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  • Pulmonary hypertension : the role and place of PDGF 

    Tannenberg, Philip (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)
    Pulmonary hypertension is a severe condition, leading to right heart dysfunction and preterm death. For pulmonary arterial hypertension (PAH), a disease group in which the primary pathology resides within the pulmonary ...
  • Role of inositol pyrophosphates in pancreatic beta cell function 

    Rajasekaran, Subu Surendran (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-25)
    Inositol pyrophosphates are high energy diphosphate containing molecules that are ubiquitous in eukaryotic cells. They have been implicated in diverse cellular processes ranging from DNA repair, telomere length regulation, ...
  • Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 Diabetes Mellitus 

    Sjögren, Rasmus (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-23)
    microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to ...
  • Impact of chronic kidney disease on the cardiovascular system : studies in non-dialysis patients and healthy people 

    Asp, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-21)
    Background: Cardiac and arterial remodeling and stiffening occur in end-stage renal disease. The presence of cardiovascular (CV) alterations in earlier-stage chronic kidney disease (CKD) is less well studied. We evaluated ...
  • Pulmonary resection for malignant tumors 

    Al-Ameri, Mamdoh (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-09)
    Resection of malignant tumors in the lung represents greater than 70% of thoracic surgeries. The continuous evolution of new surgical techniques and management of malignant diseases have improved the clinical outcomes of ...
  • Point-of-care testing of platelet P2Y12-inhibition in patients with acute coronary syndrome 

    Holm, Manne (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-05-08)
    Background: The point-of-care platelet function test Plateletworks® has been shown to identify patients with high platelet aggregation despite P2Y12 inhibition, also known as high-on-treatment platelet reactivity (HPR), who ...
  • Detecting novel effects of exercise or AMPK activation in human skeletal muscle 

    Lassiter, David (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-04-24)
    Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is ...
  • Diagnostic precision and sex differences in quantitative cardiovascular magnetic resonance 

    Nickander, Jannike (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-22)
    Correct medical treatment necessitates a correct diagnosis. Cardiac imaging aims to establish an accurate diagnosis without performing unnecessary invasive procedures. Cardiovascular magnetic resonance (CMR) has emerged ...
  • Clinical and oncopreventive outcomes of antireflux surgery 

    Maret-Ouda, John (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-15)
    Gastro-oesophageal reflux disease (GORD), with heartburn and acid regurgitation as main symptoms, is a common disease with increasing prevalence. GORD is associated with oesophageal adenocarcinoma, a cancer with demanding ...
  • In vivo regulation of pancreatic beta cell function 

    van Krieken, Pim Pieter (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-01)
    Pancreatic beta cells within the islets of Langerhans contribute to the regulation of glucose homeostasis by secretion of insulin, a hormone that stimulates the uptake of glucose by liver, muscle and fat tissue. In ...
  • Regulation of whole-body glucose and lipid metabolism by skeletal muscle 

    Schönke, Milena (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-16)
    Obesity and associated diseases like type 2 diabetes are rapidly growing health concerns across the globe. The uptake and expenditure of energy in the body are tightly regulated by a plethora of enzymes and hormones in ...
  • Colon cancer : aspects on surgical treatment and complete mesocolic excision 

    Bernhoff, Richard (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-09)
    In rectal cancer, total mesorectal excision (TME), including surgery with dissection outside the mesorectal fascia, together with pre-operative radiotherapy improves survival. An educational effort on TME improved results ...
  • Patients with femoral and tibial shaft fractures : aspects on epidemiology and pain therapy 

    Al Dabbagh, Zewar (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-12-21)
    Background: Fractures of the tibial and femoral shafts are common injuries with outcomes depending on injury mechanism, fracture pattern, patient-specific data and treatment methods. Nationwide epidemiological data on these ...
  • Capturing the breath of the heart by magnetic resonance imaging : five-dimensional cardio-respiratory resolved cine imaging during free breathing 

    Holst, Karen (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-23)
    Cardiac imaging with cardiovascular magnetic resonance has the advantage of enabling dynamic visualizations, several quantifiable measures, and good soft-tissue contrast. However, a major drawback is the need for breath ...
  • Detection and staging of colonic lesions using computed tomography and magnetic resonance imaging 

    Rollvén, Erik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-22)
    In Sweden, more than 6000 new patients were diagnosed with colorectal cancer in 2015 of which over 4000 patients had colon cancer and 1800 died from the disease. It is the second most common cancer after breast- and prostate ...
  • Quality of life in patients with thyroid cancer 

    Hedman, Christel (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-02)
    Background: The prevalence of differentiated thyroid cancer (DTC) is increasing as a consequence of rising incidence, young age at diagnosis and excellent survival. The established treatment is surgery, followed by radioiodine ...
  • Locally recurrent rectal cancer : aspects on management, surgery and outcome 

    Westberg, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-01)
    Locally recurrent rectal cancer (LRRC) is a severe condition associated with a high morbidity and mortality, affecting about 150-200 people/year in Sweden. After improvements in management and treatment of primary rectal ...
  • Studies of SNAP-25 in regulated membrane fusion : metabolic consequences and tuning of intracellular Ca(2+) dynamics in beta cells 

    Daraio, Teresa (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Increased release of insulin is usually regarded as a symptom of metabolic syndrome, contributing to insulin resistance in peripheral organs thus affecting glucose and insulin homeostasis. The existing animal models to ...
  • Transcriptional, epigenetic and lipidomic responses to metabolic interventions : implications for human obesity 

    Nylén, Carolina (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Obesity is increasing worldwide in an epidemic manner and better prevention and treatments are urgently needed. Obesity is strongly associated with insulin resistance and predisposes for type 2 diabetes. A deeper understanding ...
  • Bone disease and diabetes mellitus 

    Ugarph-Morawski, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-09-01)
    Diabetes Mellitus (DM) and Osteoporosis (OP) frequently co-exist with advanced age and imply large health challenges worldwide. The last decades there has been a growing interest regarding fracture risk in DM. Currently ...

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