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  • Alphavirus-host interactions : how to unravel the proviral activity of G3BP 

    Götte, Benjamin (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-08-30)
    The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically ...
  • Relation between nutritional status, the outcome of infection and immune responses 

    Terán, Graciela (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-08-16)
    A causal interaction between nutrition and the outcome of different infections has been known since long time ago. Moreover, responses of human beings to infection are diverse and demarcated by immunity. A deficient and ...
  • Effects of DNA damage and vesicular exchange in P. falciparum 

    Hjelmqvist, Daisy (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-28)
    Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...
  • Identification and characterization of small molecules targeting MYC function 

    Yan, Qinzi (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-21)
    The MYC family genes (c-, N- and L-MYC) encode potent oncoproteins/transcription factors regulating fundamental cellular processes involved in cell proliferation, metabolism and survival, and they play an important role ...
  • Exploration of host cells during old world alphavirus infection : modulation of RNA granules and the PI3K/AKT pathway 

    Liu, Lifeng (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-03)
    As obligate intracellular parasites, viruses have to explore and modulate cellular pathways for their survival. Mechanistic studies of virus–host interactions provide a better understanding of viral infection and cellular ...
  • Decoding the tumor microenvironment : a B-cell and Macrophage perspective 

    Boura, Vanessa F. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-02)
    The immune system plays a role in many different functions in our body, and disease is no exception. Cancer is one of the biggest challenges of the twenty first century and vast efforts have been made to understand this ...
  • Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer 

    Zhang, Fan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-26)
    Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes ...
  • Elucidation of the cell signaling pathways mediating innate immunity and host-pathogen interactions 

    Nabar, Neel R. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-14)
    The ability to generate a robust immune response is integral to organismal homeostasis. Cells of the innate immune system are considered the first responders of immunity, and are therefore responsible for sensing both ...
  • Cooperativity between MYC and other oncogenic factors : implications for tumorigenesis and targeting of MYC 

    Zakaria, Siti Mariam (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-08)
    Normal cell homeostasis in a tissue requires a delicate balance between cell growth, maintenance and death, tightly controlled by an intricate interplay between proto-oncogenes and tumor suppressor genes. When the balance ...
  • Developing new models of childhood malignancies using human induced pluripotent stem cells 

    Marin Navarro, Ana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-02-15)
    Early onset diseases such as childhood malignancies and neurodevelopmental disorders have been intricate to study. For many years, research has relied and dependent upon different animal systems. Despite the usefulness of ...
  • The role of growth factors in white fat browning and metabolic disease 

    Fischer, Carina (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-01-16)
    The adipose tissue is composed of a variety of cell types that constantly cross-communicate with each other to allow the tissue to operate and to adapt to various external stimuli. The diversity of these cell populations ...
  • The functional impact of gut microbiota on CNS regulation of local and systemic homeostasis 

    Abbaspour, Afrouz (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-08-24)
    The “gut microbiota” is widely accepted as an integral part of the gut homeostasis, and is thought to contribute to the establishment of intestinal barrier. Growing body of research suggest that the influence of gut ...
  • Impact of intestinal worms on distal immune response and control of co-infections 

    Feng, Xiaogang (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-08-23)
    Parasitic worm infections have been suggested to impair control of secondary infections and vaccine efficacy. However, the experimental data regarding the capacity of intestinal nematodes to modulate host immune responses ...
  • Repertoire diversity and maturation of HIV-1 vaccine-induced B cell responses 

    Phad, Ganesh Eknath (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-06-04)
    In the work presented in this thesis, I characterized B cell responses in rhesus macaques inoculated with HIV-1 envelope glycoprotein (Env)-based vaccines to define genetic and functional properties of the elicited ...
  • p53 transcriptional activity as a tool to uncover novel and diverse druggable targets in cancer 

    Ladds, Marcus James Graeme Watson (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-05-28)
    The transcription factor p53 is one of the most studied tumour suppressors with over 90 000 publications in PubMed referring to the protein. It is also the most frequently mutated gene across all cancer types with around ...
  • Pneumococcal interactions with the host : threats and therapeutic approaches 

    Codemo, Mario (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-05-22)
  • Impaired response to HBV vaccination in HIV-1 infected children : immunopathological mechanisms 

    Bekele Feyissa, Yonas (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-05-08)
    HBV vaccination prevents HBV infection and related liver cancer. Immunological dysfunctions of Tfh and B cells in HIV-1 infected individuals may affect the response to HBV vaccine. The general objective of this thesis ...
  • Tumor microenvironment : the paradoxical action of fibroblasts 

    Alkasalias, Twana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-22)
    The term tumor refers to an abnormal and pathological tissue characterized by a massive cell growth; it comprises various populations of transformed and malignant cells. These cells cross-communicate with each other and ...
  • Receptor localization and dynamics of murine natural killer cells at single cell level : using advanced fluorescence microscopy 

    Bagawath Singh, Sunitha (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-21)
    Natural Killer (NK) cells are immune cells and important for the defense against virally infected and malignant cells. NK cells are regulated by germline encoded activating and inhibitory receptors. Activating receptors ...
  • In vivo bioluminescence imaging in preclinical trials of genetic vaccines 

    Petkov, Stefan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-15)
    DNA immunization is a rapidly developing vaccine platform for infectious diseases, cancer and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of ...

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