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Recent Submissions

  • Regulation of whole-body glucose and lipid metabolism by skeletal muscle 

    Schönke, Milena (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-16)
    BSTRACT Obesity and associated diseases like type 2 diabetes are rapidly growing health concerns across the globe. The uptake and expenditure of energy in the body are tightly regulated by a plethora of enzymes and ...
  • Colon cancer : aspects on surgical treatment and complete mesocolic excision 

    Bernhoff, Richard (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-09)
    In rectal cancer, total mesorectal excision (TME), including surgery with dissection outside the mesorectal fascia, together with pre-operative radiotherapy improves survival. An educational effort on TME improved results ...
  • Patients with femoral and tibial shaft fractures : aspects on epidemiology and pain therapy 

    Al Dabbagh, Zewar (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-12-21)
    Background: Fractures of the tibial and femoral shafts are common injuries with outcomes depending on injury mechanism, fracture pattern, patient-specific data and treatment methods. Nationwide epidemiological data on these ...
  • Capturing the breath of the heart by magnetic resonance imaging : five-dimensional cardio-respiratory resolved cine imaging during free breathing 

    Holst, Karen (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-23)
    Cardiac imaging with cardiovascular magnetic resonance has the advantage of enabling dynamic visualizations, several quantifiable measures, and good soft-tissue contrast. However, a major drawback is the need for breath ...
  • Detection and staging of colonic lesions using computed tomography and magnetic resonance imaging 

    Rollvén, Erik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-22)
    In Sweden, more than 6000 new patients were diagnosed with colorectal cancer in 2015 of which over 4000 patients had colon cancer and 1800 died from the disease. It is the second most common cancer after breast- and prostate ...
  • Quality of life in patients with thyroid cancer 

    Hedman, Christel (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-02)
    Background: The prevalence of differentiated thyroid cancer (DTC) is increasing as a consequence of rising incidence, young age at diagnosis and excellent survival. The established treatment is surgery, followed by radioiodine ...
  • Locally recurrent rectal cancer : aspects on management, surgery and outcome 

    Westberg, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-01)
    Locally recurrent rectal cancer (LRRC) is a severe condition associated with a high morbidity and mortality, affecting about 150-200 people/year in Sweden. After improvements in management and treatment of primary rectal ...
  • Studies of SNAP-25 in regulated membrane fusion : metabolic consequences and tuning of intracellular Ca(2+) dynamics in beta cells 

    Daraio, Teresa (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Increased release of insulin is usually regarded as a symptom of metabolic syndrome, contributing to insulin resistance in peripheral organs thus affecting glucose and insulin homeostasis. The existing animal models to ...
  • Transcriptional, epigenetic and lipidomic responses to metabolic interventions : implications for human obesity 

    Nylén, Carolina (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Obesity is increasing worldwide in an epidemic manner and better prevention and treatments are urgently needed. Obesity is strongly associated with insulin resistance and predisposes for type 2 diabetes. A deeper understanding ...
  • Bone disease and diabetes mellitus 

    Ugarph-Morawski, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-09-01)
    Diabetes Mellitus (DM) and Osteoporosis (OP) frequently co-exist with advanced age and imply large health challenges worldwide. The last decades there has been a growing interest regarding fracture risk in DM. Currently ...
  • In vivo and in vitro studies of apolipoprotein CIII in diabetes 

    Åvall, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-08-23)
    Apolipoprotein CIII (apoCIII) is an important regulator of lipid metabolism and it is also known to have pro-inflammatory properties. From the point of view of diabetes it is interesting that both insulin deficiency and ...
  • Diagnosis, treatment and evaluation of chronic venous disease 

    Sinabulya, Helen (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-19)
    BACKGROUND AND AIMS: Varicose veins (VVs) are the most common manifestation of chronic venous disease (CVD) in the Western hemisphere. Recent research shows that the disease encompasses the global population and with ...
  • Psychological distress following oesophageal cancer treatment : is there a need for psychological support? 

    Hellstadius, Ylva (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-12)
    Oesophageal cancer is associated with a poor prognosis, an extensive treatment pathway and a difficult recovery process. Previous studies have shown that oesophageal cancer patients suffer from great physical impact of the ...
  • On preoperative treatment selection and magnetic resonance imaging in rectal cancer 

    Hansson Elliot, Anders (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-20)
    In Sweden, 2000 patients are diagnosed with rectal cancer annually. Developments in surgery have improved survival and the addition of preoperative radiotherapy (RT) or chemoradiotherapy (CRT) has reduced local recurrence ...
  • Appetite control : genetic, immunological and neurobiological aspects 

    Lindfors, Charlotte (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-31)
    The overall goal of this thesis is to develop a better understanding of the brain’s regulation of appetite, i.e. the hypothalamic regulation of hunger and satiety signals. The correct regulation of appetite is crucial, ...
  • Breast cancer in young women : aspects on mortality and local recurrence 

    Fredholm, Hanna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-17)
    The general aim of the thesis was to gain increased insight into the long-term prognosis for young women with breast cancer. In a population-based cohort of 22,017 women with breast cancer, we studied prognosis by ...
  • Complicated peptic ulcer disease : prevention and treatment 

    Sverdén, Emma (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-15)
    Peptic ulcer is a common disease worldwide and its complications can cause serious clinical problems. While the incidence of uncomplicated peptic ulcer disease is decreasing, the incidence of more complex ulcer disease is ...
  • Identification and evaluation of novel prognostic genetic markers for childhood acute lymphoblastic leukemia 

    Ivanov Öfverholm, Ingegerd (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-02)
    Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due to advances in risk stratification and treatment, survival rates have increased drastically the last decades. Currently, ...
  • Evaluation of a metal-on-metal total hip arthroplasty 

    Dahlstrand, Henrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-01-17)
    Background After the introduction of the Metasul system by Weber in 1988, total hip arthroplasty (THA) with metal-on-metal (MoM) bearings became increasingly popular in the 1990s. MoM bearings aimed to reduce the ...
  • Aspects of biliary tract cancer : incidence and reproductive risk factors 

    Kilander, Carl (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-21)
    Biliary tract cancer, including cancer of the extra-hepatic bile ducts, cancer of the Ampulla of Vater and gallbladder cancer, is a devastating disease with poor prognosis. The incidence of biliary tract cancer is ...

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