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  • Investigations of body mass, gastrointestinal, and dietary factors influencing the emergence and maintenance of eating disorders 

    Wiklund, Camilla (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-10-20)
    Eating disorders are severe psychiatric illnesses, characterized by dysregulated eating and distorted attitudes toward weight and body shape, causing enormous suffering for patients and their families. Although great ...
  • Molecular epidemiology studies on risk factors for breast cancer and disease aggressiveness 

    Ugalde Morales, Emilio (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-09-10)
    Breast cancer is a heterogeneous disease. Aggressive subtypes are characterized by faster growth rates, increased capability to invade and metastasize, leading to poorer clinical outcomes. In this thesis, we use a molecular ...
  • Novel statistical methods for genome-wide association summary statistics 

    Ning, Zheng (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-08-20)
    A general objective of genetic studies is to understand the genetic basis of complex traits such as height, body mass index (BMI), disease endpoints, etc. Such researches have been facilitated due to the completion of ...
  • Lipids, apolipoproteins, and prognosis of amyotrophic lateral sclerosis 

    Ingre, Caroline; Chen, Lin; Zhan, Yiqiang; Termorshuizen, Jet; Yin, Li; Fang, Fang (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-06-08)
    Objective: To determine whether lipids and apolipoproteins predict prognosis of patients with amyo- trophic lateral sclerosis in a cohort study of 99 patients with amyotrophic lateral sclerosis who were diagnosed during ...
  • Etiology and prognosis of gastroesophageal cancers 

    Ekheden, Isabella (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-05-19)
    Gastric and esophageal cancer – gastroesophageal cancers, belong to the most fatal malignancies in the world. Understanding the cause of these diseases is key to interventions such as primary prevention and/or surveillance ...
  • Personality, stress and risk of Parkinson's disease 

    Sieurin, Johanna (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-05-08)
    The objective of this thesis was to investigate the relationship of personality and stress with subsequent risk of Parkinson’s disease (PD). In Study I, we conducted a population-based cohort study using questionnaire ...
  • Artificial intelligence for streamlining prostate cancer diagnostics 

    Ström, Peter (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-24)
    With around 1.2 million cases per year, prostate cancer is the second most common cancer among men. It is usually a slow growing disease that affects older men. It is also a cancer that is heterogenous, often multifocal, ...
  • Risk factors and tumor characteristics of interval cancers by mammographic density 

    Holm, Johanna; Humphreys, Keith; Li, Jingmei; Ploner, Alexander; Cheddad, Abbas; Eriksson, Mikael; Törnberg, Sven; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-23)
    Purpose: To compare tumor characteristics and risk factors of interval breast cancers and screen-detected breast cancers, taking mammographic density into account. Patients and Methods: Women diagnosed with invasive ...
  • Associations of breast cancer risk prediction tools with tumor characteristics and metastasis 

    Holm, Johanna; Li, Jingmei; Darabi, Hatef; Eklund, Martin; Eriksson, Mikael; Humphreys, Keith; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-23)
    Purpose: The association between established risk factors for breast cancer and subtypes or prognosis of the disease is not well known. We analyzed whether the Tyrer-Cuzick–predicted 10-year breast cancer risk score (TCRS), ...
  • Breast cancer genetic risk profile is differentially associated with interval and screen-detected breast cancers 

    Li, Jingmei; Holm, Johanna; Bergh, Jonas C.S.; Eriksson, Mikael; Darabi, Hatef; Lindström, Linda Sofie; Törnberg, Sven A.; Hall, Per F.L.; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)
    Background: Polygenic risk profiles computed from multiple common susceptibility alleles for breast cancer have been shown to identify women at different levels of breast cancer risk. We evaluated whether this genetic ...
  • Assessment of breast cancer risk factors reveals subtype heterogeneity 

    Holm, J; Eriksson, L; Ploner, A; Eriksson, M; Rantalainen, M; Li, J; Hall, P; Czene, K (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)
    Subtype heterogeneity for breast cancer risk factors has been suspected, potentially reflecting etiological differences and implicating risk prediction. Reports are conflicting regarding presence of heterogeneity for many ...
  • Time-dependent risk of depression, anxiety, and stress-related disorders in patients with invasive and in situ breast cancer 

    Yang, Haomin; Brand, Judith S.; Fang, Fang; Chiesa, Flaminia; Johansson, Anna L.V.; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)
    Despite concerns about the mental health of breast cancer patients, little is known regarding the temporal risk pattern and risk factors of common mental disorders among these patients. We estimated standardized incidence ...
  • Time from breast cancer diagnosis to therapeutic surgery and breast cancer prognosis : a population-based cohort study 

    Eriksson, Louise; Bergh, Jonas; Humphreys, Keith; Wärnberg, Fredrik; Törnberg, Sven; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)
    Theoretically, time from breast cancer diagnosis to therapeutic surgery should affect survival. However, it is unclear whether this holds true in a modern healthcare setting in which breast cancer surgery is carried out ...
  • Stress during cancer diagnostic workup 

    Shen, Qing (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-03-24)
    Receiving a cancer diagnosis is an extremely stressful life event. Cancer patients have been reported to experience an excessive risk of stress-related health outcomes including suicide. The time period between the first ...
  • Prevention and prognosis of cervical cancer : the interplay of human papillomavirus, vaccination and screening 

    Lei, Jiayao (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-02-26)
    Human papillomavirus (HPV) is the major cause of cervical cancer. The well-established natural history from HPV infection to the occurrence of invasive cervical cancer serves as the basis for prevention of cervical cancer ...
  • Epidemiological studies on socioeconomic inequalities and cardiovascular disease : prevention, progression and prognosis 

    Malki, Ninoa (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-02-20)
    Cardiovascular disease (CVD) accounts for 30% of global mortality and is the most common cause of death in the world. Population-wide prevention strategies as well as healthcare interventions have led to a decrease in ...
  • DNA methylation and aging : a longitudinal study of old Swedish twins 

    Wang, Yunzhang (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-01-09)
    DNA methylation is a well-known biomarker of aging. Many previous studies have reported the change of DNA methylation patterns with age, and analyzed DNA methylation in association with aging outcomes. However, most ...
  • Amyotrophic lateral sclerosis and multiple sclerosis associated neuroinflammation : nationwide epidemiological studies on etiology, comorbidities, and treatment 

    Longinetti, Elisa (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-11-26)
    Amyotrophic lateral sclerosis (ALS) is a relatively rare but fatal neurodegenerative disease characterized by progressive muscle paralysis, due to loss of upper and lower motor neurons. Signs of neuroinflammation have been ...
  • Epidemiology, prevention and control of Legionnaires’ disease in Europe 

    Beauté, Julien (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-11-22)
    Legionnaires’ disease (LD) is a water-borne infection cause by Gram-negative bacteria Legionella spp. with virtually no person-to-person transmission. The clinical presentation is a severe pneumonia with a case fatality ...
  • Statistical models of breast cancer tumour growth and spread 

    Isheden, Gabriel (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-11-18)
    In this thesis, we develop statistical methods for studying tumour growth and metastatic lymph node spread in breast cancer. The methods can be used for analysing breast cancer disease progression before diagnosis. They ...

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