Now showing items 1-20 of 259

    • On astrocytes and neural stem cells : a study of reactive and canonical neurogenesis 

      Zamboni, Margherita (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-12-14)
      The mammalian central nervous system has limited regenerative capacity and the long-lasting functional impairment resulting from trauma and neurodegenerative disease derives from a failure to repopulate neuronal cell ...
    • RNA-binding proteins in transcription and genome integrity 

      Pederiva, Chiara (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-11-19)
      For decades, it was believed that RNA was merely an intermediate step between DNA and protein effectors. It is now appreciated that RNA is an extremely versatile molecule that affects almost every aspect inside a cell. ...
    • Tipping the scales in cancer : novel mechanisms of inhibiting protein degradation 

      Giovannucci, Tatiana A. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-11-18)
      Protein homeostasis (in short, ‘proteostasis’) requires the timely degradation of proteins to retain control on protein quality, amount and function. Two main proteolytic systems, the ubiquitin-proteasome system (UPS) and ...
    • Scarring and regeneration in the central nervous system 

      Kalkitsas, Jannis (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-11-12)
      In response to injury, tissues employ conserved reparative mechanisms to heal the damage and recover their function. The reparative success varies according to the organism, the tissue or organ, and the age of the specimen. ...
    • Understanding the role and regulation of Polη for damage-induced cohesion 

      Wu, Pei-Shang (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-10-28)
      In response to DSBs, de novo sister chromatid cohesion can be established after DNA replication in Saccharomyces cerevisiae. The damage-induced cohesion is formed close to the break and genome-wide on undamaged chromosomes. ...
    • A fishing expedition for antidiabetic drugs : identifying new avenues to stimulate beta-cell regeneration 

      Karampelias, Christos (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-10-15)
      All types of diabetes are characterized by loss of the insulin-producing β-cells that reside in the pancreas. While current treatments can manage the disease, there is still no cure available. Understanding and promoting ...
    • Single-cell analysis of mammalian cardiogenesis elucidating an essential role of outflow tract progenitors 

      Zhou, Chikai (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-09-14)
      The heart is the first organ to form and start to function during mammalian embryogenesis. This complex organ system is constructed by a diverse set of cell types, involving mesodermal precursors and heart progenitors, ...
    • Cell lineage analysis in humans 

      Hård, Joanna (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-07-29)
      Delineating a cell’s history, where it came from and what has happened to it, can provide clues as to how tissues and organs are formed and function in the healthy state and in disease. The gold standard for tracing the ...
    • Regulation of G2 phase and long-term consequences of DNA damage 

      Middleton, Anna Won (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-04-08)
      Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated ...
    • Developmental dynamics of cardiac progenitors and their role in congenital heart defects 

      Mononen, Mimmi (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-03-01)
      Cardiac progenitors are the fundamental building blocks of the heart and play a central role in the pathogenesis of congenital heart defects. Recent single-cell RNA sequencing studies have revealed that the cell populations ...
    • Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract. 

      Sahara, Makoto; Santoro, Federica; Sohlmér, Jesper; Zhou, Chikai; Witman, Nevin; Leung, Chuen Yan; Mononen, Mimmi; Bylund, Kristine; Gruber, Peter; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
      The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
    • Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors 

      Xu, Jiejia; Zhou, Chikai; Foo, Kylie S.; Yang, Ran; Xiao, Yao; Bylund, Kristine; Sahara, Makoto; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
      Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators ...
    • From oncogenic replication stress to drug resistance : F-box proteins as signalling hubs in cancer 

      Brunner, Andrä (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-01-28)
      Cancer arises from cells that acquire genetic and epigenetic changes during the course of a, sometimes decades-long, somatic evolutionary process. These changes result in deregulation of a multitude of cellular processes ...
    • Investigating adipose tissue turnover in humans using radiocarbon dating 

      Fu, Keng-Yeh (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-12-28)
      Obesity, defined as an excessive accumulation of body fat, is considered one of the major health challenges facing the world today. Adipocyte and lipid turnover determine the number and the size of fat cells, respectively. ...
    • Neural stem cells in the spinal cord : identity, function and potential 

      Stenudd, Moa (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-12-23)
      A large body of work has been dedicated to understanding and remedying the pathological processes that take place after spinal cord injury. Despite these efforts, treatment options are limited and patients with spinal cord ...
    • The neurogenic potential of astrocytes : a story of transformation and renewal 

      Santopolo, Giuseppe (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-10-15)
      To not simply repair an organ, but to regenerate and fully recover its function, like there was no injury at all, that is the goal of regenerative medicine. Of all the organs in the human body, the most delicate and ...
    • Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease 

      Tsoi, Yat Long (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-08-14)
      Notch signaling is an evolutionary conserved contact-dependent cell-cell communication pathway. This “contact” spans from hydra to fruit flies to human; orchestrating development, homeostasis and cancer, thus the Requiem, ...
    • Oxygen sensing in myeloid cells : implications for physiology and cancer 

      Gojković, Miloš (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-07-31)
      All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O2) through inspiration. In the lungs, O2 is gathered by erythrocytes that consequently deliver it to all cells by the ...
    • From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes 

      Herzog Croona, Laura K. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-18)
      Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, ...
    • X-chromosome upregulation is driven by increased burst frequency 

      Larsson , Anton J. M.; Coucoravas, Christos; Sandberg, Rickard; Reinius, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and BiophysicsInst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-12)
      Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...