RSS submission
 

Collections

Recent Submissions

  • Pulmonary hypertension : the role and place of PDGF 

    Tannenberg, Philip (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)
    Pulmonary hypertension is a severe condition, leading to right heart dysfunction and preterm death. For pulmonary arterial hypertension (PAH), a disease group in which the primary pathology resides within the pulmonary ...
  • Role of inositol pyrophosphates in pancreatic beta cell function 

    Rajasekaran, Subu Surendran (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)
    Inositol pyrophosphates are high energy diphosphate containing molecules that are ubiquitous in eukaryotic cells. They have been implicated in diverse cellular processes ranging from DNA repair, telomere length regulation, ...
  • Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 diabetes mellitus 

    Sjögren, Rasmus (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-23)
    microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to ...
  • Impact of chronic kidney disease on the cardiovascular system : studies in non-dialysis patients and healthy people 

    Asp, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-21)
    Background: Cardiac and arterial remodeling and stiffening occur in end-stage renal disease. The presence of cardiovascular (CV) alterations in earlier-stage chronic kidney disease (CKD) is less well studied. We evaluated ...
  • Pulmonary resection for malignant tumors 

    Al-Ameri, Mamdoh (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-09)
    Resection of malignant tumors in the lung represents greater than 70% of thoracic surgeries. The continuous evolution of new surgical techniques and management of malignant diseases have improved the clinical outcomes of ...
  • Point-of-care testing of platelet P2Y12-inhibition in patients with acute coronary syndrome 

    Holm, Manne (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-08)
    Background: The point-of-care platelet function test Plateletworks® has been shown to identify patients with high platelet aggregation despite P2Y12 inhibition, also known as high-on-treatment platelet reactivity (HPR), who ...
  • Detecting novel effects of exercise or AMPK activation in human skeletal muscle 

    Lassiter, David Gray (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-04-24)
    Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is ...
  • Diagnostic precision and sex differences in quantitative cardiovascular magnetic resonance 

    Nickander, Jannike (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-22)
    Correct medical treatment necessitates a correct diagnosis. Cardiac imaging aims to establish an accurate diagnosis without performing unnecessary invasive procedures. Cardiovascular magnetic resonance (CMR) has emerged ...
  • Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population 

    Doorakkers, Eva; Lagergren, Jesper; Engstrand, Lars; Brusselaers, Nele (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-22)
    OBJECTIVE: Gastric infection with Helicobacter pylori is a strong risk factor for non-cardia gastric adenocarcinoma. The aim of this study was to assess whether the risk of gastric adenocarcinoma and non-cardia ...
  • Clinical and oncopreventive outcomes of antireflux surgery 

    Maret-Ouda, John (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-15)
    Gastro-oesophageal reflux disease (GORD), with heartburn and acid regurgitation as main symptoms, is a common disease with increasing prevalence. GORD is associated with oesophageal adenocarcinoma, a cancer with demanding ...
  • Recurrence of reflux after laparoscopic antireflux surgery : reply 

    Maret-Ouda, John; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
  • Nordic registry-based cohort studies : possibilities and pitfalls when combining Nordic registry data 

    Maret-Ouda, John; Tao, Wenjing; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    Aims: All five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have nationwide registries with similar data structure and validity, as well as personal identity numbers enabling linkage between registries. ...
  • Association between laparoscopic antireflux surgery and recurrence of gastroesophageal reflux 

    Maret-Ouda, John; Wahlin, Karl; El-Serag, Hashem B.; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    IMPORTANCE: Cohort studies, mainly based on questionnaires and interviews, have reported high rates of reflux recurrence after antireflux surgery, which may have contributed to a decline in its use. Reflux recurrence ...
  • Cohort profile: The Nordic Antireflux Surgery Cohort (NordASCo) 

    Maret-Ouda, John; Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-06)
    PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare ...
  • In vivo regulation of pancreatic beta cell function 

    van Krieken, Pim Pieter (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-01)
    Pancreatic beta cells within the islets of Langerhans contribute to the regulation of glucose homeostasis by secretion of insulin, a hormone that stimulates the uptake of glucose by liver, muscle and fat tissue. In ...
  • Regulation of whole-body glucose and lipid metabolism by skeletal muscle 

    Schönke, Milena (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-16)
    Obesity and associated diseases like type 2 diabetes are rapidly growing health concerns across the globe. The uptake and expenditure of energy in the body are tightly regulated by a plethora of enzymes and hormones in ...
  • Gastrectomy compared to oesophagectomy for Siewert II and III gastro-oesophageal junctional cancer in relation to resection margins, lymphadenectomy and survival. 

    Kauppila, Joonas Henrikki; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-12)
    It is unclear whether gastrectomy or oesophagectomy offer better outcomes for gastro-oesophageal junction (GOJ) cancer. A total of 240 patients undergoing total gastrectomy (n = 85) or oesophagectomy (n = ...
  • Tenascin-C and fibronectin in normal esophageal mucosa, Barrett's esophagus, dysplasia and adenocarcinoma. 

    Kauppila, Joonas Henrikki; Bogdanoff, Sara; Leppänen, Joni; Lehenkari, Petri; Saarnio, Juha; Karttunen, Tuomo; Huhta, Heikki; Helminen, Olli (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)
    BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is ...
  • Meta-analysis of health-related quality of life after minimally invasive versus open oesophagectomy for oesophageal cancer. 

    Kauppila, Joonas Henrikki; Xie, Shaohua; Johar, Asif; Markar, Sheraz; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)
    BACKGROUND: The aim of this systematic review and meta-analysis was to compare health-related quality of life (HRQoL) outcomes between minimally invasive and open oesophagectomy for cancer at different postoperative time ...
  • All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study) 

    Ness-Jensen, Eivind; Gottlieb-Vedi, Eivind; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-11)
    OBJECTIVE: Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers. The aim of ...

View more