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  • Novel treatment strategies for multidrug-resistant tuberculosis 

    Davies Forsman, Lina (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-15)
    Tuberculosis is the leading cause of death from a single infectious agent in the world, surpassing the annual death toll of both malaria and HIV combined. The rise in multidrug- resistant tuberculosis (MDR-TB) has further ...
  • Stable high-sensitivity cardiac troponin T levels and outcomes 

    Roos, Andreas (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-15)
    Background: Many patients who seek medical attention because of chest pain in the emergency department (ED), without myocardial infarction (MI) as a final diagnosis, will have cardiac troponin (cTn) levels above the upper ...
  • Burden of disease and identification of intervention targets in extended-spectrum β-lactamase-associated infections 

    Isendahl, Joakim (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-09)
    Extended-spectrum β-lactamase-producing Enterobacteriaceae (EPE) have surged globally since the early 2000s, partly due to dissemination of CTX-M-15 producing Escherichia coli (E. coli) sequence type 131 and its sub-lineages ...
  • Epidemiological studies on diverticular disease of the colon 

    Granlund, Johan (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-07)
    Objective: The aims of this thesis were to evaluate if there is an association between diverticular disease and colorectal cancer (Paper I), to assess any genetic contribution to the occurrence of diverticular disease ...
  • Tuberculosis control in Sweden 

    Jonsson, Jerker (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-07)
    Sweden is a low tuberculosis (TB) incidence country with an incidence of 5.3 cases per 100 000 inhabitants 2017. The majority of new TB cases in Sweden are diagnosed among migrants from high TB incidence countries. Data ...
  • Heart failure : role of metabolic biomarkers, ejection fraction, and sex 

    Faxén, Ulrika Ljung (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-30)
    Background: Heart failure (HF) is common and associated with impaired quality of life (QoL) and poor prognosis. There is a ternary classification of HF based on ejection fraction (EF): HF with preserved(HFpEF), mid-range ...
  • Epidemiological and pathophysiological studies on diverticular disease in the colon 

    Järbrink-Sehgal, M. Ellionore (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-30)
    Background: Diverticular disease of the colon is common and is associated with a high and increasing societal burden with great economical and human costs. Prevalence increases with age and with an overall aging population, ...
  • FAM167A-BLK is a susceptibility locus in autoimmune diseases : characterization of the FAM167 gene family 

    Mentlein, Lara (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-26)
    Autoimmune diseases are complex multifactorial diseases, and their pathogenesis is only partially understood, but both genetic, as well as environmental factors, have been correlated to an increased risk for the diseases. ...
  • Anti-citrulline immunity in rheumatoid arthritis : characterization of peptide-HLA interactions and CD4+ T cell responses 

    Gerstner, Christina (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-25)
    Rheumatoid Arthritis (RA) is a complex, systemic autoimmune disorder characterized by chronic inflammation in small joints in hands and feet. It is a common disease that if untreated leads to joint destruction, disability, ...
  • Effects of a structured lifestyle program for individuals with high cardiovascular risk 

    Lidin, Matthias (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-19)
    Cardiovascular disease (CVD) is the leading cause of death in Sweden as well as in the rest of the world. CVD is mainly caused by unhealthy lifestyle habits and lifestyle-related risk factors. National and international ...
  • Locus specific DNA methylation in human immunological responses 

    Ahlén Bergman, Emma (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-18)
    All cells in the human body contains the same genome. Yet, there are hundreds of different cell types, with widely different phenotype, and function. The differential gene expression leading to this diversity is tightly ...
  • Adaptive immunity in urothelial cancer : molecular and clinical aspects 

    Krantz, David (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-10-05)
    In the battle between the immune system and cancer, tolerance mechanisms otherwise protective against autoimmunity, are exploited to halt the anti-tumor immune response. In this model, tumors turn distinct parts of the ...
  • Antibody responses to Plasmodium falciparum as markers of exposure and tools to monitor malaria transmission 

    Yman, Victor (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-28)
    Plasmodium falciparum malaria has the highest death toll of all human parasitic diseases and nearly half of the global population is living at risk of infection. Reducing the malaria burden with the goal of achieving ...
  • The role of adjuvant-induced innate immune activation in shaping vaccine responses 

    Thompson, Elizabeth (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-27)
    Adjuvants are components added to non-live vaccine formulations to enhance the effect of the vaccine by alerting the immune system to initiate a response against the vaccine. Powerful new adjuvants will be critical for ...
  • Gene regulation in psoriatic keratinocytes: microRNAs and cytokine responses 

    Srivastava, Ankit (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-21)
    Psoriasis is the most common chronic skin inflammation in adults which affects 2-4% of the world population. Keratinocytes are the key structural cells in epidermis which hyper-proliferate and undergo aberrant differentiation ...
  • Extracellular vesicles : mediators of immune modulation in the lung and as therapeutic vehicles 

    Ullsten-Wahlund, Casper (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-18)
    Extracellular vesicles (EVs) are released from all cell types, and carry a wide setup of proteins, nucleic acids, lipids and other cargo. The overall aim of this thesis is to explore EV-based immune therapy, but also to ...
  • HIV susceptibility factors in the human genital mucosa 

    Röhl, Maria (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-14)
    Heterosexual HIV transmission is the most common viral transmission route worldwide. To establish a persistent infection the virus needs to cross the mucosal surface of the genital tract. The genital mucosa is thus considered ...
  • T cells in solid tumors : investigating the immunomodulation in the tumor microenvironment 

    Hartana, Ciputra Adijaya (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-03)
    The immune system protects human from cancer through an immunosurveillance mechanism. However, the progressive nature of tumor cells to differentiate and the complexity of the tumor microenvironment may result in the ...
  • Long-term health hazards from diagnostic X-ray exposure 

    Nordenskjöld, Arvid (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-08-23)
    Medical imaging is an important function in the diagnosis and management of disease and its use have been increasing with technological advancements. A large part of medical imaging uses ionizing radiation as medium for ...
  • Immune mechanisms in chronic rheumatic muscle inflammation, myositis 

    Tang, Quan (Inst för medicin, Solna / Dept of Medicine, Solna, 2018-08-10)
    The idiopathic inflammatory myopathies (IIM), shortly named myositis, is a group of heterogeneous and rare autoimmune diseases with the target tissue of skeletal muscle. It is not curable and affects the daily life of ...

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