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Recent submissions

  • The role of thyroid hormone function and prokineticin-1 in pregnancy and offspring outcome in women with polycystic ovary syndrome 

    Trouva, Anastasia (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-03-06)
    Thyroid disorders are common in women with polycystic ovary syndrome (PCOS) and both conditions are associated with adverse pregnancy outcomes, such as intrauterine growth restriction, preterm delivery, and gestational ...
  • Exploring the gut microbiome in ADHD and schizophrenia spectrum disorder 

    Stiernborg, Miranda (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)
    Emerging research indicates a complex relationship between the gut bacterial microbiome and psychiatric disorders, though findings are not always consistent. The gut-brain axis, involving gut microbiota, plays a crucial ...
  • Cardiovascular magnetic resonance imaging of myocardium and pulmonary arterial pressure 

    Abdula, Goran (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)
    Heart failure (HF) is a clinical syndrome characterized by high morbidity and mortality. HF can be associated with alteration in myocardial tissue composition such as focal myocardial fibrosis, also referred to as scarring, ...
  • The efficacy of continuous peripheral blocks after cardiothoracic surgery as evaluated by opioid use, pain, and recovery 

    Larsson, Mark (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-09)
    Pain after cardiothoracic surgery is most intense the first postoperative days and for the most part mild to moderate. International guidelines recommend a multimodal analgesic strategy that includes local anesthetics for ...
  • Cardiovascular magnetic resonance evaluation of effusive and constrictive physiologies 

    Thalén, Simon Olof Anders (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-31)
    This thesis presents an exploration of cardiovascular magnetic resonance (CMR) in the evaluation of effusive and constrictive heart conditions. Central to the thesis is advanced CMR as a diagnostic tool in pericardial ...
  • Apolipoprotein CIII in the pathophysiology of diabetes mellitus 

    Recio López, Patricia (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-24)
    It has previously been shown that high levels of apolipoprotein CIII (apoCIII) are related to both type-1 (T1D) and type-2 diabetes (T2D). In this thesis, mechanisms whereby apoCIII affects diet- and genetically-induced ...
  • Prostate cancer : investigating diagnosis, treatment and outcomes 

    Möller, Axel (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-19)
    Background: Prostate cancer is difficult to study. The prostate is located so that it is hard to palpate and because of the dense pelvic bones it is hard to visualize using radiology such as computed tomography. The prostate ...
  • The bicuspid aortic valve and thoracic aortic disease 

    Granath, Carl (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-11-14)
    About 1% of the population is born with an aortic valve composed of only two cusps, called a bicuspid aortic valve. Bicuspid aortic valve is associated with a high risk of both aortic valve disease and ascending aortic ...
  • Studies on the acute porphyrias : with special reference to women’s health 

    Vassiliou, Daphne (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-11-01)
    The acute porphyrias are a group of rare inherited disorders of the metabolism of heme. Three acute porphyrias comprise most of the cases: acute intermittent porphyria (AIP), hereditary coproporphyria (HCP) and variegate ...
  • Central nervous system malformations and epilepsy in children : genetic, imaging, and clinical aspects 

    Kolbjer, Sintia (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-31)
    Malformations of cortical development frequently lead to neurodevelopmental disabilities and epilepsy in children. Nevertheless, comprehensive prevalence data based on population studies are scarce. The objective of this ...
  • The role of T-type calcium channels in human pancreatic β cell maturity 

    Zhao, Kaixuan (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-27)
    This PhD work has optimized a series of in vivo, ex vivo and in vitro approaches to recapitulate, intervene and appraise in vivo maturation of naïve β cells within human induced pluripotent stem cell-derived islets ...
  • Complex genomic rearrangements in rare brain disorders : genetic architecture and molecular consequences 

    Schuy, Jakob (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-23)
    Structural variants (SVs) within the genome, such as deletions, duplications, inversions, and translocations, are common but underappreciated causes of rare diseases. Complex genomic rearrangements involving two or more ...
  • Severe COVID-19 and routine biomarker patterns 

    Sjöström, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-10)
    In acute infectious diseases, the composition of the blood changes. That includes proteins, blood cells and smaller solutes. Routine blood tests have a fundamental role in the diagnosis and follow-up of patients with ...
  • Cardiovascular disease and health anxiety in patients with differentiated thyroid cancer 

    Zoltek, Maximilian (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-09-22)
    Background Differentiated thyroid cancer (DTC) accounts for over 90% of all thyroid malignancies, and is typically treated with a total thyroidectomy and radioactive iodine (RAI) to eliminate both macro- and microscopic ...
  • Liquid biopsies in pediatric oncology : towards clinical implementation 

    Arthur, Cecilia (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-09-06)
    During the last few years, liquid biopsies based on cell-free DNA (cfDNA) have become approved for clinical use in several areas of adult oncology. Due to the minimally invasive nature of this procedure, liquid biopsies ...
  • The anterior chamber of the eye as an islet transplantation site in type-2 diabetes 

    Tun, Sai Bo Bo (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-08-31)
    Diabetes mellitus is a chronic disease, one of the leading causes of death and a consistent financial burden globally. It occurs when insulin is insufficient for glucose homeostasis. Pancreatic islet transplantation drew ...
  • Depression and delirium in cardiac surgery patients 

    Falk, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-05-04)
    Depression is common in persons with cardiac disease, and there is a well-known association between depression and increased cardiovascular morbidity and mortality. Preoperative depression has been associated with ...
  • Studies of congenital genetic aberrations behind childhood leukemia 

    Bang, Benedicte (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-05-03)
    Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, and most frequently (85%) of B-cell precursor type (BCP-ALL). Acquired chromosomal rearrangements or aneuploidies are the recurrent, often prenatal, ...
  • Rare complications in cancer surgery 

    Björklund, Johan (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-28)
    Background: Curative cancer surgery aims to reduce mortality and morbidity related symptoms caused by the cancer. The surgery is often done at a time when the patient is presenting lesser or no symptoms and at a time when ...
  • Pelvic fractures : epidemiology and treatment 

    Lundin, Natalie (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-04-20)
    The epidemiology of pelvic and acetabular fractures has been sparsely described and up-to date information on incidence, demographic distributions and treatment are lacking. Surgical treatment of pelvic and acetabular ...

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