Bleeding in abdominal aortic aneurysm repair
Author: Montán, Carl
Date: 2015-05-29
Location: Rehabsalen, Norrbackainstitutet, Karolinska Universitetssjukhuset
Time: 09.00 2015.05.29
Department: Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery
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Thesis (20.36Mb)
Abstract
Background and aims: Massive bleeding in open abdominal aortic aneurysm (AAA) repair is associated with worse outcome. However, few studies have investigated specific problems related to perioperative bleeding and blood transfusion in elective or emergent AAA repair with open (OR) or endovascular (EVAR) aneurysm repair. The overall aim of this thesis project was to investigate the clinical problem of bleeding in open and endovascular repair in both ruptured and elective AAA, including treatment of bleeding and association to risk factors and outcome in this patient group.
Patients and Methods: The studies were retrospective and based on medical records (all) and regional and national registries (Papers II-IV). Paper I studied the Fascia Suture Technique (FST) as closure method for hemostasis in 160 femoral access sites after EVAR in AAA patients. Paper II investigated ruptured (rAAA) and non-rAAA cases undergoing EVAR in 525 patients. Perioperative bleeding and the association to mortality and morbidity was investigated. Paper III investigated preoperative coagulation tests and their association to preoperative hypotension and perioperative bleeding and outcome in 91 rAAA patients. Paper IV studied blood transfusion in 369 ruptured AAA (rAAA) patients undergoing OR or EVAR. Timing of blood transfusion and time dependent ratios of blood products were studied and related to method of repair and outcome.
Results: In Paper I FST was associated with a 91% success rate. Complications were two pseudoaneurysms (PA) at 30-day follow-up and nine <1cm PA at 1-year. No specific preoperative risk factor for failure of the method was found. In Paper II a perioperative bleeding of >2 liters was independently associated with increased mortality (non-rAAA patients odds ratio 30; 95% CI [3.6, 145], rAAA patients odds ratio 10.7; 95% CI [3.2, 36.1]) and morbidity in non- and rAAA cases. Open femoral access, branched EVAR and larger diameter introducers were associated with increased perioperative blood loss. In Paper III low preoperative fibrinogen concentration (<1.5 g/L) was significantly associated with preoperative hypotension (systolic blood pressure <70 mmHg), increased perioperative bleeding and worse outcome after rAAA. In Paper IV delayed platelet transfusion (>1h) was associated with increased mortality in rAAA patients requiring massive transfusion (>10 units within 24 h or 4 units within 1 h). Fifty-five percent of rAAA patients repaired by EVAR received massive transfusion. Transfusion ratios of 1:1 for fresh frozen plasma (FFP):red blood cells (RBC) were associated with lower mortality. Ratios of platelets (PLT):RBC increased significantly over the study period.
Conclusions: • Fascia Suture Technique proved feasible and safe with a low complication rate. Introducer size had no impact on outcome. No preoperative risk factors for failure were found. • A perioperative blood loss exceeding 2 liters in EVAR was independently associated with increased mortality and morbidity in both acute and elective AAA patients. Procedural risk factors for increased perioperative bleeding were open femoral access, fascia suture technique, branched stent grafts and aneurysm diameter. • Preoperative fibrinogen concentrations below 1.5 g/L were associated with a ten-fold increased risk of perioperative bleeding of more than 2 liters in rAAA. Low fibrinogen concentration should be suspected in patients with preoperative hypotension. • A ratio FFP: RBC close to 1:1 in EVAR and open repaired patients was associated with lower mortality. • Delayed (>1h) platelet transfusion was associated with significantly increased mortality. Ratios of PLT:RBC have increased over the last years. • Transfusion strategies in patients undergoing rAAA treatment with EVAR or open repair need further research. Also the definitive role of fibrinogen in patients with rAAA and hemodynamic shock need to be investigated in future studies.
Patients and Methods: The studies were retrospective and based on medical records (all) and regional and national registries (Papers II-IV). Paper I studied the Fascia Suture Technique (FST) as closure method for hemostasis in 160 femoral access sites after EVAR in AAA patients. Paper II investigated ruptured (rAAA) and non-rAAA cases undergoing EVAR in 525 patients. Perioperative bleeding and the association to mortality and morbidity was investigated. Paper III investigated preoperative coagulation tests and their association to preoperative hypotension and perioperative bleeding and outcome in 91 rAAA patients. Paper IV studied blood transfusion in 369 ruptured AAA (rAAA) patients undergoing OR or EVAR. Timing of blood transfusion and time dependent ratios of blood products were studied and related to method of repair and outcome.
Results: In Paper I FST was associated with a 91% success rate. Complications were two pseudoaneurysms (PA) at 30-day follow-up and nine <1cm PA at 1-year. No specific preoperative risk factor for failure of the method was found. In Paper II a perioperative bleeding of >2 liters was independently associated with increased mortality (non-rAAA patients odds ratio 30; 95% CI [3.6, 145], rAAA patients odds ratio 10.7; 95% CI [3.2, 36.1]) and morbidity in non- and rAAA cases. Open femoral access, branched EVAR and larger diameter introducers were associated with increased perioperative blood loss. In Paper III low preoperative fibrinogen concentration (<1.5 g/L) was significantly associated with preoperative hypotension (systolic blood pressure <70 mmHg), increased perioperative bleeding and worse outcome after rAAA. In Paper IV delayed platelet transfusion (>1h) was associated with increased mortality in rAAA patients requiring massive transfusion (>10 units within 24 h or 4 units within 1 h). Fifty-five percent of rAAA patients repaired by EVAR received massive transfusion. Transfusion ratios of 1:1 for fresh frozen plasma (FFP):red blood cells (RBC) were associated with lower mortality. Ratios of platelets (PLT):RBC increased significantly over the study period.
Conclusions: • Fascia Suture Technique proved feasible and safe with a low complication rate. Introducer size had no impact on outcome. No preoperative risk factors for failure were found. • A perioperative blood loss exceeding 2 liters in EVAR was independently associated with increased mortality and morbidity in both acute and elective AAA patients. Procedural risk factors for increased perioperative bleeding were open femoral access, fascia suture technique, branched stent grafts and aneurysm diameter. • Preoperative fibrinogen concentrations below 1.5 g/L were associated with a ten-fold increased risk of perioperative bleeding of more than 2 liters in rAAA. Low fibrinogen concentration should be suspected in patients with preoperative hypotension. • A ratio FFP: RBC close to 1:1 in EVAR and open repaired patients was associated with lower mortality. • Delayed (>1h) platelet transfusion was associated with significantly increased mortality. Ratios of PLT:RBC have increased over the last years. • Transfusion strategies in patients undergoing rAAA treatment with EVAR or open repair need further research. Also the definitive role of fibrinogen in patients with rAAA and hemodynamic shock need to be investigated in future studies.
List of papers:
I. Short- and Midterm Results of the Fascia Suture Technique for Closure of Femoral Artery Access Sites After EndovascularAneurysm Repair. Carl Montán, Leena Lehti, Jan Holst, Katarina Björses and Timothy A. Resch. Journal of Endovascular Therapy, December 2011, Volume 18, Number 6, Pages 789-796
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II. Perioperative Hemorrhage in Endovascular Abdominal Aneurysm Repair Affects Outcome Carl Montán, Marcus Wannberg, Jan Holst and Carl Magnus Wahlgren European Journal of Vascular and Endovascular Surgery, July 2013, Volume 46, Issue 1, Pages 87–92
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III. Preoperative hypofibrinogenemia is associated with increased intraoperative bleeding in ruptured abdominal aortic aneurysms Carl Montán, Fredrik Johansson, Ulf Hedin and Carl Magnus Wahlgren Thrombosis Research, March 2015, Volume 135, Issue 3, Pages 443-448
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IV. Massive blood transfusion in patients with ruptured abdominal aortic aneurysms Carl Montán, Ulf Hammar, Agneta Wikman, Eva Berlin, Jan Holst, Jonas Malmstedt and Carl Magnus Wahlgren [Manuscript]
I. Short- and Midterm Results of the Fascia Suture Technique for Closure of Femoral Artery Access Sites After EndovascularAneurysm Repair. Carl Montán, Leena Lehti, Jan Holst, Katarina Björses and Timothy A. Resch. Journal of Endovascular Therapy, December 2011, Volume 18, Number 6, Pages 789-796
Fulltext (DOI)
Pubmed
View record in Web of Science®
II. Perioperative Hemorrhage in Endovascular Abdominal Aneurysm Repair Affects Outcome Carl Montán, Marcus Wannberg, Jan Holst and Carl Magnus Wahlgren European Journal of Vascular and Endovascular Surgery, July 2013, Volume 46, Issue 1, Pages 87–92
Fulltext (DOI)
Pubmed
View record in Web of Science®
III. Preoperative hypofibrinogenemia is associated with increased intraoperative bleeding in ruptured abdominal aortic aneurysms Carl Montán, Fredrik Johansson, Ulf Hedin and Carl Magnus Wahlgren Thrombosis Research, March 2015, Volume 135, Issue 3, Pages 443-448
Fulltext (DOI)
Pubmed
View record in Web of Science®
IV. Massive blood transfusion in patients with ruptured abdominal aortic aneurysms Carl Montán, Ulf Hammar, Agneta Wikman, Eva Berlin, Jan Holst, Jonas Malmstedt and Carl Magnus Wahlgren [Manuscript]
Institution: Karolinska Institutet
Supervisor: Wahlgren, Carl Magnus
Issue date: 2015-05-06
Rights:
Publication year: 2015
ISBN: 978-91-7549-951-2
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