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  • The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast 

    Tran, Martin (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-03-15)
    The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, ...
  • Mapping the genome and characterization of an acetyltransferase of Trypanosoma cruzi 

    Ochaya, Stephen O (Institutionen för cell- och molekylärbiologi (CMB) / Department of Cell and Molecular Biology, 2006-05-02)
    Trypanosoma cruzi (T.cruzi) is a flagellate protozoan parasite that causes Chagas' disease and is most common in Latin American countries. The disease currently infects over 13 million persons and about 100 million more ...
  • The ABC of the cell cycle: roles of the mammalian Cdc25 isoforms 

    Lundgren, Andreas (Institutionen för cell- och molekylärbiologi (CMB) / Department of Cell and Molecular Biology, 2006-02-03)
    Cell cycle progression is mediated by Cyclin dependent kinases (Cdks) in complex with Cyclins. The activity of the Cyclin-Cdk complexes is regulated through a variety of levels: expression and proteolysis of Cyclins, ...
  • Analysis of HIF-1alpha degradation and function 

    André, Helder (Institutionen för cell- och molekylärbiologi (CMB) / Department of Cell and Molecular Biology, 2005-11-18)
    HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, ...
  • Signaling via the bHLH-PAS proteins AhR and HIF 

    Bosdotter, Cecilia (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2012-06-04)
    This thesis concerns some mechanistic properties of the basic helix-loop-helix/PAS (bHLH-PAS) factors aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1 alpha (HIF-1α). The bHLH-PAS family of proteins is ...
  • Plasticity of salamander skeletal muscle cells 

    Borg, Paula (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2012-03-06)
    Regeneration is unevenly spread throughout the animal kingdom. Some of the invertebrates have a very high regenerative capacity but the capacity to replace lost or damaged tissues in mammals is limited. Among the vertebrates, ...
  • Identification and functional characterization of Epstein-Barr Virus Encoded Deconjugases 

    Hildebrand, Sebastian (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2011-03-07)
    The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory mechanism of various cellular activities. ...

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