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  • The male predominance in esophageal adenocarcinoma 

    Xie, Shaohua; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-02-21)
    The incidence of esophageal adenocarcinoma (EAC) has increased rapidly during the past four decades in many Western populations, including North America and Europe. The established etiological factors for EAC include ...
  • Duration of Second Stage of Labour at Term and Pushing Time: Risk Factors for Postpartum Haemorrhage 

    Looft, Emelie; Simic, Marija; Ahlberg, Mia; Snowden, Jonathan M.; Cheng, Yvonne W.; Stephansson, Olof (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-02-21)
    BACKGROUND: Prolonged labour is associated with increased risk of postpartum haemorrhage (PPH), but the role of active pushing time and the relation with management during labour remains poorly understood. METHODS: A ...
  • A model for predicting individuals' absolute risk of esophageal adenocarcinoma : moving toward tailored screening and prevention 

    Shaohua, Xie; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-02-15)
    Esophageal adenocarcinoma (EAC) is characterized by rapidly increasing incidence and poor prognosis, stressing the need for preventive and early detection strategies. We used data from a nationwide ...
  • Depression or anxiety in adult twins is associated with asthma diagnosis but not with offspring asthma 

    Tedner, SG; Lundholm, Cecilia; Olsson, Henrik; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-17)
    BACKGROUND: Asthma is common in both children and adults in the Western world, just like anxiety and depression. While some research has revealed that these diseases might share important environmental and ...
  • Robust Linear Models for Cis-eQTL Analysis 

    Rantalainen, Mattias; Lindgren, Cecilia M; Holmes, Christopher C (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    Expression Quantitative Trait Loci (eQTL) analysis enables characterisation of functional genetic variation influencing expression levels of individual genes. In outbread populations, including humans, eQTLs ...
  • The influence of childhood asthma on puberty and height in Swedish adolescents 

    Protudjer, Jennifer Lisa; Lundholm, Cecilia; Bergström, Anna; Kull, Inger; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    BACKGROUND: Evidence relating to the effect of asthma on puberty or height is inconclusive. We aimed to examine whether the exposure of childhood asthma, including timing and phenotypes, and inhaled corticosteroid ...
  • Determining breast cancer histological grade from RNA-sequencing data 

    Wang, Mei; Klevebring, Daniel; Lindberg, Johan; Czene, Kamila; Grönberg, Henrik; Rantalainen, Mattias (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    BACKGROUND: The histologic grade (HG) of breast cancer is an established prognostic factor. The grade is usually reported on a scale ranging from 1 to 3, where grade 3 tumours are the most aggressive. However, grade 2 ...
  • Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers 

    Rantalainen, Mattias; Klevebring, Daniel; Lindberg, Johan; Ivansson, Emma; Rosin, Gustaf; Kis, Lorand; Celebiouglu, Fuat; Fredriksson, Irma; Czene, Kamila; Frisell, Jan; Hartman, Johan; Bergh, Jonas; Grönberg, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    Sequencing-based breast cancer diagnostics have the potential to replace routine biomarkers and provide molecular characterization that enable personalized precision medicine. Here we investigate the concordance between ...
  • Study design requirements for RNA sequencing-based breast cancer diagnostics 

    Mer, Arvind Singh; Klevebring, Daniel; Grönberg, Henrik; Rantalainen, Mattias (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    Sequencing-based molecular characterization of tumors provides information required for individualized cancer treatment. There are well-defined molecular subtypes of breast cancer that provide improved ...
  • Early exposure to dogs and farm animals and the risk of childhood asthma 

    Fall, Tove; Lundholm, Cecilia; Örtqvist, Anne K; Fall, Katja; Fang, Fang; Hedhammar, Åke; Kämpe, Olle; Ingelsson, Erik; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    IMPORTANCE: The association between early exposure to animals and childhood asthma is not clear, and previous studies have yielded contradictory results. OBJECTIVE: To determine whether exposure to dogs ...
  • Snus and risk of gastroesophageal reflux. A population-based case-control study : the HUNT study 

    Lie, Tina Malene; Bomme, Maria; Hveem, Kristian; Hansen, Jane Møller; Ness-Jensen, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-01-04)
    Objective: Tobacco smoking is a risk factor for gastroesophageal reflux, but whether other tobacco products increase the risk is unclear. The aim of this study was to investigate if snus increases the risk of ...
  • Risk factors of admission for acute colonic diverticulitis in a population-based cohort study : the HUNT Study, Norway 

    Talabani, Aras Jamal; Lydersen, Stian; Ness-Jensen, Eivind; Endreseth, Birger Henning; Edna, Tom-Harald (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-01-04)
    AIM To assess risk factors of hospital admission for acute colonic diverticulitis. METHODS The study was conducted as part of the second wave of the population-based North Trondelag Health Study (HUNT2), ...
  • The observed association between maternal anxiety and adolescent asthma : children of twin design suggest familial effects 

    Havland, Ida; Lundholm, Cecilia; Lichtenstein, Paul; Neiderhiser, Jenae M; Ganiban, Jody M; Spotts, Erica L; Walum, Hasse; Reiss, David; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    BACKGROUND: Previous studies indicate that maternal anxiety is associated with asthma in the adolescent child, but mechanisms are unclear. OBJECTIVE: To investigate the association between maternal anxiety ...
  • Asthma during pregnancy in a population-based study--pregnancy complications and adverse perinatal outcomes 

    Rejnö, Gustaf; Lundholm, Cecilia; Gong, Tong; Larsson, Kjell; Saltvedt, Sissel; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    BACKGROUND: Asthma is one of the most common chronic diseases, and prevalence, severity and medication may have an effect on pregnancy. We examined maternal asthma, asthma severity and control in relation to ...
  • Parental socioeconomic status, childhood asthma and medication use : a population-based study 

    Gong, Tong; Lundholm, Cecilia; Rejnö, Gustaf; Mood, Carina; Långström, Niklas; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    BACKGROUND: Little is known about how parental socioeconomic status affects offspring asthma risk in the general population, or its relation to healthcare and medication use among diagnosed children. METHODS: ...
  • Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis 

    Örtqvist, Anne K; Lundholm, Cecilia; Kieler, Helle; Ludvigsson, Jonas F; Fall, Tove; Ye, Weimin; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    OBJECTIVE: To investigate the association between exposure to antibiotics in fetal and early life and asthma in childhood, with adjustment for confounding factors. DESIGN: Nationwide prospective population ...
  • Antibiotic treatment and length of hospital stay in relation to delivery mode and prematurity 

    Ahlén, Katia; Örtqvist, Anne; Gong, Tong; Wallas, Alva; Ye, Weimin; Lundholm, Cecilia; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    AIM: To investigate how 1) maternal delivery mode and 2) prematurity in infants are associated to antibiotic treatment and length of hospital stay. METHODS: Women having given birth and infants 0-12 months ...
  • Metabolic syndrome and esophageal and gastric cancer 

    Lin, Yulan; Ness-Jensen, Eivind; Hveem, Kristian; Lagergren, Jesper; Lu, Yunxia (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-20)
    BACKGROUND: The role of the metabolic syndrome in the etiology of esophageal and gastric cancer is unclear. METHODS: This was a large nationwide cohort study based on data from 11 prospective population-based ...
  • Anthropometry-based obesity phenotypes and risk of colorectal adenocarcinoma: a large prospective cohort study in Norway 

    Lu, Yunxia; Ness-Jensen, Eivind; Martling, Anna; Hveem, Kristian (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-20)
    BACKGROUND: It is unclear whether obesity phenotypes measured by different anthropometric indices are associated with a risk of colorectal adenocarcinoma by anatomical location. METHODS: We compiled harmonized ...
  • Psychiatric disorders and suicide attempts in Swedish survivors of the 2004 southeast Asia tsunami: a 5 year matched cohort study. 

    Arnberg, Filip K.; Gudmundsdóttir, Ragnhildur; Butwicka, Agnieszka; Fang, Fang; Lichtenstein, Paul; Hultman, Christina M.; Valdimarsdóttir, Unnur A. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-12-19)
    BACKGROUND: Survivors of natural disasters are thought to be at an increased risk of psychiatric disorders, however the extent of this risk, and whether it is linked to pre-existing psychopathology, is not ...

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