Now showing items 1-20 of 253

    • Single-cell analysis of mammalian cardiogenesis elucidating an essential role of outflow tract progenitors 

      Zhou, Chikai (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-09-14)
      The heart is the first organ to form and start to function during mammalian embryogenesis. This complex organ system is constructed by a diverse set of cell types, involving mesodermal precursors and heart progenitors, ...
    • Cell lineage analysis in humans 

      Hård, Joanna (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-07-29)
      Delineating a cell’s history, where it came from and what has happened to it, can provide clues as to how tissues and organs are formed and function in the healthy state and in disease. The gold standard for tracing the ...
    • Regulation of G2 phase and long-term consequences of DNA damage 

      Middleton, Anna Won (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-04-08)
      Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated ...
    • Developmental dynamics of cardiac progenitors and their role in congenital heart defects 

      Mononen, Mimmi (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-03-01)
      Cardiac progenitors are the fundamental building blocks of the heart and play a central role in the pathogenesis of congenital heart defects. Recent single-cell RNA sequencing studies have revealed that the cell populations ...
    • Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract. 

      Sahara, Makoto; Santoro, Federica; Sohlmér, Jesper; Zhou, Chikai; Witman, Nevin; Leung, Chuen Yan; Mononen, Mimmi; Bylund, Kristine; Gruber, Peter; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
      The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
    • Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors 

      Xu, Jiejia; Zhou, Chikai; Foo, Kylie S.; Yang, Ran; Xiao, Yao; Bylund, Kristine; Sahara, Makoto; Chien, Kenneth R. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyInst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-15)
      Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators ...
    • From oncogenic replication stress to drug resistance : F-box proteins as signalling hubs in cancer 

      Brunner, Andrä (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-01-28)
      Cancer arises from cells that acquire genetic and epigenetic changes during the course of a, sometimes decades-long, somatic evolutionary process. These changes result in deregulation of a multitude of cellular processes ...
    • Investigating adipose tissue turnover in humans using radiocarbon dating 

      Fu, Keng-Yeh (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-12-28)
      Obesity, defined as an excessive accumulation of body fat, is considered one of the major health challenges facing the world today. Adipocyte and lipid turnover determine the number and the size of fat cells, respectively. ...
    • Neural stem cells in the spinal cord : identity, function and potential 

      Stenudd, Moa (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-12-23)
      A large body of work has been dedicated to understanding and remedying the pathological processes that take place after spinal cord injury. Despite these efforts, treatment options are limited and patients with spinal cord ...
    • The neurogenic potential of astrocytes : a story of transformation and renewal 

      Santopolo, Giuseppe (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-10-15)
      To not simply repair an organ, but to regenerate and fully recover its function, like there was no injury at all, that is the goal of regenerative medicine. Of all the organs in the human body, the most delicate and ...
    • Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease 

      Tsoi, Yat Long (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-08-14)
      Notch signaling is an evolutionary conserved contact-dependent cell-cell communication pathway. This “contact” spans from hydra to fruit flies to human; orchestrating development, homeostasis and cancer, thus the Requiem, ...
    • Oxygen sensing in myeloid cells : implications for physiology and cancer 

      Gojković, Miloš (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-07-31)
      All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O2) through inspiration. In the lungs, O2 is gathered by erythrocytes that consequently deliver it to all cells by the ...
    • From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes 

      Herzog Croona, Laura K. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-18)
      Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, ...
    • X-chromosome upregulation is driven by increased burst frequency 

      Larsson , Anton J. M.; Coucoravas, Christos; Sandberg, Rickard; Reinius, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and BiophysicsInst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-12)
      Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...
    • Differential microRNA and metabolic expressions in neuroendocrine and cervical carcinomas 

      Scicluna, Patrick (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-03-26)
      MicroRNAs (miRNAs) are important regulators of many biological processes involved in cancer development and progression. However, the functional roles of miRNAs in some cancer types are still poorly understood. The aim of ...
    • Novel properties of mature adipocytes in obesity and hyperinsulinemia 

      Li, Qian (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-02-10)
      Adipose tissue expansion and dysfunction, which leads to obesity and related metabolic diseases (e.g., diabetes and hypertension) are currently the most costly challenges for public health, yet the mechanisms underlying ...
    • To scar or not to scar : origin and function of fibrotic tissue in the central nervous system 

      Dias, David Oliveira (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-11-20)
      After injury, the adult mammalian central nervous system lacks long-distance axon regeneration, and insufficient repair results in the formation of a multicellular and compartmentalized scar. A great body of work has ...
    • Tailoring bioinformatics strategies for the characterization of the human microbiome in health and disease 

      Barrientos Somarribas, Mauricio (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-08-22)
      The human microbiome is a very active area of research due to its potential to explain health and disease. Advances in high throughput DNA sequencing in the last decade have catalyzed the growth of microbiome research; ...
    • Exploration of large molecular datasets using global gene networks : computational methods and tools 

      Jeggari, Ashwini Priya (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-08-02)
      Defining gene expression profiles and mapping complex interactions between molecular regulators and proteins is a key for understanding biological processes and the functional properties of cells, which is therefore, the ...
    • Single-cell RNA sequencing for subtype discovery in Plasmodium falciparum and mammalian cells 

      Ngara, Mtakai (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2019-04-25)
      Since the dawn of massively parallel sequencing technologies in mid-2000s their utility in profiling the expression of genes in a genome-wide fashion has matured and progressed from cell populations to individual cells. ...