Doktorsavhandlingar / Doctoral Theses
Recent submissions
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Coordination of gene expression programs
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-01-24)Most cellular processes depend on the activity and interactions of proteins. The proteome, i.e. the entire set of proteins in a specific condition, is shaped by regulation of transcription, mRNA-degradation, -processing, ... -
Dihydroorotate dehydrogenase : new insights into an old target
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-01-24)Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. ... -
Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-01-23)BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic ... -
Traditional yoga and clinical burnout : quality of life and biomarkers before and after treatment
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2020-01-23)Background. Stress-related disorders including clinical burnout (CB) are one of the main causes of sickness absenteeism in many Western countries. Little is known about the situation of CB patients, and objective markers ... -
Organization of brain circuits that control motivated behaviors
(Inst för neurovetenskap / Dept of Neuroscience, 2020-01-22)Eudemonia (Greek: εὐδαιμονία) is an anthropocentric term describing the absolute well-being in the Aristotelian ethics, along with the terms “arête” (virtue) and “phronesis” (wisdom from an ethical and practical point ... -
Optimizing computed tomography : quality assurance, radiation dose and contrast media
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-01-22)Computed tomography (CT) is an important modality in radiology; it enables imaging of the inside of patients without superimposed anatomy. The radiation dose and quality of a CT image are highly dependent on the CT scanner, ... -
Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2020-01-17)The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. ... -
Mantle cell lymphoma : studies of predictive markers, the role of the microenvironment in disease development and identification of new potential targets for therapy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2020-01-16)Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma and accounts for 5-10 % of all non-Hodgkin lymphomas (NHL). In Sweden, the incidence of NHL is 21.6 and 15.3 per 100 000 persons for men and women, respectively, ... -
Cognitive behavioral therapy for stress-related disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-01-16)Background: Stress-related disorders in the form of adjustment disorder (AD) and exhaustion disorder (ED) are prevalent and associated with significant suffering, functional impairment and high societal costs. Cognitive ... -
Exploring paths to youth suicide and sudden violent death : a multimethod case-control investigation
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-01-16)Suicide and other forms of sudden violent death are the most common causes of death among young people worldwide. Both suicide and other forms of sudden violent death are more frequent among males than females. Risk ... -
Evaluation of prostheses in shoulder arthroplasty : methods for assessment of outcome
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-01-15)Today, the shoulder joint is the third most commonly replaced joint after the hip and knee joints and the incidence is increasing. In Sweden, 1863 primary Shoulder Arthroplasties and 195 revisions were performed in 2017. ... -
Demyelinating conditions regulated by ROS pathways outside and inside the brain
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-01-14)Multiple sclerosis (MS) is a chronic inflammatory condition of the central nervous system with immune-mediated damage on myelinated nerve tracts. Accumulating evidence support a role for autoreactive T-lymphocytes ... -
Ultrasound assessment and risk prediction in women with endometrial cancer
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2020-01-09)Background: Endometrial cancer is the most common gynecological cancer in the industrialized world, constituting 4.5% of all cancer in Swedish women. Standard surgery is hysterectomy and bilateral salpingo-oophorectomy, ... -
DNA methylation and aging : a longitudinal study of old Swedish twins
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-01-09)DNA methylation is a well-known biomarker of aging. Many previous studies have reported the change of DNA methylation patterns with age, and analyzed DNA methylation in association with aging outcomes. However, most ... -
Major lower limb amputation in peripheral arterial disease : treatment outcome, risk factors, and health-related quality of life
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-01-09)Critical limb ischemia is the end stage of peripheral arterial disease. These patients have a high risk of amputation and death regardless of revascularization. One of the most important questions for the patient and the ... -
Family-based prevention of childhood obesity : long-term outcomes, challenges and implications for future research
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-01-03)Background: Childhood obesity is considered to be one of the most serious health challenges of the 21st century. There have been indications that the prevalence has reached a plateau in high-income countries, yet the ... -
Retinal tumorigenesis and neurodegeneration : strategies to promote tumor cell death and support retinal cell survival to preserve vision
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-12-27)Our vision is central to our quality of life enabling us to interact with our environment and lead productive lives. The ability to see begins in the retina, one of the paramount features of the eye, as it takes on the ... -
The papilla of Vater : issues relevant to transpapillary cannulation and clinical management.
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-12-20)Background: Many endoscopists have since the beginning of endoscopic retrograde cholangiopancreatography (ERCP) commented on the variation in the macroscopic appearance of the papilla of Vater. How the macroscopic appearance ... -
Clinical, microbiological and immunological effects of antiseptics in periodontal treatment
(Inst för odontologi / Dept of Dental Medicine, 2019-12-19)Periodontal diseases are characterized by high prevalence in many populations and the chronic and progressive course of the disease. A fundamental stage of treatment is mechanical debridement of the tooth surface. During ... -
Brain immune mechanisms in schizophrenia : experimental and clinical characterization
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-12-19)The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine ...