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  • Mode of obstetrical delivery and type 1 diabetes : a sibling design study 

    Khashan, Ali S; Kenny, Louise C; Lundholm, Ceciclia; Kearney, Patricia M; Gong, Tong; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)
    OBJECTIVES: We investigated the association between cesarean section (CS) and type 1 diabetes (T1D), and if the association remains after accounting for familial confounding by using a sibling-control design. ...
  • Are carriers of CYP21A2 mutations less vulnerable to psychological stress? A population-based national cohort study 

    Nordenström, A.; Butwicka, A.; Linden Hirschberg, A.; Almqvist, C.; Nordenskjöld, A.; Falhammar, H.; Frisen, L. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)
    Background Congenital adrenal hyperplasia (CAH) is one of the most common monogenic autosomal recessive disorders with an incidence of one in 15 000. About one in 70 individuals in the general population are carriers ...
  • The influence of childhood asthma on puberty and height in Swedish adolescents 

    Protudjer P., J.L.; Lundholm, C.; Bergström, A.; Kull, I.; Almqvist, C. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)
    BACKGROUND: Evidence relating to the effect of asthma on puberty or height is inconclusive. We aimed to examine whether the exposure of childhood asthma, including timing and phenotypes, and inhaled corticosteroid ...
  • Asthma and height in twins : a cohort and within-pair analyses study. 

    Protudjer, Jennifer; Lundholm, Cecilia; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)
    In singletons, asthma may be associated with shorter height and delayed growth during adolescence. Yet, these studies do not account for heritability of asthma, puberty/menarche, and height. We aimed to study ...
  • Menopausal hormone therapy and the risk of esophageal and gastric cancer 

    Brusselaers, Nele; Maret-Ouda, John; Konings, Peter; El-Serag, HB; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-24)
    A protective effect of female sex hormones has been suggested to explain the male predominance in esophageal and gastric adenocarcinoma, but evidence is lacking. We aimed to test whether menopausal hormone therapy (MHT) ...
  • TGF-β affects the differentiation of human GM-CSF+ CD4+ T cells in an activation- and sodium-dependent manner 

    Éliás, Szabolcs; Schmidt, Angelika; Kannan, Venkateshan; Andersson, John; Tegnér, Jesper (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-05-24)
    The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is involved in the pathogenesis of chronic inflammatory diseases such as multiple sclerosis. However, the environmental cues promoting differentiation ...
  • Paternal age at childbirth and eating disorders in offspring 

    Javaras, K.N.; Rickert, M.E.; Thornton, L.M.; Peat, C.M.; Baker, J.H.; Birgegard, A.; Norring, C.; Landen, M.; Almqvist, C.; Larsson, H.; Lichtenstein, P.; Bulik, C.M.; D'Onofrio, B.M. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-05-24)
    Background. Advanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated paternal age’s relationship ...
  • Comparative analysis of protocols to induce human CD4+Foxp3+ regulatory T cells by combinations of IL‐2, TGF‐beta, retinoic acid, rapamycin and butyrate 

    Schmidt, Angelika; Eriksson, Matilda; Shang, Ming-Mei; Weyd, Heiko; Tegnér, Jesper (Inst för medicin, Solna / Dept of Medicine, SolnaKarolinska Institute, KI, 2017-05-24)
    Regulatory T cells (Tregs) suppress other immune cells and are critical mediators of peripheral tolerance. Therapeutic manipulation of Tregs is subject to numerous clinical investigations including trials for adoptive ...
  • The risk of mortality following secondary fundoplication in a population-based cohort study 

    Maret-Ouda, John; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-16)
    BACKGROUND: Mortality following laparoscopic fundoplication has been found to be negligible. However, some patients require secondary fundoplication, and the risk of mortality following such procedure is ...
  • Marital status, education, and income in relation to the risk of esophageal and gastric cancer by histological type and site 

    Lagergren, Jesper; Andersson, Gunnar; Talbäck, Mats; Drefahl, Sven; Bihagen, Erik; Härkönen, Juho; Feychting, Maria; Ljung, Rickard (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-10)
    BACKGROUND: Marital status, income, and education might influence the risk of esophageal and gastric cancer, but the literature is limited. A large study addressing subtypes of these tumors was used to clarify these ...
  • Gestational age and birth weight and the risk of childhood type 1 diabetes : a population-based cohort and sibling design study 

    Khashan, Ali S; Kenny, Louise C; Lundholm, Cecilia; Kearny, Patricia M; Gong, Tong; McNamee, Roseanne; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-05-10)
    Objectives: We investigated the effects of gestational age, birthweight, small for gestational age (SGA) and large for gestational age (LGA) on childhood type 1 diabetes. Methods: We conducted a population-based ...
  • Helicobacter pylori eradication in the Swedish population 

    Doorakkers, Eva; Lagergren, Jesper; Gajulapuri, Vijaya Krishna; Callens, Steven; Engstrand, Lars; Brusselaers, Nele (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell BiologyInst för molekylär medicin och kirurgi / Dept of Molecular Medicine and SurgeryKing's College LondonGhent University Belgium, 2017-04-28)
    Objectives: Helicobacter pylori (H. pylori) is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of ...
  • Eradication of Helicobacter pylori and gastric and oesophageal cancer : a systematic review and meta-analysis of cohort studies 

    Doorakkers, Eva; Lagergren, Jesper; Engstrand, Lars; Brusselaers, Nele (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell BiologyInst för molekylär medicin och kirurgi / Dept of Molecular Medicine and SurgeryKing's College London, 2017-04-28)
    Background: Helicobacter pylori (H. pylori) is associated with an increased risk of gastric adenocarcinoma and gastric mucosa associated lymphoid tissue (MALT) lymphoma, and a seemingly decreased risk of oesophageal ...
  • Why oesophageal adenocarcinoma is occurring more frequently 

    Doorakkers, Eva; Brusselaers, Nele (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-28)
    The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk ...
  • Parental antibiotics and childhood asthma : a population-based study 

    Örtqvist, A.K.; Lundholma, C.; Fang, F.; Fall, T.; Almqvist, C. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-04-28)
    In this population-based study on antibiotic treatment before, during and after pregnancy, using paternal exposure as negative control, we confirm that associations between maternal antibiotic exposure and childhood asthma ...
  • Intratumoral lactate metabolism in Barrett’s esophagus and adenocarcinoma 

    Kauppila, Joonas; Huhta, Heikki; Helminen, Olli; Palomäki, Sami; Lehenkari, Petri; Saarnio, Juha; Karttunen, Tuomo (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-25)
    Background: Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are activated in various cancers, but their expression in ...
  • Extent of lymphadenectomy and prognosis after esophageal cancer surgery 

    Lagergren, Jesper; Mattsson, Fredrik; Zylstra, Janine; Chang, Fuju; Gossage, James; Mason, Robert; Lagergren, Pernilla; Davies, Andrew (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)
    IMPORTANCE: The prognostic role of the extent of lymphadenectomy during surgery for esophageal cancer is uncertain and requires clarification. OBJECTIVE: To clarify whether the number of removed lymph nodes influences ...
  • Weekday of oesophageal cancer surgery in relation to early postoperative outcomes in a nationwide Swedish cohort study 

    Lagergren, Jesper; Mattsson, Fredrik; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)
    Objectives: Later weekday of surgery for oesophageal cancer seems to increase 5-year mortality, but the mechanisms are unclear. We hypothesised that early postoperative reoperations and mortality might explain this ...
  • Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer 

    Kazemi, Mohammad Hossein (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-04-24)
    Tumor cells overcome anti-tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and ...
  • Risk of eating disorders in immigrant populations 

    Mustelin, L.; Hedman, A.; Thornton, L.M.; Kuja-Halkola, R.; Keski-Rahkonen, A.; Cantor-Graae, E.; Almqvist, C.; Lichtenstein, P.; Mortensen, P.B.; Böcker Pedersen, C.; Bulik, C.M. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-04-24)
    Objective: The risk of certain psychiatric disorders is elevated among immigrants. To date, no population studies on immigrant health have addressed eating disorders. We examined whether risk of eating disorders in first- ...

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