Doktorsavhandlingar / Doctoral Theses - C1 (MTC): Recent submissions
Now showing items 141-160 of 514
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Genetic vaccination against acute viral disease
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-11-12)This thesis describes the development of recombinant vaccines based on the Semliki Forest virus (SFV) expression system. Immunisation of mice with recombinant virus particles, a layered DNA/RNA plasmid vector, and recombinant ... -
Molecular and cellular mechanisms during adherence and cell signaling of pathogenic Neisseria to host cells
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-11-11)The pathogenic members of the genus Neisseria include N. gonorrhoeae and N. meningitidis. Both organisms are obligate human pathogens that colonize mucosal surfaces. Pili, long hair-like structures that extend from the ... -
Studies in DNA immunization
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-10-29)This thesis describes investigations and developments of DNA immunization techniques, which were applied in the study of two different pathogens; HIV-1 and Chlamydia pneumoniae. DNA vaccines, i.e. naked plasmid DNA encoding ... -
Type-specific human papillomavirus antibodies : detection, characterization and application in seroepidemiology
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-11-05)Background: Human Papillomavirus (HPV) is a sexually transmitted DNA virus that causes several human cancers, notably cervical and other anogenital cancers. The antibody response to this virus is of interest both because ... -
Natural killer cell tolerance : influence of the MHC class I expression in the host
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-10-22)Development of self-tolerance in the immune system is characterized by somatic processes aiming at permanently eliminating, or silencing, potentially autoreactive lymphocytes. Such tolerance mechanisms are of outmost ... -
Drug resistance in mycobacterium tuberculosis
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-10-28)Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find ... -
Innate and acquired immunity to Leishmania in humans : the role of the host versus the parasite
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-10-01)Leishmania are intracellular protozoan parasites of macrophages which induce chronic diseases in man. The study of this parasite has been instrumental in elucidating many facets of the immune system. Our study set out to ... -
Mechanisms of immune escape in EBV associated malignancies : Hodgkin's disease and Burkitt's lymphoma
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-09-10)The work presented in this thesis is focused on the analysis of the mechanisms operating in the immune escape of two Epstein-Barr virus (EBV) associated tumors: Hodgkin's Disease (HD) and Burkitt's lymphoma (BL). EBV ... -
HIV-1 and HIV-2 infections in Guinea-Bissau, West Africa : studies of immune responses, prevailing viruses and epidemiological trends
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-09-17)This thesis encompasses immunological, virological and epidemiological studies of HIV-1 and HIV-2 infections in Guinea-Bissau. We have established a robust and reliable diagnostic strategy based on a combination of ... -
Nucleator-driven assembly of curli organelles and their pathophysiological role in E. coli septic shock
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-09-10)The understanding of how polymeric surface structures are assembled in bacteria is one of general interests, which can provide insight into details of macromolecule interactions, and study how proteins fold into domains ... -
Lymphoid development and function in MHC class I deficient mice
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-09-03)MHC class I molecules present short peptide fragments, derived from proteins synthesized in the cytosol, to specific CTL. The MHC class I molecule is a heterotrimer encompassed of a polymorphic transmembrane glycoprotein ... -
CD8+ T cell specificity in thymic selection and in the recognition of antigen
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-08-27)Specificity mediated by the T cell receptor (TCR) is of fundamental importance for the ability of T cells to function, and regulate humoral immunity and effector mechanisms of the innate immune system. T cells recognize ... -
Immune and gene therapies for cancer and infectious diseases
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-08-10)Annually more than 20 million deaths are globally caused because of infections or cancer. This accounts for 41.5% of annual deaths. New techniques are supposed to constitute our tools in the fight against these types of ... -
Interaction between gastric pathogen Helicobacter pylori and host cells
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-08-09)H. pylori plays a causative role in the pathogenesis of gastritis, gastric atrophy, gastric and duodenal ulcer, and is believed to predispose to gastric adenocarcinoma as well as low-grade B-cell lymphoma. Lewisb ... -
Significance of HIV-1 genetic subtypes
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-04-30)The human immunodeficiency virus type 1 (HIV-1) displays high genetic variability. Phylogenetic studies have shown that a majority of HIV-1 sequences cluster into one large group called M (major), whereas a few are clearly ... -
T cell antigen receptor usage, phenotype and cytokine production in human diseases
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-04-16)T lymphocytes are of critical importance for initiating and controlling immune responses, as the T cell receptor (TCR) for antigen allows a highly specific antigen recognition. Determination of TCR usage and characterization ... -
Taeniasis and cysticercosis in Honduras : epidemiological, serological, and clinical aspects
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1999-01-15)Taenia solium taeniasis and cysticercosis are recognised as important and increasing public health problems in Latin America. These infections not only have a significant socio-economical impact due to chronic morbidity, ... -
Early events of EBV mediated B cell transformation
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1998-12-24)Epstein-Barr virus (EBV) efficiently immortalizes B cells in vitro leading to the establishment of lymphoblastoid cell lines (LCLs). Genes encoding RB and p53 are frequently deleted or mutated in human tumors. EBV immortalized ... -
T-cell mediated control of Epstein-Barr virus infection : viral mechanisms of immune escape
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 1998-12-31)Mechanisms regulating the immunogenicity of Epstein-Barr Virus (EBV)-encoded CTL peptide epitopes and their contribution to the escape of virus infected cells from CTL-mediated immunosurveillance were the subject of these ... -
Giardiasis in Leon, Nicaragua : prevalence and protection
(Institutionen för mikrobiologi, tumör- och cellbiologi / Department of Microbiology, Tumor and Cell Biology, 2006-11-20)Giardia intestinalis is endemic in Nicaragua and affects children early in their lives. Infected individuals may be asymptomatic or suffer from acute or chronic diarrhea, malabsorption and weight loss. The prevalence of ...