Now showing items 1-20 of 7492

  • Between two lungs : proteomic and metabolomic approaches in inflammatory lung diseases 

    Heyder, Tina (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-06-15)
    This doctoral thesis presents results on proteomic and metabolomic profiling of two distinct inflammatory lung diseases: sarcoidosis and chronic obstructive pulmonary disease (COPD). Chronic inflammatory lung diseases ...
  • Mode of obstetrical delivery and type 1 diabetes : a sibling design study 

    Khashan, Ali S; Kenny, Louise C; Lundholm, Ceciclia; Kearney, Patricia M; Gong, Tong; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)
    OBJECTIVES: We investigated the association between cesarean section (CS) and type 1 diabetes (T1D), and if the association remains after accounting for familial confounding by using a sibling-control design. ...
  • Are carriers of CYP21A2 mutations less vulnerable to psychological stress? A population-based national cohort study 

    Nordenström, A.; Butwicka, A.; Linden Hirschberg, A.; Almqvist, C.; Nordenskjöld, A.; Falhammar, H.; Frisen, L. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)
    Background Congenital adrenal hyperplasia (CAH) is one of the most common monogenic autosomal recessive disorders with an incidence of one in 15 000. About one in 70 individuals in the general population are carriers ...
  • The influence of childhood asthma on puberty and height in Swedish adolescents 

    Protudjer P., J.L.; Lundholm, C.; Bergström, A.; Kull, I.; Almqvist, C. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)
    BACKGROUND: Evidence relating to the effect of asthma on puberty or height is inconclusive. We aimed to examine whether the exposure of childhood asthma, including timing and phenotypes, and inhaled corticosteroid ...
  • Asthma and height in twins : a cohort and within-pair analyses study. 

    Protudjer, Jennifer; Lundholm, Cecilia; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)
    In singletons, asthma may be associated with shorter height and delayed growth during adolescence. Yet, these studies do not account for heritability of asthma, puberty/menarche, and height. We aimed to study ...
  • Touching cognition : somatosensory processing and plasticity deficits in mouse barrel cortex 

    Juczewski, Konrad (Inst för neurovetenskap / Dept of Neuroscience, 2017-06-07)
    Senses together with thoughts and experience are key factors that shape our cognition. Touch is an important source of sensory information. Disturbances to the development of the somatosensory system have serious consequences ...
  • Orbital blow out fracture : to operate or not to operate - that is the question 

    Alinasab, Babak (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-06-02)
    When the eye socket is exposed to severe blunt trauma the pressure in the socket increases. As a protection mechanism to prevent the eye from disruption, the thin bony walls surrounding the eye fracture. Such a fracture ...
  • Epidemiology and emergency cardiac care services for out-of-hospital cardiac arrest in Qatar 

    Irfan, Furqan Bin (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2017-05-31)
    Background: Out-of-hospital cardiac arrest (OHCA) is a common cause of cardiac emergency and death. Worldwide, there is wide variation in epidemiology and survival of OHCA. Racial and ethnic disparities are important ...
  • Studies on the relationship between periodontitis and rheumatoid arthritis 

    Eriksson, Kaja (Inst för odontologi / Dept of Dental Medicine, 2017-05-31)
    Periodontitis and rheumatoid arthritis (RA) are both widespread multifactorial diseases, characterized by chronic inflammation leading to tissue and bone destruction around teeth or joints, respectively. An association ...
  • Tumour microenvironment in serous ovarian cancer 

    Corvigno, Sara (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-30)
    Ovarian cancer is the seventh most common malignancy in women worldwide and the most lethal gynaecological malignancy in developed countries. The epithelial subtype is divided in five main histologic groups, of which the ...
  • Evidence based care of the very preterm infant : studies on thermal care and breastfeeding in Europe 

    Wilson, Emilija (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-05-26)
    Very preterm birth occurs in approximately 1.5% of all births in Europe. Advances in neonatal intensive care has contributed to a decline in mortality and morbidity, nevertheless very preterm birth (birth before 32 weeks ...
  • Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking 

    Nigam, Saket Milind (Inst för neurovetenskap / Dept of Neuroscience, 2017-05-26)
    Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit ...
  • Brain matter matters : renewal in the human brain 

    Yeung Wong, Maggie (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-05-26)
    Many cells have a shorter life span than the organism itself and are continuously being replaced. However, for many cell types in the human body it is still largely unknown whether they turn over at all once development ...
  • Studies on microglia in tumor biology and neurobiology 

    Shen, Xianli (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-05-24)
    Microglia are innate immune cells that reside in the central nervous system (CNS). Their activities are critical for ensuring the correct microenvironment for brain development and for maintaining homeostasis in the brain ...
  • Menopausal hormone therapy and the risk of esophageal and gastric cancer 

    Brusselaers, Nele; Maret-Ouda, John; Konings, Peter; El-Serag, HB; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-24)
    A protective effect of female sex hormones has been suggested to explain the male predominance in esophageal and gastric adenocarcinoma, but evidence is lacking. We aimed to test whether menopausal hormone therapy (MHT) ...
  • From movement to skill : neural and behavioral mechanisms of motor sequence learning 

    Müβgens, Diana (Inst för neurovetenskap / Dept of Neuroscience, 2017-05-24)
    How do we learn new movements? The simple answer to this question is Through practice! Yet, a better response might be What aspect of motor learning are we talking about? Our capacity for learning new skills and for ...
  • TGF-β affects the differentiation of human GM-CSF+ CD4+ T cells in an activation- and sodium-dependent manner 

    Éliás, Szabolcs; Schmidt, Angelika; Kannan, Venkateshan; Andersson, John; Tegnér, Jesper (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-05-24)
    The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is involved in the pathogenesis of chronic inflammatory diseases such as multiple sclerosis. However, the environmental cues promoting differentiation ...
  • Hemorrhagic and thromboembolic complications following cholecystectomy 

    Strömberg, Jonas (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-05-24)
    Laparoscopic cholecystectomy for gallstone disease is one of the most common procedures in the Western world. The overall complication rate is 10%. Whereas most complications are easily managed, bile duct injuries may ...
  • Paternal age at childbirth and eating disorders in offspring 

    Javaras, K.N.; Rickert, M.E.; Thornton, L.M.; Peat, C.M.; Baker, J.H.; Birgegard, A.; Norring, C.; Landen, M.; Almqvist, C.; Larsson, H.; Lichtenstein, P.; Bulik, C.M.; D'Onofrio, B.M. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-05-24)
    Background. Advanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated paternal age’s relationship ...
  • Specification and potency of human neural stem cells for clinical transplantation 

    Vincent, Per Henrik (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-05-24)
    Neural stem cells hold promise for future treatment of spinal cord injury. Various aspects regarding cell fate specification, manufacturing and monitoring, with implications for clinical applications of these cells, are ...