Doktorsavhandlingar / Doctoral Theses
Recent submissions
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Recruitment to multicentre randomised controlled trials in stroke : lessons learnt from the effects trial
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-26)Randomised controlled trials are the gold standard for evaluation treatments. Nevertheless, recruitment into trials is still challenging and many trials fail to meet their recruitment goals within the predetermined time. ... -
Immunopathogenesis in pulmonary tuberculosis : impact of immunomodulation and diabetes co-morbidity
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2021-02-26)Even in the 21st century, tuberculosis (TB) remains a major global health threat, primarily due to the emergence of antibiotic resistance. Presence of co-morbidities such as diabetes mellitus (DM) has worsened the current ... -
Clinical aspects of device-detected arrhythmias
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2021-02-25)INTRODUCTION Cardiac implantable electronic devices (CIEDs) enable continuous monitoring of the heart rhythm. CIEDs constitute a unique opportunity for detecting arrhythmias, as the duration of cardiac monitoring is of ... -
Selenium compounds as a novel class of experimental cancer chemotherapeutics
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-02-25)Selenium is an essential micronutrient for humans, it has a narrow margin between antioxidant and pro-oxidant effects. Redox-active selenium compounds have the potency to increase ROS levels in cancer cells, providing a ... -
Method Development for [11C]carbon monoxide radiochemistry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-25)Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found extensive utility in biomedical research and in drug development. A fundamental pre-requisite for PET is the tracer, which is ... -
Risks and benefits of drinking water treatment : focusing on child health and prenatal development
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-02-24)Drinking water is our most important food item and its access is indispensable for a wellfunctioning society. Recent Swedish water-borne outbreaks have demonstrated a system vulnerability and a clear need for improved ... -
Molecular markers for prediction of response and progression free survival to novel therapies in cutaneous malignant melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-22)Drugs inhibiting the MAPK-pathway (MAPKi) and immune checkpoint inhibitors (ICI) have changed the clinical outcome of metastatic cutaneous malignant melanoma (CMM) in a significant way. Nonetheless, many patients have ... -
Adaptation of salmonella enterica to antibiotics and innate immunity effectors
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2021-02-22)Salmonella enterica is a bacterial pathogen causing major morbidity and mortality in low- and middle-income countries. The bacteria can cause a wide range of disease, ranging from the severe systemic disease typhoid fever ... -
The necessity to consider visual dysfunctions after acquired brain injury
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2021-02-19)Visual information is processed in wide and extensive networks in the brain, and forms part of executive functions, emotions and memories. An acquired brain injury (ABI) often brings about a disruption of these networks ... -
Positron emission tomography studies of the D1 dopamine receptor in schizophrenia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-19)This thesis is based on investigations of central D1-dopamine receptor (D1R) binding in vivo using positron emission tomography (PET). The aims were i) to examine the antipsychotic effect of a D1R antagonist in schizophrenia ... -
Repopulation of a microglia-depleted central nervous system : molecular characterization during homeostasis and disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-19)Microglia are predominant tissue resident macrophages within the central nervous system (CNS), and contribute to both CNS development and homeostasis. During disease conditions microglia undergo transcriptional re-programming ... -
Neurophysiological conditions for hearing in children using hearing aids or cochlear implants : an intervention and follow-up study
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-19)OBJECTIVES The four studies in this thesis examine the central auditory pathways in children with hearing loss (HL) through recording event-related potentials (ERP) and mismatch negativity (MMN). The design of the ... -
Chlamydia trachomatis infection in Sweden : time trends, risk factors, and prevalence
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-02-18)Chlamydia trachomatis (chlamydia) infection is the most common bacterial sexually transmitted infection (STI), with an estimated 127 million new cases occurring every year worldwide. Due to the asymptomatic nature of the ... -
Advancing the measurement of sedentary behaviour : classifying posture and physical (in-)activity
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-02-18)Sedentary behaviour, defined by a sitting body posture with minimal-intensity physical activity, is an emergent public health topic. The time spent sedentary is associated with the incidence of non-communicable chronic ... -
From patient to person : perspectives on the role of quality data, patient experience and patient involvement in the improvement of chronic care
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2021-02-18)Introduction. Healthcare systems in many countries face numerous challenges including the increase in the number of chronic health conditions, the expectations that significant advances in healthcare and technology imposes, ... -
Demand and capacity imbalance in the emergency department, and patient outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2021-02-16)Background An emergency department (ED) is always open and continuously needs to balance the inflow and demand for emergency service with available capacity. When demand exceeds the available capacity of an ED, it ... -
Complications following anterior cruciate ligament reconstruction
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-16)Background: Venous thromboembolism (VTE) and septic arthritis (SA) are two rare complications following anterior cruciate ligament reconstruction (ACLR). Due to their rare incidence, risk factors and outcome are difficult ... -
Mechanisms of cancer cell death by mutant p53-reactivating compound APR-246
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-11)Tumor suppressor TP53 is the most frequently mutated gene in cancer. A majority of TP53 mutations result in a mutant p53 that disrupts its DNA binding capabilities but may also acquire novel gain-of-function activities ... -
To be a child and survive a natural disaster
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-02-09)Introduction: Despite the fact that children or adolescents often are exposed to disasters, we do not know what happens to these children or adolescents in the end. Much of the international research has been concerned ... -
Aspects on advanced procedures during endoscopic retrograde cholangiopancreatography (ERCP) for complex hepatobiliary disorders
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-08)Background: The rapid development in endoscopic technology and associated skills has led to an increase in more advanced procedures being performed during endoscopic retrograde cholangiopancreatography (ERCP). Knowledge ...