RSS submission
 

Recent submissions

  • Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract. 

    Sahara, Makoto; Santoro, Federica; Sohlmér, Jesper; Zhou, Chikai; Witman, Nevin; Leung, Chuen Yan; Mononen, Mimmi; Bylund, Kristine; Gruber, Peter; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
    The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
  • Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors 

    Xu, Jiejia; Zhou, Chikai; Foo, Kylie S.; Yang, Ran; Xiao, Yao; Bylund, Kristine; Sahara, Makoto; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
    Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators ...
  • X-chromosome upregulation is driven by increased burst frequency 

    Larsson , Anton J. M.; Coucoravas, Christos; Sandberg, Rickard; Reinius, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and BiophysicsInst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-12)
    Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...
  • Serum proteases potentiate BMP-induced cell cycle re-entry of dedifferentiating muscle cells during newt limb regeneration 

    Wagner, Ines; Wang, Heng; Weissert, Philipp; Straube, Werner; Shevchenko, Anna; Gentzel, Marc; Brito, Goncalo; Tazaki, Akira; Oliveira, Catarina; Sugiura, Takuji; Shevchenko, Andrej; Simon, András; Drechsel, David; Tanaka, Elly (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-02-12)
    Limb amputation in the newt induces myofibers to dedifferentiate and re-enter the cell cycle to generate proliferative myogenic precursors in the regeneration blastema. Here we show that bone morphogenetic ...
  • Skeletal muscle dedifferentiation during salamander limb regeneration 

    Wang, Heng; Simon, Andras (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-01-24)
    Salamanders can regenerate entire limbs throughout their life. A critical step during limb regeneration is formation of a blastema, which gives rise to the new extremity. Salamander limb regeneration has historically been ...
  • High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation 

    Agostinho, Ana; Manneberg, Otto; van Schendel, Robin; Hernández-Hernández, Abrahan; Kouznetsova, Anna; Blom, Hans; Brismar, Hjalmar; Höög, Christer (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyScience for Life Laboratory, 2016-12-07)
    During meiosis, cohesin complexes mediate sister chromatid cohesion (SCC), synaptonemal complex (SC) assembly and synapsis. Here, using super-resolution microscopy, we imaged sister chromatid axes in mouse ...
  • TFAM forces mtDNA to make a U-turn 

    Hällberg, B. Martin; Nils-Göran, Larsson (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för laboratoriemedicin / Dept of Laboratory MedicineMax Planck Institute for Biology of Ageing, Köln, Germany., 2014-08-04)
    The mammalian mitochondrial transcription factor A (TFAM) is encoded in the nucleus and imported into mitochondria, where it functions as an activator of mtDNA transcription and packages mtDNA into DNA-protein aggregates ...
  • Making proteins in the powerhouse 

    Hällberg, Martin; Larsson, Nils-Göran (Inst för laboratoriemedicin / Dept of Laboratory MedicineInst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyMax Planck Institute for Biology of Ageing, Cologne, Germany, 2014-08-04)
    Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest as mitochondrial dysfunction is important in human pathology and ageing. Similar to the situation in bacteria, there is no ...