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  • Ageing, deep vein thrombosis and male gender predict poor outcome after acute Achilles tendon rupture 

    Domeij-Arverud, Erica; Anundsson, Per; Hardell, Eva; Barreng, Gunilla; Edman, Gunnar; Latifi, Ali; Labruto, Fausto; Ackermann, Paul (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)
    Background: Patients with acute Achilles tendon rupture (ATR) exhibit prolonged healing, high incidence of deep venous thrombosis (DVT) and a wide variation of functional outcome. This extensive discrepancy in outcome may ...
  • Reduced time to surgery improves patient-reported outcome after achilles tendon rupture. 

    Ackermann, Paul; Edman, Gunnar; Juthberg, Robin; Svedman, Simon (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)
    Background: Patient outcome after an acute Achilles tendon rupture (ATR) continues to be suboptimal and heterogeneous. Thus, prognostic factors are called for to optimize evidence-based ATR treatment protocols, however, ...
  • Development of probes for molecular imaging : evaluation in models of inflammation and atherosclerosis 

    Ahmed, Mona (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-02-22)
    The imaging field is rapidly evolving and in the last two decades there have been tremendous developments in the field of multimodal imaging. Multimodal molecular imaging approaches that utilize ultrasound/magnetic ...
  • Pancreatic βeta-cell insulin signaling in genetic and dietary models of obesity and insulin resistance 

    Paschen, Meike (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-02-14)
    Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood glucose levels that has reached pandemic proportions. Genome-wide association studies have linked T2DM to the function ...
  • Abdominal aortic aneurysm : uncharted aspects of rupture 

    Zommorodi, Sayid (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-01-10)
    Unlike intact abdominal aortic aneurysm (iAAA), ruptured abdominal aortic aneurysm (rAAA) is a lethal condition demanding immediate resuscitation and surgical intervention. Where the former is a silent disease with slow ...
  • Engraftment and tolerance induction in cellular therapy : focus on mesenchymal stromal cells 

    Ljung, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-12-20)
    Different cell types have been employed in the search for a cellular therapy that is applicable for the treatment of heart failure. Remuscularization strategies using stem-cell-derived cardiomyocytes have been prone to ...
  • Helicobacter pylori eradication treatment and the risk of gastric and oesophageal cancer 

    Doorakkers, Eva (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-12-19)
    Helicobacter pylori is a strong and well-established risk factor for gastric cancer, but seems to decrease the risk of oesophageal adenocarcinoma. Thus, eradication treatment for Helicobacter pylori may decrease the risk ...
  • Oesophageal cancer surgery : nutritional determinants of survivorship 

    Anandavadivelan, Poorna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-23)
    Oesophagectomy, the surgery offered as a curative treatment for cancer of the oesophagus is highly invasive with a radical change in anatomy and carries a risk for significant morbidity and mortality. The recovery is ...
  • Autologous fat transplantation to the female breast after surgery and radiotherapy assessment of patient-reported outcomes, radiology and gene expression patterns 

    Lindegren, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-22)
    Autologous fat transplantation (AFT) is commonly used as a complementary method to enhance breast appearance after breast surgery, radiotherapy and breast reconstruction. Some of the indications for AFT to the breast are ...
  • Minimally-invasive breast interventions : methods for high yield, low risk, precision biopsy and curative thermal ablation 

    Schässburger, Kai-Uwe (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-15)
    Advances in medical imaging and the introduction of population-based screening programs have increased the detection rate and overall proportion of small breast tumors. In addition, progress in technology and medical ...
  • Novel blood markers in psychosis 

    Kumar, Parvin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-12)
    Psychotic disorders such as schizophrenia maintain a 1% point prevalence in society at large. They cause much suffering to the patients and exact grave costs on society. There is an urgent need for better diagnosis and ...
  • Prognosis following cancer surgery during holiday periods 

    Lagergren, Jesper; Lagergren, Pernilla; Mattsson, Fredrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-19)
  • Weekday of cancer surgery in relation to prognosis 

    Lagergren, Jesper; Mattson, Fredrik; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-11)
    BACKGROUND: Later weekday of surgery seems to affect the prognosis adversely in oesophageal cancer, whereas any such influence on other cancer sites is unknown. This study aimed to test whether weekday of surgery influenced ...
  • Extracorporeal membrane oxygenation (ECMO) for the treatment of cardiogenic shock : identification of pre-implant outcome predictors 

    Fux, Thomas (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-10-11)
    Background: Refractory cardiogenic shock (RCS), cardiac arrest (CA) and postarrest cardiogenic shock (CS) are associated with high mortality. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used ...
  • Prosthetic aortic heart valves 

    Glaser, Natalie (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-21)
    Background Aortic valve replacement (AVR) can be performed with different types of valve prostheses. There is no perfect aortic valve prosthesis, and the prosthetic choice for each patient requires careful consideration. ...
  • Expanding the genetic and phenotypic spectrum of skeletal dysplasias 

    Hammarsjö, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-17)
    Skeletal dysplasias constitute a large and heterogeneous group of disorders, many causing disabilities with profound effects on the quality of life of the affected individuals and their families. Each individual skeletal ...
  • Improving surgical therapy for oesophageal cancer 

    Markar, Sheraz Rehan (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-14)
    Despite advances in multimodality treatment, surgery remains the mainstay of curative treatment for oesophageal cancer. However short- and long-term mortality from oesophagectomy for oesophageal cancer still shows large ...
  • Pulmonary hypertension : the role and place of PDGF 

    Tannenberg, Philip (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)
    Pulmonary hypertension is a severe condition, leading to right heart dysfunction and preterm death. For pulmonary arterial hypertension (PAH), a disease group in which the primary pathology resides within the pulmonary ...
  • Role of inositol pyrophosphates in pancreatic beta cell function 

    Rajasekaran, Subu Surendran (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)
    Inositol pyrophosphates are high energy diphosphate containing molecules that are ubiquitous in eukaryotic cells. They have been implicated in diverse cellular processes ranging from DNA repair, telomere length regulation, ...
  • Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 diabetes mellitus 

    Sjögren, Rasmus (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-23)
    microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to ...

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