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  • Serum proteases potentiate BMP-induced cell cycle re-entry of dedifferentiating muscle cells during newt limb regeneration 

    Wagner, Ines; Wang, Heng; Weissert, Philipp; Straube, Werner; Shevchenko, Anna; Gentzel, Marc; Brito, Goncalo; Tazaki, Akira; Oliveira, Catarina; Sugiura, Takuji; Shevchenko, Andrej; Simon, András; Drechsel, David; Tanaka, Elly (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-02-12)
    Limb amputation in the newt induces myofibers to dedifferentiate and re-enter the cell cycle to generate proliferative myogenic precursors in the regeneration blastema. Here we show that bone morphogenetic ...
  • Skeletal muscle dedifferentiation during salamander limb regeneration 

    Wang, Heng; Simon, Andras (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-01-24)
    Salamanders can regenerate entire limbs throughout their life. A critical step during limb regeneration is formation of a blastema, which gives rise to the new extremity. Salamander limb regeneration has historically been ...
  • High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation 

    Agostinho, Ana; Manneberg, Otto; van Schendel, Robin; Hernández-Hernández, Abrahan; Kouznetsova, Anna; Blom, Hans; Brismar, Hjalmar; Höög, Christer (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyScience for Life Laboratory, 2016-12-07)
    During meiosis, cohesin complexes mediate sister chromatid cohesion (SCC), synaptonemal complex (SC) assembly and synapsis. Here, using super-resolution microscopy, we imaged sister chromatid axes in mouse ...
  • TFAM forces mtDNA to make a U-turn 

    Hällberg, B. Martin; Nils-Göran, Larsson (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för laboratoriemedicin / Dept of Laboratory MedicineMax Planck Institute for Biology of Ageing, Köln, Germany., 2014-08-04)
    The mammalian mitochondrial transcription factor A (TFAM) is encoded in the nucleus and imported into mitochondria, where it functions as an activator of mtDNA transcription and packages mtDNA into DNA-protein aggregates ...
  • Making proteins in the powerhouse 

    Hällberg, Martin; Larsson, Nils-Göran (Inst för laboratoriemedicin / Dept of Laboratory MedicineInst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyMax Planck Institute for Biology of Ageing, Cologne, Germany, 2014-08-04)
    Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest as mitochondrial dysfunction is important in human pathology and ageing. Similar to the situation in bacteria, there is no ...

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