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  • Towards personalized immunotherapy : development of in vitro models for imaging natural killer cell behavior in the tumor microenvironment 

    Carannante, Valentina (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2022-01-27)
    Tremendous advances in the tumor immunology field have transformed immunotherapy from a promising approach to a standard clinical practice. However, a subset of cancer patients is non-responsive to immunotherapy. More ...
  • Elucidation of the molecular mechanisms of action of anti-cancer compounds reveals possible combination strategies for anti-cancer therapy 

    Zhou, Xiaolei (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-11-24)
    Cancer develops due to accumulation of mutations or epigenetic changes within normal cells, usually over a considerable period of time. When cancer patients are diagnosed at late stage, the tumor cells are often more ...
  • Altered cell metabolism and migration in nasopharyngeal carcinoma 

    Zheng, Shixing (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-10-29)
    Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer, originating from the nasopharynx. The etiology of NPC is considered a complex interaction between Epstein–Barr virus (EBV) infection, genetic ...
  • Learning from primary immunodeficiencies to treat cancer 

    Oliveira, Mariana M. S. (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-09)
    The immune system is a fine-tuned network of cells, tissues, organs and biological processes working together in order to protect our body. Immunodeficiency disorders occur when the body’s immune system is reduced or absent ...
  • Hfq- and sRNA-mediated regulation in Neisseria meningitidis 

    Karlsson, Jens (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-09-03)
    Neisseria meningitidis, also known as the meningococcus, is a human-specific pathogen that commonly colonises the nasopharynx without causing disease. For reasons unknown, N. meningitidis can traverse the nasopharyngeal ...
  • Receptor tyrosine kinase signaling and extracellular matrix cues in ovarian cancer metastasis and drug resistance 

    Moyano Galceran, Lidia (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-08-09)
    Albeit many studies have contributed towards understanding the origin, development, treatment response and evolution of high-grade serous ovarian carcinoma (HGSC), the exact supporting mechanisms are still not fully ...
  • Targeting MYC and CDK2 in cancer : impacts on senescence, apoptosis and immune modulation 

    Bazzar, Wesam (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-27)
    Cancer is a disease in which cells acquire the ability to divide uncontrollably and invade other tissues. An important component of this process is the activation of oncogenes and inactivation of tumor suppressor genes. ...
  • RNA-mediated gene regulation in Neisseria meningitidis and other nasopharyngeal pathogens 

    Eichner, Hannes (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-07)
    Neisseria meningitidis is a transient commensal bacterium of the upper respiratory tract and spreads through respiratory secretions produced by the carrier. While mostly harmless, the bacterium can cause invasive meningococcal ...
  • Pattern recognition and iNKT cell regulation of B cell activation 

    He, Chenfei (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-05-05)
    The immune system protects individuals against infections but can cause disease if the response is unbalanced. Immune responses include both innate and adaptive response, and these systems are connected. As the first line ...
  • The role of oestrogens and antibiotics on the development of cancer 

    Simin, Johanna (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-04-29)
    Despite advances in cancer treatment and surgery, cancer-related mortality remains the leading cause of death globally, harvesting over ten million lives annually. While the risk factors are both hormonal and non-hormonal, ...
  • Adaptation of Salmonella enterica to antibiotics and innate immunity effectors 

    Vestö, Kim (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-02-22)
    Salmonella enterica is a bacterial pathogen causing major morbidity and mortality in low- and middle-income countries. The bacteria can cause a wide range of disease, ranging from the severe systemic disease typhoid fever ...
  • Targeting cell envelope synthesis of Streptococcus pneumoniae and microfluidic diagnostic tool development 

    Reithuber, Elisabeth (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-01-25)
    Evolving antibiotic resistance warrants the development of new therapeutic and diagnostic approaches as part of the strategies to secure future antibacterial therapies and preserve the compounds currently available. Work ...
  • Investigating the role of p73 proteins in controlling the tumor microenvironment 

    Wolfsberger, Johanna (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-10-20)
    Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ...
  • Effects of intestinal worms on skin immunity and control of co-infection 

    Classon, Cajsa (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-08-21)
    Intestinal helminth infections remain a major health concern in developing areas of the world. Consequences of infection range from gastrointestinal discomfort to systemic manifestations. It has been suggested that ...
  • Characterization of B cell response alterations resulting from ablation of IκBNS expression 

    Khoenkhoen, Sharesta (C1, MTC, 2020-08-07)
    The immune system is a sophisticated organization of cells and tissues that cooperate in safeguarding the integrity of our body by eliminating internal and external threats. Vaccines are the most impactful medical intervention ...
  • A study on the role of T helper cells in allergic inflammation 

    Stark, Julian Mario (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-26)
    Asthma is a chronic inflammatory disease of the airways affecting hundreds of millions of people worldwide. Central to the development of asthma and allergic airway inflammation are CD4 T cells, which upon activation through ...
  • FtsH protease and ClpG disaggregase confer fitness advantages to the worldwide prevalent Pseudomonas aeruginosa clone C 

    Kamal, Shady Mansour (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-20)
    Pseudomonas aeruginosa is an environmental bacterium and a frequent nosocomial pathogen causing a wide range of opportunistic infections, especially in immunocompromised patients. Clone C is one of the most prevalent ...
  • Competence pilus biogenesis in Streptococcus pneumoniae 

    Oliveira, Vitor (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-08)
    Horizontal gene transfer drives bacterial evolution and is crucial for the pathogenicity of many bacteria that can exchange genetic material through distinct mechanisms such as natural transformation. S. pneumoniae, a ...
  • Diverse cyclic dinucleotide signals regulate Escherichia coli lifestyle transition 

    Li, Fengyang (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-04-29)
    Bacteria have the ability to change their lifestyle to adapt to various environmental conditions. Cyclic dinucleotides (cDNs) are ubiquitous second messengers that can regulate fundamental lifestyle switches, such as ...
  • p53-dependent and -independent mechanisms of p53-targeting small molecules 

    Zhu, Jiawei (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-03-05)
    Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function. ...

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