The p73 gene was first discovered in 1997 as a family member of p53, and since then this gene has been studied extensively in cancer biology. Among its two main classes of isoforms, TAp73 acts as a tumor suppressor, while ...

Despite its discovery 20 years ago, the accumulated knowledge about the Rho member RhoD is scarce. Instead, the vast majority of studies concerning Rho GTPases has focused on the three classical members RhoA, Cdc42 and ...

Malaria remains one of the most significant global public health challenges. Nearly half of the world’s population remains at risk, largely in African Region. In the past decade, considerable progress has been made in the ...

Streptococcus pneumoniae is commonly found as an asymptomatic colonizer of the nasopharynx of children, but it can also translocate to normally sterile body sites and cause severe diseases, like pneumonia, septicemia or ...

Inflammation is a homeostatically fundamental feature of the host defence surveillance system made up of an army of sentinel cells that guard against foreign intrusion. At the onslaught of an attack, primary immune responders ...

Most approved successful human vaccines induce neutralizing antibody titers maintained above a given threshold for long-term protection against potential pathogen exposure. The pathogens targeted by these vaccines are ...

Our immune system is a complex network made up of physical barriers and specialized proteins, cells and organs that all work together to prevent pathogens from causing disease in the body. Once the immune system has ...

Background: Before the era of combination therapy (c-ART) more than 90 % of the patients with HIV-infection died of one or more opportunistic infections (OI). We and others noted early on that CMV was an important pathogen ...

Plasmodium falciparum malaria is an infectious disease that on despite of the ongoing eradication efforts is still endemic in more than 100 countries, sometimes causing severe disease that leads to the death of around half ...

Streptococcus pneumoniae is a major cause of severe infections such as pneumonia, septicemia and meningitis, but also a common colonizer of the nasopharynx in children. In most individuals colonization is harmless and ...