Doktorsavhandlingar / Doctoral Theses - C8 (MEB): Recent submissions
Now showing items 41-60 of 250
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Etiology and early detection of pancreatic cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-11-08)Pancreatic cancer is one of the most dismal malignancies. Although its incidence and prevalence are relatively low, the disease burden is still an important health issue, especially in terms of mortality. Primary prevention ... -
An epidemiological study on nasopharyngeal carcinoma
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-10-25)Nasopharyngeal carcinoma (NPC) is a malignancy known for its unique geographic and ethnic distribution characterized by particularly high incidence in southern China, Southeast Asia, and North and East Africa, but being ... -
Biological ages : correlations, genetic determinants, and health outcomes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-10-08)Population aging is a global trend and requires better evidence-based guidance. This thesis studied population aging from a molecular epidemiological angle. The overall work is centered on the “biological age (BA)”, which, ... -
Attention-deficit/hyperactivity disorder and educational outcomes : etiology, treatment effects, and occupational outcomes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-08-12)Attention-Deficit/Hyperactivity Disorder is one of the most prevalent childhood-onset developmental disorders, and is associated with a wide range of problematic functional outcomes such as low educational attainment (EA), ... -
Improved statistical methodology for high-throughput omics data analysis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-07-19)Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ... -
Causes and consequences of stress and tobacco exposure in utero on birth size, asthma and academic achievement
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-03-01)The objective of this thesis was to further the understanding of the consequences of stress and smoking during pregnancy, the causes of intrauterine growth and asthma as well as the consequences of asthma on school performance ... -
Chlamydia trachomatis infection in Sweden : time trends, risk factors, and prevalence
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-02-18)Chlamydia trachomatis (chlamydia) infection is the most common bacterial sexually transmitted infection (STI), with an estimated 127 million new cases occurring every year worldwide. Due to the asymptomatic nature of the ... -
Risk assessment and prevention of breast cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-12-21)One woman in eight develops breast cancer during her lifetime in the Western world. Measures are warranted to reduce mortality and to prevent breast cancer. Mammography screening reduces mortality by early detection. ... -
Attention-deficit/hyperactivity disorder and adverse health outcomes : from association to prevention
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-23)Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder, characterized by persistent inattention and/or hyperactivity-impulsivity that are inappropriate for one’s developmental ... -
Dietary habits, commensal microbiome, and nasopharyngeal carcinoma
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-19)Nasopharyngeal carcinoma (NPC) is a malignant disease characterized by unique geographic distribution endemic to southern China, Southeast Asia, and the Middle East/North Africa. It has been widely accepted that the ... -
Determinants and influence of mammographic features on breast cancer risk
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-16)Mammographic density and mammographic microcalcifications are the key imaging features in mammography examination. Mammographic density is known as a strong risk factor for breast cancer and is the radiographic appearance ... -
Investigations of body mass, gastrointestinal, and dietary factors influencing the emergence and maintenance of eating disorders
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-10-20)Eating disorders are severe psychiatric illnesses, characterized by dysregulated eating and distorted attitudes toward weight and body shape, causing enormous suffering for patients and their families. Although great ... -
Molecular epidemiology studies on risk factors for breast cancer and disease aggressiveness
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-09-10)Breast cancer is a heterogeneous disease. Aggressive subtypes are characterized by faster growth rates, increased capability to invade and metastasize, leading to poorer clinical outcomes. In this thesis, we use a molecular ... -
Novel statistical methods for genome-wide association summary statistics
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-08-20)A general objective of genetic studies is to understand the genetic basis of complex traits such as height, body mass index (BMI), disease endpoints, etc. Such researches have been facilitated due to the completion of the ... -
Etiology and prognosis of gastroesophageal cancers
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-05-19)Gastric and esophageal cancer – gastroesophageal cancers, belong to the most fatal malignancies in the world. Understanding the cause of these diseases is key to interventions such as primary prevention and/or surveillance ... -
Personality, stress and risk of Parkinson's disease
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-05-08)The objective of this thesis was to investigate the relationship of personality and stress with subsequent risk of Parkinson’s disease (PD). In Study I, we conducted a population-based cohort study using questionnaire data ... -
Artificial intelligence for streamlining prostate cancer diagnostics
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-24)With around 1.2 million cases per year, prostate cancer is the second most common cancer among men. It is usually a slow growing disease that affects older men. It is also a cancer that is heterogenous, often multifocal, ... -
Stress during cancer diagnostic workup
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-03-24)Receiving a cancer diagnosis is an extremely stressful life event. Cancer patients have been reported to experience an excessive risk of stress-related health outcomes including suicide. The time period between the first ... -
Prevention and prognosis of cervical cancer : the interplay of human papillomavirus, vaccination and screening
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-02-26)Human papillomavirus (HPV) is the major cause of cervical cancer. The well-established natural history from HPV infection to the occurrence of invasive cervical cancer serves as the basis for prevention of cervical cancer ... -
Epidemiological studies on socioeconomic inequalities and cardiovascular disease : prevention, progression and prognosis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-02-20)Cardiovascular disease (CVD) accounts for 30% of global mortality and is the most common cause of death in the world. Population-wide prevention strategies as well as healthcare interventions have led to a decrease in CVD ...