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  • Consequences of multiple sclerosis for patients in Sweden 

    Burkill, Sarah (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-11-11)
    This study aimed to consider consequences of multiple sclerosis for patients in Sweden throughout various stages of the life course. The thesis was separated into four constituent papers, which dealt with different aspects ...
  • From youth to adult : studies on chronic airway obstruction with special reference to events in the neonatal period 

    Um-Bergström, Petra (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-10-31)
    Introduction: In western countries, 6-12% of all pregnancies end preterm, i.e. before 37 weeks of gestation. After the introduction of antenatal corticosteroids and improvements of neonatal intensive care, survival rates ...
  • Survival after different forms of bystander cardiopulmonary resuscitation in out-of-hospital cardiac arrest : “to breathe or not to breathe?” 

    Riva, Gabriel (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-10-31)
    Background: Out-of-hospital cardiac arrest (OHCA) affects more than 6000 people per year in Sweden and only one in ten survive. One of the most important modifiable factors determining survival is early cardiopulmonary ...
  • Monocytes and dendritic cells : roles during human influenza and hantavirus infections 

    Vangeti, Sindhu (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-10-23)
    Viruses infect a vast majority of the other species on the planet and rarely leave the host undamaged. Most human viruses need to infect an individual to replicate and disseminate, and must contend with the full force of ...
  • Trial of labour after caesarean 

    Lindblad Wollmann, Charlotte (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-10-15)
    Background: Induction of labour and caesarean delivery are common interventions in obstetric care and over the last decades both have been steadily increasing in frequency worldwide. The two interventions are concatenated, ...
  • Epidemiological perspective of chronic immune thrombocytopenia 

    Ekstrand, Charlotta (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-10-04)
    This thesis deals with different aspects of immune thrombocytopenia disease (ITP), what happens before diagnosis, characteristics of patients at treatment start and outcomes potentially related to the disease and treatment, ...
  • Innate lymphoid cells and cholesterol metabolism in intestinal barrier function 

    Parigi, Sara Martina (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-10-02)
    The intestinal mucosa represents one of the largest barrier sites of our body, having to withstand a constant exposure to a plethora of environmental insults (including dietary compounds, xenobiotics, metabolites and ...
  • Angiogenetic and hereditary factors in endometrial disease 

    Andersson, Emil (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-09-04)
    The endometrium is a unique tissue in the adult human body because it is the only site where physiological renewal of vessels, angiogenesis, occurs. The regulation of this process under normal conditions is not fully ...
  • Mechanisms of resident T cell-driven tissue responses during the onset and recurrence of human skin inflammation 

    Gallais Sérézal, Irène (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-09-03)
    Long-lived tissue-resident memory T cells (TRM) reside in nonlymphoid organs and can drive direct cytotoxicity, focal cytokine release and potent tissue-wide anti-infectious responses upon antigenic challenge. TRM cells ...
  • Introduction of new medicines in Sweden 

    Eriksson, Irene (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-08-26)
    Payers and providers face challenges in enabling appropriate and sustainable access to new medicines. To help enable rational use of new medicines various policy options exist. In Sweden, horizon scanning, forecasting, ...
  • Identification and functional characterization of proteins involved in hepatic triglyceride metabolism 

    Taxiarchis, Apostolos (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-08-19)
    Triglycerides are the main form of energy in the tissues and liver, along with the adipose tissue, is the main organ of triglyceride metabolism and storage in the lipid-droplet organelles. A number of proteins are involved ...
  • Lineage stability and effector function of CD4+FOXP3+ regulatory T cells 

    Seitz, Christina (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-08-12)
    This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated ...
  • Molecular mechanisms of cardiovascular calcification 

    Carracedo Ortiz, Miguel (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-23)
    Cardiovascular calcification is a pathophysiological process characterized by the deposition of calcium-phosphate crystals in the arteries and the leaflets of the heart valves. In the arteries calcification causes arterial ...
  • Inhibition of mPGES-1 as therapeutic strategy in inflammation and cancer 

    Bergqvist, Filip (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-16)
    Prostaglandin E2 (PGE2) is an inflammatory and oncogenic lipid mediator. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases (COX-1 and COX-2) and the terminal enzyme microsomal prostaglandin E ...
  • Innate immune mechanisms of atherosclerosis 

    Jiang, Xintong (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-13)
    Atherosclerosis is a multi-factorial immune mediated disease in arterial wall characterized by lipid driven inflammation through activation of the immune system. Chronic vascular inflammation is an important component that ...
  • Tracing the interplay between cellular metabolism and cell cycle 

    Roci, Irena (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-13)
    Cancer cells are more vulnerable to targeting during S-G2-M cell cycle phases due to common deregulations in cell cycle checkpoint mechanisms. Most common cancer drugs target processes in the S-G2-M phases, often causing ...
  • Breast cancer : brain metastases and treatment aspects 

    Frisk, Gabriella (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-08)
    Background: In Sweden breast cancer is the most common malignant cancer disease among women, with 8000 new individual cases each year. The prognosis is generally very good, but nevertheless many patients still die of breast ...
  • Identification and functional characterization of irritable bowel syndrome (IBS) risk genes and variants 

    Zheng, Tenghao (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-08)
    As one of the most prevalent functional gastrointestinal disorders (FGIDs), irritable bowel syndrome (IBS) affects more than 10% of the general population worldwide with a higher prevalence in women. The primary clinical ...
  • Remote ischemic conditioning to protect the heart in myocardial infarction : therapeutic intervention and underlying mechanisms 

    Verouhis, Dinos (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-03)
    Background Urgent reperfusion of the occluded coronary artery halts the ischemic insult to the myocardium and is the single most important action to limit infarct size in ST-elevation myocardial infarction. However, ...
  • Cellular and molecular factors in the pathogenesis of systemic autoimmunity and comorbidities 

    Ivanchenko, Margarita (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-02)
    Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE) are systemic rheumatic autoimmune diseases having a major impact on patient’s wellbeing. Besides fatigue, pain and direct damage to exocrine glands in SS, and ...

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