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  • Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease 

    Tsoi, Yat Long (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-08-14)
    Notch signaling is an evolutionary conserved contact-dependent cell-cell communication pathway. This “contact” spans from hydra to fruit flies to human; orchestrating development, homeostasis and cancer, thus the Requiem, ...
  • Oxygen sensing in myeloid cells : implications for physiology and cancer 

    Gojković, Miloš (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-07-31)
    All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O2) through inspiration. In the lungs, O2 is gathered by erythrocytes that consequently deliver it to all cells by the ...
  • From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes 

    Herzog Croona, Laura K. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-18)
    Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, ...
  • Differential microRNA and metabolic expressions in neuroendocrine and cervical carcinomas 

    Scicluna, Patrick (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-03-26)
    MicroRNAs (miRNAs) are important regulators of many biological processes involved in cancer development and progression. However, the functional roles of miRNAs in some cancer types are still poorly understood. The aim of ...
  • Novel properties of mature adipocytes in obesity and hyperinsulinemia 

    Li, Qian (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-02-10)
    Adipose tissue expansion and dysfunction, which leads to obesity and related metabolic diseases (e.g., diabetes and hypertension) are currently the most costly challenges for public health, yet the mechanisms underlying ...
  • To scar or not to scar : origin and function of fibrotic tissue in the central nervous system 

    Dias, David Oliveira (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-11-20)
    After injury, the adult mammalian central nervous system lacks long-distance axon regeneration, and insufficient repair results in the formation of a multicellular and compartmentalized scar. A great body of work has ...
  • Tailoring bioinformatics strategies for the characterization of the human microbiome in health and disease 

    Barrientos Somarribas, Mauricio (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-08-22)
    The human microbiome is a very active area of research due to its potential to explain health and disease. Advances in high throughput DNA sequencing in the last decade have catalyzed the growth of microbiome research; ...
  • Exploration of large molecular datasets using global gene networks : computational methods and tools 

    Jeggari, Ashwini Priya (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-08-02)
    Defining gene expression profiles and mapping complex interactions between molecular regulators and proteins is a key for understanding biological processes and the functional properties of cells, which is therefore, the ...
  • Single-cell RNA sequencing for subtype discovery in Plasmodium falciparum and mammalian cells 

    Ngara, Mtakai (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-04-25)
    Since the dawn of massively parallel sequencing technologies in mid-2000s their utility in profiling the expression of genes in a genome-wide fashion has matured and progressed from cell populations to individual cells. ...
  • Novel aspects of neuroblastoma : to hypoxia and beyond 

    Westerlund, Isabelle (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-02-27)
    Neuroblastoma (NB) is a pediatric cancer arising from the neural crest cells forming the sympathetic nervous system. Just as other types of pediatric cancer the driving mutations of neuroblastoma are few and the tumors are ...
  • The role of HIF-1alpha in epigenetic regulation of transcription 

    Vojnovic, Nikola (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-11-27)
    The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating ...
  • A genome-wide screen for essential genes that controls the formation of human heart progenitors 

    Xu, Jiejia (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-11-14)
    The heart is a complex organ system composed of multiple types of tissues. These tissues are produced by a diverse set of muscle and non-muscle cells, originated from a few pools of progenitors. During the heart development, ...
  • Structural-functional studies of mitochondrial matrix proteins 

    Shahzad, Saba (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-11-01)
    The mitochondrion is the powerhouse of the eukaryotic cell. Most of the energy required to carry out cellular processes is generated inside mitochondria via the process of oxidative phosphorylation. The machinery required ...
  • Molecular mechanisms of salamander limb regeneration 

    Brito, Gonçalo M. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-09-21)
    Salamanders, like newts and axolotls, stand out among adult vertebrates for their outstanding capacity to regenerate whole body parts and restore complex structures upon injury. One of the best-known examples is their ...
  • Identification of novel pathways of regulation of AHR and HIF-­1 function 

    Gralla, Michael (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-09-14)
    Mammalian bHLH-Pas (basic HLH (helix-loop-helix)-PER-ARNT-SIM) proteins belong to the bHLH superfamily of transcription factors. Members of the family have a broad spectrum of functions that among others sense and regulate ...
  • Investigating the pathological heart and its regenerative potential 

    Graham, Evan Lee (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-07-31)
    Cardiovascular disease is a leading contributor to mortality the world over, affecting millions of people each year. This, combined with its associated monetary and societal costs, has made the investigation of the ...
  • Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites 

    Pfeiffer, Annika (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-05-25)
    Protecting genome integrity is a vital task that is constantly challenged by various genotoxic stresses. Among different types of DNA damage, double-strand breaks (DSBs) constitute a particular threat since they result ...
  • Let's talk about SOX : diverse key players in the transcriptional regulation of neural stem cells 

    Klum, Susanne (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-05-25)
    The development of the central nervous system relies on neural stem cells. How these stem cells either maintain their identity as self-renewing progenitors or differentiate into cells of the neuronal or glial lineage are ...
  • SOX in development and disease 

    Kurtsdotter, Idha (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-04-26)
    As stem cells are needed not only to build our bodies during development, but also to maintain tissue function during adulthood, it is of great importance to the organism to maintain their integrity. However, stem cells ...
  • Dopamine : a versatile player in development, regeneration and disease 

    Pinheiro, Tiago (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-03-06)
    The dopamine neurotransmitter is present in all multicellular organisms. In the brain, the dopaminergic system orchestrates reward-motivation pathways and is involved in the control of voluntary movements and endocrine ...

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