Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience
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Scare or care? How immunological processes shape perception of sickness-relevant stimuli in humans
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-04-23)Humans and other animals have developed several defense systems to handle living in a pathogen-rich world. These defense systems include immune responses, as well as behavioral responses aimed at supporting immune ... -
Noninvasive estimation of intracranial pressure with optic nerve sheath diameter sonography
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-03-26)Background: Modern neurointensive care aims to prevent or mitigate secondary cerebral insults after severe primary cerebral insults, such as subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI). Optimization of ... -
Translational studies of glucocerebrosidase in Parkinson´s disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-03-14)A number of genetic variants have been linked to Parkinson’s disease (PD). Among these, mutations in the GBA1 gene are identified as one of the most common risk factors for developing PD. The connection between increased ... -
Novel ophthalmological assessments for detection of optic pathway gliomas in children
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-22)Optic pathway gliomas (OPGs) are vision-threatening brain lesions that are extremely important to detect at young age for appropriate medical intervention. Children with neurofibromatosis type 1 (NF1) are particularly at ... -
Development of novel and accessible treatments for trichotillomania and skin-picking disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-15)Background: Trichotillomania (TTM) and Skin-picking disorder (SPD) are psychiatric conditions characterized by recurrent and excessive hair-pulling and skin-picking, respectively. These behaviors result in significant hair ... -
Am I mad, bad or dangerous? A novel intervention approach for unwanted intrusive thoughts
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-14)Background: Unwanted intrusive thoughts (UITs) containing unacceptable and taboo themes is regarded as a common and, for most, transient cognitive phenomenon. However, these thoughts can become so frequent and distressing ... -
Parkinson's disease and Gaucher disease : focus on the GBA1 link
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-13)Parkinson’s disease (PD) is the 2nd most common neurodegenerative disorder in the world, characterized by both motor as well as many non-motor features. There are many symptomatic treatments available, that may shift ... -
Does online parent training measure up to group parent training in real-world settings?
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-12)Background: Disruptive behavior problems involve recurrent patterns of defiance, aggression, and hostility that interfere with normal functioning. Disruptive behaviors are commonly observed in children and adolescents and ... -
Clinical characteristics and treatment outcomes in body dysmorphic disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-02-01)Body dysmorphic disorder (BDD) is an early onset mental disorder characterized by a preoccupation with perceived flaws in physical appearance. Research on the presentation of the disorder is sparse, especially on young ... -
Reduced variability of bursting activity during working memory
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)Working memories have long been thought to be maintained by persistent spiking. However, mounting evidence from multiple-electrode recording (and single-trial analyses) shows that the underlying spiking is better characterized ... -
Working memory control dynamics follow principles of spatial computing
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)Working memory (WM) allows us to remember and selectively control a limited set of items. Neural evidence suggests it is achieved by interactions between bursts of beta and gamma oscillations. However, it is not clear how ... -
Multimodal and multiscale brain networks : understanding aging, Alzheimer’s disease, and other neurodegenerative disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-24)The human brain can be modeled as a complex network, often referred to as the connectome, where structural and functional connections govern its organization. Several neuroimaging studies have focused on understanding the ... -
From cytologic features to serum markers: advancing prognostication of uveal melanoma
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-08)Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. As surveys show, almost all patients diagnosed with UM want prognostic information. However, the tools available today for early prognostication ... -
Genetic, neurodevelopmental and psychiatric studies of Turner syndrome
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2023-11-20)Turner Syndrome (TS) is a genetic condition characterized by the partial or complete loss of one sex chromosome. Associations with neurodevelopmental and psychiatric disorders has been suggested in TS, but findings are ... -
Respiratory influences on pupil size dynamics and visual recognition memory
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2023-11-16)Breathing, a fundamental rhythm of life, has traditionally been associated with the exchange of oxygen and carbon dioxide. However, recent research in both animal models and humans has unveiled additional roles of respiration ... -
Optimization of in vivo cell tracking methods with long-lived radionuclides for PET imaging
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2023-11-15)Stem cell transplantation and cell therapy are the standard treatments for many diseases; however, many suffer from complications, and the therapeutic efficiency can be challenging to predict. The off-target accumulation ... -
Self-assessed visual function in cataract surgery using Catquest-9SF
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2023-11-14)The cataract disease is the leading cause of preventable blindness in high-income countries alone as well as globally despite the groundbreaking technological advancements in recent years and steadily increasing number ... -
The adolescent drinker : correlates and predictors of alcohol consumption among Swedish youth
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2023-11-06)Background: Drinking among adolescents has declined in most high-income countries during the past two decades. In Sweden, the reduction in youth drinking has been more pronounced than in many other parts of the world. The ... -
Treatment of alcohol dependence in primary care
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2023-10-12)Alcohol dependence is a common disorder and contributes to substantial morbidity and mortality globally. Only 10-20 percent engage in treatment, which makes alcohol dependence the mental disorder with the largest treatment ... -
Nonsuicidal self-injury in adolescence : attempts to improve and develop treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2023-10-05)Nonsuicidal self-injury (NSSI) and NSSI disorder are common in adolescence and associated with adverse outcomes, including suicide attempts. Detecting vulnerable children and adolescents is essential to decrease the risk ...