Doktorsavhandlingar / Doctoral Theses
Recent Submissions
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Endocrine and paracrine factors related to pregnancy and infertility
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2019-05-24)Unexplained infertility, one of the common gynecological disorders, affecting 10 to 15 % of women worldwide. Recurrent pregnancy loss affects approximately 1 to 3 % of pregnant women with an unknown etiology in 50 % of ... -
The development of the human immune system during the first five years of life
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-05-24)I Systems immunology is a scientific field combining high-throughput analytic technologies and integrative data analysis to study the immune system from a holistic perspective. As the immune system is a complex integrated ... -
Educational leadership in health professions education
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2019-05-24)The aim of this thesis was to explore perceptions and experiences of educational leaders leading educational change and development in health professions and interprofessional education. The sensitising concepts of the ... -
The role of new ultrasound modalities to refine the diagnostic workup on women with cervical carcinoma
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-05-24)Background: Cervical cancer is the fourth most common female cancer in the world and has traditionally been clinically staged not including imaging. Despite that, clinicians depend on diagnostic imaging in the management ... -
Airborne occupational exposures and risk of developing rheumatoid arthritis
(Institutet för miljömedicin / Institute of Environmental Medicine, 2019-05-24)Background: Rheumatoid Arthritis (RA) is an autoimmune, inflammatory disease with multifaceted aetiology. Cigarette smoke is the strongest environmental risk factor of RA, and research suggests that airborne exposures may ... -
Inter-hospital transports of critically ill children
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2019-05-24)There is an increasing need for inter-hospital transports of seriously ill children as a result of centralization of intensive care for children to dedicated pediatric intensive care units (PICU). This thesis has explored ... -
Molecular mechanisms of cardiovascular calcification
(Inst för medicin, Solna / Dept of Medicine, Solna, 2019-05-23)Cardiovascular calcification is a pathophysiological process characterized by the deposition of calcium-phosphate crystals in the arteries and the leaflets of the heart valves. In the arteries calcification causes arterial ... -
Cadasil : a pure model for studying cerebral small vessel disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2019-05-23)Cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) is caused by a mutation on the NOTCH3 gene. The pathological driver behind this disease is the loss of vascular smooth ... -
Effects of BCG-treatment on urinary bladder cancer with focus on nitric oxide
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2019-05-23)Intravesical Bacillus Calmette-Guérin is used as a single agent or adjuvant therapy in the treatment of non-muscle invasive bladder cancer. In spite being one of the most efficient immunological treatments in cancer, BCG ... -
On GABAergic interneuron diversity and maturation
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-23)GABAergic interneurons provide finely, distinct styles of inhibition granted by their unique targeting preferences, molecular profiles, and morphological silhouettes. A central quest of my thesis was to explore what ... -
To give birth in water
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-05-23)The aim of this thesis was to study waterbirth in a Swedish context and to bring focus on clinical outcomes and women’s experiences associated with waterbirth. The literature describes advantages for women giving birth ... -
Pediatric acute neuropsychiatric syndrome : diagnosis, biomarkers and treatment
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-05-23)Background: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) are proposed diagnoses combining a clinical picture ... -
Identification of the adult septic patient in the prehospital and emergency department setting
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-05-22)Sepsis is one of the most urgent conditions encountered within emergency care but is often difficult to recognize due to its non-specific presentations. One third of the patients lack the classic sign of infection; i.e. ... -
Music therapy : an intervention effecting quality of life and health in children going through hematopoietic stem cell transplantation
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2019-05-21)Hematopoietic stem cell transplantation (HSCT) is an established treatment for several types of leukemic, hematopoietic, and metabolic diseases. The child is isolated during 4-6 weeks, followed by extensive follow-up for ... -
Possibilities of dried blood spots as a matrix in therapeutic drug monitoring of antiepileptic drugs in children
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-05-21)For children with epilepsy, therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is essential for treatment. TDM monitoring requires two visits to a health care unit, first for collection of the blood sample ... -
Identification and characterization of small molecules targeting MYC function
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2019-05-21)The MYC family genes (c-, N- and L-MYC) encode potent oncoproteins/transcription factors regulating fundamental cellular processes involved in cell proliferation, metabolism and survival, and they play an important role ... -
Consequences of inadequate use of glucose lowering drugs and associated risk factors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-21)Diabetes Mellitus is characterized by chronically elevated blood glucose levels, hyperglycaemia. Consistent adherence to appropriate glucose-lowering drug therapy is fundamental to prevent disease progression, diabetes-related ... -
Pathways to labour market marginalisation : aspects of common mental disorders, migration status and age
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2019-05-21)Background: Labour market marginalisation (LMM), measured as sickness absence (SA)/disability pension (DP) or unemployment, differs between young immigrants and natives in several countries. The aim of this project was ... -
Evaluation of postmortem toxicological results
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-20)Postmortem diagnosis of fatal intoxications is complicated. Autopsy findings indicative of an intoxication related death are scarce and mostly unspecific. Instead, the diagnosis is more dependent on the circumstances ... -
Hand assessment for infants : development, internal scale validity, reliability and normative reference values
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2019-05-20)Infants use their hands to explore the world and neural event in the developing brain can affect the infant’s ability to use the hands. An infant that has suffered a brain lesion may show clinical signs of unilateral ...