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Recent submissions
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Inflammatory activation of the kynurenine pathway-studies with lipopolysaccharides
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-27)Neuroinflammation is increasingly recognised as playing an important role in several major psychiatric disorders. The mechanisms by which neuroinflammation influences neurotransmitter systems have for long been unknown. ... -
PET studies of the serotonin system in relation to behavioral phenotypes in psychiatry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-27)Behavioral phenotypes beyond core symptoms of diagnoses have become an area of high interest in psychiatric research. All major psychiatric diagnoses are associated with deficits in cognitive function, including impairments ... -
Dispatch of lay responders to out-of-hospital cardiac arrests
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-27)Background and aim Out-of-hospital cardiac arrest (OHCA) remains a major public-health problem affecting around 300 000 Europeans each year. If treatment is not started within a couple of minutes the chances of ... -
Microparticles in hemophilia - friend or foe? : to improve hemostasis or to induce atherothrombosis?
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-27)As one of the most well-known inherited bleeding disorders, hemophilia A (HA) is caused by the deficiency or dysfunction of coagulation factor VIII (FVIII). Patients with HA (PWHA) suffer from abnormal bleeding after ... -
The burden of back pain : evaluation of costs and health outcomes
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2020-11-27)Background: Back pain is a leading cause of disability in the world. Beyond the negative impact on people’s health and quality of life, back pain is associated with substantial costs both within and outside the health care ... -
Experimental approaches and clinical opportunities in metabolic liver diseases
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-11-27)Metabolic liver diseases are uncommon individually, however, collectively they represent significant cause of morbidity and mortality globally. The liver has many diverse functions, such as; detoxification from hazardous ... -
From brain to muscle and back : novel approaches to harness the benefits of exercise
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-27)As the world population is growing older and more sedentary every day, the need for new approaches to combat chronic diseases grows steadily. Physical exercise improves health and reduces the risk of developing a plethora ... -
Links between stress, sleep, and inflammation : a translational perspective of resilience
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-27)Most individuals will experience one or more extremely traumatic events during their lifetime. For the most part, humans are resilient and have a tremendous capacity to bounce back from hardships; however, for a critical ... -
Genetics of systemic autoimmunity and comorbidities
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-11-26)Sjögren‘s syndrome (SS) is a systemic autoimmune disease that typically affects the salivary and lacrimal glands leading to dry eyes and dry mouth, but the patients may also have systemic involvement. Most patients with ... -
Coeliac disease in children and adolescents with type 1 diabetes : screening, diagnosis and prevalence
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-11-26)Background Coeliac disease (CD) is more common in children and adolescents with type 1 diabetes (T1D). Both diseases share the same high-risk genes: human leukocyte antigen (HLA) DQ2 and DQ8. Other factors than ... -
Non-conveyed patients : a thesis on epidemiology, and patients’ and ambulance clinicians’ experiences
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-25)BACKGROUND As a consequence of the increased overall number of ambulance assignments in combination with an increase in patients assessed as having non-urgent complaints, new demands are being placed on the ambulance ... -
Effects of early functional mobilization after acute Achilles tendon rupture repair
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-24)Background: Patient outcome after Achilles tendon rupture (ATR) varies greatly, and complications such as deep venous thrombosis (DVT) and tendon elongation are common. Although accelerated rehabilitation is considered ... -
Swedish children with moderate hearing loss : on the importance of monitoring auditory and early speech development the first three years
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-11-24)The overall aim of this thesis was to investigate the auditory and early speech development in a group of children born with moderate hearing loss (HL) who were fitted with hearing aids (HAs) before the age of 6 months, ... -
The association between smoking behaviour and depressive symptoms in adolescence: the role of biology and of societal influences
(Inst för global folkhälsa / Dept of Global Public Health, 2020-11-24)Tobacco use is common among people who suffer from depressive symptoms. This cooccurrence is associated with several negative health outcomes. The present thesis will contribute to the understanding of if, how, and in ... -
Perioperative risk factors and outcomes
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-11-24)Perioperative complications is an increasing issue worldwide, as surgical volume continues to grow. Myocardial and kidney injury, and myocardial infarction (MI), are known complications in non-cardiac surgery. Hemodynamic ... -
Overlooking health acculturation : a grounded theory study illustrating the complexity of intercultural consultation in Swedish primary care
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2020-11-24)Background: Intercultural consultations are perceived as complex by physicians and when asked why, ‘cultural differences’ are often mentioned. With increasing patient diversity in primary care, because of increasing global ... -
Translational studies on mitochondrial function and hypoxia in complications of diabetes mellitus
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-11-24)Diabetes Mellitus (DM) is a major concern for societies and healthcare systems globally. DMassociated morbidity and mortality is mediated by diabetic complications. Hypoxia and oxidative stress have emerged as key players ... -
Attention-deficit/hyperactivity disorder and adverse health outcomes : from association to prevention
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-23)Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder, characterized by persistent inattention and/or hyperactivity-impulsivity that are inappropriate for one’s developmental ... -
Adolescent sleep : comorbid problems and behavioral treatment of insomnia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)Background Sleep problems, especially insomnia, are common in adolescents and are often associated with other problems, such as anxiety, depression and chronic pain. Even though there are effective psychological ... -
Deliberate self-harm among adolescents : course, outcome and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-11-20)Background: Self-harm among adolescents is prevalent, and is a risk factor for suicide, which is one of the leading causes of death among youth worldwide. There is a need to better understand the role and impact of self-harm ...