Now showing items 1-20 of 221

  • Characterisation of newt neural stem cells during development and regeneration 

    Liyakath Ali, Shahul Hameed (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-02-15)
    The adult newt brain has a unique potential to regenerate neurons after injury. Ependymoglial cells that line the ventricular system of the newt brain are critical for neuronal regeneration, since they reenter the cell ...
  • Serum proteases potentiate BMP-induced cell cycle re-entry of dedifferentiating muscle cells during newt limb regeneration 

    Wagner, Ines; Wang, Heng; Weissert, Philipp; Straube, Werner; Shevchenko, Anna; Gentzel, Marc; Brito, Goncalo; Tazaki, Akira; Oliveira, Catarina; Sugiura, Takuji; Shevchenko, Andrej; Simon, András; Drechsel, David; Tanaka, Elly (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-02-12)
    Limb amputation in the newt induces myofibers to dedifferentiate and re-enter the cell cycle to generate proliferative myogenic precursors in the regeneration blastema. Here we show that bone morphogenetic ...
  • Skeletal muscle dedifferentiation during salamander limb regeneration 

    Wang, Heng; Simon, Andras (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-01-24)
    Salamanders can regenerate entire limbs throughout their life. A critical step during limb regeneration is formation of a blastema, which gives rise to the new extremity. Salamander limb regeneration has historically been ...
  • Structural and functional basis of mitochondrial tRNA processing 

    Sridhara, Sagar (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-11-28)
    The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) ...
  • Cell cycle regulation and DNA damage response : a record of polo-like kinase 1 activity 

    Hukasova, Elvira (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-11-02)
    Division and cell proliferation is an essence of life. A human cell has in its core a very simple yet a very complex machinery to coordinate cell cycle activities and events. A somatic human cell has as a base four ...
  • Transcriptional regulation of development in time and space 

    Hagey, Daniel W. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-10-13)
    Human development requires the generation of trillions of cells with myriad functions from a single cell. This requires that restriction of stem cell fate competence and proliferation are precisely temporally and spatially ...
  • Astrocytes : a reservoir for new neurons 

    Magnusson, Jens (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-09-08)
    The goal of regenerative medicine is to be able to help the body to replace worn-out cells and tissues. To achieve this goal, one approach being pursued today is to recruit and boost the body’s own mechanisms for cell ...
  • Global regulation of gene expression in stem cells and regeneration 

    Abdullayev, Ilgar (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-08-17)
    Rapid developments in genomics and transcriptomics fields have made it possible to ask new questions as well as solve various old problems in biology that were not achievable previously. Novel techniques such as RNA ...
  • Brain matter matters : renewal in the human brain 

    Yeung Wong, Maggie (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-05-26)
    Many cells have a shorter life span than the organism itself and are continuously being replaced. However, for many cell types in the human body it is still largely unknown whether they turn over at all once development ...
  • Cell renewal : terms and conditions may apply 

    Réu, Pedro (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-04-10)
    The longevity and turnover of the different constituent cells of an organism define its development, size, health, and biological age. The present thesis discusses the renewal rates and functions of cells in several ...
  • The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast 

    Tran, Martin (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-03-15)
    The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, ...
  • Transcriptional regulation of neuronal differentiation in the developing CNS 

    Rraklli, Vilma (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-02-02)
    The central nervous system (CNS) is responsible for our intellectual and cognitive functions and it comprises the brain and spinal cord. Generation of the CNS occurs during embryonic development from the neural tube that ...
  • SOX transcription factors : multifaceted regulators of central nervous system development 

    Zaouter, Cécile (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-26)
    The central nervous system (CNS) is composed of three major cell types, namely neurons, astrocytes and oligodendrocytes that are mainly generated during embryonic stages by multipotent neural progenitor cells (NPCs). The ...
  • The role of KIF1Bß in neuroblastoma tumour suppression during sympathetic neuron development 

    Fell, Stuart (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-19)
    Neuroblastoma, the most common extra-cranial childhood tumour, is believed to arise from precursor cells of the sympathetic nervous system (neuroblasts). Hemizygous loss of chromosome 1p36 strongly correlates with poor ...
  • Resolving developing neuronal lineages in the ventral midbrain 

    Kee, Nigel (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-01-09)
    The numerous cells and cell types of our bodies originate from a fertilised egg. Through the study of the developing embryo, we have come to understand much about how different cells in different tissues arise from this ...
  • High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation 

    Agostinho, Ana; Manneberg, Otto; van Schendel, Robin; Hernández-Hernández, Abrahan; Kouznetsova, Anna; Blom, Hans; Brismar, Hjalmar; Höög, Christer (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular BiologyScience for Life Laboratory, 2016-12-07)
    During meiosis, cohesin complexes mediate sister chromatid cohesion (SCC), synaptonemal complex (SC) assembly and synapsis. Here, using super-resolution microscopy, we imaged sister chromatid axes in mouse ...
  • Investigating cell turnover in the healthy and diseased adult human brain 

    Huttner, Hagen B. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-11-18)
    For decades it was thought that cells that lost in the human central nervous system because of ageing or disease – different from other cell tissues – cannot be replaced and that in humans all neurons are generated during ...
  • The Smc5/6 complex : the mysterious guardian of genome stability 

    Berta, Davide G. (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-11-02)
    An intricate network of proteins ensures the faithful transmission of genetic information through cell generations. The Structural Maintenance of Chromosomes (SMC) protein complex family plays a pivotal role in maintaining ...
  • The role of the cohesin loader in genome stability : a journey from yeast to human 

    Giordano, Fosco (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-10-11)
    Structural Maintenance of Chromosome (SMC) complexes, as their name suggests, have a central role in maintaining the higher structure of genomes, from bacteria to human, and in doing so protecting their integrity. ...
  • Molecular organization and in situ assembly of the human skin barrier 

    Hollander, Lianne den (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2016-10-07)
    A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease. To ...