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  • Allosteric regulation of synaptic processes 

    Dutta Roy, Ranjita (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-27)
    Glutamatergic neurotransmission is of key importance for short-term and long-term plasticity in the hippocampus, a part of the medial temporal lobe which is responsible for processes of explicit semantic and spatial ...
  • Epidemiologic studies on rheumatic muscle inflammation, myositis 

    Svensson, John (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-24)
    Observational study designs are often used in medical research. Swedish national registers have successfully been used as data sources for such observational studies in other rheumatic diseases. The Swedish health care ...
  • Risk factors for autoimmune-mediated congenital heart block 

    Meisgen, Sabrina (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-24)
    Placental transfer of maternal Ro/SSA and La/SSB autoantibodies during pregnancy is associated with conduction disturbances and inflammation in the developing fetal heart, termed autoimmune-mediated congenital heart block ...
  • Rectal cancer survivorship : work loss and long-term morbidity 

    Chen, Lingjing (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-23)
    In the last few decades, due to early detection and advances in treatments, rectal cancer survival has been improved significantly. Meanwhile, rectal cancer survivors and health practitioners are facing more challenges ...
  • Studies on pneumococcal polysaccharides and their effect on immune cells 

    Sundberg Kövamees, Marianne (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-17)
    Streptococcus pneumoniae is a major cause of morbidity and mortality in children and adults worldwide. The spectrum of infections caused by Streptococcus pneumoniae is well-characterized. The bacteria is transmitted via ...
  • Study of autoimmune reactions in rheumatoid arthritis 

    Reed, Evan (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-14)
    Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects approximately 1% of the population worldwide. Despite being rather common, the etiopathology of RA remains unclear. Approximately two-thirds of ...
  • Eczema in childhood and adolescence 

    Johansson, Emma (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-08)
    Background: Eczema (atopic dermatitis) is an itchy inflammatory skin disease that affects many children and adolescents. Eczema associated with IgE antibodies is called atopic eczema (AE), while other eczema is called ...
  • Functional analysis of genetic risk markers 

    Gådin, Jesper Robert (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-02)
    Regulatory variants are the main factors responsible for genetic predisposition to how e.g. humans react differently to the environment. Therefore, it is important to locate and measure their effects, which can result in ...
  • Innovative approaches to study basophil function in inflammation 

    Aljadi, Zenib (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-10-16)
    Basophils are circulating granulocytes. They are very rare and represent less than 1% of peripheral blood leukocytes. Basophils connect the innate and adaptive immune responses by the secretion of a variety of immune-mediators ...
  • In vitro testing of drug sensitivity in tumor cells from effusion 

    Hillerdal, Carl-Olof (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-10-12)
    Malignant mesothelioma has a mean overall survival of around 1 year and lung adenocarcinoma with pleural spread has a mean overall survival of around 5 months. Both diseases cause fluid accumulation in the pleura, which ...
  • Epidemiological studies of medication use and effectiveness in bipolar disorder 

    Wingård, Louise (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-09-19)
    In the last decades, new treatments for bipolar disorder (BD) have emerged, prompting a decrease in the use of lithium – the former “gold standard” for relapse prevention, and increasing the possibilities for individualized ...
  • The role of telomerase reverse transcriptase in human malignancies : genetic polymorphisms and promoter mutations 

    Yuan, Xiaotian (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-09-15)
    Telomerase is a ribonucleoprotein with its catalytic subunit telomerase reverse transcriptase (TERT) as a key component, lengthening telomeres. In differentiated human cells, telomerase is silent due to the transcriptional ...
  • Cutaneous malignant melanoma : body site, sun exposure, genetic factors and prognosis 

    Gordon, Daniela (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-09-14)
    Background: The interplay between tumor site, ultraviolet radiation (UVR) exposure, genetic factors and various epidemiological parameters of cutaneous melanoma is complex. In this thesis, we aimed to investigate the impact ...
  • Molecular studies on the autoantibody-mediated bone destruction in rheumatoid arthritis 

    Krishnamurthy, Akilan (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-09-14)
    Autoantibody-positive rheumatoid arthritis (RA), also called seropositive RA, is characterised by the presence of anti citrullinated proteins antibodies (ACPA) that can be detected in blood several years before disease ...
  • Cardiovascular disease in rheumatoid arthritis : risk factors, clinical presentation, treatment and prognosis 

    Mantel, Ängla (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-08-18)
    It is well known that patients with rheumatoid arthritis (RA) are at increased risk of developing or dying from cardiovascular disease (CVD). There are several important questions remaining regarding the association between ...
  • Antibody-associated inflammation in and outside the joint in rheumatoid arthritis 

    Joshua, Vijay (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-08-17)
    Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by pain, chronic inflammation and joint destruction. Epidemiological investigations in large populationbased cohorts have identified both genetic ...
  • Psychosocial factors and preterm birth : national register-based studies 

    Liu, Can (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-06-29)
    Every year, approximately fifteen million infants are born preterm, defined as prior to 37 gestational weeks. Preterm birth is the number one cause of neonatal mortality, which kills more than one million babies every ...
  • Between two lungs : proteomic and metabolomic approaches in inflammatory lung diseases 

    Heyder, Tina (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-06-15)
    This doctoral thesis presents results on proteomic and metabolomic profiling of two distinct inflammatory lung diseases: sarcoidosis and chronic obstructive pulmonary disease (COPD). Chronic inflammatory lung diseases ...
  • TGF-β affects the differentiation of human GM-CSF+ CD4+ T cells in an activation- and sodium-dependent manner 

    Éliás, Szabolcs; Schmidt, Angelika; Kannan, Venkateshan; Andersson, John; Tegnér, Jesper (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-05-24)
    The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is involved in the pathogenesis of chronic inflammatory diseases such as multiple sclerosis. However, the environmental cues promoting differentiation ...
  • Comparative analysis of protocols to induce human CD4+Foxp3+ regulatory T cells by combinations of IL‐2, TGF‐beta, retinoic acid, rapamycin and butyrate 

    Schmidt, Angelika; Eriksson, Matilda; Shang, Ming-Mei; Weyd, Heiko; Tegnér, Jesper (Inst för medicin, Solna / Dept of Medicine, SolnaKarolinska Institute, KI, 2017-05-24)
    Regulatory T cells (Tregs) suppress other immune cells and are critical mediators of peripheral tolerance. Therapeutic manipulation of Tregs is subject to numerous clinical investigations including trials for adoptive ...

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