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  • The trident of the pancreatic duct : stemness, morphogenesis and endocrinogenesis 

    Mi, Jiarui (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-29)
    Different subtypes of diabetes are all featured by the deterioration and loss of functional β-cell. Currently, there is still lack of therapeutic strategies to cure diabetes. However, harnessing the innate stem cell ...
  • Not just a pipe's dream : plumbing the contribution of cell diversity to oesophageal homeostasis 

    Grommisch, David (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-22)
    Epithelial barrier tissues like the skin, intestine, and oesophagus form a physical barrier that protects our body from external threats. To accurately fulfil their function, epithelial barriers are subject to constant ...
  • Principles of transcriptional bursting in mammalian cells 

    Larsson, Anton (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-22)
    In mammalian cells, transcription occurs in discrete bursts leading to fluctuations in transcripts from expressed genes. Although this behavior was first reported not long after the discovery of messenger RNA (mRNA), the ...
  • Epidermal stem cells at the point of no return 

    Annusver, Karl (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-17)
    The skin is our main barrier against outside harm, and it helps to maintain internal homeostasis. These functions are mostly fulfilled by the epidermis, which is the outermost layer of the skin, formed from keratinocytes ...
  • Studies on genetic and epigenetic regulation of gene expression dynamics 

    Hartmanis, Leonard (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-03-10)
    The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes ...
  • Investigating novel roles of topoisomerase regulatory interactions in transcription 

    Kuzin, Vladislav (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-01-25)
    Drugs targeting DNA Topoisomerases (TOPs, TOP1 and TOP2) are mainstays of anti-cancer therapy. While they have proven effective, the toxicity of current TOP drugs caused by DNA damage-induced apoptosis of non-cancer cells, ...
  • Fibrosis in the central nervous system : the role of perivascular cells 

    Holl, Daniel (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-11-25)
    Regeneration in the adult mammalian central nervous system (CNS) is very limited. One limiting factor is the formation of chronic scar tissue, which inhibits axonal regeneration and functional recovery. While scar formation ...
  • Translational studies of epithelial cancer 

    Classon, Johanna (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-11-16)
    Tumors stemming from specialized epithelial cells cause the most common cancer types and are among the leading causes of death in the western world. Although great strides have been made in early cancer detection, defining ...
  • Degradation and sequestration : cellular strategies to counteract proteotoxic stress 

    Xu, Shanshan (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-10-06)
    Maintenance of proteome homeostasis (proteostasis) is essential to preserve cellular function in response to intrinsic and extrinsic stress conditions. This is regulated by the proteostasis network, which is comprised ...
  • Generation of cell diversity in the developing brainstem and its modeling in vitro 

    Kozhevnikova, Mariya (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-09-26)
    The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional ...
  • Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure 

    De Genst, Erwin; Foo, Kylie S; Xiao, Yao; Rohner, Eduarde; de Vries, Emma; Sohlmér, Jesper; Witman, Nevin; Hidalgo, Alejandro; Kolstad, Terje R S; Louch, William E; Pehrsson, Susanne; Park, Andrew; Ikeda, Yasuhiro; Li, Xidan; Mayr, Lorenz M; Wickson, Kate; Jennbacken, Karin; Hansson, Kenny; Fritsche-Danielson, Regina; Hunt, James; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-19)
    The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca2+ ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling. ...
  • Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy 

    Beverborg, Niels Grote; Spater, Daniela; Knoll, Ralph; Hidalgo, Alejandro; Yeh, Steve T; Elbeck, Zaher; Sillje, Herman H W; Eijgenraam, Tim R; Siga, Humam; Zurek, Magdalena; Palmer, Malin; Pehrsson, Susanne; Albery, Tamsin; Bomer, Nils; Hoes, Martijn F; Boogerd, Cornelis J; Frisk, Michael; van Rooij, Eva; Damle, Sagar; Louch, William E; Wang, Qing-Dong; Fritsche-Danielson, Regina; Chien, Kenneth R; Hansson, Kenny M; Mullick, Adam E; de Boer, Rudolf A; van der Meer, Peter (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-18)
    Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. ...
  • An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation 

    Rohner, Eduarde; Witman, Nevin; Sohlmér, Jesper; De Genst, Erwin; Louch, William E; Sahara, Makoto; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-17)
    Background: The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be ...
  • Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors 

    Poch, Christine M; Foo, Kylie S; De Angelis, Maria Teresa; Jennbacken, Karin; Santamaria, Gianluca; Bähr, Andrea; Wang, Qing-Dong; Reiter, Franziska; Hornaschewitz, Nadja; Zawada, Dorota; Bozoglu, Tarik; My, Ilaria; Meier, Anna; Dorn, Tatjana; Hege, Simon; Lehtinen, Miia L; Tsoi, Yat Long; Hovdal, Daniel; Hyllner, Johan; Schwarz, Sascha; Sudhop, Stefanie; Jurisch, Victoria; Sini, Marcella; Fellows, Mick D; Cummings, Matthew; Clarke, Jonathan; Baptista, Ricardo; Eroglu, Elif; Wolf, Eckhard; Klymiuk, Nikolai; Lu, Kun; Tomasi, Roland; Dendorfer, Andreas; Gaspari, Marco; Parrotta, Elvira; Cuda, Giovanni; Krane, Markus; Sinnecker, Daniel; Hoppmann, Petra; Kupatt, Christian; Fritsche-Danielson, Regina; Moretti, Alessandra; Chien, Kenneth R; Laugwitz, Karl-Ludwig (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-02)
    Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft ...
  • Towards a cohesive understanding of the DNA damage response as a therapeutic target 

    Scherzer, Martin (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-06-01)
    At the basis of the complexity that forms a human being is a highly regulated interplay of factors found at a molecular, cellular, and macroscopic level. Ever since we evolved to work this way, even the slightest dysregulation ...
  • A modular mRNA approach to study and treat phospholamban mediated cardiomyopathies 

    Rohner, Eduarde (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-05-30)
    In the heart, phospholamban (PLN) is a key regulator of calcium cycling through its inhibitory effect on the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump. For more than two decades, modulating calcium channels ...
  • Ultrasound-guided in utero lentivirus transduction of the murine nervous system to investigate nervous system disorders 

    Mangold, Katrin (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-05-18)
    Neurodevelopment is a highly dynamic process involving hundreds of molecular different cell types. Gain and loss of function studies provide valuable insight into the gene regulatory networks that orchestrate this morphological ...
  • Maintenance of neuronal identity and function 

    Toskas, Konstantinos (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-03-03)
    Neurons in the CNS acquire specific characteristics throughout development and maintain them for the entire lifespan. Instructive regulation of the transcription machinery ensures the acquisition of identity by spatiotemporal ...
  • On astrocytes and neural stem cells : a study of reactive and canonical neurogenesis 

    Zamboni, Margherita (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-12-14)
    The mammalian central nervous system has limited regenerative capacity and the long-lasting functional impairment resulting from trauma and neurodegenerative disease derives from a failure to repopulate neuronal cell ...
  • RNA-binding proteins in transcription and genome integrity 

    Pederiva, Chiara (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-11-19)
    For decades, it was believed that RNA was merely an intermediate step between DNA and protein effectors. It is now appreciated that RNA is an extremely versatile molecule that affects almost every aspect inside a cell. ...

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