Doktorsavhandlingar / Doctoral Theses - C8 (MEB): Recent submissions

Now showing items 21-40 of 249

    • Developmental trajectories of attention-deficit/hyperactivity disorder into adulthood and aging : multimorbidity and polypharmacy 

      Zhang, Le (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-16)
      Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by developmentally inappropriate levels of inattentiveness, hyperactivity, and impulsivity. Previous studies have shown ...

    • Epidemiological studies on frailty and its associations with mortality, dementia, and polypharmacy 

      Bai, Ge (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-12)
      Frailty describes the status of decreased physiological reserves and increased vulnerability to adverse outcomes. As the aging population increases, frailty has become an important public health concern. However, longitudinal ...

    • Personalized prostate cancer management : AI-assisted prostate pathology and improved active surveillance 

      Olsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-01-11)
      Prostate cancer is a major global health concern and is the most common cancer-related cause of death in Sweden. Prostate cancer screening using PSA has been shown to reduce prostate cancer mortality but also leads to ...

    • Prostate cancer testing in Sweden : the interplay between cost and effectiveness 

      Hao, Shuang (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-11-16)
      As a major cause of male deaths in Sweden, prostate cancer constitutes an essential public health issue to the society. Early detection through an organised testing program with the prostate-specific antigen (PSA) test and ...

    • Artificial intelligence for breast cancer precision pathology 

      Wang, Yinxi (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-11-09)
      Breast cancer is the most common cancer type in women globally but is associated with a continuous decline in mortality rates. The improved prognosis can be partially attributed to effective treatments developed for subgroups ...

    • Epidemiology, prevention and control of hepatitis A virus infection in the European Union 

      Severi, Ettore (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-10-13)
      Hepatitis A is an acute liver disease caused by the hepatitis A virus (HAV) and transmitted via the faecal-oral route through person-to-person transmission, contaminated food or water. The frequency and severity of symptoms ...

    • Epidemiological studies on gastroesophageal reflux disease and esophageal cancer 

      Zhang, Ji (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-08-17)
      Esophageal cancer is the seventh most common cancer and a lethal malignancy causing a considerably high number of deaths around the world. Despite intensive studies on risk factors associated with esophageal cancer, there ...

    • Register-based studies of infertility and the use of assisted reproductive techniques : possibilities and challenges 

      Wang, Chen (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-08-04)
      The implementation of assisted reproductive techniques (ART) has enabled over 10 million births in the past 45 years. Concern for excess risks of adverse birth outcomes has largely, but not entirely, been mitigated by ...

    • Machine learning methods for precision medicine 

      Gonzalez Ginestet, Pablo (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-06-17)
      In precision medicine, predicting the risk of an event during a specific period may help, for example, to identify patients that need early preventive treatment. Modern machine learning (ML) techniques are therefore ideal ...

    • A clinical epidemiological study on end-stage liver disease in Ghana 

      Nartey, Yvonne Ayerki (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-06-01)
      End-stage liver disease (ESLD), including advanced liver cirrhosis and hepatocellular carcinoma (HCC), is the final stage of long-standing injury to the liver due to risk factors such as chronic viral hepatitis and alcoholic ...

    • Microscopic colitis : epidemiology, death and associated disorders 

      Bergman, David (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-05-16)
      Microscopic colitis (MC) is the most recently recognized inflammatory condition of the large intestine. MC is an umbrella term for two disease entities, namely lymphocytic colitis (LC) and collagenous colitis (CC). These ...

    • Breast cancer natural history models and risk prediction in mammography screening cohorts 

      Strandberg, Rickard (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-03-31)
      In this thesis, the foundations are laid for a new natural history model for breast cancer—specifically designed to take advantage of detailed screening cohorts. Three diverse applications of this model are then presented. ...

    • The gut-brain axis in Parkinson’s disease : epidemiological studies on causes, underlying mechanisms and novel treatments 

      Kang, Xiaoying (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-02-24)
      Parkinson’s disease (PD) is an age-related neurodegenerative disease with highly heterogeneous symptomatology. Little is known about why PD occurs. The gastrointestinal tract has been postulated as an origin of PD pathology, ...

    • Depression in youth and adults : etiology, outcomes, and comorbidities 

      Leone, Marica (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-02-02)
      Depression is a common and debilitating mental disorder characterized by low mood, loss of interest in activities, and long-lasting functional impairment. It is a worldwide psychiatric illness with a wide range of ages of ...

    • The development of psychiatric disorders and adverse behaviors : from context to prediction 

      Tate, Ashley (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-01-28)
      Psychiatric disorders by definition cause significant impairment in an individual’s daily functioning. Certain disorders, such as borderline personality disorder (BPD) and eating disorders, have worse prognosis and high ...

    • Medical and surgical treatment of inflammatory bowel disease 

      Forss, Anders (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-01-19)
      Inflammatory bowel disease (IBD), with its two main entities Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition affecting the entire gastrointestinal tract. IBD is associated ...

    • Convergent etiology among schizophrenia, eating disorders, and other medical conditions 

      Zhang, Ruyue (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-12-13)
      Schizophrenia and eating disorders (EDs) are complex traits with considerable somatic and psychiatric morbidity. Despite distinct diagnostic criteria and few symptoms in common, significant genetic correlations between ...

    • Behavioural outcomes of treatment with selective serotonin reuptake inhibitors 

      Lagerberg, Tyra (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-12-13)
      Mood and anxiety disorders are some of the biggest contributors to morbidity worldwide, and may be lethal. Appropriate treatment is therefore paramount. Antidepressant medications constitute the primary pharmacological ...

    • Drug safety and effectiveness in relation to kidney function : a pharmacoepidemiological approach 

      Trevisan, Marco (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-11-11)
      Kidney function plays an important role in drug safety and effectiveness. As many medications are excreted by the kidneys, patients with reduced kidney function are at a higher risk of supra-therapeutic or toxic drug levels. ...

    • Etiology and early detection of pancreatic cancer 

      Yu, Jingru (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-11-08)
      Pancreatic cancer is one of the most dismal malignancies. Although its incidence and prevalence are relatively low, the disease burden is still an important health issue, especially in terms of mortality. Primary prevention ...