Doktorsavhandlingar / Doctoral Theses
Recent Submissions
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Maternal mental health matters : childbirth related care in Yemen seen through women’s eyes
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2018-05-23)Background: Yemen has a high maternal mortality and a persistent high home birth rate. Though maternal mortality still lies at the heart of maternal health indicators, there is a growing concern about the impact of mental ... -
Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 Diabetes Mellitus
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-23)microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to ... -
Interneuron diversity and function in the zebrafish locomotor circuits
(Inst för neurovetenskap / Dept of Neuroscience, 2018-05-23)One of the most essential features of an animal’s behavior is the ability to navigate and interact with its environment. The generation of the locomotor rhythm is carried out by networks of neurons in the spinal cord, so ... -
Severe obesity in young adults : characterization and treatment outcomes with emphasis on mental health aspects
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-05-23)Background: Obesity (body mass index [BMI] ≥30 kg/m2) is associated with a range of physical and psychiatric comorbidities and premature mortality. Young adulthood (here 16-25 years) constitutes a vulnerable period for ... -
Profiling and exploiting lipid-based nanoparticles in vitro and in vivo
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-05-22)One of the major hurdles for therapeutic applications is the efficient delivery of bioactive molecules to the site of action. The high flexibility and biosafety of lipid-based nanoparticles has greatly enhanced their ... -
Pneumococcal interactions with the host : threats and therapeutic approaches
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2018-05-22) -
Hepatic 3D spheroids as a model system for drug-induced liver injury and cytochrome P450 induction
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-21)Drug-induced liver injury (DILI) is a major cause of post-marketing drug withdrawals and restricted-use warnings. In addition, unexpected adverse hepatic drug reactions occurring in the clinical phases of development are ... -
Socioeconomic development initiatives and women’s welfare in rural Bangladesh
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2018-05-21)Background: Socioeconomic development initiatives (SDIs) are not only regarded as vehicles for poverty eradication but as promotion of women‟s welfare in terms of their economic independence, empowerment, and safety from ... -
Impact of chronic kidney disease on the cardiovascular system : studies in non-dialysis patients and healthy people
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-21)Background: Cardiac and arterial remodeling and stiffening occur in end-stage renal disease. The presence of cardiovascular (CV) alterations in earlier-stage chronic kidney disease (CKD) is less well studied. We evaluated ... -
Aspects of fracture risk in elderly women
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-05-18)The main purpose of this thesis was to identify and further specify factors relevant for the assessment of fracture risk. The studies were conducted on two different cohorts of elderly women. The Osteoporosis Prospective ... -
Cellular and network mechanisms in neurodegenerative disorders : neurotoxicity and rescue strategies
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2018-05-17)The brain can be described as a complex network and its functioning depends on an efficient communication between all its components. Large-scale communication is made possible by neuronal-network oscillations. Oscillations ... -
Development of multi-cellular human lung models to study inflammatory mechanisms and cell-cell interactions
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-05-17)It is well known that exposure to toxicants in the environment is associated with a wide range of health effects. The airway epithelium which forms the first line of defense, plays critical roles in the defence against ... -
Neuroimmune mechanisms in chronic inflammation : translational studies of the inflammatory reflex
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-05-16)A functional immune system is crucial for our survival from the pathogens and toxins we are constantly subjected to. For reasons only partially understood, in some individuals the immune response instead target self antigens, ... -
Improving the quality of care for hip fracture patients : studies on fast-track to surgery and adverse events
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-16)Hip fractures in the elderly are common and are associated with high comorbidity and mortality. Their care and treatment present challenges for nurses and other healthcare professionals and impose a substantial burden on ... -
Determinants of interval cancer and tumor size among breast cancer screening participants
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-05-15)Breast cancer is the most common cancer of women in Sweden and globally. In the more affluent countries, mammography screening has been in place for a few decades and has successfully reduced mortality. However, there ... -
Striatal glutamatergic neurotransmission and plasticity in Parkinson's disease and aging
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2018-05-15)Parkinson's disease (PD) is a devastating neurodegenerative disorder with aging as the main risk factor. PD is characterized by severe movement disturbances but is also associated with non-motor symptoms. Affected motor ... -
Effectiveness and cost-effectiveness of early childhood obesity prevention
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2018-05-15)Background: Due to individual health-related and social consequences, but also due to its immense cost burden, obesity remains a large public health challenge for which effective and cost-effective prevention is lacking. ... -
Platelet function and thrombin generation in ischemic stroke : clinical correlates and prognostic importance
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-05-15)Platelet function is central to atherothombotic diseases and antiplatelet agents prevent non-cardioembolic ischemic stroke (IS). Individual differences in platelet reactivity may limit the response to antiplatelet treatment, ... -
Magnetic resonance imaging and spectroscopy in at-risk populations and preclinical Alzheimer's disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2018-05-15)Alzheimer’s disease (AD) is the most common form of dementia. One of the earliest and most distinct features of AD is memory loss, followed by difficulties in learning and a decline in cognitive abilities. People afflicted ... -
Coronary care networks in the resource-limited setting : systems of care in South Africa
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2018-05-15)BACKGROUND: Owing to an epidemiological transition observed throughout Sub- Saharan Africa, South Africa is experiencing an increase in the incidence of myocardial infarction. ST-elevation myocardial infarction (STEMI) ...