Doktorsavhandlingar / Doctoral Theses - C1 (MTC): Recent submissions
Now showing items 101-120 of 514
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Mechanisms of tumor microenvironment in promoting metastasis
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-11-07)Tumor tissues contain diverse cell populations that relentlessly cross-communicate with each other in the tumor microenvironment. In addition to malignant cells, infiltration of other host cells including inflammatory ... -
Constraints for dendritic cell differentiation : analysis of autocrine inhibitory mechanisms with therapeutic implications
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-11-03)The discovery of dendritic cells (DCs) was followed by an intensive research period aiming at the identification of mechanisms that could induce or inhibit adaptive immune responses through the manipulation of these cells. ... -
Dysfunctional phenotype of T cells and their contribution to impaired B cell function during HIV-1 infection
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-08-29)Microbial translocation and increased immune activation have been involved in functional T cell impairments and disease progression during HIV-1 infection. The impact of microbial translocation on the phenotype of memory ... -
Exploring the cancer cell attractor in the Epstein-Barr virus infection model
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-05-27)It has been proposed, based on the theory of complex gene regulatory networks, that cell types, including cancer cells, represent attractor states of the network dynamics. In this study, we proposed an Epstein - Barr virus ... -
A tripartite of immune-, epithelial-, and nervous-systems in the homeostatic regulation of the gut
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-05-24)Various cell types in the intestinal mucosa are constantly exposed to complex signals emanating from the lumen, including the microbiota and its metabolites. How these bilateral interactions in turn influences intestinal ... -
NK cell education and adhesion molecules : implications for immunotherapy
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-05-19)NK cells have a key role in immune surveillance. They detect aberrant expression of stressinduced molecules and MHC class I molecules with an array of activating and inhibitory receptors. Inhibitory receptors are not only ... -
Malaria and polypeptides of Plasmodium falciparum at the infected erythrocyte surface
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-03-11)Malaria is one of the top three most lethal infectious diseases in the world after tuberculosis and HIV. The disease is caused by intracellular parasites of the genus Plasmodium spp. To date, five Plasmodium spp have ... -
Who is killing whom? Hantaviruses vs programmed cell death
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-02-17)Hantaviruses belong to the Bunyaviridae family of negative stranded RNA viruses. They carry a tri-segmented genome and consist of four structural proteins. The four structural proteins are two glycoproteins Gn and Gc, a ... -
iNKT cell regulation of B cell activation in inflammation
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-01-14)The ability to combat infections through the generation of specific immune responses is critical to our survival. The immune system can react to and combat virtually any molecule presented to it, including those derived ... -
Exploring immunotherapeutic targets in the tumor microenvironment
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-11-19)The immune system has developed along with the evolution of increasingly complex cellular organisms to sustain homeostasis and protect from threats. Cancer, a detrimental side effect of increasing organismic complexity, ... -
Characterization of virulence in clinical isolates of Streptococcus pneumoniae
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-11-02)The immune system together with competing pneumococcal strains and other bacterial species, impose a selective pressure on the pneumococcus that leads to the expansion of certain lineages and the remission of others. Our ... -
Microbial and epigenetic factors in the pathogenesis of nasopharyngeal carcinoma
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-10-19)While uncommon in most of the world, nasopharyngeal carcinoma (NPC) shows an unusual geographic and ethnic distribution, being highly prevalent in Southern China and Southeast Asia. Genetic susceptibility, Epstein-Barr ... -
Characterization of HIV-1 RNA and DNA during long-term suppressive therapy
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-10-09)Human immunodeficiency virus (HIV) is the virus causing acquired immune deficiency syndrome (AIDS). Since the discovery of HIV/AIDS over three decades ago, this disease has claimed millions of lives. One of the major ... -
Bioinformatic analyses of the structural and functional complexity in chromosomal interactomes
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-09-24)Evolution requires information storage systems with different demands with respect to persistence. While the genome provides a mechanism for long term, static and accurate information storage, it is incapable of mediating ... -
NK cells and missing self recognition : genetic control, mhc class i dependent education and potential use in cancer therapy
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-09-14)NK cells belong to the innate immune system and are important in the defense against virus infections and malignant cells. They mediate their effector functions via release of cytotoxic granules and by cytokine production ... -
Single cell studies of natural killer cell immune surveillance
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-05-08)Our immune system protects us from microbes such as viruses, bacteria and parasitic worms. The immune system also plays a key role in fighting cancer and in carrying out a function termed ‘immune surveillance’, natural ... -
Chemical genetics and immunomodulation in Salmonella enterica serovar typhimurium infection
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-04-08)Salmonella sp. are versatile bacteria that survive and replicate in a plethora of environmental niches and hosts, including humans. The illnesses caused by various serovars in humans range from mild gastroenteritis to ... -
Molecular methods in malaria control in the era of pre-elimination
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-03-03)Increased funding combined with effective malaria control methods for prevention, diagnosis, and treatment, has resulted in a 30% reduction of the global malaria burden over the last decade. As malaria prevalence declines ... -
Molecular epidemiology of streptococcus pneumoniae
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-02-20)Streptococcus pneumoniae, also named pneumococci, is often part of the normal flora in the nasopharynx of healthy children. However, pneumococci are also a major cause of morbidity and mortality world-wide, and colonization ... -
Aiming at malaria elimination in Zanzibar
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-02-06)Following the increase of the international funding for implementation of the combined malaria control strategies in the past decade, a significant reduction of malaria attributed morbidity and mortality has been achieved. ...