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  • Global regulation of gene expression in stem cells and regeneration 

    Abdullayev, Ilgar (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-08-17)
    Rapid developments in genomics and transcriptomics fields have made it possible to ask new questions as well as solve various old problems in biology that were not achievable previously. Novel techniques such as RNA ...
  • Brain matter matters : renewal in the human brain 

    Yeung Wong, Maggie (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-05-26)
    Many cells have a shorter life span than the organism itself and are continuously being replaced. However, for many cell types in the human body it is still largely unknown whether they turn over at all once development ...
  • Cell renewal : terms and conditions may apply 

    Réu, Pedro (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-04-10)
    The longevity and turnover of the different constituent cells of an organism define its development, size, health, and biological age. The present thesis discusses the renewal rates and functions of cells in several ...
  • The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast 

    Tran, Martin (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-03-15)
    The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, ...
  • Transcriptional regulation of neuronal differentiation in the developing CNS 

    Rraklli, Vilma (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-02-02)
    The central nervous system (CNS) is responsible for our intellectual and cognitive functions and it comprises the brain and spinal cord. Generation of the CNS occurs during embryonic development from the neural tube that ...
  • SOX transcription factors : multifaceted regulators of central nervous system development 

    Zaouter, Cécile (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-26)
    The central nervous system (CNS) is composed of three major cell types, namely neurons, astrocytes and oligodendrocytes that are mainly generated during embryonic stages by multipotent neural progenitor cells (NPCs). The ...
  • The role of KIF1Bß in neuroblastoma tumour suppression during sympathetic neuron development 

    Fell, Stuart (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-19)
    Neuroblastoma, the most common extra-cranial childhood tumour, is believed to arise from precursor cells of the sympathetic nervous system (neuroblasts). Hemizygous loss of chromosome 1p36 strongly correlates with poor ...
  • Resolving developing neuronal lineages in the ventral midbrain 

    Kee, Nigel (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-09)
    The numerous cells and cell types of our bodies originate from a fertilised egg. Through the study of the developing embryo, we have come to understand much about how different cells in different tissues arise from this ...
  • High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation 

    Agostinho, Ana; Manneberg, Otto; van Schendel, Robin; Hernández-Hernández, Abrahan; Kouznetsova, Anna; Blom, Hans; Brismar, Hjalmar; Höög, Christer (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyScience for Life Laboratory, 2016-12-07)
    During meiosis, cohesin complexes mediate sister chromatid cohesion (SCC), synaptonemal complex (SC) assembly and synapsis. Here, using super-resolution microscopy, we imaged sister chromatid axes in mouse ...
  • Investigating cell turnover in the healthy and diseased adult human brain 

    Huttner, Hagen B. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-11-18)
    For decades it was thought that cells that lost in the human central nervous system because of ageing or disease – different from other cell tissues – cannot be replaced and that in humans all neurons are generated during ...
  • The Smc5/6 complex : the mysterious guardian of genome stability 

    Berta, Davide G. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-11-02)
    An intricate network of proteins ensures the faithful transmission of genetic information through cell generations. The Structural Maintenance of Chromosomes (SMC) protein complex family plays a pivotal role in maintaining ...
  • The role of the cohesin loader in genome stability : a journey from yeast to human 

    Giordano, Fosco (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-10-11)
    Structural Maintenance of Chromosome (SMC) complexes, as their name suggests, have a central role in maintaining the higher structure of genomes, from bacteria to human, and in doing so protecting their integrity. ...
  • Molecular organization and in situ assembly of the human skin barrier 

    Hollander, Lianne den (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-10-07)
    A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease. To ...
  • Trypanosoma cruzi genome plasticity and evolution 

    Talavera-López, Carlos (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-08-24)
    Trypanosoma cruzi, a protozoan from the Kinetoplastidae family, is the etiologic agent of Chagas disease, a major public health problem affecting mostly the poorest areas of Latin America. Due to the complex nature of the ...
  • Notch in cancer and cancer metabolism : six degrees of intracellular turbulence 

    Landor, Sebastian K.-J. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-08-12)
    Notch signaling is an evolutionarily conserved cell-to-cell contact-dependent signaling mechanism in multicellular organisms directing cellular fates both in early development and adult tissues. In metazoans the Notch ...
  • Cyclins on the move : a time and a place for cyclin A2 and cyclin B1 in the human cell cycle 

    Silva Cascales, Helena (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-05-27)
    The ultimate aim of the cell cycle is to create an identical daughter cell. Therefore, correct progression through the different phases of the cell cycle is crucial to ensure faithful cell division. Successful execution ...
  • Actin and myosin in transcription and chromatin regulation 

    Almuzzaini, Bader (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-05-02)
    In mammalian cells, actin and myosin have emerged as regulators of nuclear structure and function, involved in chromatin remodeling and histone modifications, and in different phases of gene transcription. Actin and myosin ...
  • Regulation of the vertebrate transcriptome in development and disease 

    Storvall, Helena (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-01-15)
    In the last decade we have seen a tremendous development in the omics area (genomics, transcriptomics, proteomics etc.), making high throughput methods increasingly costeffective and available. The development in ...
  • Studies on early cellular responses during Epstein-Barr virus infection 

    Chen, Xinsong (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2015-11-27)
    The human gamma-herpesvirus Epstein-Barr virus (EBV) has been implicated in the pathogenesis of a broad spectrum of lymphoid and epithelial cell malignancies. A characteristic property of the virus is the capacity to ...
  • From molecule to neuron : thyroid hormone action in the brain 

    Gralla, Susi (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2015-10-16)
    The importance of thyroid hormone (TH) for mental health has been known for decades. With the identification of the thyroid hormone receptors α and β (TRα, TRβ), TR dependent mechanisms involved in brain development were ...

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