtsdotter, Idha (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-04-26)
    As stem cells are needed not only to build our bodies during development, but also to maintain tissue function during adulthood, it is of great importance to the organism to maintain their integrity. However, stem cells ...
  • Dopamine : a versatile player in development, regeneration and disease 

    Pinheiro, Tiago (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-03-06)
    The dopamine neurotransmitter is present in all multicellular organisms. In the brain, the dopaminergic system orchestrates reward-motivation pathways and is involved in the control of voluntary movements and endocrine ...
  • Characterisation of newt neural stem cells during development and regeneration 

    Liyakath Ali, Shahul Hameed (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-02-15)
    The adult newt brain has a unique potential to regenerate neurons after injury. Ependymoglial cells that line the ventricular system of the newt brain are critical for neuronal regeneration, since they reenter the cell ...
  • Serum proteases potentiate BMP-induced cell cycle re-entry of dedifferentiating muscle cells during newt limb regeneration 

    Wagner, Ines; Wang, Heng; Weissert, Philipp; Straube, Werner; Shevchenko, Anna; Gentzel, Marc; Brito, Goncalo; Tazaki, Akira; Oliveira, Catarina; Sugiura, Takuji; Shevchenko, Andrej; Simon, András; Drechsel, David; Tanaka, Elly (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-02-12)
    Limb amputation in the newt induces myofibers to dedifferentiate and re-enter the cell cycle to generate proliferative myogenic precursors in the regeneration blastema. Here we show that bone morphogenetic ...
  • Skeletal muscle dedifferentiation during salamander limb regeneration 

    Wang, Heng; Simon, Andras (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-01-24)
    Salamanders can regenerate entire limbs throughout their life. A critical step during limb regeneration is formation of a blastema, which gives rise to the new extremity. Salamander limb regeneration has historically been ...
  • Structural and functional basis of mitochondrial tRNA processing 

    Sridhara, Sagar (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-11-28)
    The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) ...
  • Cell cycle regulation and DNA damage response : a record of polo-like kinase 1 activity 

    Hukasova, Elvira (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-11-02)
    Division and cell proliferation is an essence of life. A human cell has in its core a very simple yet a very complex machinery to coordinate cell cycle activities and events. A somatic human cell has as a base four ...
  • Transcriptional regulation of development in time and space 

    Hagey, Daniel W. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-10-13)
    Human development requires the generation of trillions of cells with myriad functions from a single cell. This requires that restriction of stem cell fate competence and proliferation are precisely temporally and spatially ...
  • Astrocytes : a reservoir for new neurons 

    Magnusson, Jens (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-09-08)
    The goal of regenerative medicine is to be able to help the body to replace worn-out cells and tissues. To achieve this goal, one approach being pursued today is to recruit and boost the body’s own mechanisms for cell ...
  • Global regulation of gene expression in stem cells and regeneration 

    Abdullayev, Ilgar (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-08-17)
    Rapid developments in genomics and transcriptomics fields have made it possible to ask new questions as well as solve various old problems in biology that were not achievable previously. Novel techniques such as RNA ...
  • Brain matter matters : renewal in the human brain 

    Yeung Wong, Maggie (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-05-26)
    Many cells have a shorter life span than the organism itself and are continuously being replaced. However, for many cell types in the human body it is still largely unknown whether they turn over at all once development ...
  • Cell renewal : terms and conditions may apply 

    Réu, Pedro (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-04-10)
    The longevity and turnover of the different constituent cells of an organism define its development, size, health, and biological age. The present thesis discusses the renewal rates and functions of cells in several ...
  • The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast 

    Tran, Martin (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-03-15)
    The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, ...
  • Transcriptional regulation of neuronal differentiation in the developing CNS 

    Rraklli, Vilma (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-02-02)
    The central nervous system (CNS) is responsible for our intellectual and cognitive functions and it comprises the brain and spinal cord. Generation of the CNS occurs during embryonic development from the neural tube that ...
  • SOX transcription factors : multifaceted regulators of central nervous system development 

    Zaouter, Cécile (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-26)
    The central nervous system (CNS) is composed of three major cell types, namely neurons, astrocytes and oligodendrocytes that are mainly generated during embryonic stages by multipotent neural progenitor cells (NPCs). The ...

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