Doktorsavhandlingar / Doctoral Theses
Recent Submissions
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Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2018-09-21)Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The cancer stem cells of GBM (GSCs) are notorious for being invasive as well as resistant to radiation and chemotherapy. The current ... -
Molecular mechanisms of salamander limb regeneration
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-09-21)Salamanders, like newts and axolotls, stand out among adult vertebrates for their outstanding capacity to regenerate whole body parts and restore complex structures upon injury. One of the best-known examples is their ... -
Regulation and function of ciliary dyslexia candidate genes
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2018-09-20)Dyslexia is defined as an unexpected difficulty in reading despite normal intelligence, senses and instruction. It is the most common learning disability with estimated 5-10% of the population affected. Its heredity is ... -
Pituitary dysfunction and relation to cognitive and global outcome after traumatic brain injury or aneurysmal subarachnoid haemorrhage
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-09-19)Traumatic brain injury (TBI) and aneurysmal subarachnoid haemorrhage (aSAH) are leading causes of deaths and may cause permanent physical, cognitive, behavioural, and psychosocial disabilities limiting daily activities in ... -
Novel tools for the study and diagnosis of bacterial infections : exploring the intersection of microbiology and microfabrication
(Inst för neurovetenskap / Dept of Neuroscience, 2018-09-18)The alarming increase in antibiotic resistance calls for new approaches to study and diagnose bacterial infections. In my thesis, I worked at the intersection of microbiology, microfabrication, and optical probes to ... -
Extracellular vesicles : mediators of immune modulation in the lung and as therapeutic vehicles
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-18)Extracellular vesicles (EVs) are released from all cell types, and carry a wide setup of proteins, nucleic acids, lipids and other cargo. The overall aim of this thesis is to explore EV-based immune therapy, but also to ... -
Diet, lifestyle and chronic kidney disease
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-09-18)Chronic kidney disease (CKD) is a rapidly growing public health problem, affecting 5-10% of the general population, and individuals with CKD have a substantially increased risk of morbi-mortality. Early detection and ... -
Antiepileptic drug utilization : need of sex-specific information and decision support
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2018-09-17)Antiepileptic drugs are used for the treatment of epilepsy and for other neurological and psychiatric conditions, and therefore is prescribing of antiepileptic drugs a concern for physicians from many disciplines. The age ... -
Statistical models of breast cancer tumour progression for mammography screening data
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-09-17)In this thesis we propose a novel statistical natural history model and illustrate how it can be applied to epidemiological breast cancer screening data to increase knowledge about how breast cancers progress over time ... -
Support for physical activity in individuals with prediabetes and type 2 diabetes in primary care : the Sophia Step Study
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2018-09-14)A health promoting-care approach includes supporting the individual to increase control over and to improve his or her health to obtain the best possible wellbeing and quality of life. In prediabetes and type 2 diabetes ... -
HIV susceptibility factors in the human genital mucosa
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-14)Heterosexual HIV transmission is the most common viral transmission route worldwide. To establish a persistent infection the virus needs to cross the mucosal surface of the genital tract. The genital mucosa is thus considered ... -
Identification of novel pathways of regulation of AHR and HIF-1 function
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-09-14)Mammalian bHLH-Pas (basic HLH (helix-loop-helix)-PER-ARNT-SIM) proteins belong to the bHLH superfamily of transcription factors. Members of the family have a broad spectrum of functions that among others sense and regulate ... -
Factors of importance for labor induction
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2018-09-14)Background What initiates the onset of labor is still not clarified, and it is debated whether expectant or active management is the best for the woman and the fetus. Active management means induction of labor (IOL) ... -
The only constant is change : exploring the evolvement of health and social care integration
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2018-09-13)Introduction: Health and social care services, in Sweden and worldwide, struggle to provide comprehensive care and support for people with complex needs. As these services are currently structured, it is difficult to provide ... -
Quantification of inflammatory mediators to explore molecular mechanisms and sub-phenotypes of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-09-07)This thesis summarizes a series of studies using liquid chromatography coupled to mass spectrometry methodologies to quantify metabolites of fatty acids (i.e., oxylipins) and histamine in different samples from experimental ... -
Novel insights into echocardiographic assessment of cardiac function following heart surgery
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2018-09-07)Assessment of cardiac function is a fundamental in everyday clinical decision making and is essential diagnostic tool for choosing therapy in patients with cardiac disease. Currently, echocardiography is the integral part ... -
Teaming over time : team and team leadership development through different interventions
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2018-09-06)Organizing work in groups or teams is becoming almost the norm in contemporary organizations (West, 2012; Wheelan, 2005). This has implications on leadership, team membership and the way organization are designed to favor ... -
Using a life-course approach to better understand depression in older age
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2018-09-05)This doctoral thesis aimed to explore the prevalence of depression, and to identify risk factors, secular changes, and consequences of depression in late adulthood from a life-course perspective. The four studies in this ... -
Relating to risk : sexual behaviour and risk perception among men who have sex with men
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2018-09-05)Background: Men who have sex with men (MSM) are a key population for HIV worldwide. Overall HIV incidence is declining but over the past years the proportion of HIV diagnoses attributed to sex between men has remained ... -
T cells in solid tumors : investigating the immunomodulation in the tumor microenvironment
(Inst för medicin, Solna / Dept of Medicine, Solna, 2018-09-03)The immune system protects human from cancer through an immunosurveillance mechanism. However, the progressive nature of tumor cells to differentiate and the complexity of the tumor microenvironment may result in the ...