Doktorsavhandlingar / Doctoral Theses
Recent submissions
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Trends in population health in an era of increasing longevity
(Institutet för miljömedicin / Institute of Environmental Medicine, 2022-01-26)In Sweden, the number of older adults over the age of 85 increased by 75% since 1990 while the number of centenarians has almost quadrupled. Rapid population ageing is a global phenomenon and projected to continue in almost ... -
Pelvic pain due to endometriosis and dysmenorrhea
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2022-01-24)Background Approximately 70% of women in reproductive age suffer from dysmenorrhea around the world but no prevalence study has been made in Sweden for 35 years. Dysmenorrhea, painful menstruation, can be a sign of ... -
Point-of-care diagnostics of childhood central nervous system infections, with a focus on usability in low-resource settings
(Inst för global folkhälsa / Dept of Global Public Health, 2022-01-24)Background: The inaccessibility of laboratory services sustains the high burden of paediatric infectious diseases, such as central nervous system (CNS) infections, in low-resource settings. New contextually fit and ... -
Anterior cruciate ligament injuries in football
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2022-01-21)Anterior cruciate ligament (ACL) injuries and football are clearly intertwined. ACL injuries are principally sustained when participating in pivoting activities and, as it is such a popular sport, football is consequently ... -
Developing and democratizing tools for spatially resolved profiling of genome and transcriptome
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2022-01-21)The common thread of the work presented in this thesis is the development and democratization of tools that facilitate the spatial profiling of genome and transcriptome. Paper I1 describes iFISH, a resource that ... -
Perioperative management and molecular patterns in patients with obstructive sleep apnea
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-20)Obstructive sleep apnea (OSA) is a common disorder, both in the general and surgical population. While there is a steadily increased awareness of the disorder both in the society as a whole and within health care, ... -
Serious conditions in patients presenting with non-specific chief complaints to the Emergency Medical Service (EMS)
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2022-01-20)BACKGROUND Ambulance clinicians encounter patients presenting with non-specific chief complaints on a daily basis. Such complaints can also be described as “decreased general health condition” “general malaise” and ... -
Novel skeletal stem and progenitor cells and their regulation
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-20)The development of bone and cartilage, which provide the framework of the skeletal system, is complex. In this context stem and progenitor cells play a crucial role by producing differentiated cells. Hormones are important ... -
Untangling the contribution of untranslated regions to mRNA translation in health and disease
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-01-19)Protein homeostasis is essential for living organisms and a consequence of steps of the gene expression pathway such as transcription, mRNA translation as well as the degradation of mRNA and proteins. These major cellular ... -
Medical and surgical treatment of inflammatory bowel disease
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-01-19)Inflammatory bowel disease (IBD), with its two main entities Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition affecting the entire gastrointestinal tract. IBD is associated ... -
Motor and cognitive abilities in Parkinson’s disease with a brain activity perspective : performance at baseline and the effects of a balance training program
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-01-18)Background: Around one per cent of the population over 60 years of age have Parkinson’s disease (PD). PD is a progressive and complicated disease presenting a wide range of symptoms. More knowledge of the common impairments ... -
Aspects of risk factors, pathophysiology and outcomes in trauma
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-14)Trauma is a global health concern. Many trauma patients succumb on the scene or in the immediate phase after trauma. Patients surviving the initial phase may die at a later stage or suffer debilitating consequences in ... -
Neuropathic pain in an elderly population of an urban area of iran with a special focus on carpal tunnel syndrome : epidemiological aspects, clinical characteristics, and non-surgical therapy
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-01-14)Background: People are getting older, and aging problems and disorders are increasing fast. Knowing the rates, causes, symptomatology, treatment, relief, and prognosis of associated disorders can help and facilitate the ... -
Pre-analytical errors in blood sampling procedures in paediatric hospital care
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2022-01-14)Introduction Blood tests are important for diagnosing and treating children who are hospitalised with illnesses. The blood test process follows the specific phases of pre-analysis, analysis and post-analysis. Most ... -
Interplay between blood-brain barrier disruption and neuroinflammation following severe traumatic brain injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-01-13)A severe traumatic brain injury (TBI) holds deleterious consequences for the afflicted, its next-of-kin and society. Still today, prognosis is semi-desolate. One explanation for this might be pathophysiological processes ... -
Adaptive immune responses to tick-borne encephalitis virus and SARS-CoV-2
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2022-01-11)Tick-borne encephalitis virus (TBEV) and SARS-CoV-2 are two unrelated viruses that currently cause substantially different public health burdens and distinct pathologies in humans. TBEV infection leads to neurological ... -
Modelling of steatosis and insulin resistance development in human hepatic 3d spheroids : mechanisms and genetic aspects
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-10)Hepatic steatosis and insulin resistance are common disease manifestations seen in metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) patients. Aberrant hepatic lipid accumulation leads ... -
Potential role of MAIT cells in cancer immunotherapy and viral infection
(Inst för odontologi / Dept of Dental Medicine, 2022-01-04)Mucosa-associated invariant T (MAIT) cells are an unconventional T cell subset with specialized antimicrobial functions. In humans, MAIT cells are characterized by their effector memory phenotype, rapid cytolytic capacity, ... -
CRISPR-based drug target discovery : implications for CRISPR-based therapies
(Inst för medicin, Solna / Dept of Medicine, Solna, 2022-01-04)The CRISPR system was discovered in prokaryotic cells, and it is now one of the most efficient molecular tools to modify genes in eukaryotic cells. It is widely used to inactivate or modify genes in cell lines, animal ... -
Engineered extracellular vesicles for biomedical applications
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-12-28)Nature's very own nanoparticle, Extracellular vesicles (EVs), are lipid membrane-enclosed vesicles encapsulated with diverse biomolecules and are actively secreted by all cell types for intercellular communication. The ...