Now showing items 1-20 of 7413

  • PET studies on the immune cell marker TSPO in first episode psychosis patients 

    Collste, Karin (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-04-28)
    Several lines of evidence are indicative of a role for immune activation in the pathophysiology of schizophrenia. Nevertheless, studies using positron emission tomography (PET) and radioligands for the translocator protein ...
  • Inhibition of 19S proteasome duebiquitinases as a promising strategy in cancer therapy 

    Mazurkiewicz, Magdalena (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-04-28)
    The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, ...
  • Eradication of Helicobacter pylori and gastric and oesophageal cancer : a systematic review and meta-analysis of cohort studies 

    Doorakkers, Eva; Lagergren, Jesper; Engstrand, Lars; Brusselaers, Nele (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell BiologyInst för molekylär medicin och kirurgi / Dept of Molecular Medicine and SurgeryKing's College London, 2017-04-28)
    Background: Helicobacter pylori (H. pylori) is associated with an increased risk of gastric adenocarcinoma and gastric mucosa associated lymphoid tissue (MALT) lymphoma, and a seemingly decreased risk of oesophageal ...
  • Cruciate ligament injury : crunching the numbers 

    Nordenvall, Richard (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-04-28)
    Cruciate Ligament (CL) injury is a serious injury that occurs primarily during activities like soccer, handball, floorball, alpine skiing, etc. Patients are generally young and the injury often results in early discontinuation ...
  • Why oesophageal adenocarcinoma is occurring more frequently 

    Doorakkers, Eva; Brusselaers, Nele (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-28)
    The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important risk ...
  • Long-term effects of mother-infant psychoanalysis 

    Winberg Salomonsson, Majlis (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2017-04-28)
    This thesis is a long-term follow-up study of mothers and infants with “baby worries” or mother-infant relational disturbances, who took part in a Randomized Controlled Trial when the children were, on average, five ...
  • Parental antibiotics and childhood asthma : a population-based study 

    Örtqvist, A.K.; Lundholma, C.; Fang, F.; Fall, T.; Almqvist, C. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-04-28)
    In this population-based study on antibiotic treatment before, during and after pregnancy, using paternal exposure as negative control, we confirm that associations between maternal antibiotic exposure and childhood asthma ...
  • On lumbar disc herniation : aspects of outcome after surgical treatment 

    Elkan, Peter (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-04-28)
    Knowledge about sciatica has grown immensely since the days of Hippocrates. Even so one must be impressed with the anatomical insights of those ancient times. Today we are able to describe at a molecular level how the ...
  • Development of income following sickness absence from the workplace or long-term unemployment, and among individuals with Multiple Sclerosis 

    Wiberg, Michael (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-04-27)
    The overall aim of this thesis was to gain knowledge of how reduced work capacity due to morbidity is associated with subsequent individual economic outcomes and how different components of the Swedish welfare system were ...
  • Innate mechanisms in upper airway inflammation with focus on epithelium and neutrophils 

    Arebro, Julia (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-04-27)
    Mucosal inflammation is a key feature in allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). The traditional idea of the epithelium as a simple barrier and neutrophils as a homogenous cell ...
  • Exercise and regulation of metabolic function in human skeletal muscle: with special reference to PGC-1α and the mitochondria 

    Gidlund, Eva-karin (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-04-26)
    Regular physical activity is highly associated with many health benefits and regular exercise training is used in the prevention and treatment of a large number of disease conditions, including type 2 diabetes, cardiovascular ...
  • Towards improved trauma care outcomes in India : studies of rates, trends and causes of mortality in urban Indian university hospitals 

    Roy, Nobhojit (Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2017-04-26)
    Introduction Injury is a serious threat to global public health. Every six seconds someone in the world dies as a result of injury, adding up to five million people a year. This is more than the number of deaths due to ...
  • Intratumoral lactate metabolism in Barrett’s esophagus and adenocarcinoma 

    Kauppila, Joonas; Huhta, Heikki; Helminen, Olli; Palomäki, Sami; Lehenkari, Petri; Saarnio, Juha; Karttunen, Tuomo (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-25)
    Background: Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are activated in various cancers, but their expression in ...
  • Exploring connectivity : invention, innovation and knowledge transfer in the university-industry interface 

    Dahlborg, Charlotta (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2017-04-25)
    Universities are expected to create knowledge and be involved in knowledge transfer with society. This is accomplished through the universities’ three missions; 1) teaching, 2) research and 3) innovation and social ...
  • Extent of lymphadenectomy and prognosis after esophageal cancer surgery 

    Lagergren, Jesper; Mattsson, Fredrik; Zylstra, Janine; Chang, Fuju; Gossage, James; Mason, Robert; Lagergren, Pernilla; Davies, Andrew (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)
    IMPORTANCE: The prognostic role of the extent of lymphadenectomy during surgery for esophageal cancer is uncertain and requires clarification. OBJECTIVE: To clarify whether the number of removed lymph nodes influences ...
  • Weekday of oesophageal cancer surgery in relation to early postoperative outcomes in a nationwide Swedish cohort study 

    Lagergren, Jesper; Mattsson, Fredrik; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-24)
    Objectives: Later weekday of surgery for oesophageal cancer seems to increase 5-year mortality, but the mechanisms are unclear. We hypothesised that early postoperative reoperations and mortality might explain this ...
  • Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer 

    Kazemi, Mohammad Hossein (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-04-24)
    Tumor cells overcome anti-tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and ...
  • Risk of eating disorders in immigrant populations 

    Mustelin, L.; Hedman, A.; Thornton, L.M.; Kuja-Halkola, R.; Keski-Rahkonen, A.; Cantor-Graae, E.; Almqvist, C.; Lichtenstein, P.; Mortensen, P.B.; Böcker Pedersen, C.; Bulik, C.M. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-04-24)
    Objective: The risk of certain psychiatric disorders is elevated among immigrants. To date, no population studies on immigrant health have addressed eating disorders. We examined whether risk of eating disorders in first- ...
  • The association between childhood relocations and subsequent risk of suicide attempt, psychiatric problems, and low academic achievement 

    Bramson, L.M.; Rickert, M.E.; Class, Q.A.; Sariaslan, A.; Almqvist, C.; Larsson, H.; Lichtenstein, P.; D'Onofrio, B.M. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-04-24)
    Background: Given the frequency with which families change residences, the effects of childhood relocations have gained increasing research attention. Many researchers have demonstrated that childhood relocations are ...
  • Depression or anxiety in adult twins is associated with asthma diagnosis but not with offspring asthma 

    Tedner, S.G.; Lundholm, C.; Olsson, H.; Almqvist, C. (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-04-24)
    Background: Asthma is common in both children and adults in the Western world, just like anxiety and depression. While some research has revealed that these diseases might share important environmental and pathophysiological ...