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  • CMV-infection in gay men with AIDS 

    Grützmeier, Sven (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-02-03)
    Background: Before the era of combination therapy (c-ART) more than 90 % of the patients with HIV-infection died of one or more opportunistic infections (OI). We and others noted early on that CMV was an important pathogen ...
  • Memory B-cell function and antibody profiles in malaria : their role in protection against disease in infancy 

    Lugaajju, Allan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-02-02)
    Malaria infection is of huge public health importance in developing countries, including Uganda. Antibody immunity assumes a paramount part in the disease control however there’s a great need to study components of ...
  • Surface antigens in Plasmodium falciparum malaria : PfEMP1 and SURFIN4.2 

    Quintana Varon, Maria del Pilar (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-01-04)
    Plasmodium falciparum malaria is an infectious disease that on despite of the ongoing eradication efforts is still endemic in more than 100 countries, sometimes causing severe disease that leads to the death of around ...
  • Urinary tract infections in pregnancy : studies in vivo and in vitro 

    Sekikubo, Musa (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-11-09)
    The risk of urinary tract infection (UTI) in pregnant women is increased and predisposes them to acute pyelonephritis together with poor pregnancy outcomes. Increased frequency of micturition, nocturia and lower abdominal ...
  • Streptococcus pneumoniae and the host : activation, evasion and modulation of the human innate immune system 

    Spelmink, Laura (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-11-08)
    Streptococcus pneumoniae is a major cause of severe infections such as pneumonia, septicemia and meningitis, but also a common colonizer of the nasopharynx in children. In most individuals colonization is harmless and ...
  • Mechanisms of tumor microenvironment in promoting metastasis 

    Andersson, Patrik (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-11-07)
    Tumor tissues contain diverse cell populations that relentlessly cross-communicate with each other in the tumor microenvironment. In addition to malignant cells, infiltration of other host cells including inflammatory ...
  • Constraints for dendritic cell differentiation : analysis of autocrine inhibitory mechanisms with therapeutic implications 

    Nasi, Aikaterini (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-11-03)
    The discovery of dendritic cells (DCs) was followed by an intensive research period aiming at the identification of mechanisms that could induce or inhibit adaptive immune responses through the manipulation of these ...
  • Dysfunctional phenotype of T cells and their contribution to impaired B cell function during HIV-1 infection 

    Lantto Graham, Rebecka (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-08-29)
    Microbial translocation and increased immune activation have been involved in functional T cell impairments and disease progression during HIV-1 infection. The impact of microbial translocation on the phenotype of memory ...
  • Exploring the cancer cell attractor in the Epstein-Barr virus infection model 

    Li, Qin (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-05-27)
    It has been proposed, based on the theory of complex gene regulatory networks, that cell types, including cancer cells, represent attractor states of the network dynamics. In this study, we proposed an Epstein - Barr virus ...
  • A tripartite of immune-, epithelial-, and nervous-systems in the homeostatic regulation of the gut 

    Chng, Song Hui (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-05-24)
    Various cell types in the intestinal mucosa are constantly exposed to complex signals emanating from the lumen, including the microbiota and its metabolites. How these bilateral interactions in turn influences intestinal ...
  • NK cell education and adhesion molecules : implications for immunotherapy 

    Wagner, Arnika Kathleen (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-05-19)
    NK cells have a key role in immune surveillance. They detect aberrant expression of stressinduced molecules and MHC class I molecules with an array of activating and inhibitory receptors. Inhibitory receptors are not only ...
  • Immunoreactive proteins in Taenia solium/cysticercus cellulosae 

    Nhancupe, Noémia Jeremias (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-03-17)
    Cysticercosis caused by Taenia solium is a common zoonotic parasitic disease in Latin America, Asia, Africa, and parts of Oceania, and it is responsible for many cases of epileptic seizures. Imaging techniques used to ...
  • Malaria and polypeptides of Plasmodium falciparum at the infected erythrocyte surface 

    Palmkvist, Mia (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-03-11)
    Malaria is one of the top three most lethal infectious diseases in the world after tuberculosis and HIV. The disease is caused by intracellular parasites of the genus Plasmodium spp. To date, five Plasmodium spp have ...
  • Who is killing whom? Hantaviruses vs programmed cell death 

    Gupta, Shawon (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-02-17)
    Hantaviruses belong to the Bunyaviridae family of negative stranded RNA viruses. They carry a tri-segmented genome and consist of four structural proteins. The four structural proteins are two glycoproteins Gn and Gc, a ...
  • iNKT cell regulation of B cell activation in inflammation 

    Landgraff Hägglöf, Thomas (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-01-14)
    The ability to combat infections through the generation of specific immune responses is critical to our survival. The immune system can react to and combat virtually any molecule presented to it, including those derived ...
  • Exploring immunotherapeutic targets in the tumor microenvironment 

    Georgoudaki, Anna-Maria (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-11-19)
    The immune system has developed along with the evolution of increasingly complex cellular organisms to sustain homeostasis and protect from threats. Cancer, a detrimental side effect of increasing organismic complexity, ...
  • Characterization of virulence in clinical isolates of Streptococcus pneumoniae 

    Norman, Erik Martin (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-11-02)
    The immune system together with competing pneumococcal strains and other bacterial species, impose a selective pressure on the pneumococcus that leads to the expansion of certain lineages and the remission of others. Our ...
  • Microbial and epigenetic factors in the pathogenesis of nasopharyngeal carcinoma 

    Zhou, Xiaoying (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-10-19)
    While uncommon in most of the world, nasopharyngeal carcinoma (NPC) shows an unusual geographic and ethnic distribution, being highly prevalent in Southern China and Southeast Asia. Genetic susceptibility, Epstein-Barr ...
  • Characterization of HIV-1 RNA and DNA during long-term suppressive therapy 

    Stockenström, Susanne von (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-10-09)
    Human immunodeficiency virus (HIV) is the virus causing acquired immune deficiency syndrome (AIDS). Since the discovery of HIV/AIDS over three decades ago, this disease has claimed millions of lives. One of the major ...
  • Bioinformatic analyses of the structural and functional complexity in chromosomal interactomes 

    Fernandez Woodbridge, Alejandro (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-09-24)
    Evolution requires information storage systems with different demands with respect to persistence. While the genome provides a mechanism for long term, static and accurate information storage, it is incapable of mediating ...

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