Now showing items 1-20 of 7589

  • Interleukin-22 binding protein in multiple sclerosis and experimental inflammation models 

    Lindahl, Hannes (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-10-20)
    Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. Although the cause of the disease is unknown, several genetic and environmental risk factors have been identified. By ...
  • Light to moderate alcohol consumption and acute myocardial infarction, heart failure and atrial fibrillation 

    Gémes, Katalin (Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2017-10-20)
    Background and aim: A large number of studies found an inverse association between light to moderate alcohol consumption and the risk of acute myocardial infarction (AMI) and heart failure (HF). Whether this consumption ...
  • Cardiovascular function in normal pregnancy and fetal growth 

    Iacobaeus, Charlotte (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-10-20)
    Background: Pregnancy is a challenge to a woman’s cardiovascular system, and extensive haemodynamic changes are required for optimal utero-placental circulation and fetal growth. The aim of this thesis was firstly to ...
  • Chorangiomas : histopthological, clinical and genetic studies 

    Sirotkina, Meeli (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-10-20)
    Chorangioma (CA), although, is the most common non-trophoblastic, vascular, tumor-likelesion of the placenta with incidence approximately 0.5-1% of all examined placentas, the specific etiology and genetic background of ...
  • Organization of basal ganglia circuits 

    Fürth, Daniel (Inst för neurovetenskap / Dept of Neuroscience, 2017-10-17)
    Anatomical regions and how we define boundaries between and within structures in the brain put a constraint on our understanding of the brain. More than a century of research on the brain has revealed its fundamental ...
  • Immunotherapy for pancreatic cancer 

    Meng, Qingda (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-10-17)
    Patients with pancreatic cancer have a short life expectancy, and only 20% of the patients diagnosed with pancreatic cancer can undergo surgery. Chemotherapy does not work well: Gemcitabine is the standard regimen with ...
  • A continuing educational intervention in primary health care using the ConPrim model 

    Berggren, Erika (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-10-17)
    Background and aim: The overall aim of this thesis was to evaluate an intervention about “Nutritional care for patients cared for at home” developed using an interprofessional continuing educational model adapted for primary ...
  • Indoor environment and tobacco smoke exposure in relation to allergic disease and lung function 

    Thacher, Jesse D. (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-10-17)
    Asthma and other allergy related diseases are the most common chronic diseases in childhood, and have become a major public health concern. The rapid increase in the occurrence of these diseases, especially in high-income ...
  • Understanding structural features of biomolecular interactions : from classical simulations to ab intio calculations 

    Hartono, Yossa Dwi (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-10-17)
    The structures of biomolecules and their interactions dictate their functions. In this thesis, five papers are presented to illustrate how the dynamics of biomolecules can be investigated and derivation of desired ...
  • Fetal and neonatal alloimmune thrombocytopenia : immunological mechanisms and clinical consequences 

    Refsum, Erle (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-10-17)
    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition that may occur in connection with pregnancy, when maternal antibodies directed against paternally inherited platelet antigens cross the placenta ...
  • Innovative approaches to study basophil function in inflammation 

    Aljadi, Zenib (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-10-16)
    Basophils are circulating granulocytes. They are very rare and represent less than 1% of peripheral blood leukocytes. Basophils connect the innate and adaptive immune responses by the secretion of a variety of immune-mediators ...
  • Transcriptional regulation of development in time and space 

    Hagey, Daniel W. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-10-13)
    Human development requires the generation of trillions of cells with myriad functions from a single cell. This requires that restriction of stem cell fate competence and proliferation are precisely temporally and spatially ...
  • In vitro testing of drug sensitivity in tumor cells from effusion 

    Hillerdal, Carl-Olof (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-10-12)
    Malignant mesothelioma has a mean overall survival of around 1 year and lung adenocarcinoma with pleural spread has a mean overall survival of around 5 months. Both diseases cause fluid accumulation in the pleura, which ...
  • Immune responses against tumors controlled by the actin cytoskeleton : lessons from primary immunodeficiencies 

    Kritikou, Joanna Sara (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-10-11)
    The actin cytoskeleton and its regulators are vital for cellular processes such as cell motility and immune synapse formation. In this study, the aim was to dissect the role of two of those regulators, WASp and MKL1, in ...
  • Studies of SNAP-25 in regulated membrane fusion : metabolic consequences and tuning of intracellular Ca(2+) dynamics in beta cells 

    Daraio, Teresa (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Increased release of insulin is usually regarded as a symptom of metabolic syndrome, contributing to insulin resistance in peripheral organs thus affecting glucose and insulin homeostasis. The existing animal models to ...
  • PET studies on the mechanisms of action of antidepressant and antipsychotic drugs 

    Yang, Kai-Chun (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-10-06)
    Positron emission tomography (PET) is a non-invasive molecular imaging technique suitable for examination of neurochemical biomarkers in the living brain. Among these applications, PET studies are used to facilitate the ...
  • Transcriptional, epigenetic and lipidomic responses to metabolic interventions : implications for human obesity 

    Nylén, Carolina (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Obesity is increasing worldwide in an epidemic manner and better prevention and treatments are urgently needed. Obesity is strongly associated with insulin resistance and predisposes for type 2 diabetes. A deeper understanding ...
  • From policy to practice : exploring the implementation of a national policy for improving health and social care 

    Strehlenert, Helena (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2017-10-06)
    Introduction: Worldwide, health and social care systems struggle to develop processes that deliver coordinated, high quality care efficiently and at acceptable cost. For various reasons, many problems related to health ...
  • European Bioimaging Facility Survey Report 

    Lyytinen, Jaakko; Lundqvist, Daniel (Inst för klinisk neurovetenskap / Dept of Clinical NeuroscienceKarolinska Institutet, 2017-10-05)
    This report describes the results of a survey undertaking by NatMEG (the Swedish national facility for magnetoencephalography; www.natmeg.se), performed under the auspices of Swedish Bioimaging. The three Swedish national ...
  • Pediatric inflammatory bowel disease : clinical and immunological aspects on remission treatment 

    Rolandsdotter, Helena J. (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2017-10-05)
    Background - Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are lifelong conditions characterized by abdominal pain, bloody diarrhea and fatigue. The incidence and prevalence ...