• Metabolic effects and long-term safety of childhood growth hormone treatment 

  Tidblad, Anders (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-09-16)

  The overall aim of this thesis was to investigate the metabolic effects and long-term safety of childhood growth hormone (GH) treatment. In order to achieve this aim, the different projects consist of a two-part clinical ...

• Socioeconomic influences on late-life health and mortality : exploring genetic and environmental interplay 

  Ericsson, Malin (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-09-13)

  The objective of this thesis was to increase the understanding of socioeconomic differences in health and mortality in old age - in a genetically informative setting. Data from the Swedish Twin Registry (STR), different ...

• Cancer after bariatric surgery : risk and prognosis 

  Tao, Wenjing (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-09-13)

  Obesity is a major public health challenge with a rapidly growing prevalence worldwide. The condition increases the risk of multiple diseases, including cancer in different locations. Current evidence on the effect of ...

• Energy expenditure and accelerometer cut-points for sedentary behavior and physical activity in spinal cord injury : implication for guiding and prevention 

  Holmlund, Tobias (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-09-13)

  Background: A motor-complete spinal cord injury (SCI) alters the prerequisites for physical activity (PA) and subsequently energy expenditure. Persons with SCI above thoracic level six have a compromised physiological ...

• Single-stranded DNA : methods and application in nanotechnology 

  Bernardinelli, Giulio (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-09-13)

  Basic molecular and cell research, production of recombinant proteins, diagnostic detection of genetic mutations, construction of nanostructures and high-throughput DNA sequencing are only a few examples of the diverse set ...

• Dopamine, decision-making, and aging : neural and behavioural correlates 

  de Boer, Lieke (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-09-12)

  On any given day, we make tons of decisions. These can be as simple as deciding how to dress or what to eat, or more complex, such as whether to spend or invest money. Good decision-making involves being able to select the ...

• Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling 

  Arvidsson, Gustav (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-09-10)

  Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective ...

• Multiple sclerosis : from genetic variants to biomarkers 

  Bedri, Sahl Khalid (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-09-06)

  Multiple sclerosis (MS) is a common chronic autoimmune and neurodegenerative disease of the central nervous system (CNS). MS is a debilitating disease that affects young adults, especially females. Why we develop MS? Is ...

• Sickness & behavior in ME/CFS (Chronic Fatigue Syndrome) 

  Jonsjö, Martin (Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-09-06)

  Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic debilitating condition characterized by physical and mental fatigue with a heightened sensitivity to exertion. To date, the causes are ...

• Novel diagnostic methods for rapid characterization of extended-spectrum beta-lactamase- and carbapenemase-producing Enterobacteriaceae 

  Kabir, Muhammad Humaun (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-09-06)

  Klebsiella pneumoniae and Escherichia coli are two of the most clinically important pathogens of the family Enterobacteriaceae. Both can cause severe infections includ-ing urinary tract infections (UTI), bloodstream ...

• Somatic mutations in healthy cells and age-associated diseases 

  Helgadottir, Hafdis (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-09-05)

  Aging is a complex process that affects all living organisms. As we age, the biological functions are affected, resulting in a decline of the tissue and possibly age-related diseases. Several environmental and genetic ...

• Angiogenetic and hereditary factors in endometrial disease 

  Andersson, Emil (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-09-04)

  The endometrium is a unique tissue in the adult human body because it is the only site where physiological renewal of vessels, angiogenesis, occurs. The regulation of this process under normal conditions is not fully ...

• Mechanisms of resident T cell-driven tissue responses during the onset and recurrence of human skin inflammation 

  Gallais Sérézal, Irène (Inst för medicin, Solna / Dept of Medicine, Solna, 2019-09-03)

  Long-lived tissue-resident memory T cells (TRM) reside in nonlymphoid organs and can drive direct cytotoxicity, focal cytokine release and potent tissue-wide anti-infectious responses upon antigenic challenge. TRM cells ...

• Molecular insights into Hutchinson-Gilford progeria syndrome and age-associated disease : from mechanisms to treatment strategy 

  Revêchon, Gwladys (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-08-30)

  Aging is a complex process that occurs as we grow old and is associated with a gradual decline of tissue functions. Scientists have been trying to understand the mechanisms that drive such phenomenon by studying premature ...

• Alphavirus-host interactions : how to unravel the proviral activity of G3BP 

  Götte, Benjamin (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-08-30)

  The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically ...

• Purification, profiling and bioengineering of extracellular vesicles 

  Corso, Giulia (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-08-30)

  The nano-sized membrane enclosed extracellular vesicles (EVs) transfer macromolecular information in the form of proteins, nucleic acids and lipids across cells. They are important mediators of cell-to-cell communication, ...

• Risk prediction in prostate cancer diagnostics : current challenges and improvements 

  Palsdottir, Thorgerdur (Karolinska Institutet Universitetsbiblioteket / Karolinska Institutet University Library, 2019-08-30)

  Prostate cancer has been considered a disease of elderly men, and thus historically less focus has been on prostate cancer research than many other cancer types. However, as life expectancy is increasing all over the world, ...

• Can improved paediatric pneumonia diagnostic aids support frontline health workers in low resource settings? : large scale evaluation of four respiratory rate timers and five pulse oximeters in Cambodia, Ethiopia, South Sudan and Uganda 

  Baker, Kevin (Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2019-08-29)

  Background: Pneumonia is the leading cause of infectious death in children under-five in sub-Saharan Africa and Southeast Asia. Currently, the diagnostic criterion for pneumonia is based on increased respiratory rate (RR) ...

• Too much, too late? Drug prescribing for older people near the end of life 

  Morin, Lucas (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-08-28)

  Background. The burden of drugs prescribed to older persons at the end of life has recently drawn increasing scrutiny. Growing evidence suggests that patients with lifelimiting diseases and poor prognosis are prescribed ...

• Non-invasive imaging for improved cardiovascular diagnostics : shear wave elastography, relative pressure estimation, and tomographic reconstruction 

  Marlevi, David (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-08-28)

  Throughout the last century, medical imaging has come to revolutionise the way we diagnose disease, and is today an indispensable part of virtually any clinical practice. In cardiovascular care imaging is extensively ...

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