Doktorsavhandlingar / Doctoral Theses - C8 (MEB): Recent submissions
Now showing items 121-140 of 250
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Health outcomes of women with breast cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2014-12-17)The overall survival of breast cancer patients has increased quite remarkably in the past decades in the developed countries due to substantial improvements in diagnosis and treatment. As a consequence, the proportion of ... -
Human papillomavirus and cervical carcinoma in situ : implications for future screening
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2000-08-11)The principal aim of this thesis was to study the temporal relationship between human papillomavirus type 16 (HPV 16) infection and cervical carcinoma in situ, particularly focusing on the effect of viral load. Other aims ... -
Factors related to the occurrence of gastric adenocarcinoma subtypes
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2000-04-07)Gastric cancer is the second most common cancer worldwide, but the etiology remains poorly understood. A spontaneous global decline has reduced the number of victims in most Western countries while Japan and China have ... -
Teenage childbearing : pregnancy outcomes and long-term consequences for the mothers
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 1999-12-31)The purposes of the thesis were to study effects of low maternal age on adverse pregnancy outcomes, predictors of teenage childbearing, and long-term effects of teenage motherhood on the women's social situation later in ... -
Penicillin-resistant pneumococci in Sweden : epidemiology and public health response
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2005-12-30)Since 1996, all identified cases of pneumococci with a MIC for penicillin G > 0.5 mg/L (penicillin resistant pneumococci: PRP) have been registered according to the Swedish Communicable Disease Act. In the same year, an ... -
Regression on high-dimensional predictor space : with application in chemometrics and microarray data
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2004-11-26)This thesis focuses on regression methodology for prediction and classification in situations where there are many predictors but limited number of observations. This situation is common in chemometrics and microarray ... -
Genetic susceptibility to breast and endometrial cancer
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2004-09-10)Hormones are central in the carcinogenic process in the breast and in the uterine epithelium. Individual genetically determined variation in the response to hormonal influence may alter susceptibility to breast and endometrial ... -
Epidemiological studies of Helicobacter pylori and its relation to cancer and precancerous lesions in the upper gastrointestinal tract
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2004-05-21)Helicobacter pylori infection is strongly associated with gastric cancer risk. The carcinogenic process is supposed to occur step by step, from a normal gastric epithelium via gastritis, atrophy, intestinal metaplasia to ... -
Medical interventions and gastric cancer risk : an observational approach
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2004-05-14)Helicobacter pylori infection is undoubtedly the most important risk factor for gastric cancer. A causal relationship with gastric cancer, however, has not been clearly established and the carcinogenic mechanism is still ... -
New evidence on germ-cell testicular cancer aetiology
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2004-01-09)Testicular cancer has been increasing in incidence for at least 50 years in many populations, but its etiology remains elusive. We investigated several prenatal and postnatal factors in association with germ-cell testicular ... -
Aspects of gastroesophageal reflux and risk for esophageal cancer : an epidemiological approach
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2003-10-24)Aims: The aims of this study were to confirm, in a prospective study, the link between gastroesophageal reflux. and risk of adenocarcinoma of the esophagus and gastroesophageal junction observed in retrospective studies, ... -
Does cancer originate in utero?
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2002-02-22)The purpose of the present thesis was to evaluate Trichopoulos' hypothesis that breast cancer can originate in utero, and to examine the role of antenatal estrogen exposure in the etiology of testicular cancer. First, ... -
Epidemiological studies of stillbirth and early neonatal death
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2002-02-15)The aim of this thesis was to investigate risk factors for stillbirth and early neonatal death. The associations between matemal weight, weight gain during pregnancy, hemoglobin concentration, socioeconomic status and ... -
Epidemiological studies of host susceptibility in malignant lymphomas and colorectal cancer
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2001-03-16)The aim of this thesis was to investigate the role of host susceptibility in malignant lymphomas and colorectal cancer. Specifically, the associations between infection and malignant lymphomas, skin cancer and survival ... -
Dietary prevention of gastrointestinal cancer : epidemiologic studies of fruit, vegetables and cereals
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2000-12-22)The widely accepted inverse associations between fruit, vegetables, dietary fiber and colorectal cancer risk, have recently been called into question. In addition, dietary studies of certain cancers, such as adenocarcinomas ... -
The role of physical activity in the prevention of breast and endometrial cancer
(Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics, 2000-09-15)The aim of this thesis was to explore through epidemiologic studies the role of physical activity in preventing breast and endometrial cancer in women. First, we assessed risk for endometrial (Paper I) and breast ... -
Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2014-09-09)Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) ... -
On neuroinflammation in psychotic disorders
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2014-09-05)Neuroinflammation has been implicated in several psychiatric conditions. Based on experimental studies, the glia-derived tryptophan metabolite kynurenic acid (KYNA) may be especially relevant for positive psychotic symptoms ... -
Etiological risk factors and clinical characteristics of childhood non-Hodgkin lymphoma in Uganda
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2014-08-14)Introduction: Incidence of non-Hodgkin lymphoma (NHL) has increased greatly over time, especially in children. Improved diagnostic methods alone cannot explain this increase, especially the increase observed in sub-Saharan ... -
Lipid-related genes and their associations with coronary heart disease
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2014-04-25)Coronary heart disease (CHD) is a complex disease caused by the long-term progression of atherosclerosis. Lipids, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and ...