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  • Gastric bypass : positive and negative health effects 

    Backman, Olof (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2017-12-15)
    Obesity is a major health problem worldwide. It is preventable in theory, but in practice no country has been able to stop the development of increasing obesity. The only available treatment with sufficient long-term ...
  • Novel aspects of atherosclerosis : focusing on new target genes and the effect of cholesterol-lowering 

    Rossignoli, M. Aránzazu (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-12-15)
    Atherosclerosis is most often the main underlying cause of cardiovascular diseases (CVDs), accounting for more than 31% of all deaths worldwide. It is driven by the uptake of low-density lipoproteins (LDL) by a dysfunctional ...
  • In vivo bioluminescence imaging in preclinical trials of genetic vaccines 

    Petkov, Stefan (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-12-15)
    DNA immunization is a rapidly developing vaccine platform for infectious diseases, cancer and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of ...
  • Structural and functional basis of mitochondrial tRNA processing 

    Sridhara, Sagar (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-11-28)
    The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) ...
  • Attention deficit hyperactivity disorder in adults : neuropsychological deficits and functional Impairments 

    Holst, Ylva (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-11-28)
    The overall aim of the present thesis was to investigate the role of neuropsychological deficits in adult ADHD. Study I examined the psychometric properties of a new rating instrument, the Adult Executive Functioning ...
  • Studies on the role of SOCS3 and STAT3 in development and function of the immune system 

    Gao, Yu (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-11-27)
    The immune system is composed of an innate and an adaptive response that protects us from the microbial attacks. The innate system provides a fast defense against infection. However, many microbes evade or overwhelm the ...
  • Allosteric regulation of synaptic processes 

    Dutta Roy, Ranjita (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-27)
    Glutamatergic neurotransmission is of key importance for short-term and long-term plasticity in the hippocampus, a part of the medial temporal lobe which is responsible for processes of explicit semantic and spatial ...
  • Understanding the interplay between gut microbiota, gut function and host genes in the generation of gastrointestinal symptoms and disease 

    Hadizadeh, Fatemeh (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-11-27)
    Irritable bowel syndrome (IBS) is a multifactorial and complex disease categorized in the functional gastrointestinal disorders (FGIDs) with an intricate pathogenesis yet far from understood. The prevalence and burden ...
  • Effectiveness and equity of cervical cancer prevention : real-life evidence from organised programmes in Sweden 

    Wang, Jiangrong (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-11-27)
    Cervical cancer incidence has substantially declined since cervical screening was implemented five decades ago. The long-term hope of eliminating cervical cancer is promising with the development of effective Human ...
  • Epidemiologic studies on rheumatic muscle inflammation, myositis 

    Svensson, John (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-24)
    Observational study designs are often used in medical research. Swedish national registers have successfully been used as data sources for such observational studies in other rheumatic diseases. The Swedish health care ...
  • On functions of neurotrophic factors in taste buds and teeth 

    Vukmanovic Nosrat, Irina (Inst för neurovetenskap / Dept of Neuroscience, 2017-11-24)
    Background: Chemosensory disorders affect approximately 15% of the U.S. population and an estimated 200,000 individuals visit a doctor each year for problems with their ability to taste or smell (NIDCD). Among the common ...
  • Functional analysis of long non-coding RNAs in cancer 

    Vidarsdottir, Linda (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-11-24)
    For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives ...
  • Skeletal muscle plasticity and energy metabolism 

    Lundell, Leonidas S (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-11-24)
    Skeletal muscle is remarkable in its ability to adjust to our needs. It can change its energy stores and usage, as well as its total mass. Furthermore, skeletal muscle adapts to deactivate reactive oxygen species produced, ...
  • Personality in relation to health, psychosocial work environment and occupational health intervention adherence 

    Villaume, Karin (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2017-11-24)
    Background: Personality is a well-studied topic within psychology and it has intrigued scientists and philosophers for centuries. It is a broad, complex and multidimensional phenomenon that constitute individuals’ typical ...
  • The use of antibiotic prophylaxis in implant dentistry : a microbiological and clinical perspective 

    Khalil, Dalia (Inst för odontologi / Dept of Dental Medicine, 2017-11-24)
    The current development of antibiotic resistance calls for prudent use of antibiotic prescription. Methods of investigating antibiotic overconsumption, include identifying areas of misuse or overuse, as well as implementing ...
  • Risk factors for autoimmune-mediated congenital heart block 

    Meisgen, Sabrina (Inst för medicin, Solna / Dept of Medicine, Solna, 2017-11-24)
    Placental transfer of maternal Ro/SSA and La/SSB autoantibodies during pregnancy is associated with conduction disturbances and inflammation in the developing fetal heart, termed autoimmune-mediated congenital heart block ...
  • Cognitive control in reinforcement learning : brain structure and function 

    Schiffler, Björn C. (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-11-23)
    Adapting behaviour according to internal or external feedback is a fundamental property of cognitive control. For example, humans tend to slow down when they make mistakes, a process called post-error slowing (PES), which ...
  • Prevention and prediction of adolescent problem behavior 

    Jalling, Camilla (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-11-23)
    Background: The adolescent period is characterized by a huge leap in social, emotional, and cognitive development. For most people, it passes without major disruptions, but for a substantial number of adolescents, it ...
  • Capturing the breath of the heart by magnetic resonance imaging : five-dimensional cardio-respiratory resolved cine imaging during free breathing 

    Holst, Karen (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-23)
    Cardiac imaging with cardiovascular magnetic resonance has the advantage of enabling dynamic visualizations, several quantifiable measures, and good soft-tissue contrast. However, a major drawback is the need for breath ...
  • Clinical decision-making in physiotherapy for low back pain in primary health care 

    Widerström, Birgitta (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-11-23)
    Background and Aims: Low-back pain (LBP) is a complex and heterogeneous disorder commonly encountered at physiotherapy clinics, with most cases associated with an unknown cause (NSLBP). Identifying LBP subgroups for ...

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