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  • B Lymphocytes in solid human malignancies 

    Zirakzadeh, Ali (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-04-21)
    Cancer remains one of the leading causes of death worldwide. Modern treatments such as immunotherapy and neoadjuvant chemotherapy exhibit promising results. However better understanding of the treatments may lead to ...
  • Role of prostaglandin E2 as a neuro-immune mediator in the cholinergic anti-inflammatory pathway 

    Revathikumar, Priya (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-04-19)
    Therapeutic implications of cholinergic anti-inflammatory pathway (CAP) activation have marked the beginning of a novel treatment strategy of passing electrical impulses along the left vagus nerve to alleviate acute and ...
  • Severe viral respiratory tract infections in children 

    Arthur Rhedin, Samuel (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-04-13)
    Respiratory tract infections (RTIs) are estimated to cause 703.000 deaths annually in children below five years. The majority of RTIs in children are caused by viruses, yet the number of antivirals approved for treatment ...
  • Persistence to antihypertensive drug treatment in Swedish primary care 

    Qvarnström, Miriam (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-03-10)
    Hypertension is The efficacy of antihypertensive drug therapy is undisputed, but large surveys report that one in four patients reach a target blood pressure of <140/90 mm Hg. Although there are several explanations to ...
  • Heart failure : studies of prognosis and advanced therapy 

    Thorvaldsen, Tonje (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-03-09)
    Background Heart failure (HF) is a major health problem affecting 2-3% of the Western population. The clinical syndrome of HF is associated with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Around 50% of ...
  • Microscopic colitis 

    Mellander, Marie-Rose (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-03-06)
    Microscopic colitis (MC) is an inflammatory bowel disease (IBD) and a common cause of chronic non-bloody diarrhoea, especially in elderly women. There are two main subtypes, lymphocytic colitis (LC) and collagenous colitis ...
  • Antithrombotic treatment of atrial fibrillation before and after the introduction of non-vitamin K antagonist oral anticoagulants (NOAC) in the Stockholm Health Care Region. 

    Forslund, Tomas (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-02-27)
    Atrial fibrillation (AF) is the most common cardiac arrhythmia and the major risk factor for thromboembolic stroke. Effective treatment with the oral anticoagulant (OAC) warfarin has been available for decades. However ...
  • PGE2 and other lipids in rheumatic diseases 

    Raouf, Joan (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-02-21)
    Despite numerous options for treatment of rheumatic diseases, there is an unfulfilled clinical need for therapeutic strategies that can reduce inflammation and prevent tissue destruction. Lipid mediators (eicosanoids and ...
  • Duration of Second Stage of Labour at Term and Pushing Time: Risk Factors for Postpartum Haemorrhage 

    Looft, Emelie; Simic, Marija; Ahlberg, Mia; Snowden, Jonathan M.; Cheng, Yvonne W.; Stephansson, Olof (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-02-21)
    BACKGROUND: Prolonged labour is associated with increased risk of postpartum haemorrhage (PPH), but the role of active pushing time and the relation with management during labour remains poorly understood. METHODS: A ...
  • Systemic lupus erythematosus : biomarkers and biologics 

    Parodis, Ioannis (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-01-26)
    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, predominantly affecting women of childbearing age. The pathogenesis of SLE is multifactorial, and the clinical phenotype and course vary considerably ...
  • The role of interferon-regulated genes in the immune system 

    Sjöstrand, Maria (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-01-25)
    Type I interferons (IFNs) are potent inducers of the first-line defense against pathogens. Their activity leads to the up- and downregulation of a large number of genes with various effects on the immune system, including ...
  • Family history, genes and gene-environment interaction in risk and prognosis of non-Hodgkin lymphoma 

    Baecklund, Fredrik (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-01-04)
    Non-Hodgkin lymphoma (NHL) is a heterogeneous group of malignant diseases arising from lymphocytes. There are about 40 subtypes according to the World Health Organizations classification system, differing in morphology, ...
  • Monoclonal gammopathy of undetermined significance : natural course and comorbidities 

    Lindqvist, Ebba K (Inst för medicin, Solna / Dept of Medicine, Solna, 2016-12-21)
    Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder characterized by an overproduction of monoclonal immunoglobulins. MGUS is asymptomatic but clinically relevant since annually 0.5-1.5% ...
  • Genetic variation of tight junction structures in intestinal inflammation 

    Norén, Elisabeth (Inst för medicin, Solna / Dept of Medicine, Solna, 2016-11-23)
    The epithelial barrier facing the external environment in the gastrointestinal (GI) tract is comprised of several components, including the tight junction (TJ) structures observed for the first time in 1963. TJ structures, ...
  • Chronic hepatitis : morbidity and mortality in patients and their children 

    Davíðsdóttir, Lóa (Inst för medicin, Solna / Dept of Medicine, Solna, 2016-11-18)
    Chronic hepatitis, morbidity and mortality of the patients and their children The spread of Hepatitis C Virus (HCV) infection started in Sweden in the end of the 1960s with a culmination in the 1970s, most likely ...
  • Regulation of mast cell function and survival in health and disease 

    Lyberg, Katarina (Inst för medicin, Solna / Dept of Medicine, Solna, 2016-11-16)
    Mast cells are sentinels of danger but they are also the major effector cells in allergic disease causing the well-known allergic symptoms caused by their mediators such as histamine and prostaglandin D2 that are released ...
  • Platelet angiogenic activities : a concert of multiple players 

    Miao, Xinyan (Inst för medicin, Solna / Dept of Medicine, Solna, 2016-11-15)
    Angiogenesis, the sprouting of new capillaries from pre-existing blood vessels, is crucial for many physiological and pathological processes. Platelets are an important player in angiogenesis, whilst understanding of ...
  • Pain, mechanisms of fatigue and autonomic function in rheumatoid arthritis 

    Altawil, Reem (Inst för medicin, Solna / Dept of Medicine, Solna, 2016-11-14)
    Rheumatoid arthritis (RA) is a disabling chronic autoimmune disease characterized by joint pain, and potentially leading to a serious decay of life quality. Pain remains the most important problem for patients with RA, and ...
  • Autoantibodies and the type I interferon system in idiopathic inflammatory myopathies 

    Ekholm, Louise (Inst för medicin, Solna / Dept of Medicine, Solna, 2016-11-08)
    Idiopathic inflammatory myopathies (IIM), also known as myositis, are rare autoimmune diseases, characterized by proximal muscle weakness and inflammatory cells in skeletal muscle tissue. The most common subgroups are ...
  • Association between diet and treatment results in patients with rheumatoid arthritis and systemic lupus erythematosus 

    Lourdudoss, Cecilia (Inst för medicin, Solna / Dept of Medicine, Solna, 2016-11-07)
    Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic autoimmune inflammatory diseases. The causes of these diseases are unknown and evidence indicates that a combination of both genetic and environmental ...

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