Doktorsavhandlingar / Doctoral Theses
Recent Submissions
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A register-based study of health equity in Swedish stroke and diabetes care delivery
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-01-18)Stroke and diabetes are relatively common conditions and have a huge impact on society’s burden of illness; over 400 million people around the world live with diabetes and 15 million have a stroke every year. Estimates on ... -
Clinical translation of a regeneration strategy for spinal cord injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-01-18)The complex and vulnerable tissue of the spinal cord does not heal after injury, leaving patients with lifelong disability after spinal cord injury (SCI). Many milestones have been reached during the last century through ... -
Quality of life and sexual health among transgender people and people living with HIV in Sweden
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2019-01-18)Background: The overarching objective of public health policy in Sweden has a clear focus on equitable health throughout the population and includes a commitment to reduce avoidable health inequalities. Trans (transgender) ... -
More than a foot : gait, gross motor skills, neurodevelopmental difficulties and health-related quality of life in children with idiopathic clubfoot
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-01-17)Introduction: Idiopathic clubfoot (IC) is one of the most common congenital musculoskeletal deformities and can affect one or both feet of the child. However, knowledge beyond the structural deformity is still limited. ... -
Outcome after surgery for isthmic spondylolisthesis and degenerative disc disease
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-01-17)Individuals with isthmic spondylolisthesis and lumbar degenerative disc disease may have low back and leg pain. Those with persistent symptoms non-responsive to conservative treatment are sometimes treated surgically. ... -
The role of SUMO pathway in pathophsiology of skeletal muscle
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-01-17)Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino ... -
Screening strategies for dysglycaemia in relation to cardiovascular risk
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-16)Background: Dysglycaemia, defined as type 2 diabetes (T2DM) or impaired glucose tolerance (IGT), is a major risk factor for cardiovascular disease (CVD). Dysglycaemia and CVD together account for more than half of worldwide ... -
The role of growth factors in white fat browning and metabolic disease
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-01-16)The adipose tissue is composed of a variety of cell types that constantly cross-communicate with each other to allow the tissue to operate and to adapt to various external stimuli. The diversity of these cell populations ... -
The roles of microRNAs in skin wound healing
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-01-15)Skin is an essential biological barrier of the human body, and wound healing is the fundamental physiological process to keep its integrity. Chronic non-healing wounds are growing socioeconomic and health concerns, which ... -
Novel immunologic cellular mechanisms in atherosclerosis and potential therapeutic implications
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-01-15)Atherosclerosis, an arterial ailment, is a major cause of cardiovascular diseases (CVD), which cause more than 17 million deaths each year and the number is expected to rise. In recent years atherosclerosis has been shown ... -
Health economic aspects of low back pain
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2019-01-11)Four out of five people experience low back pain sometime during their lifetime. Problems of the back—and to a less extent of the neck—are consistently in the top seats among the most burdensome diseases in the developed ... -
Deciphering microglia plasticity in glioma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-01-11)Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can ... -
Abdominal aortic aneurysm : uncharted aspects of rupture
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-01-10)Unlike intact abdominal aortic aneurysm (iAAA), ruptured abdominal aortic aneurysm (rAAA) is a lethal condition demanding immediate resuscitation and surgical intervention. Where the former is a silent disease with slow ... -
Metabolic and pharmacokinetic study to enhance busulphan therapeutic efficacy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-01-09)Busulphan (Bu) is an alkylating agent used in high-doses as part of the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). HSCT is a curative treatment for hematological malignancies and other ... -
Transcriptional gene signatures : passing the restriction point for routine clinical implementation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-01-03)Uncontrolled cell growth and cell division are central to the process of tumorigenesis and a number of gene expression signatures have been developed based on genes that are involved in the cell cycle. Notably, gene ... -
The meaning of acceptance and body awareness for individuals living with long-term pain : implications for rehabilitation
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2018-12-28)Background: Chronic or long-term pain, usually defined as pain lasting at least three to six months, is generally understood as a multidimensional phenomenon, often requiring a multidisciplinary rehabilitation approach. ... -
Elucidating regulatory elements : studies in chronic lymphocytic leukemia and multiple myeloma
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2018-12-21)With next generation sequencing taking center stage in genetic and epigenetic research, its applications and challenges are many. This work revolves around the application of bioinformatics in different contexts: basic ... -
Utility of hybrid SPECT/CT in Sentinel Lymph Node mapping, and 18F FDG-PET/CT for treatment response evaluation in cancer patients.
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-12-21)The Sentinel Lymph Node Biopsy (SLNB) method is currently well established in the staging of clinically node-negative breast cancer. However, there is some debate concerning the reliability of this method following previous ... -
Evaluation of immunological markers for the diagnosis of active and latent tuberculosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-12-21)Tuberculosis (TB) is the single deadliest infectious disease in the world and around one fourth of the global population is estimated to be latently infected with Mycobacterium tuberculosis (Mtb). The World Health Organization ... -
Individually tailored internet-based treatment for depression and comorbid conditions
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-12-21)Background: Depression is a large societal problem. People suffering from depression are heterogeneous and have a high degree of comorbid conditions. Pharmacological treatment is widespread, but not effective for all ...