Doktorsavhandlingar / Doctoral Theses - C8 (MEB): Recent submissions
Now showing items 161-180 of 250
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Adiponectin : genetic determinants and relations with subclinical cardiovascular disease
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-12-21)Cardiovascular disease (CVD) is a major cause of morbidity and premature death in Sweden and globally, which besides the substantial individual suffering, puts large restraints on the public health system. Adiponectin is ... -
Human papillomavirus test and vaccination : impact on cervical cancer screening and prevention
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-12-19)Human papillomavirus (HPV) is the world’s most common sexually transmitted infection and its consequence cervical cancer is one of the world’s most common cancer forms. Revolutionary advances in HPV testing and HPV vaccination ... -
Mammographic density and breast cancer phenotypes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-10-16)Mammographic density is one of the strongest risk factors for breast cancer and has been thoroughly studied as such. Extensive mammographic density also decreases screening sensitivity, thereby increasing the risk of ... -
Assessing infection risk and evaluating prevention strategies in the era of HPV-vaccines
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-10-15)Aim: This thesis aims to provide a multidimensional assessment of infection risks and to evaluate strategies for HPV prevention including vaccination with quadrivalent HPV-vaccines, dose-level vaccine effectiveness and ... -
The genetic and molecular markers of ischemic stroke : risk, prognosis, and treatment
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-09-28)Stroke is a major cause of mortality and morbidity worldwide, with ischemic stroke (IS) being the predominant type. With the current ageing population, IS burden will inevitably escalate leading to increasing demand for ... -
Prenatal influences on health outcomes over the lifespan : effects of smoking, socio-economic status and foetal growth
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2012-09-07)The most remarkable development during a person‟s life takes place in utero. Through about 280 days of proliferation and differentiation one single cell is developed into a human being. As this is the time when the whole ... -
Contralateral breast cancer : risk and prognosis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-08-16)The objective of this thesis was to investigate different aspects of contralateral breast cancer. This disease is of increasing importance as the mortality of breast cancer is decreasing while the incidence remains very ... -
Statistical methods for the detection and analyses of structural variants in the human genome
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-08-16)Structural variations (SVs) are an important and abundant source of variation in the human genome, encompassing a greater proportion of the genome as compared to single nucleotide polymorphisms (SNPs). This thesis investigates ... -
Violent crime : addressing causation with family-based methods
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-05-15)Violent crime is an important public health problem, and incurs major costs for society. The effect of interventions has so far been modest, often attributed to a research focus on risk factors for crime, but a relative ... -
Genetic and hormonal influences on affiliative behavior in humans
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-05-10)Affiliative bonds between romantic partners are widespread pan-culturally and an important part of human nature and society. Still, knowledge about the biological correlates of human pair bonds is sparse. Studies in rodents, ... -
Mathematical model development to investigate the pharmacokinetic variability of two anticancer drugs
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-02-28)Pharmacokinetic variability in a population is the variability in plasma drug concentrations among individuals. It may, for instance, be caused by differences in genes coding for drug-transport proteins and metabolizing ... -
Genetic association and risk prediction of breast cancer from an epidemiological and biostatistical perspective
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-02-16)The main purposes of this thesis were to analyse common genetic variation in candidate genes and candidate pathways in relation to breast cancer risk, prognosticators and survival, to develop statistical methods for genetic ... -
Socioeconomic factors and the influence of comorbidity in the management and survival in lung and prostate cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2012-01-27)Aim: The presence of co-existing disease is common in cancer patients, and for many cancer forms outcomes are associated with socioeconomic status. The present thesis aimed to explore possible associations between socioeconomic ... -
Identification of protein signatures of genomic stability/instability in epithelial cancers
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2011-11-17)Aneuploidy is a consistent genetic alteration of the cancer genome. At early steps in the sequence of malignant transformation during human tumorigenesis, chromosomal aneuploidies can be the first detectable genetic ... -
Cancer patient survival in Sweden : theory and application
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2011-11-15)Cancer patient survival in Sweden is generally increasing, and Sweden compares well in an international perspective. Despite these achievements, there are nevertheless socio-economic and regional differences in survival ... -
Health outcomes associated with cognitive impairment
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2011-09-09)In this thesis, we aimed to determine whether persons with cognitive impairment no dementia (CIND) were at higher risk for negative health outcomes, and if so, to stratify persons with CIND into high and low risk groups. ... -
Molecular epidemiologic studies on helicobacter pylori infection and stomach cancer risk
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2011-06-23)Helicobacter pylori (H. pylori) infection increases stomach cancer risk. The aim of this thesis was to study genetic susceptibility from the host and to develop molecular methods for future characterization of bacterial ... -
Health consequences of adverse fetal growth : studies in twins
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2011-05-27)Findings of associations between birth weight and adult health outcomes have been taken to indicate that fetal growth – and fetal nutrition in particular – may program future health and disease in the developing individual. ... -
Cancer and calcium : epidemiological studies of cancer incidence and survival
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2011-03-15)Studies have shown that there could be an association between dietary calcium and cancer, and more specifically it has been suggested that serum calcium is involved in the etiology of cancers of the prostate. In order to ... -
Genomics and bioinformatics strategies in the study of aging and Alzheimer disease
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2011-02-17)To understand complex phenotypes, medical research has evolved from the study of single genes and proteins to approaches that encompass more comprehensive catalogues of molecules. Among the more widely used are genome-wide ...