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  • Skeletal muscle PGC-1α1 and KAT enzymes at the intersection between depression and metabolic disease 

    Agudelo, Leandro Z. (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-01-10)
    Depression and metabolic diseases are leading causes of disability and major contributors to socioeconomic burden worldwide. Physical activity exerts many beneficial effects that confer direct health improvement in ...
  • Circadian rhythms in the auditory system 

    Basinou, Vasiliki (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-12-27)
    Circadian clocks have been found in numerous cell types and tissues of the body, allowing organisms to coordinate their daily biological functions. They generate cycles of behavioral and physiological processes with a ...
  • NADPH oxidase and xanthine oxidoreductase as targets and regulators of the nitrate-nitrite-nitric oxide pathway 

    Peleli, Maria (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-11-11)
    Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) and xanthine oxidoreductase (XOR) with a concomitant decrease in the bioavailability of nitric oxide (NO) from eNOS contributes to the development of ...
  • Aspects on extracorporeal life support for severe acute respiratory failure with special reference to the influenza A/H1N1 2009 pandemic 

    Holzgraefe, Bernhard (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-11-03)
    Extracorporeal membrane oxygenation provides pulmonary and circulatory support. First abandoned from the majority of the intensive care community because of disappointing results in several trials (with questionable ...
  • Mechanisms of pain in autoimmunity : the role of antibodies 

    Wigerblad, Gustaf (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-10-18)
    Chronic pain in autoimmune diseases, like rheumatoid arthritis (RA), is a common and life- changing problem for many patients. Treatment is usually aimed at reducing inflammation and preserving the function of affected ...
  • Imbalanced kynurenine pathway in schizophrenia and depression : immunological and genetic aspects 

    Liu, Xicong (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-09-30)
    Kynurenic acid (KYNA), an end metabolite of the kynurenine pathway along tryptophan degradation, has gained increasing interest in the pathophysiology of psychiatric disorders. Elevated levels of KYNA have been found in ...
  • Transcriptional regulation of ribosome biogenesis in skeletal muscle growth 

    Liu, Chang (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-05-30)
    Resistance exercise induces skeletal muscle hypertrophy via repeated exercise bouts. The increased muscle protein synthesis together with altered muscle protein degradation contribute to the adaptation of muscle mass. The ...
  • Neurally adjusted ventilatory assist : from animal studies to clinical practice 

    Campoccia Jalde, Francesca (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-05-20)
    Patients in the Intensive Care Unit (ICU) undergoing ventilator treatment may experience asynchrony with the ventilator, which has been associated with increased need of sedation, sleep disruption, prolonged mechanical ...
  • Colon cancer specific cytochrome P450 2W1 : polymorphism, membrane topology and endogenous roles in development 

    Guo, Jia (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-05-19)
    Cytochrome P450 2W1 (CYP2W1) belongs to a family of drug metabolizing monooxygenases with an unidentified yet endogenous function. CYP2W1 expression pattern has characteristic features of oncofetal genes. Previous studies ...
  • Intravenous induction of anaesthesia in children : aspects on propofol and etomidate 

    Nyman, Yvonne (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-04-29)
    Propofol is today the most commonly used drug for induction of anaesthesia and for short-term sedation. However, one specific problem is that intravenous injection of propofol often results in quite severe injection pain, ...
  • Ionic modulators of stem cell state 

    Omelyanenko, Anna (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-04-27)
    Tissue generation during development and maintenance throughout life relies on the proliferation and sequential specification of a group of cells. Stem cells are defined by the properties of self-renewal (division to produce ...
  • Sense of Coherence (SOC) in women treated for breast cancer and its relation to treatment outcome 

    Lindblad, Carina (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-04-20)
    Breast cancer incidence has, on average increased by 1.4 % annually during the last decades. Early detection and advances in treatment are the main contributing factors for the favourable outcome in terms of five- and ...
  • Chronic pain and arthritis – studies of mechanisms in the regulation of hypersensitivity 

    Su, Jie (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-04-15)
    Chronic pain is one of the most devastating symptoms reported by rheumatoid arthritis (RA) patients. Current treatment strategies are focusing on dampening the inflammatory and immunological aspects of RA, but unfortunately ...
  • Abnormal coagulation and platelet function in patients with severe traumatic brain injury 

    Nekludov, Michael (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-03-22)
    Traumatic brain injury (TBI) is associated with a high mortality and severe long-term morbidity in survivors. TBI often affects previously healthy young persons, and represents one of the most common causes of death among ...
  • Skin conductance variability and stressful exposures in critical care 

    Günther, Anders (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2016-02-19)
    Numerous stressors affect the intensive care unit (ICU) patient. The ICU environment is busy and noisy, with monitoring and treatment around the clock. ICU patients may have problems in getting some sleep, due to lighting ...
  • Structural and functional analysis of WNT receptors : with emphasis on FZD6 

    Petersen, Julian (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2015-12-17)
    Many cellular processes are dependent on the activation of G protein-coupled receptors (GPCRs). The development of drugs that can specifically target GPCRs and their corresponding signalling cascades is of high interest. ...
  • The search for human skeletal muscle memory : exercise effects on the transcriptome and epigenome 

    Lindholm, Maléne (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2015-11-05)
    Regular physical activity is an environmental stimulus that is highly associated to many health benefits, while physical inactivity is detrimental for health and physical function. Regular exercise training is used in ...
  • The role of sarcoplasmic calcium in skeletal muscle training adaptation 

    Ivarsson, Niklas (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2015-10-29)
    Current research shows a clear correlation between strong mitochondrial capacity, healthy muscle and general public health. A sedentary lifestyle increases the risk of a whole host of so called ‘western diseases’, while ...
  • Critical care in low resource settings 

    Baker, Tim (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2015-10-08)
    Background: Critical care is the care of patients with immediately life-threatening disease or injury. The substantial global burden of critical illness is especially high in low resource settings. There is a striking lack ...
  • Evaluation and development of a capnodynamic method for estimation of pulmonary blood flow in a porcine model 

    Hällsjö Sander, Caroline (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2015-09-21)
    Effective pulmonary blood flow (EPBF) i.e. cardiac output (CO) minus shunt flow could be estimated by a capnodynamic equation. Via introduction of short pauses in the ventilatory pattern the required alterations of carbon ...

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