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  • Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics 

    Fernandez Lahore, Gonzalo (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-07-29)
    Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic ...
  • Executive functions and successful behavior 

    Vestberg, Torbjörn (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-07-28)
    Executive functions are the underlying mechanisms that drive top-down regulation of information processing. While suboptimal executive functions have been investigated in various groups of patients, their impact and ...
  • Improved statistical methodology for high-throughput omics data analysis 

    Deng, Wenjiang (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-07-19)
    Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ...
  • Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction 

    Foo, Kylie S.; Lehtinen, Miia L.; Lian, Xiaojun; Xu, Jiejia; Keung, Wendy; Geng, Lin; Kolstad, Terje R.S.; Thams, Sebastian; Wong, Andy On-tik; Wong, Nicodemus; Bylund, Kristine; Zhou, Chikai; He, Xiaobing; Jin, Shao-Bo; Clarke, Jonathan; Lendahl, Urban; Li, Ronald A.; Louch, William E.; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, HuddingeStem Cell and Regenerative Medicine Consortium, LKS Faculty of Medicine, The University of HongKong, Hong Kong, ChinaDr. Li Dak-Sum Research Centre, University of Hong Kong-Karolinska Institutet Collaborations in Regenerative Medicine, The Universityof Hong Kong, Hong Kong, ChinaInstitute for Experimental MedicalResearch, Oslo University Hospital and University of Oslo, Oslo, Norway, 2021-07-01)
    The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ...
  • Mechanisms of flavor perception : how odor and taste interact when we eat 

    Fondberg, Robin (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-06-02)
    Every time we eat, our brains are bombarded with sensory information from the olfactory and gustatory modalities. Through a binding process that is not fully understood, the odor and taste are then merged into flavor, a ...
  • Sexual violence : epidemiology, treatment and health care access 

    Rajan, Gita (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-06-01)
    Sexual violence is recognized by the World Health Organization as a “… global public health problem of epidemic proportions, requiring urgent action” [1]. In Sweden, the estimated incidence of penetrative sexual violence ...
  • Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer 

    Huguet Ninou, Anna (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)
    Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues ...
  • Exploring mTOR-dependent regulation of mRNA translation in cancer 

    Liu, Hui (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)
    Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation ...
  • Atopic dermatitis in adults : epidemiological studies of comorbidity and studies of patients on systemic treatment 

    Ivert, Lina (Inst för medicin, Solna / Dept of Medicine, Solna, 2021-06-01)
    Background: Atopic dermatitis (AD) is one of the most common chronic skin disorders globally. It is an itchy inflammatory skin disease that can have a detrimental impact on health-related quality of life. In recent years, ...
  • Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition 

    Lehto, Jemina (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)
    The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies ...
  • Enterprise within the enterprise : a study of management and performance in a public health care delivery organisation 

    Ohrling, Mikael (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-06-01)
    Background The challenges in healthcare are an everyday struggle for managers. Efficiency and responsiveness of public sector services have been of interest over the past decades. Different reforms have been launched. ...
  • Number of siblings and survival from childhood leukaemia : a national register-based cohort study from Sweden 

    Mogensen, Hanna; Modig, Karin; Talbäck, Mats; Erdmann, Friederike; Heyman, Mats; Feychting, Maria; Tettamanti, Giorgio (Institutet för miljömedicin / Institute of Environmental MedicineInst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2021-05-31)
    Background: Previous studies suggest worse leukaemia survival for children with siblings, but the evidence is sparse, inconsistent and does not consider clinical factors. We explored the associations between number of ...
  • Detecting prolonged sitting bouts with the ActiGraph GT3X 

    Kuster, Roman P; Grooten, Wilhelmus J A; Baumgartner, Daniel; Blom, Victoria; Hagströmer, Maria; Ekblom, Örjan (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
    The ActiGraph has a high ability to measure physical activity; however, it lacks an accurate posture classification to measure sedentary behavior. The aim of the present study was to develop an ActiGraph (waist-worn, 30 ...
  • Network asynchrony underlying increased broadband gamma power 

    Guyon, Nicolas; Zacharias, Leonardo Rakauskas; de Oliveira, Eliezyer Fermino; Kim, Hoseok; Leite, João Pereira; Lopes-Aguiar, Cleiton; Carlén, Marie (Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)
    Synchronous activity of cortical inhibitory interneurons expressing parvalbumin (PV) underlies expression of cortical γ rhythms. Paradoxically, deficient PV inhibition is associated with increased broadband γ power in the ...
  • Active sitting with backrest support: Is it feasible? 

    Kuster, Roman P; Bauer, Christoph M; Gossweiler, Lukas; Baumgartner, Daniel (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
    Ergonomics science recommends office chairs that promote active sitting to reduce sitting related complaints. Since current office chairs do not fulfil this recommendation, a new chair was developed by inverting an existing ...
  • Where to place which sensor to measure sedentary behaviour? A method development and comparison among various sensor placements and signal types 

    Kuster, Roman P; Baumgartner, Daniel; Hagströmer, Maria; Grooten, Wilhelmus J A (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
    Background: Sedentary Behaviour (SB) is associated with several chronic diseases and especially office workers are at increased risk. SB is defined by a sitting or reclined body posture with an energy expenditure ≤1.5 ...
  • Adult trkB signaling in parvalbumin interneurons is essential to prefrontal network dynamics 

    Guyon, Nicolas; Zacharias, Leonardo Rakauskas; van Lunteren, Josina Anna; Immenschuh, Jana; Fuzik, Janos; Märtin, Antje; Xuan, Yang; Zilberter, Misha; Kim, Hoseok; Meletis, Konstantinos; Lopes-Aguiar, Cleiton; Carlén, Marie (Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)
    Inhibitory interneurons expressing parvalbumin (PV) are central to cortical network dynamics, generation of c oscillations, and cognition. Dysfunction of PV interneurons disrupts cortical information processing and cognitive ...
  • Neuroinflammation and its resolution in Alzheimer's disease 

    Wang, Ying (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
    Alzheimer's disease (AD) is the most common dementia with high prevalence among an increasing aged population. Despite the existence of symptom-reliving drugs for AD, the clinical trials performed until now have failed ...
  • Post-migration stress and mental health among refugees : a population-based survey among refugees from Syria recently resettled in Sweden 

    Malm, Andreas (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-31)
    Refugees are exposed to several risk factors for mental ill health before, during, and after the migration. While the impact of traumatic experiences on the mental health of refugees is well-known, the effect of adverse ...
  • Optimization of intermittent preventive therapy for malaria during pregnancy : effectiveness of dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine 

    Mlugu, Eulambius Mathias (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-28)
    Malaria is a Tropical disease caused by different parasites species of genius Plasmodium. Because of pregnancy associated lowered immunity, women who are pregnant are at higher risk to malaria infection than non-pregnant ...

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