Doktorsavhandlingar / Doctoral Theses
Recent Submissions
-
Panorama of diseases associated with breast cancer
(Karolinska Institutet Universitetsbiblioteket / Karolinska Institutet University Library, 2018-11-16)Breast cancer is the most common cancer in women. Although the incidence of breast cancer has increased over time, so too has patient survival. Given these trends, the prevalence of breast cancer has steadily increased in ... -
Radiomics in cancer prognosis : applications and limitations of quantitative texture analysis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-16)Medical imaging has become an integral part of clinical diagnostics since the discovery of X- rays at the end of the 19th century. Recent advances in computing power have opened up the possibility to extract quantitative ... -
Exploring the role of mesenchymal stromal cells in endometriosis
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-16)Endometriosis is a chronic inflammatory disease where there is growth of endometrial tissue in ectopic sites, most commonly within the pelvic cavity. The major symptoms of this disease are chronic pelvic pain and infertility. ... -
The impact of transcriptional mutagenesis on cellular homeostasis
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-11-16)DNA is exposed to chemical and physical agents that represent a continuous threat to its integrity by formation of DNA lesions. Despite the existence and efficiency of DNA repair systems in cells, some lesions may not be ... -
Impact of alcohol and drug abuse on hippocampal neurogenesis in humans
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-16)Hippocampus is one of the few brain regions in which adult neurogenesis is known to occur. Adult neurogenesis in the hippocampus is considered to be important for higher cognitive function, most notably in memory processes ... -
Novel treatment strategies for multidrug-resistant tuberculosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-15)Tuberculosis is the leading cause of death from a single infectious agent in the world, surpassing the annual death toll of both malaria and HIV combined. The rise in multidrug- resistant tuberculosis (MDR-TB) has further ... -
Robot-assisted laparoscopy and sentinel node biopsy in high risk endometrial cancer
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2018-11-15)Surgery is standard treatment for early stage endometrial cancer (EC), the most common gynaecological malignancy in developed countries. Traditionally, surgery has been performed by laparotomy (LT). Comprehensive surgical ... -
Cellular consequences of preterm birth : telomere biology, immune development and oxidative stress
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-15)Preterm infants are at risk for oxidative stress just by being born. The extra-uterine environment is relatively oxygen-rich, their antioxidant defenses are immature, diseases and treatments in the neonatal period will ... -
Minimally-invasive breast interventions : methods for high yield, low risk, precision biopsy and curative thermal ablation
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-15)Advances in medical imaging and the introduction of population-based screening programs have increased the detection rate and overall proportion of small breast tumors. In addition, progress in technology and medical ... -
Auditory organotypic cultures and progenitor cell implantation
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2018-11-15)According to the WHO, about 5 % of the world’s population suffers from disabling hearing loss. In people above the age of 65 the number is more than 30 %. Common effects of this condition are poor speech discrimination and ... -
Stable high-sensitivity cardiac troponin T levels and outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-15)Background: Many patients who seek medical attention because of chest pain in the emergency department (ED), without myocardial infarction (MI) as a final diagnosis, will have cardiac troponin (cTn) levels above the upper ... -
Craniofacial development after three different palatoplasties in children born with isolated cleft palate
(Inst för odontologi / Dept of Dental Medicine, 2018-11-14)Introduction: Different palatoplasties are applied for the surgical correction of children born with an isolated cleft in the palate (ICP). During the last decades the Veau-Wardill-Kilner (VWK), Minimal Incision (MI) and ... -
A genome-wide screen for essential genes that controls the formation of human heart progenitors
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-11-14)The heart is a complex organ system composed of multiple types of tissues. These tissues are produced by a diverse set of muscle and non-muscle cells, originated from a few pools of progenitors. During the heart development, ... -
Kidney diseases : insights from omics approaches
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-11-12)Chronic kidney diseases (CKDs) affects about 11-15% of adults worldwide. When it progresses to the end-stage renal disease (ESRD), there is no effective medication for cure, the only treatment being chronic dialysis or ... -
Novel blood markers in psychosis
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-11-12)Psychotic disorders such as schizophrenia maintain a 1% point prevalence in society at large. They cause much suffering to the patients and exact grave costs on society. There is an urgent need for better diagnosis and ... -
Early-life selenium status and cognitive development
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-11-12)Selenium is an essential element that is found in food sources such as meat, fish, and cereals. The essentiality of selenium was demonstrated in the 1950s, and the interest in its health effects has been growing ever since. ... -
It’s my party : Opportunities for older adults to influence everyday activities in a nursing home setting
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2018-11-09)The overall aim of the thesis was to contribute with knowledge about how influence was enacted and negotiated by nursing home residents in everyday activities. The thesis applied a dialogical approach, incorporating ... -
Bridging theory and practice : learning design for AR-based continuing professional development in a primary care setting
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2018-11-09)Background: General practitioners (GPs) are the gatekeepers of health care in most societies, serving as patients’ first point of contact. Continuing professional development (CPD) is needed for GPs to improve their ... -
Burden of disease and identification of intervention targets in extended-spectrum β-lactamase-associated infections
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-11-09)Extended-spectrum β-lactamase-producing Enterobacteriaceae (EPE) have surged globally since the early 2000s, partly due to dissemination of CTX-M-15 producing Escherichia coli (E. coli) sequence type 131 and its sub-lineages ... -
Severe health anxiety : novel approaches to diagnosis and psychological treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-11-09)Background: It has long been known that severe health anxiety is a common psychiatric condition associated with significant distress, functional impairment, and societal costs. Nevertheless, challenges remain with regard ...