Doktorsavhandlingar / Doctoral Theses
Recent Submissions
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Organization of basal ganglia circuits
(Inst för neurovetenskap / Dept of Neuroscience, 2017-10-17)Anatomical regions and how we define boundaries between and within structures in the brain put a constraint on our understanding of the brain. More than a century of research on the brain has revealed its fundamental ... -
Immunotherapy for pancreatic cancer
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-10-17)Patients with pancreatic cancer have a short life expectancy, and only 20% of the patients diagnosed with pancreatic cancer can undergo surgery. Chemotherapy does not work well: Gemcitabine is the standard regimen with ... -
A continuing educational intervention in primary health care using the ConPrim model
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-10-17)Background and aim: The overall aim of this thesis was to evaluate an intervention about “Nutritional care for patients cared for at home” developed using an interprofessional continuing educational model adapted for primary ... -
Indoor environment and tobacco smoke exposure in relation to allergic disease and lung function
(Institutet för miljömedicin / Institute of Environmental Medicine, 2017-10-17)Asthma and other allergy related diseases are the most common chronic diseases in childhood, and have become a major public health concern. The rapid increase in the occurrence of these diseases, especially in high-income ... -
Understanding structural features of biomolecular interactions : from classical simulations to ab intio calculations
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2017-10-17)The structures of biomolecules and their interactions dictate their functions. In this thesis, five papers are presented to illustrate how the dynamics of biomolecules can be investigated and derivation of desired ... -
Fetal and neonatal alloimmune thrombocytopenia : immunological mechanisms and clinical consequences
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-10-17)Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition that may occur in connection with pregnancy, when maternal antibodies directed against paternally inherited platelet antigens cross the placenta ... -
Innovative approaches to study basophil function in inflammation
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-10-16)Basophils are circulating granulocytes. They are very rare and represent less than 1% of peripheral blood leukocytes. Basophils connect the innate and adaptive immune responses by the secretion of a variety of immune-mediators ... -
Transcriptional regulation of development in time and space
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2017-10-13)Human development requires the generation of trillions of cells with myriad functions from a single cell. This requires that restriction of stem cell fate competence and proliferation are precisely temporally and spatially ... -
In vitro testing of drug sensivity in tumor cells from effusion
(Inst för medicin, Solna / Dept of Medicine, Solna, 2017-10-12)Malignant mesothelioma has a mean overall survival of around 1 year and lung adenocarcinoma with pleural spread has a mean overall survival of around 5 months. Both diseases cause fluid accumulation in the pleura, which ... -
Immune responses against tumors controlled by the actin cytoskeleton : lessons from primary immunodeficiencies
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2017-10-11)The actin cytoskeleton and its regulators are vital for cellular processes such as cell motility and immune synapse formation. In this study, the aim was to dissect the role of two of those regulators, WASp and MKL1, in ... -
Studies of SNAP-25 in regulated membrane fusion : metabolic consequences and tuning of intracellular Ca(2+) dynamics in beta cells
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)Increased release of insulin is usually regarded as a symptom of metabolic syndrome, contributing to insulin resistance in peripheral organs thus affecting glucose and insulin homeostasis. The existing animal models to ... -
PET studies on the mechanisms of action of antidepressant and antipsychotic drugs
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2017-10-06)Positron emission tomography (PET) is a non-invasive molecular imaging technique suitable for examination of neurochemical biomarkers in the living brain. Among these applications, PET studies are used to facilitate the ... -
Transcriptional, epigenetic and lipidomic responses to metabolic interventions : implications for human obesity
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)Obesity is increasing worldwide in an epidemic manner and better prevention and treatments are urgently needed. Obesity is strongly associated with insulin resistance and predisposes for type 2 diabetes. A deeper understanding ... -
From policy to practice : exploring the implementation of a national policy for improving health and social care
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2017-10-06)Introduction: Worldwide, health and social care systems struggle to develop processes that deliver coordinated, high quality care efficiently and at acceptable cost. For various reasons, many problems related to health ... -
Pediatric inflammatory bowel disease : clinical and immunological aspects on remission treatment
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2017-10-05)Background - Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are lifelong conditions characterized by abdominal pain, bloody diarrhea and fatigue. The incidence and prevalence ... -
Quality and efficacy of early intensive autism intervention : a matter of trust, knowledge, and supervision?
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2017-10-05)In contrast to previous research, mainly focusing on child characteristics and on quantity of treatment as essential moderating and predicting outcome factors of Early Intensive Behavioral Intervention (EIBI), the overall ... -
Role of spinal and peripheral HMGB1 in arthritis-induced pain
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2017-10-03)Chronic pain is one of the most debilitating and repeatedly reported symptoms by rheumatoid arthritis (RA) patients. Despite good disease control achieved with disease modifying antirheumatic drugs (DMARDs), joint pain ... -
Effects of excess glucocorticoids on neural cell fate : long lasting consequences of adverse prenatal factors
(Inst för neurovetenskap / Dept of Neuroscience, 2017-10-02)The developing nervous system is particularly vulnerable to high level of glucocorticoids (GCs). Excess GCs is often associated with decreased birth weight in relation to gestational age, and to increased risk of psychiatric ... -
The female voice in vocally demanding professions : field studies using portable voice accumulators
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2017-09-29)Objectives: Methods to register voice use outside the voice clinic, at work, are important for assessment of work-related voice disorders. Such methods must be reliable and valid and at the same time practical and easy ... -
Injuries, risk factors, consequences and injury perceptions in adolescent elite athletes
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-09-28)Background: Injury and health data are not fully explored in adolescent elite athletes, yet essential for understanding injury risk, consequences of injuries and developing injury preventive programs. Aims: To explore ...