Doktorsavhandlingar / Doctoral Theses - C1 (MTC): Recent submissions

Now showing items 121-140 of 514

    • Germinal centers : why and why not? The humoral response in primary immunodeficiency 

      Dahlberg, Carin (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-02-06)
      An efficient and regulated immune system is required for protection against pathogens. B cells are required for a humoral response. For a sustained humoral response against pathogens germinal center (GC) reactions are ...

    • Employing epigenetic marks to detect cancer : studies on nasopharyngeal carcinoma and lung cancer 

      Nawaz, Imran (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-02-02)
      Tumor suppressor genes (TSGs) or oncogenes aberrantly methylated in transcription control regions during early carcinogenesis are potential tools for early detection of cancer. We have identified suitable genes and explored ...

    • Regulation of bacterial adaptive behavior by the second messenger cyclic-di-GMP and host components 

      Le Guyon, Soazig (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-01-15)
      To optimize survival and growth, bacteria have evolved adaptive behaviors that respond to relevant environmental signals. A switch from the motile to the sessile lifestyle is probably the most ancient behavioral transition ...

    • Crimean-Congo hemorragic fever virus : studies on molecular pathogenesis and host-cell interactions 

      Karlberg, Helen (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-01-12)
      Crimean-Congo haemorrhagic fever (CCHF) disease in humans shows a spectrum of severity, from mild to acute. The pathogenesis of this and other viral haemorrhagic fevers (VHF) is associated with alteration of vascular barrier ...

    • Angiogenesis modulates obesity and insulin sensitivity 

      Honek, Jennifer (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2014-12-17)
      Both white and brown fat are highly vascularized tissues and vascular functions in adipose tissues remain largely unknown. In this thesis work, we aimed to study blood vessels in modulation of adipose tissue functions under ...

    • Folding and retention of rotavirus glycoproteins in the endoplasmic reticulum 

      Mirazimi, Ali (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-05-19)
      The endoplasmic reticulum (ER) is a membrane bound organelle composed of a network of cisternae stretching throughout the cytoplasm. Functionally, the ER performs many essential processes, such as glycosylation, and ...

    • HIV-1 infection in Tanzania with special reference to early diagnosis in children and preparations for vaccine trials 

      Lyamuya, Eligius Francis (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-05-18)
      The studies reported in this thesis aimed at identifying simple, suitable and affordable assays for HIV monitoring and for early diagnosis in children, and establishing the suitability of a potential cohort for HIV vaccine ...

    • p53 functional loss by mutation and p53 antagonizing proteins during tumor development 

      Wang, Qian (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-05-04)
      p53 is the most common target for genetic alterations in human cancers. Inactivation of wild type p53 function by point mutation, deletion or complexing with antagonizing proteins such as MDM2 and DNA tumor viral oncoproteins, ...

    • Methods for detection of HIV-2/SIV infections 

      Walther Jallow, Lilian (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-05-05)
      The main objective of this thesis was to develop and improve laboratory methods for detection of HIV-2 in infected humans and detection of HIV-2/SIV in experimentally infected cynomolgus monkeys. Early in the HIV epidemic ...

    • Biochemical and epidemiological characterization of serogroup C rotavirus 

      Nilsson, Mikael (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-05-03)
      Rotaviruses are classified into seven serogroups (A-G) on the basis of antigenic and genetic properties. Group A rotavirus is the most common cause of diarrhea in infants and young children in both developing and developed ...

    • The HER2/neu oncoprotein and dendritic cells in immunity against tumors 

      Rongcun, Yang (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-03-24)
      It is now well established that small peptide epitopes bound to the major histocompatibility complex (MHC), derived from processed proteins synthesized by the tumor cells, can be recognized as antigens by cytotoxic T ...

    • Glycoprotein B of human cytomegalovirus : target for neutralising antibodies, ligand for cellular receptors, inducer of autoimmunity? 

      Silvestri, Michel (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-04-06)
      Human cytomegalovirus (HCMV), a member of the Herpesviridae, is widespread in humans, causing persistent infections mostly without any clinical symptoms. However in immunosuppressed individuals HCMV still represents a ...

    • Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults 

      Björndal, Åsa (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-02-04)
      Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and ...

    • Carbohydrate-mediated adhesion in Plasmodium falciparum malaria 

      Barragan, Antonio (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2000-02-02)
      Characterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected ...

    • Suppressive DNA vaccination in experimental autoimmune encephalomyelitis 

      Lobell, Anna (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-11-26)
      This thesis describes the development of a novel method to suppress an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), by vaccination with DNA encoding autoantigenic peptides. DNA ...

    • Leishmania and HIV-1 interaction : immunopathogenic mechanisms 

      Wolday, Dawit (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-12-27)
      Both Leishmania and HIV can infect and multiply in macrophages, and both can dysregulate the T-helper (Th) immune system. This thesis was, therefore, undertaken to unravel some of the underlying immunopathogenic mechanisms ...

    • Mechanisms of immune dysfunction in human lymphomas 

      Sjöberg, Jan (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-11-26)
      Accumulating data suggest that tumor-induced immune dysfunction counteracts presumptively efficient tumor-specific immune responses, and thus contributes to disease progression. In the present work, focus was given on ...

    • Immunity and immunosuppression in the tumor-host interaction 

      Petersson, Max (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-11-25)
      With the advent of new methods in molecular biology and in peptide isolation, a number of tumor-associated antigens and their epitopes have been identified and characterized. However, tumors often grow progressively evolving ...

    • Glucocorticoid in T cell differentiation 

      Xue, Yintong (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-11-23)
      Thymocytes differentiate into mature T cells with an immunological restriction for self major histocompatibility complex (MHC) antigens. Cells that do not recognize self MHC expressed on thymic epithelial cells (TEC) die ...

    • Chronic hepatitis B : immunological, virological and clinical aspects in the natural course and during the combined prednisolone and interferon-alpha-2b therapy 

      Fei, Guo-Zhong (Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-11-15)
      The aims of this study were to characterize the IgM and IgG antibody responses to well-defined B-cell epitopes within the preS2 region of the HBV envelope proteins in sera from Chinese and Caucasian patients with chronic ...