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  • Touching cognition : somatosensory processing and plasticity deficits in mouse barrel cortex 

    Juczewski, Konrad (Inst för neurovetenskap / Dept of Neuroscience, 2017-06-07)
    Senses together with thoughts and experience are key factors that shape our cognition. Touch is an important source of sensory information. Disturbances to the development of the somatosensory system have serious consequences ...
  • Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking 

    Nigam, Saket Milind (Inst för neurovetenskap / Dept of Neuroscience, 2017-05-26)
    Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit ...
  • From movement to skill : neural and behavioral mechanisms of motor sequence learning 

    Müβgens, Diana (Inst för neurovetenskap / Dept of Neuroscience, 2017-05-24)
    How do we learn new movements? The simple answer to this question is Through practice! Yet, a better response might be What aspect of motor learning are we talking about? Our capacity for learning new skills and for ...
  • Tissue microbiology : an integrated approach for intravital studies of host-pathogen interactions 

    Choong, Ferdinand Xiankeng (Inst för neurovetenskap / Dept of Neuroscience, 2017-05-08)
    A bacteria infection in the living host is the summation of a myriad of interactions. Reductionistic and sacrificial experiment models cannot replicate this complexity. The Tissue Microbiology approach overcomes this by ...
  • Neural circuitry mechanisms in decision-making 

    Wang, Xinming (Inst för neurovetenskap / Dept of Neuroscience, 2017-04-07)
    The brain is the exclusive organ that makes decisions for humans and the society. In this thesis, I will discuss recent advances in the understanding of neuroscientific mechanisms in decision-making. Decision-making is not ...
  • Body-ownership and visual perception 

    Hoort, Björn van der (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-30)
    The idea that our body plays an important role in visual perception has a long history in storytelling and philosophy. Some ideas are very intuitive. For example, few will disagree with the notion that smaller people ...
  • Gut microbes and the developing brain 

    Arentsen, Tim (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-17)
    The discovery that commensal gut microbiota can influence host development and physiology beyond the gastrointestinal (GI) tract has triggered a paradigm shift in our conceptualization of the origin of human diseases. A ...
  • Molecular determinants of endocannabinoid-mediated brain development 

    Calvigioni, Daniela (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-10)
    The enchanting process of brain development entails a fragile and finite time window, throughout which biochemical imbalances and external insults can potentially affect developing neuronal circuits. Within the numerous ...
  • Identification of pathways of degeneration and protection in motor neuron diseases 

    Nichterwitz, Susanne (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-09)
    Motor neuron diseases preferentially affect specific neuronal populations with distinct clinical features even if disease-causing genes are expressed in many cell types. In spinal muscular atrophy (SMA), somatic motor ...
  • Calcium-binding proteins as markers and functional determinants of neurons in pain networks 

    Zhang, Mingdong (Inst för neurovetenskap / Dept of Neuroscience, 2017-03-02)
    The thesis focuses on the anatomical and cellular distribution of three EF-hand calcium binding proteins, secretagogin, neuronal calcium-binding protein 1 (NECAB1) and NECAB2 in dorsal root ganglia (DRGs) and spinal cord ...
  • Experimental, mild blast-induced traumatic brain injury : focus on the monoamine and galanin systems 

    Kawa, Lizan (Inst för neurovetenskap / Dept of Neuroscience, 2017-02-14)
    Traumatic brain injury (TBI) is a common cause of mortality and morbidity among civilians and servicemen alike. The spectrum of TBIs encompasses mild to severe cases, with the predominate number of TBIs being mild (mTBI). ...
  • Molecular and epigenetic control of CNS tumour and progenitor cells 

    Gracias, Aileen (Inst för neurovetenskap / Dept of Neuroscience, 2017-02-09)
    Despite advances in diagnosis and treatment, CNS tumours continue to result in high mortality and morbidity. Glioblastoma mutliforme (GBM), the most common primary brain tumour, is a recurrent tumour that despite advances ...
  • Functional role of cerebrospinal fluid contacting cells in the spinal cord and hypothalamus 

    Jalalvand, Elham (Inst för neurovetenskap / Dept of Neuroscience, 2017-01-12)
    Cerebrospinal fluid-contacting (CSF-c) cells are found lining the walls of the central canal and the ventricles throughout the vertebrate phylum, but their function has remained elusive. The aim here was to investigate ...
  • Anatomical and functional characterization of serotonergic neurocircuitry 

    Pollak Dorocic, Iskra (Inst för neurovetenskap / Dept of Neuroscience, 2016-12-19)
    The serotonin system arises from a small collection of brainstem structures called the raphe nuclei and innervates much of the central nervous system. A relatively small number of serotonin neurons modulate a wide variety ...
  • Non-linear synaptic integration on dendrites of striatal medium-spiny neuron : a computational study 

    Du, Kai (Inst för neurovetenskap / Dept of Neuroscience, 2016-11-25)
    Striatum is the main input nucleus of basal ganglia. Medium-spiny neurons (MSNs), the principal neurons of the striatum, receive convergent excitatory inputs from cortex and thalamus, thus “gate” the information flow to ...
  • Neuropeptides in the human postmortem brain : focus on galanin and its receptors in depression 

    Barde, Swapnali (Inst för neurovetenskap / Dept of Neuroscience, 2016-11-25)
    Neuropeptides represent the most diverse family of messenger molecules in the nervous system, which are co-expressed with key neurotransmitters in several brain regions. They modulate synaptic neurotransmission and have, ...
  • Molecular coding and physiological roles of excitatory neurons in motor control 

    Ribeiro Caldeira, Vanessa (Inst för neurovetenskap / Dept of Neuroscience, 2016-11-24)
    Locomotion is a complex motor action that provides humans and other animals with the ability to move through the environment. In vertebrate locomotion, supraspinal centers convey the initiating or terminating command signals ...
  • Att bedöma behov : utredningar av ungdomar som begått kriminella handlingar 

    Åström, Therese (Inst för neurovetenskap / Dept of Neuroscience, 2016-11-04)
    Syftet med föreliggande avhandling var att undersöka socialsekreterares utredningar och bedömningar av ungdomar som uppvisat kriminellt beteende, samt matchning mellan bedömda behov och rekommenderade behandlingsinsatser. ...
  • Multisensory mechanisms of body ownership and self-location 

    Guterstam, Arvid (Inst för neurovetenskap / Dept of Neuroscience, 2016-08-05)
    Having an accurate sense of the spatial boundaries of the body is a prerequisite for interacting with the environment and is thus essential for the survival of any organism with a central nervous system. Every second, ...
  • Neurotensin and cortical arousal : an in vitro study 

    Case, Lovisa (Inst för neurovetenskap / Dept of Neuroscience, 2016-05-31)
    The information processing associated with wakefulness occurs during what is commonly referred to as a cortical desynchronized state. In contrast, deep sleep is accompanied by slow, synchronized electrical activity, perhaps ...

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