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  • Why oesophageal adenocarcinoma is occurring more frequently 

    Doorakkers, Eva; Brusselaers, Nele (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-28)
    The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk ...
  • Intratumoral lactate metabolism in Barrett’s esophagus and adenocarcinoma 

    Kauppila, Joonas; Huhta, Heikki; Helminen, Olli; Palomäki, Sami; Lehenkari, Petri; Saarnio, Juha; Karttunen, Tuomo (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-25)
    Background: Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are activated in various cancers, but their expression in ...
  • Extent of lymphadenectomy and prognosis after esophageal cancer surgery 

    Lagergren, Jesper; Mattsson, Fredrik; Zylstra, Janine; Chang, Fuju; Gossage, James; Mason, Robert; Lagergren, Pernilla; Davies, Andrew (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)
    IMPORTANCE: The prognostic role of the extent of lymphadenectomy during surgery for esophageal cancer is uncertain and requires clarification. OBJECTIVE: To clarify whether the number of removed lymph nodes influences ...
  • Weekday of oesophageal cancer surgery in relation to early postoperative outcomes in a nationwide Swedish cohort study 

    Lagergren, Jesper; Mattsson, Fredrik; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)
    Objectives: Later weekday of surgery for oesophageal cancer seems to increase 5-year mortality, but the mechanisms are unclear. We hypothesised that early postoperative reoperations and mortality might explain this ...
  • On preoperative treatment selection and magnetic resonance imaging in rectal cancer 

    Hansson Elliot, Anders (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-20)
    In Sweden, 2000 patients are diagnosed with rectal cancer annually. Developments in surgery have improved survival and the addition of preoperative radiotherapy (RT) or chemoradiotherapy (CRT) has reduced local recurrence ...
  • Appetite control : genetic, immunological and neurobiological aspects 

    Lindfors, Charlotte (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-31)
    The overall goal of this thesis is to develop a better understanding of the brain’s regulation of appetite, i.e. the hypothalamic regulation of hunger and satiety signals. The correct regulation of appetite is crucial, ...
  • Breast cancer in young women : aspects on mortality and local recurrence 

    Fredholm, Hanna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-17)
    The general aim of the thesis was to gain increased insight into the long-term prognosis for young women with breast cancer. In a population-based cohort of 22,017 women with breast cancer, we studied prognosis by ...
  • Complicated peptic ulcer disease : prevention and treatment 

    Sverdén, Emma (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-15)
    Peptic ulcer is a common disease worldwide and its complications can cause serious clinical problems. While the incidence of uncomplicated peptic ulcer disease is decreasing, the incidence of more complex ulcer disease is ...
  • Identification and evaluation of novel prognostic genetic markers for childhood acute lymphoblastic leukemia 

    Ivanov Öfverholm, Ingegerd (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-02)
    Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due to advances in risk stratification and treatment, survival rates have increased drastically the last decades. Currently, ...
  • The male predominance in esophageal adenocarcinoma 

    Xie, Shaohua; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-02-21)
    The incidence of esophageal adenocarcinoma (EAC) has increased rapidly during the past four decades in many Western populations, including North America and Europe. The established etiological factors for EAC include ...
  • A model for predicting individuals' absolute risk of esophageal adenocarcinoma : moving toward tailored screening and prevention 

    Shaohua, Xie; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-02-15)
    Esophageal adenocarcinoma (EAC) is characterized by rapidly increasing incidence and poor prognosis, stressing the need for preventive and early detection strategies. We used data from a nationwide ...
  • Evaluation of a metal-on-metal total hip arthroplasty 

    Dahlstrand, Henrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-01-17)
    Background After the introduction of the Metasul system by Weber in 1988, total hip arthroplasty (THA) with metal-on-metal (MoM) bearings became increasingly popular in the 1990s. MoM bearings aimed to reduce the ...
  • Snus and risk of gastroesophageal reflux. A population-based case-control study : the HUNT study 

    Lie, Tina Malene; Bomme, Maria; Hveem, Kristian; Hansen, Jane Møller; Ness-Jensen, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-01-04)
    Objective: Tobacco smoking is a risk factor for gastroesophageal reflux, but whether other tobacco products increase the risk is unclear. The aim of this study was to investigate if snus increases the risk of ...
  • Risk factors of admission for acute colonic diverticulitis in a population-based cohort study : the HUNT Study, Norway 

    Talabani, Aras Jamal; Lydersen, Stian; Ness-Jensen, Eivind; Endreseth, Birger Henning; Edna, Tom-Harald (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-01-04)
    AIM To assess risk factors of hospital admission for acute colonic diverticulitis. METHODS The study was conducted as part of the second wave of the population-based North Trondelag Health Study (HUNT2), ...
  • Aspects of biliary tract cancer : incidence and reproductive risk factors 

    Kilander, Carl (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-21)
    Biliary tract cancer, including cancer of the extra-hepatic bile ducts, cancer of the Ampulla of Vater and gallbladder cancer, is a devastating disease with poor prognosis. The incidence of biliary tract cancer is ...
  • Metabolic syndrome and esophageal and gastric cancer 

    Lin, Yulan; Ness-Jensen, Eivind; Hveem, Kristian; Lagergren, Jesper; Lu, Yunxia (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-20)
    BACKGROUND: The role of the metabolic syndrome in the etiology of esophageal and gastric cancer is unclear. METHODS: This was a large nationwide cohort study based on data from 11 prospective population-based ...
  • Anthropometry-based obesity phenotypes and risk of colorectal adenocarcinoma: a large prospective cohort study in Norway 

    Lu, Yunxia; Ness-Jensen, Eivind; Martling, Anna; Hveem, Kristian (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-20)
    BACKGROUND: It is unclear whether obesity phenotypes measured by different anthropometric indices are associated with a risk of colorectal adenocarcinoma by anatomical location. METHODS: We compiled harmonized ...
  • Metabolic predispositions and increased risk of colorectal adenocarcinoma by anatomical locations: a large population-based cohort study in Norway 

    Lu, Yunxia; Ness-Jensen, Eivind; Hveem, Kristian; Martling, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-19)
    Whether different definitions of metabolic syndrome (MetS) are differently associated with colorectal adenocarcinoma (CA) by anatomical location is unclear. A population-based cohort study, the Cohort of ...
  • Risk factors on the development of new-onset gastroesophageal reflux symptoms. A population-based prospective cohort study: the HUNT study 

    Hallan, Andreas; Bomme, Maria; Hveem, Kristian; Hansen, Jane Møller; Ness-Jensen, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-19)
    OBJECTIVES: Gastroesophageal reflux disease (GERD) is a highly prevalent disorder. This study assessed the risk factors of new-onset gastroesophageal reflux symptoms (GERS). METHODS: The study was based on ...
  • Risk factors of having cholecystectomy for gallstone disease in a prospective population-based cohort study 

    Talseth, Arne; Ness-Jensen, Eivind; Edna, Tom-Harald; Hveem, Kristian (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-16)
    BACKGROUND: The relationship between different lifestyle factors and the risk of needing cholecystectomy for gallstone disease is not clear. This study aimed to assess the association between anthropometric, ...

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