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  • Prosthetic aortic heart valves 

    Glaser, Natalie (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-21)
    Background Aortic valve replacement (AVR) can be performed with different types of valve prostheses. There is no perfect aortic valve prosthesis, and the prosthetic choice for each patient requires careful consideration. ...
  • Expanding the genetic and phenotypic spectrum of skeletal dysplasias 

    Hammarsjö, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-17)
    Skeletal dysplasias constitute a large and heterogeneous group of disorders, many causing disabilities with profound effects on the quality of life of the affected individuals and their families. Each individual skeletal ...
  • Improving surgical therapy for oesophageal cancer 

    Markar, Sheraz Rehan (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-08-14)
    Despite advances in multimodality treatment, surgery remains the mainstay of curative treatment for oesophageal cancer. However short- and long-term mortality from oesophagectomy for oesophageal cancer still shows large ...
  • Pulmonary hypertension : the role and place of PDGF 

    Tannenberg, Philip (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)
    Pulmonary hypertension is a severe condition, leading to right heart dysfunction and preterm death. For pulmonary arterial hypertension (PAH), a disease group in which the primary pathology resides within the pulmonary ...
  • Role of inositol pyrophosphates in pancreatic beta cell function 

    Rajasekaran, Subu Surendran (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)
    Inositol pyrophosphates are high energy diphosphate containing molecules that are ubiquitous in eukaryotic cells. They have been implicated in diverse cellular processes ranging from DNA repair, telomere length regulation, ...
  • Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 diabetes mellitus 

    Sjögren, Rasmus (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-23)
    microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to ...
  • Impact of chronic kidney disease on the cardiovascular system : studies in non-dialysis patients and healthy people 

    Asp, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-21)
    Background: Cardiac and arterial remodeling and stiffening occur in end-stage renal disease. The presence of cardiovascular (CV) alterations in earlier-stage chronic kidney disease (CKD) is less well studied. We evaluated ...
  • Pulmonary resection for malignant tumors 

    Al-Ameri, Mamdoh (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-09)
    Resection of malignant tumors in the lung represents greater than 70% of thoracic surgeries. The continuous evolution of new surgical techniques and management of malignant diseases have improved the clinical outcomes of ...
  • Point-of-care testing of platelet P2Y12-inhibition in patients with acute coronary syndrome 

    Holm, Manne (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-08)
    Background: The point-of-care platelet function test Plateletworks® has been shown to identify patients with high platelet aggregation despite P2Y12 inhibition, also known as high-on-treatment platelet reactivity (HPR), who ...
  • Detecting novel effects of exercise or AMPK activation in human skeletal muscle 

    Lassiter, David Gray (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-04-24)
    Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is ...
  • Diagnostic precision and sex differences in quantitative cardiovascular magnetic resonance 

    Nickander, Jannike (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-22)
    Correct medical treatment necessitates a correct diagnosis. Cardiac imaging aims to establish an accurate diagnosis without performing unnecessary invasive procedures. Cardiovascular magnetic resonance (CMR) has emerged ...
  • Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population 

    Doorakkers, Eva; Lagergren, Jesper; Engstrand, Lars; Brusselaers, Nele (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-22)
    OBJECTIVE: Gastric infection with Helicobacter pylori is a strong risk factor for non-cardia gastric adenocarcinoma. The aim of this study was to assess whether the risk of gastric adenocarcinoma and non-cardia ...
  • Clinical and oncopreventive outcomes of antireflux surgery 

    Maret-Ouda, John (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-15)
    Gastro-oesophageal reflux disease (GORD), with heartburn and acid regurgitation as main symptoms, is a common disease with increasing prevalence. GORD is associated with oesophageal adenocarcinoma, a cancer with demanding ...
  • Recurrence of reflux after laparoscopic antireflux surgery : reply 

    Maret-Ouda, John; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
  • Nordic registry-based cohort studies : possibilities and pitfalls when combining Nordic registry data 

    Maret-Ouda, John; Tao, Wenjing; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    Aims: All five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have nationwide registries with similar data structure and validity, as well as personal identity numbers enabling linkage between registries. ...
  • Association between laparoscopic antireflux surgery and recurrence of gastroesophageal reflux 

    Maret-Ouda, John; Wahlin, Karl; El-Serag, Hashem B.; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    IMPORTANCE: Cohort studies, mainly based on questionnaires and interviews, have reported high rates of reflux recurrence after antireflux surgery, which may have contributed to a decline in its use. Reflux recurrence ...
  • Cohort profile: The Nordic Antireflux Surgery Cohort (NordASCo) 

    Maret-Ouda, John; Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-06)
    PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare ...
  • In vivo regulation of pancreatic beta cell function 

    van Krieken, Pim Pieter (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-01)
    Pancreatic beta cells within the islets of Langerhans contribute to the regulation of glucose homeostasis by secretion of insulin, a hormone that stimulates the uptake of glucose by liver, muscle and fat tissue. In ...
  • Regulation of whole-body glucose and lipid metabolism by skeletal muscle 

    Schönke, Milena (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-16)
    Obesity and associated diseases like type 2 diabetes are rapidly growing health concerns across the globe. The uptake and expenditure of energy in the body are tightly regulated by a plethora of enzymes and hormones in ...
  • Gastrectomy compared to oesophagectomy for Siewert II and III gastro-oesophageal junctional cancer in relation to resection margins, lymphadenectomy and survival. 

    Kauppila, Joonas Henrikki; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-12)
    It is unclear whether gastrectomy or oesophagectomy offer better outcomes for gastro-oesophageal junction (GOJ) cancer. A total of 240 patients undergoing total gastrectomy (n = 85) or oesophagectomy (n = ...

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