Dietary prevention of gastrointestinal cancer : epidemiologic studies of fruit, vegetables and cereals
Author: Terry, Paul
Date: 2001-01-12
Location: Hörsalen, Scheelelaboratoriet, Institutionen för medicinsk biokemi och biofysik (MBB), Tomtebodavägen 6
Time: 9.00
Department: Institutionen för medicinsk epidemiologi och biostatistik / Department of Medical Epidemiology and Biostatistics
Abstract
The widely accepted inverse associations between fruit, vegetables,
dietary fiber and colorectal cancer risk, have recently been called into
question. In addition, dietary studies of certain cancers, such as
adenocarcinomas of the esophagus and gastric cardia, and prospective
cohort studies of stomach cancer, remain scarce.
To study cancers of the esophagus, gastroesophageal junction (cardia),
stomach, colon and rectum in relation to diet, we analyzed data from
three large studies in Sweden: a nation-wide case-control study of
cancers of the esophagus and gastric cardia, a nationwide cohort of
Swedish twins, and a population-based prospective cohort study of women
living in two counties in Central Sweden.
We found fruit, vegetables and antioxidants to be inversely related with
all of the studied cancers except gastric cardia cancer. For esophageal
and cardia cancers, the absolute risk is so low that tens of thousands of
people in the highest risk strata of age and sex would need to increase
their consumption in order to prevent one case per year. In relation to
stomach cancer, our data hint that individuals with very low consumption
of fruit and vegetables were at especially high risk. In relation to
colorectal cancer, the inverse association was limited to those who
consumed very low amounts of fruit and vegetables (less than 2 servings
per day).
Cereal fiber intake showed an inverse association only with cancer risk
only in the gastric cardia. Intake of fiber from fruit or vegetables, on
the other hand, was unrelated to cardia cancer risk. We can speculate
that nitrosamine-scavenging mechanisms of cereal fiber may be more
important in the gastric cardia than elsewhere in the gastrointestinal
tract, in turn due to a suggested higher production of nitrosamines in
the proximal stomach.
While intervention efforts to prevent certain cancer through dietary
changes may not be cost effective (such as in the prevention of the rare
esophageal cancers), the overall benefit to health, including the
prevention of digestive tract cancers, warrants continued efforts to
inform and influence the public regarding adequate consumption of these
foods.
List of papers:
I. Terry P, Lagergren J, Ye W, Nyren O, Wolk A (2000). "Antioxidants and cancers of the esophagus and gastric cardia" Int J Cancer 87(5): 750-4
Pubmed
II. Terry P, Lagergren J, Wolk A, Nyrén O (2000). "Fruit and vegetable intake in the prevention of esophageal and cardia cancers." (Submitted)
III. Terry P, Lagergren J, Ye W, Wolk A, Nyren O (2001). "Inverse association between intake of cereal fiber and risk of gastric cardia cancer" Gastroenterology 120(2): 387-91
Pubmed
IV. Terry P, Nyren O, Yuen J (1998). "Protective effect of fruits and vegetables on stomach cancer in a cohort of Swedish twins" Int J Cancer 76(1): 35-7
Pubmed
V. Terry P, Giovannucci E, Michels KB, Bergqvist L, Hansen H, Holmberg L, Wolk A (2000). "Fruit, vegetables, dietry fiber and the risk of colorectal cancer: a prospective cohort study in a population with relatively low consumption of fruit and vegetables and high consumption of cereals." (Submitted)
I. Terry P, Lagergren J, Ye W, Nyren O, Wolk A (2000). "Antioxidants and cancers of the esophagus and gastric cardia" Int J Cancer 87(5): 750-4
Pubmed
II. Terry P, Lagergren J, Wolk A, Nyrén O (2000). "Fruit and vegetable intake in the prevention of esophageal and cardia cancers." (Submitted)
III. Terry P, Lagergren J, Ye W, Wolk A, Nyren O (2001). "Inverse association between intake of cereal fiber and risk of gastric cardia cancer" Gastroenterology 120(2): 387-91
Pubmed
IV. Terry P, Nyren O, Yuen J (1998). "Protective effect of fruits and vegetables on stomach cancer in a cohort of Swedish twins" Int J Cancer 76(1): 35-7
Pubmed
V. Terry P, Giovannucci E, Michels KB, Bergqvist L, Hansen H, Holmberg L, Wolk A (2000). "Fruit, vegetables, dietry fiber and the risk of colorectal cancer: a prospective cohort study in a population with relatively low consumption of fruit and vegetables and high consumption of cereals." (Submitted)
Issue date: 2000-12-22
Publication year: 2001
ISBN: 91-628-4592-6
Statistics
Total Visits
Views | |
---|---|
Dietary ...(legacy) | 250 |
Dietary ... | 92 |
Total Visits Per Month
September 2023 | October 2023 | November 2023 | December 2023 | January 2024 | February 2024 | March 2024 | |
---|---|---|---|---|---|---|---|
Dietary ... | 1 | 3 | 1 | 0 | 0 | 1 | 1 |
Top country views
Views | |
---|---|
China | 43 |
Germany | 41 |
United States | 39 |
Sweden | 26 |
South Korea | 11 |
United Kingdom | 10 |
Ireland | 7 |
Finland | 6 |
Greece | 6 |
France | 5 |
Top cities views
Views | |
---|---|
Kiez | 18 |
Beijing | 16 |
Seoul | 11 |
Dublin | 7 |
Athens | 6 |
Birmingham | 6 |
Sunnyvale | 5 |
Ashburn | 4 |
Ballerup | 3 |
Bromma | 3 |