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  • Improving stroke risk prediction and individualised treatment in carotid atherosclerosis 

    Karlöf, Eva (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-05-28)
    Background: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. Currently, this risk estimation is based on measurements of stenosis and neurological symptoms, ...
  • Diabetes, metformin and gastric adenocarcinoma 

    Zheng, Jiaojiao (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-05-18)
    Diabetes may increase the risk and mortality of certain cancers, but its association with gastric adenocarcinoma is not clear. On the other hand, metformin, a first-line treatment for diabetes, may reduce cancer risks ...
  • Nutrient-regulated skeletal muscle metabolism and circadian clock 

    Sardon Puig, Laura (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-04-30)
    The prevalence of obesity has tripled in the last four decades, becoming a major risk for the development of cardiometabolic diseases such as type 2 diabetes. Obesity is associated with pathological storage of lipids in ...
  • Systems biology of mitochondrial dysfunction 

    Schober, Florian A. (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-04-12)
    The human body consumes vast amounts of metabolites that are transformed into one another, modified to useful building blocks and broken down to harvest their energy. Mitochondria are at the core of this metabolic turnover ...
  • Antireflux surgery in the prevention of supra-esophageal cancer and mortality 

    Yanes, Manar (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-03-02)
    Gastroesophageal reflux disease (GERD), mainly characterized by heartburn or regurgitation, is a common condition in the Western world with an increasing prevalence. GERD is associated with an increased risk of adenocarcinoma ...
  • Left ventricular remodeling and function in ischemic heart disease and aortic valve disease 

    Jenner, Jonas (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-03-01)
    Background: Cardiac remodeling is a broad term that refers to structural and functional alterations of the heart in response to chronic changes in loading conditions or left ventricular (LV) contractile performance. Different ...
  • Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization 

    Karlöf, E; Seime, T; Dias, N; Lengqvist, M; Witasp, A; Almqvist, H; Kronqvist, M; Gådin, JR; Odeberg, J; Maegdefessel, L; Stenvinkel, P; Perisic Matic, L; Hedin, U (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)
    Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ...
  • Complications following anterior cruciate ligament reconstruction 

    Kraus Schmitz, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-16)
    Background: Venous thromboembolism (VTE) and septic arthritis (SA) are two rare complications following anterior cruciate ligament reconstruction (ACLR). Due to their rare incidence, risk factors and outcome are difficult ...
  • Studies on meniscus surgery with focus on preservation and meniscus function 

    Rönnblad, Erik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-12-23)
    The aim of this thesis was to investigate the effect of surgical preservation and restoration of the meniscus on knee function and outcomes. In Study I, 4497 patients with primary hamstring ACLR were evaluated ...
  • Identification of disease genes in rare neurological conditions 

    Engvall, Martin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-12-18)
    This thesis is about improving diagnosis and treatment to persons affected by rare diseases. Diagnosis before treatment is a principle often told to medical students. But what if a diagnosis can’t be made with the resources ...
  • Evaluation of an automatic urinometer including use of silicone oil to decrease biofilm formation due to proteinuria, hemoglobinuria and bacterial growth 

    Slettengren, Martin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-12-18)
    Background: A new capacitance-based automatic urinometer (AU) facilitates continuous urine output (UO) measurement, which may help to predict and diagnose acute kidney injury (AKI). To prevent mismeasurement due to ...
  • Microparticles in hemophilia - friend or foe? : to improve hemostasis or to induce atherothrombosis? 

    Zong, Yanan (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-27)
    As one of the most well-known inherited bleeding disorders, hemophilia A (HA) is caused by the deficiency or dysfunction of coagulation factor VIII (FVIII). Patients with HA (PWHA) suffer from abnormal bleeding after ...
  • Effects of early functional mobilization after acute Achilles tendon rupture repair 

    Aufwerber, Susanna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-24)
    Background: Patient outcome after Achilles tendon rupture (ATR) varies greatly, and complications such as deep venous thrombosis (DVT) and tendon elongation are common. Although accelerated rehabilitation is considered ...
  • Translational studies on mitochondrial function and hypoxia in complications of diabetes mellitus 

    Xu, Cheng (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-24)
    Diabetes Mellitus (DM) is a major concern for societies and healthcare systems globally. DMassociated morbidity and mortality is mediated by diabetic complications. Hypoxia and oxidative stress have emerged as key players ...
  • Family history and prognosis of prostate cancer 

    Jansson, Fredrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-20)
    Background: Prostate Cancer (PCa) is the second most common malignancy among men in the world. In Sweden about 10,000 new cases are diagnosed each year. Mortality rates have been rather stable but have declined the past ...
  • Epidemiological and experimental studies on sarcoma with focus on gastrointestinal stromal tumors 

    Karlsson, Fredrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-18)
    Sarcoma is the common denominator for malignant tumors of mesenchymal origin. Sarcomas encompass almost 100 diagnoses with different histology, molecular features and natural history, and may present in any part of the ...
  • Exploring the gut-brain axis in Attention-Deficit Hyperactivity Disorder 

    Yang, Liu (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-13)
    There is a bidirectional interaction between the gut and the brain, termed the gut-brain axis (GBA), involving e.g. the gut microbiota, and connecting the peripheral intestinal elements to the central nervous system ...
  • Clinical and radiological aspects of traumatic pelvic ring injury 

    Bakhshayesh, Peyman (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-10-21)
    Epidemiological data regarding High-Energy Traumatic Pelvic Ring Injury in Sweden was missing. Further, there was no data regarding current knowledge and level of experience of Swedish first line trauma officers about ...
  • Oncological safety and health-related quality of life after reconstructive breast cancer surgery 

    Coudé Adam, Hannah (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-10-02)
    The main aim of this thesis was to gain knowledge about the oncological safety of nipple- sparing mastectomy (NSM) with immediate implant-based reconstruction and delayed Deep Inferior Epigastric Perforator (DIEP) flap ...
  • Geometric, biomechanical and molecular analyses of abdominal aortic aneurysm 

    Lindquist Liljeqvist, Moritz (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-08-20)
    Background Abdominal aortic aneurysm (AAA) is defined as a dilatation of the abdominal aorta of 30 mm in diameter or more. Main risk factors are smoking, age and male sex. Pathophysiological features include ...

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