Doktorsavhandlingar / Doctoral Theses - C1 (MTC): Recent submissions

Now showing items 61-80 of 512

    • Identification and characterization of small molecules targeting MYC function 

      Yan, Qinzi (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-21)
      The MYC family genes (c-, N- and L-MYC) encode potent oncoproteins/transcription factors regulating fundamental cellular processes involved in cell proliferation, metabolism and survival, and they play an important role ...

    • Exploration of host cells during old world alphavirus infection : modulation of RNA granules and the PI3K/AKT pathway 

      Liu, Lifeng (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-03)
      As obligate intracellular parasites, viruses have to explore and modulate cellular pathways for their survival. Mechanistic studies of virus–host interactions provide a better understanding of viral infection and cellular ...

    • Decoding the tumor microenvironment : a B-cell and macrophage perspective 

      Boura, Vanessa F (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-02)
      The immune system plays a role in many different functions in our body, and disease is no exception. Cancer is one of the biggest challenges of the twenty first century and vast efforts have been made to understand this ...

    • Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer 

      Zhang, Fan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-26)
      Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes ...

    • Elucidation of the cell signaling pathways mediating innate immunity and host-pathogen interactions 

      Nabar, Neel R (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-14)
      The ability to generate a robust immune response is integral to organismal homeostasis. Cells of the innate immune system are considered the first responders of immunity, and are therefore responsible for sensing both ...

    • Cooperativity between MYC and other oncogenic factors : implications for tumorigenesis and targeting of MYC 

      Zakaria, Siti Mariam (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-03-08)
      Normal cell homeostasis in a tissue requires a delicate balance between cell growth, maintenance and death, tightly controlled by an intricate interplay between proto-oncogenes and tumor suppressor genes. When the balance ...

    • Developing new models of childhood malignancies using human induced pluripotent stem cells 

      Marin Navarro, Ana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-02-15)
      Early onset diseases such as childhood malignancies and neurodevelopmental disorders have been intricate to study. For many years, research has relied and dependent upon different animal systems. Despite the usefulness of ...

    • The role of growth factors in white fat browning and metabolic disease 

      Fischer, Carina (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-01-16)
      The adipose tissue is composed of a variety of cell types that constantly cross-communicate with each other to allow the tissue to operate and to adapt to various external stimuli. The diversity of these cell populations ...

    • The functional impact of gut microbiota on CNS regulation of local and systemic homeostasis 

      Abbaspour, Afrouz (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-08-24)
      The “gut microbiota” is widely accepted as an integral part of the gut homeostasis, and is thought to contribute to the establishment of intestinal barrier. Growing body of research suggest that the influence of gut ...

    • Impact of intestinal worms on distal immune response and control of co-infections 

      Feng, Xiaogang (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-08-23)
      Parasitic worm infections have been suggested to impair control of secondary infections and vaccine efficacy. However, the experimental data regarding the capacity of intestinal nematodes to modulate host immune responses ...

    • Repertoire diversity and maturation of HIV-1 vaccine-induced B cell responses 

      Phad, Ganesh Eknath (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-06-04)
      In the work presented in this thesis, I characterized B cell responses in rhesus macaques inoculated with HIV-1 envelope glycoprotein (Env)-based vaccines to define genetic and functional properties of the elicited antibodies ...

    • p53 transcriptional activity as a tool to uncover novel and diverse druggable targets in cancer 

      Ladds, Marcus James Graeme Watson (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-05-28)
      The transcription factor p53 is one of the most studied tumour suppressors with over 90 000 publications in PubMed referring to the protein. It is also the most frequently mutated gene across all cancer types with around ...

    • Pneumococcal interactions with the host : threats and therapeutic approaches 

      Codemo, Mario (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-05-22)
      Streptococcus pneumoniae (the pneumococcus) is a Gram-positive bacterium responsible for substantial morbidity and mortality worldwide. Apart from causing severe pneumonia, septicemia or meningitis, pneumococci are also ...

    • Impaired response to HBV vaccination in HIV-1 infected children : immunopathological mechanisms 

      Bekele Feyissa, Yonas (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-05-08)
      HBV vaccination prevents HBV infection and related liver cancer. Immunological dysfunctions of Tfh and B cells in HIV-1 infected individuals may affect the response to HBV vaccine. The general objective of this thesis was ...

    • Tumor microenvironment : the paradoxical action of fibroblasts 

      Alkasalias, Twana (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-22)
      The term tumor refers to an abnormal and pathological tissue characterized by a massive cell growth; it comprises various populations of transformed and malignant cells. These cells cross-communicate with each other and ...

    • Receptor localization and dynamics of murine natural killer cells at single cell level : using advanced fluorescence microscopy 

      Bagawath Singh, Sunitha (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-21)
      Natural Killer (NK) cells are immune cells and important for the defense against virally infected and malignant cells. NK cells are regulated by germline encoded activating and inhibitory receptors. Activating receptors ...

    • In vivo bioluminescence imaging in preclinical trials of genetic vaccines 

      Petkov, Stefan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-15)
      DNA immunization is a rapidly developing vaccine platform for infectious diseases, cancer and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of ...

    • Studies on the role of SOCS3 and STAT3 in development and function of the immune system 

      Gao, Yu (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-11-27)
      The immune system is composed of an innate and an adaptive response that protects us from the microbial attacks. The innate system provides a fast defense against infection. However, many microbes evade or overwhelm the ...

    • Immune responses against tumors controlled by the actin cytoskeleton : lessons from primary immunodeficiencies 

      Kritikou, Joanna Sara (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-10-11)
      The actin cytoskeleton and its regulators are vital for cellular processes such as cell motility and immune synapse formation. In this study, the aim was to dissect the role of two of those regulators, WASp and MKL1, in ...

    • Exploring the role of p73-isoforms during tumor development 

      Sakil, Habib Abdullah Mohammad (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-09-28)
      The p73 gene was first discovered in 1997 as a family member of p53, and since then this gene has been studied extensively in cancer biology. Among its two main classes of isoforms, TAp73 acts as a tumor suppressor, while ...