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  • Transfusion in critically ill patients: short- and long-term outcomes 

    Halmin, Märit (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-02-23)
    A blood transfusion is a common treatment for a range of conditions. Over 112 million blood transfusions are administered each year worldwide and many patients are thereby exposed to the possible risks associated with the ...
  • Bipolar disorder and lithium treatment : etiologies and consequences 

    Song, Jie (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-02-02)
    Bipolar disorder is a chronic disabling psychiatric disorder marked by episodic disruptive mood swings, accompanied by disturbances in cognition and behavior. Without effective treatment, bipolar disorder can have devastating ...
  • Depression or anxiety in adult twins is associated with asthma diagnosis but not with offspring asthma 

    Tedner, SG; Lundholm, Cecilia; Olsson, Henrik; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-17)
    BACKGROUND: Asthma is common in both children and adults in the Western world, just like anxiety and depression. While some research has revealed that these diseases might share important environmental and ...
  • Robust Linear Models for Cis-eQTL Analysis 

    Rantalainen, Mattias; Lindgren, Cecilia M; Holmes, Christopher C (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    Expression Quantitative Trait Loci (eQTL) analysis enables characterisation of functional genetic variation influencing expression levels of individual genes. In outbread populations, including humans, eQTLs ...
  • The influence of childhood asthma on puberty and height in Swedish adolescents 

    Protudjer, Jennifer Lisa; Lundholm, Cecilia; Bergström, Anna; Kull, Inger; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    BACKGROUND: Evidence relating to the effect of asthma on puberty or height is inconclusive. We aimed to examine whether the exposure of childhood asthma, including timing and phenotypes, and inhaled corticosteroid ...
  • Determining breast cancer histological grade from RNA-sequencing data 

    Wang, Mei; Klevebring, Daniel; Lindberg, Johan; Czene, Kamila; Grönberg, Henrik; Rantalainen, Mattias (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    BACKGROUND: The histologic grade (HG) of breast cancer is an established prognostic factor. The grade is usually reported on a scale ranging from 1 to 3, where grade 3 tumours are the most aggressive. However, grade 2 ...
  • Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers 

    Rantalainen, Mattias; Klevebring, Daniel; Lindberg, Johan; Ivansson, Emma; Rosin, Gustaf; Kis, Lorand; Celebiouglu, Fuat; Fredriksson, Irma; Czene, Kamila; Frisell, Jan; Hartman, Johan; Bergh, Jonas; Grönberg, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    Sequencing-based breast cancer diagnostics have the potential to replace routine biomarkers and provide molecular characterization that enable personalized precision medicine. Here we investigate the concordance between ...
  • Study design requirements for RNA sequencing-based breast cancer diagnostics 

    Mer, Arvind Singh; Klevebring, Daniel; Grönberg, Henrik; Rantalainen, Mattias (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    Sequencing-based molecular characterization of tumors provides information required for individualized cancer treatment. There are well-defined molecular subtypes of breast cancer that provide improved ...
  • Early exposure to dogs and farm animals and the risk of childhood asthma 

    Fall, Tove; Lundholm, Cecilia; Örtqvist, Anne K; Fall, Katja; Fang, Fang; Hedhammar, Åke; Kämpe, Olle; Ingelsson, Erik; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    IMPORTANCE: The association between early exposure to animals and childhood asthma is not clear, and previous studies have yielded contradictory results. OBJECTIVE: To determine whether exposure to dogs ...
  • The observed association between maternal anxiety and adolescent asthma : children of twin design suggest familial effects 

    Havland, Ida; Lundholm, Cecilia; Lichtenstein, Paul; Neiderhiser, Jenae M; Ganiban, Jody M; Spotts, Erica L; Walum, Hasse; Reiss, David; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    BACKGROUND: Previous studies indicate that maternal anxiety is associated with asthma in the adolescent child, but mechanisms are unclear. OBJECTIVE: To investigate the association between maternal anxiety ...
  • Asthma during pregnancy in a population-based study--pregnancy complications and adverse perinatal outcomes 

    Rejnö, Gustaf; Lundholm, Cecilia; Gong, Tong; Larsson, Kjell; Saltvedt, Sissel; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    BACKGROUND: Asthma is one of the most common chronic diseases, and prevalence, severity and medication may have an effect on pregnancy. We examined maternal asthma, asthma severity and control in relation to ...
  • Parental socioeconomic status, childhood asthma and medication use : a population-based study 

    Gong, Tong; Lundholm, Cecilia; Rejnö, Gustaf; Mood, Carina; Långström, Niklas; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    BACKGROUND: Little is known about how parental socioeconomic status affects offspring asthma risk in the general population, or its relation to healthcare and medication use among diagnosed children. METHODS: ...
  • Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis 

    Örtqvist, Anne K; Lundholm, Cecilia; Kieler, Helle; Ludvigsson, Jonas F; Fall, Tove; Ye, Weimin; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    OBJECTIVE: To investigate the association between exposure to antibiotics in fetal and early life and asthma in childhood, with adjustment for confounding factors. DESIGN: Nationwide prospective population ...
  • Antibiotic treatment and length of hospital stay in relation to delivery mode and prematurity 

    Ahlén, Katia; Örtqvist, Anne; Gong, Tong; Wallas, Alva; Ye, Weimin; Lundholm, Cecilia; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    AIM: To investigate how 1) maternal delivery mode and 2) prematurity in infants are associated to antibiotic treatment and length of hospital stay. METHODS: Women having given birth and infants 0-12 months ...
  • Psychiatric disorders and suicide attempts in Swedish survivors of the 2004 southeast Asia tsunami: a 5 year matched cohort study. 

    Arnberg, Filip K.; Gudmundsdóttir, Ragnhildur; Butwicka, Agnieszka; Fang, Fang; Lichtenstein, Paul; Hultman, Christina M.; Valdimarsdóttir, Unnur A. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-12-19)
    BACKGROUND: Survivors of natural disasters are thought to be at an increased risk of psychiatric disorders, however the extent of this risk, and whether it is linked to pre-existing psychopathology, is not ...
  • Selective serotonin re-uptake inhibitor use during pregnancy: association with offspring birth size and gestational age. 

    Viktorin, Alexander; Lichtenstein, Paul; Lundholm, Cecilia; Almqvist, Catarina; D'Onofrio, Brian M.; Larsson, Henrik; Landén, Mikael; Magnusson, Patrik KE (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-12-19)
    BACKGROUND: Depression around the time of pregnancy affects at least 1 in 8 women and treatment with selective serotonin re-uptake inhibitors (SSRIs) in pregnant women has been increasing, but research on ...
  • Exome sequencing of contralateral breast cancer identifies metastatic disease 

    Klevebring, Daniel; Lindberg, Johan; Rockberg, Julia; Hilliges, Camilla; Hall, Per; Sandberg, Maria; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-12-05)
    Women with contralateral breast cancer (CBC) have significantly worse prognosis compared to women with unilateral cancer. A possible explanation of the poor prognosis of patients with CBC is that in a subset ...
  • Worse quality of life in young and recently-diagnosed breast cancer survivors compared to female survivors of other cancers: A cross-sectional study 

    Li, Jingmei; Humphreys, Keith; Eriksson, Mikael; Dar, Huma; Brandberg, Yvonne; Hall, Per; Czene, Kamila; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and BiostatisticsKarolinska Institutet, 2016-12-05)
    Family history of cancer is a well-known risk factor but the role of family history in survival is less clear. The aim of this study was to investigate the association between family history and cancer survival ...
  • Differences in survival for patients with familial and sporadic cancer 

    Lee, Myeongjee; Reilly, Marie; Lindström, Linda Sofie; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-12-05)
    Family history of cancer is a well-known risk factor but the role of family history in survival is less clear. The aim of this study was to investigate the association between family history and cancer survival ...
  • Risk of hospitalization and death due to bone fractures after breast cancer: a registry-based cohort study 

    Colzani, Edoardo; Clements, Mark; Johansson, Anna L.V.; Liljegren, Annelie; He, Wei; Brand, Judith; Adolfsson, Jan; Fornander, Tommy; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-12-01)
    BACKGROUND: Bone fractures may have an impact on prognosis of breast cancer. The long-term risks of bone fracture in breast cancer patients have not been thoroughly studied. METHODS: Poisson regression was ...

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