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  • Roles of SNAP-25 isoforms in activity-dependent long-term synaptic plasticity 

    Irfan, Muhammad (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-28)
    SNARE proteins, SNAP-25, syntaxin 1A and VAMP2 constitute the functional units which join together to form the core SNARE complex. The SNARE complex carries out the vital function of membrane fusion of intracellular vesicles ...
  • Effects of BCG-treatment on urinary bladder cancer with focus on nitric oxide 

    Thiel, Tomas (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-23)
    Intravesical Bacillus Calmette-Guérin is used as a single agent or adjuvant therapy in the treatment of non-muscle invasive bladder cancer. In spite being one of the most efficient immunological treatments in cancer, BCG ...
  • Genetic causes and molecular mechanisms underlying rare metabolic bone diseases 

    Costantini, Alice (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-16)
    The skeletal system provides support for the body, enables movement and protects inner organs. Moreover, it supplies blood cells and acts as a reservoir for minerals and fat. Several external factors, including ...
  • Barrett's esophagus and the risk of adenocarcinoma 

    Holmberg, Dag (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-15)
    Barrett’s esophagus is the precursor lesion of esophageal adenocarcinoma, a tumor with increasing incidence and poor prognosis. The overall aim of the thesis was to assess risk and prognosis in patients with Barrett’s ...
  • Coagulation during and after cardiopulmonary bypass with focus on heparin, protamine, aprotinin and platelet function 

    Kjellberg, Gunilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-10)
    Background: Heparin and protamine dosing for anticoagulation during cardiopulmonary bypass (CPB) and its reversal after CPB, respectively, is usually given according to body weight. Excess protamine may impair coagulation. ...
  • Next generation sequencing to find genetic risk factors in familial cancer 

    Thutkawkorapin, Jessada (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-08)
    In 2015, Cancer is the second leading cause of death worldwide. Genetic predisposition in familial cancer cases is largely unexplained. At the same time, rapid development in sequencing technology results in an unprecedented ...
  • Aspects of arterial wall healing : re-endothelialization, intimal hyperplasia and vascular remodeling 

    Röhl, Samuel (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-08)
    Cardiovascular disease is the leading cause of mortality in the world. Despite prevention, the need for interventions remains high. Patients with type 2 diabetes mellitus have an increased cardiovascular burden and are at ...
  • Preoperative radiotherapy in rectal cancer : aspects on fractionation and timing of surgery 

    Erlandsson, Johan (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-04-30)
    Neo-adjuvant radiotherapy (RT) in rectal cancer (RC) reduces the risk for local recurrence (LR). The optimal fractionation or time to surgery is not determined. The focus areas of this thesis are different RT-courses and ...
  • Radiation-induced vascular inflammation : translational studies 

    Christersdottir Björklund, Tinna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-04-18)
    Radiotherapy has been shown to increase the risk for localized cardiovascular disease in a growing population of cancer survivors. However, irradiation, as a risk factor for vascular complications in free flap surgery, has ...
  • Structural genomic variation in human disease 

    Pettersson, Maria (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-04-12)
    Structural variants (SVs) are physical changes in the structure of chromosomes and include both unbalanced copy number variants (CNVs) and balanced events (translocations, inversions and insertions). Many SVs constitute ...
  • Ageing, deep vein thrombosis and male gender predict poor outcome after acute Achilles tendon rupture 

    Domeij-Arverud, Erica; Anundsson, Per; Hardell, Eva; Barreng, Gunilla; Edman, Gunnar; Latifi, Ali; Labruto, Fausto; Ackermann, Paul (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)
    Background: Patients with acute Achilles tendon rupture (ATR) exhibit prolonged healing, high incidence of deep venous thrombosis (DVT) and a wide variation of functional outcome. This extensive discrepancy in outcome may ...
  • Reduced time to surgery improves patient-reported outcome after achilles tendon rupture. 

    Ackermann, Paul; Edman, Gunnar; Juthberg, Robin; Svedman, Simon (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-03-14)
    Background: Patient outcome after an acute Achilles tendon rupture (ATR) continues to be suboptimal and heterogeneous. Thus, prognostic factors are called for to optimize evidence-based ATR treatment protocols, however, ...
  • Development of probes for molecular imaging : evaluation in models of inflammation and atherosclerosis 

    Ahmed, Mona (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-02-22)
    The imaging field is rapidly evolving and in the last two decades there have been tremendous developments in the field of multimodal imaging. Multimodal molecular imaging approaches that utilize ultrasound/magnetic ...
  • Pancreatic beta-cell insulin signaling in genetic and dietary models of obesity and insulin resistance 

    Paschen, Meike (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-02-14)
    Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood glucose levels that has reached pandemic proportions. Genome-wide association studies have linked T2DM to the function ...
  • Abdominal aortic aneurysm : uncharted aspects of rupture 

    Zommorodi, Sayid (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-01-10)
    Unlike intact abdominal aortic aneurysm (iAAA), ruptured abdominal aortic aneurysm (rAAA) is a lethal condition demanding immediate resuscitation and surgical intervention. Where the former is a silent disease with slow ...
  • Engraftment and tolerance induction in cellular therapy : focus on mesenchymal stromal cells 

    Ljung, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-12-20)
    Different cell types have been employed in the search for a cellular therapy that is applicable for the treatment of heart failure. Remuscularization strategies using stem-cell-derived cardiomyocytes have been prone to ...
  • Helicobacter pylori eradication treatment and the risk of gastric and oesophageal cancer 

    Doorakkers, Eva (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-12-19)
    Helicobacter pylori is a strong and well-established risk factor for gastric cancer, but seems to decrease the risk of oesophageal adenocarcinoma. Thus, eradication treatment for Helicobacter pylori may decrease the risk ...
  • Oesophageal cancer surgery : nutritional determinants of survivorship 

    Anandavadivelan, Poorna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-23)
    Oesophagectomy, the surgery offered as a curative treatment for cancer of the oesophagus is highly invasive with a radical change in anatomy and carries a risk for significant morbidity and mortality. The recovery is ...
  • Autologous fat transplantation to the female breast after surgery and radiotherapy assessment of patient-reported outcomes, radiology and gene expression patterns 

    Lindegren, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-22)
    Autologous fat transplantation (AFT) is commonly used as a complementary method to enhance breast appearance after breast surgery, radiotherapy and breast reconstruction. Some of the indications for AFT to the breast are ...
  • Minimally-invasive breast interventions : methods for high yield, low risk, precision biopsy and curative thermal ablation 

    Schässburger, Kai-Uwe (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-15)
    Advances in medical imaging and the introduction of population-based screening programs have increased the detection rate and overall proportion of small breast tumors. In addition, progress in technology and medical ...

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