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  • A study on the role of T helper cells in allergic inflammation 

    Stark, Julian Mario (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-26)
    Asthma is a chronic inflammatory disease of the airways affecting hundreds of millions of people worldwide. Central to the development of asthma and allergic airway inflammation are CD4 T cells, which upon activation through ...
  • FtsH protease and ClpG disaggregase confer fitness advantages to the worldwide prevalent Pseudomonas aeruginosa clone C 

    Kamal, Shady Mansour (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-20)
    Pseudomonas aeruginosa is an environmental bacterium and a frequent nosocomial pathogen causing a wide range of opportunistic infections, especially in immunocompromised patients. Clone C is one of the most prevalent ...
  • Competence pilus biogenesis in Streptococcus pneumoniae 

    Oliveira, Vitor (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-08)
    Horizontal gene transfer drives bacterial evolution and is crucial for the pathogenicity of many bacteria that can exchange genetic material through distinct mechanisms such as natural transformation. S. pneumoniae, a ...
  • Diverse cyclic dinucleotide signals regulate escherichia coli lifestyle transition 

    Li, Fengyang (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-04-29)
    Bacteria have the ability to change their lifestyle to adapt to various environmental conditions. Cyclic dinucleotides (cDNs) are ubiquitous second messengers that can regulate fundamental lifestyle switches, such as ...
  • p53-dependent and -independent mechanisms of p53-targeting small molecules 

    Zhu, Jiawei (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-03-05)
    Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function. ...
  • Dihydroorotate dehydrogenase : new insights into an old target 

    Popova, Gergana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-01-24)
    Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. ...
  • Retinal tumorigenesis and neurodegeneration : strategies to promote tumor cell death and support retinal cell survival to preserve vision 

    Mollick, Tanzina (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-27)
    Our vision is central to our quality of life enabling us to interact with our environment and lead productive lives. The ability to see begins in the retina, one of the paramount features of the eye, as it takes on the ...
  • Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases 

    Sendel, Anton (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-18)
    The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, ...
  • Definition of immunoglobulin germline genes by next generation sequencing for studies of antigen-specific b cell responses 

    Vázquez Bernat, Néstor (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-21)
    Immunoglobulins play a critical role in the adaptive immune system, existing as cell surface-expressed B cell receptors and secreted antibodies. Circulating antibodies are the main correlate of protective immunity for most ...
  • Bacterial communities and antibiotic resistance in human-impacted water environments 

    Guzman Otazo, Carol Jessica (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-07)
    From a One-Health concept the health of humans, animals and the environment is interconnected and what happens to one of the domains will affect the other two simultaneously. This concept can be applied not only to the ...
  • Revealing the secrets of MARCO : a target for cancer immunotherapy 

    Eisinger, Silke (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-11-06)
    Our immune system protects us from infectious agents and sustains the homeostasis in our body. However, the immune system can also play a role in initiation and progression of diseases such as autoimmune diseases and cancer. ...
  • Exploring B cell responses in Plasmodium falciparum malaria 

    Rönnberg, Caroline (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-10-18)
    Plasmodium falciparum malaria remains one of the most devastating infectious diseases today. Small children in sub-Saharan Africa carry the heaviest burden of morbidity and mortality. Immunity to malaria is not well ...
  • Alphavirus-host interactions : how to unravel the proviral activity of G3BP 

    Götte, Benjamin (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-08-30)
    The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically ...
  • Relation between nutritional status, the outcome of infection and immune responses 

    Terán, Graciela (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-08-16)
    A causal interaction between nutrition and the outcome of different infections has been known since long time ago. Moreover, responses of human beings to infection are diverse and demarcated by immunity. A deficient and ...
  • Effects of DNA damage and vesicular exchange in P. falciparum 

    Hjelmqvist, Daisy (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-28)
    Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...
  • Identification and characterization of small molecules targeting MYC function 

    Yan, Qinzi (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-21)
    The MYC family genes (c-, N- and L-MYC) encode potent oncoproteins/transcription factors regulating fundamental cellular processes involved in cell proliferation, metabolism and survival, and they play an important role ...
  • Exploration of host cells during old world alphavirus infection : modulation of RNA granules and the PI3K/AKT pathway 

    Liu, Lifeng (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-03)
    As obligate intracellular parasites, viruses have to explore and modulate cellular pathways for their survival. Mechanistic studies of virus–host interactions provide a better understanding of viral infection and cellular ...
  • Decoding the tumor microenvironment : a B-cell and Macrophage perspective 

    Boura, Vanessa F. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-02)
    The immune system plays a role in many different functions in our body, and disease is no exception. Cancer is one of the biggest challenges of the twenty first century and vast efforts have been made to understand this ...
  • Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer 

    Zhang, Fan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-26)
    Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes ...
  • Elucidation of the cell signaling pathways mediating innate immunity and host-pathogen interactions 

    Nabar, Neel R. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-14)
    The ability to generate a robust immune response is integral to organismal homeostasis. Cells of the innate immune system are considered the first responders of immunity, and are therefore responsible for sensing both ...

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