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  • Identification and functional characterization of proteins involved in hepatic triglyceride metabolism 

    Taxiarchis, Apostolos (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-08-19)
    Triglycerides are the main form of energy in the tissues and liver, along with the adipose tissue, is the main organ of triglyceride metabolism and storage in the lipid-droplet organelles. A number of proteins are involved ...
  • Lineage stability and effector function of CD4+FOXP3+ regulatory T cells 

    Seitz, Christina (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-08-12)
    This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated ...
  • Molecular mechanisms of cardiovascular calcification 

    Carracedo Ortiz, Miguel (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-23)
    Cardiovascular calcification is a pathophysiological process characterized by the deposition of calcium-phosphate crystals in the arteries and the leaflets of the heart valves. In the arteries calcification causes arterial ...
  • Inhibition of mPGES-1 as therapeutic strategy in inflammation and cancer 

    Bergqvist, Filip (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-16)
    Prostaglandin E2 (PGE2) is an inflammatory and oncogenic lipid mediator. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases (COX-1 and COX-2) and the terminal enzyme microsomal prostaglandin E ...
  • Innate immune mechanisms of atherosclerosis 

    Jiang, Xintong (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-13)
    Atherosclerosis is a multi-factorial immune mediated disease in arterial wall characterized by lipid driven inflammation through activation of the immune system. Chronic vascular inflammation is an important component that ...
  • Tracing the interplay between cellular metabolism and cell cycle 

    Roci, Irena (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-13)
    Cancer cells are more vulnerable to targeting during S-G2-M cell cycle phases due to common deregulations in cell cycle checkpoint mechanisms. Most common cancer drugs target processes in the S-G2-M phases, often causing ...
  • Breast cancer : brain metastases and treatment aspects 

    Frisk, Gabriella (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-08)
    Background: In Sweden breast cancer is the most common malignant cancer disease among women, with 8000 new individual cases each year. The prognosis is generally very good, but nevertheless many patients still die of breast ...
  • Identification and functional characterization of irritable bowel syndrome (IBS) risk genes and variants 

    Zheng, Tenghao (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-08)
    As one of the most prevalent functional gastrointestinal disorders (FGIDs), irritable bowel syndrome (IBS) affects more than 10% of the general population worldwide with a higher prevalence in women. The primary clinical ...
  • Remote ischemic conditioning to protect the heart in myocardial infarction : therapeutic intervention and underlying mechanisms 

    Verouhis, Dinos (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-03)
    Background Urgent reperfusion of the occluded coronary artery halts the ischemic insult to the myocardium and is the single most important action to limit infarct size in ST-elevation myocardial infarction. However, ...
  • Cellular and molecular factors in the pathogenesis of systemic autoimmunity and comorbidities 

    Ivanchenko, Margarita (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-02)
    Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE) are systemic rheumatic autoimmune diseases having a major impact on patient’s wellbeing. Besides fatigue, pain and direct damage to exocrine glands in SS, and ...
  • Suicide, violent crime, divorce and mortality in deployed military veterans 

    Pethrus, Carl-Martin (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-30)
    It has long been known that individuals deployed to war and conflict zones might suffer from mental health problems after returning home. This thesis investigated suicide, violent crime, divorce and marriage in deployed ...
  • The interplay between lipoproteins, immunity and tryptophan metabolism in atherosclerosis 

    Polyzos, Konstantinos A. (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-29)
    Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide. Atherosclerosis is initiated by the infiltration and accumulation of low-density lipoprotein (LDL) cholesterol in the vascular wall, ...
  • Mast cell development in health and systemic mastocytosis 

    Grootens, Jennine (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-24)
    Hematopoietic progenitors in the bone marrow differentiate into several immune cells, including mast cells. Mast cell progenitors leave the bone marrow, circulate through the blood, and home to the periphery where they ...
  • Physical function, physical activity and quality of life in systemic sclerosis 

    Pettersson, Henrik (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-11)
    Background and aims. Systemic sclerosis (SSc) is a multisystem rheumatic disease characterized by fibrosis, vasculopathy and immune system activation. There is a dearth of knowledge how different subphenotypes such as ...
  • The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes 

    Schollin Ask, Lina (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-05)
    Background: The rotavirus causes the most severe cases of viral gastroenteritis in small children worldwide, resulting in both high morbidity and mortality. The World Health Organization has recommended vaccination against ...
  • Immune mechanisms that determine the quality of antibody responses to vaccines 

    Lindgren, Gustaf (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-04-03)
    Effective vaccines for many dangerous infectious diseases are still lacking. An improved understanding of the mechanisms that determine the quality of vaccine responses is essential to guide future attempts to design ...
  • T cell signatures and modulation by regulatory T cells 

    Joshi, Rubin Narayan (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-03-22)
    CD4 T cells are crucial coordinators of protective immune responses against microbes and tumors. However, immune responses misdirected towards self-antigens are the hallmarks of autoimmune diseases. Regulatory T cells ...
  • New insights on type 2 immunity key drivers : mast cells and group 2 innate lymphoid cells 

    Ravindran, Avinash (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-22)
    Type 2 immune responses are characterized by the production of cytokines IL-4, IL-5 and IL-13. They are known to have crucial physiological and pathophysiological functions in the body. Data from recent studies indicate ...
  • Gene environment-interaction and cardiovascular phenotype in obesity and diabetes 

    Hussain, Shafaat (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-22)
    Although a large body of evidence supports the notion that genes determine cardio-metabolic traits and outcomes, the non-genetic regulation of these events has recently gained increasing attention. Plastic chemical ...
  • Following the white rabbit : release and regulation of HMGB1 in inflammation 

    Sowinska, Agnieszka (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-02-21)
    Dysregulated inflammatory responses are characterized by excessive release of endogenous pro-inflammatory molecules, danger-associated molecular patterns (DAMPs). A prototypical DAMP, High Mobility Group Box 1 protein ...

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