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Recent submissions
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Conformational dynamics in microRNAs : the example of miR-34a targeting Sirt1 mRNA
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-06-17)In biology, regulatory mechanisms are essential to achieve complex tasks, as virtually every process can be positively or negatively modulated in its outcome, upon different cues. In humans, microRNAs (miRNAs) ... -
Lipids, apolipoproteins, and prognosis of amyotrophic lateral sclerosis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-06-08)Objective: To determine whether lipids and apolipoproteins predict prognosis of patients with amyo- trophic lateral sclerosis in a cohort study of 99 patients with amyotrophic lateral sclerosis who were diagnosed during ... -
Fibrinogen-binding proteins from Staphylococcus aureus
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-06-08)Staphylococcus aureus produces a large number of proteins that specifically bind to molecules from plasma or from the human extracellular matrix where they are involved in processes associated with the colonization of the ... -
Exploring chromatin organization and transcription in S.pombe and hematopoietic development
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-05-28)DNA in the eukaryotic nucleus is organized into histone-DNA complex, so-called chromatin, through forming an array of nucleosomes. Each nucleosome consists of a 147bp DNA wrapped around a histone octamer harboring two ... -
Extensive tooth wear in adults : classification and prosthetic treatment
(Inst för odontologi / Dept of Dental Medicine, 2020-05-27)Background: Tooth wear (TW) is an insidious and cumulative mul- tifactorial process that may comprise erosion, abrasion or attrition, and combinations thereof. These different processes are of chemical or physical origin ... -
Common respiratory virus infections in cystic fibrosis : from immunity to vaccine
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-27)Cystic fibrosis is the most common lethal monogenetic disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator protein which is responsible for appropriate ion and water ... -
Endometrial regeneration : unraveling the mysteries of the stroma
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-05-27)The healthy endometrium has the unique capacity of shedding and regenerating its functional layer once every menstrual cycle, under the regulation of hormones, progenitor cell populations and inflammatory mediators. ... -
Immunometabolic network interactions of the kynurenine pathway in cutaneous malignant melanoma
(Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-26)Cancer is the second leading cause of mortality worldwide, and melanoma represents the most aggressive and deadliest form of skin cancer. Despite the various therapeutic approaches, metastatic melanoma is a disease with ... -
A study on the role of T helper cells in allergic inflammation
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-26)Asthma is a chronic inflammatory disease of the airways affecting hundreds of millions of people worldwide. Central to the development of asthma and allergic airway inflammation are CD4 T cells, which upon activation through ... -
Cerebral oedema after reperfusion therapy in patients with ischaemic stroke : predictors, outcomes and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-26)Introduction: Reperfusion therapy by intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT) are established treatments in ischaemic stroke. Cerebral oedema (COED), caused by dysfunction the blood brain ... -
Hygiene at CT and MRI
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-26)Background: Preventing the spread of infections is a constant battle against microorganisms. Hospital-acquired infections (HAIs) with multidrug-resistant (MDR) bacteria are a global problem today and causes suffering for ... -
Immunopathogenesis of multiple sclerosis : big roles for small RNAs
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-21)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and the leading cause of neurological disability in young adults. The exact cause of MS remains elusive despite enormous progress ... -
FtsH protease and ClpG disaggregase confer fitness advantages to the worldwide prevalent Pseudomonas aeruginosa clone C
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-20)Pseudomonas aeruginosa is an environmental bacterium and a frequent nosocomial pathogen causing a wide range of opportunistic infections, especially in immunocompromised patients. Clone C is one of the most prevalent ... -
Magnetic resonance imaging techniques for diagnostics in Parkinson’s disease and atypical parkinsonism
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-20)Background: Parkinson’s disease (PD) is a neurodegenerative disease characterized by rigidity, hypokinesia, tremor and postural instability. PD is a clinical diagnosis based on neurological examination, patient history ... -
Total hip arthroplasty, osteolysis and cardiovascular disease in patients with osteoarthritis of the hip
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-05-20)The pathogenesis of OA and CVD is currently related to inflammatory processes. It is unknown how OA and its surgical treatment impact the cardiovascular system. Hypotheses We hypothesized that (1) THA ... -
Outcome of gastric cancer surgery in Sweden
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-20)Gastric cancer worldwide is the fifth most common cancer and has the third highest cancer related mortality. Curative treatment includes surgical resection but comes with risk of complications and the optimal surgery ... -
Evaluation of biomarkers in chronic inflammatory diseases
(Institutet för miljömedicin / Institute of Environmental Medicine, 2020-05-20)The overall aim of this thesis was to assess the role of biomarkers in chronic inflammatory disease. The goal of the first study was to investigate the association of sIL-6R and sgp130 levels and risk of first myocardial ... -
Innate-like T cells in the immunopathogenesis of HIV-1 infection
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-20)The immunodynamics of HIV infection have been studied for over three decades in the hopes of determining underlying mechanisms that contribute to the sustained immune dysfunction observed even in individuals on therapy. ... -
Redesigning an emergency department for interprofessional teamwork : a longitudinal evaluation of the impact on patient flow and team behaviour
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-05-19)Objective: Crowding in emergency departments (EDs) has negative effects on patients and staff, whereas effective teamwork in healthcare has positive effects. Triage interventions and streaming of specific patient categories ... -
Etiology and prognosis of gastroesophageal cancers
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-05-19)Gastric and esophageal cancer – gastroesophageal cancers, belong to the most fatal malignancies in the world. Understanding the cause of these diseases is key to interventions such as primary prevention and/or surveillance ...