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  • Detection and staging of colonic lesions using computed tomography and magnetic resonance imaging 

    Rollvén, Erik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-22)
    In Sweden, more than 6000 new patients were diagnosed with colorectal cancer in 2015 of which over 4000 patients had colon cancer and 1800 died from the disease. It is the second most common cancer after breast- and prostate ...
  • Quality of life in patients with thyroid cancer 

    Hedman, Christel (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-02)
    Background: The prevalence of differentiated thyroid cancer (DTC) is increasing as a consequence of rising incidence, young age at diagnosis and excellent survival. The established treatment is surgery, followed by radioiodine ...
  • Locally recurrent rectal cancer : aspects on management, surgery and outcome 

    Westberg, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-11-01)
    Locally recurrent rectal cancer (LRRC) is a severe condition associated with a high morbidity and mortality, affecting about 150-200 people/year in Sweden. After improvements in management and treatment of primary rectal ...
  • Studies of SNAP-25 in regulated membrane fusion : metabolic consequences and tuning of intracellular Ca(2+) dynamics in beta cells 

    Daraio, Teresa (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Increased release of insulin is usually regarded as a symptom of metabolic syndrome, contributing to insulin resistance in peripheral organs thus affecting glucose and insulin homeostasis. The existing animal models to ...
  • Transcriptional, epigenetic and lipidomic responses to metabolic interventions : implications for human obesity 

    Nylén, Carolina (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-10-06)
    Obesity is increasing worldwide in an epidemic manner and better prevention and treatments are urgently needed. Obesity is strongly associated with insulin resistance and predisposes for type 2 diabetes. A deeper understanding ...
  • Bone disease and diabetes mellitus 

    Ugarph-Morawski, Anna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-09-01)
    Diabetes Mellitus (DM) and Osteoporosis (OP) frequently co-exist with advanced age and imply large health challenges worldwide. The last decades there has been a growing interest regarding fracture risk in DM. Currently ...
  • In vivo and in vitro studies of apolipoprotein CIII in diabetes 

    Åvall, Karin (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-08-23)
    Apolipoprotein CIII (apoCIII) is an important regulator of lipid metabolism and it is also known to have pro-inflammatory properties. From the point of view of diabetes it is interesting that both insulin deficiency and ...
  • Diagnosis, treatment and evaluation of chronic venous disease 

    Sinabulya, Helen (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-19)
    BACKGROUND AND AIMS: Varicose veins (VVs) are the most common manifestation of chronic venous disease (CVD) in the Western hemisphere. Recent research shows that the disease encompasses the global population and with ...
  • Psychological distress following oesophageal cancer treatment : is there a need for psychological support? 

    Hellstadius, Ylva (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-12)
    Oesophageal cancer is associated with a poor prognosis, an extensive treatment pathway and a difficult recovery process. Previous studies have shown that oesophageal cancer patients suffer from great physical impact of the ...
  • On preoperative treatment selection and magnetic resonance imaging in rectal cancer 

    Hansson Elliot, Anders (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-04-20)
    In Sweden, 2000 patients are diagnosed with rectal cancer annually. Developments in surgery have improved survival and the addition of preoperative radiotherapy (RT) or chemoradiotherapy (CRT) has reduced local recurrence ...
  • Appetite control : genetic, immunological and neurobiological aspects 

    Lindfors, Charlotte (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-31)
    The overall goal of this thesis is to develop a better understanding of the brain’s regulation of appetite, i.e. the hypothalamic regulation of hunger and satiety signals. The correct regulation of appetite is crucial, ...
  • Breast cancer in young women : aspects on mortality and local recurrence 

    Fredholm, Hanna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-17)
    The general aim of the thesis was to gain increased insight into the long-term prognosis for young women with breast cancer. In a population-based cohort of 22,017 women with breast cancer, we studied prognosis by ...
  • Complicated peptic ulcer disease : prevention and treatment 

    Sverdén, Emma (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-15)
    Peptic ulcer is a common disease worldwide and its complications can cause serious clinical problems. While the incidence of uncomplicated peptic ulcer disease is decreasing, the incidence of more complex ulcer disease is ...
  • Identification and evaluation of novel prognostic genetic markers for childhood acute lymphoblastic leukemia 

    Ivanov Öfverholm, Ingegerd (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-03-02)
    Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due to advances in risk stratification and treatment, survival rates have increased drastically the last decades. Currently, ...
  • Evaluation of a metal-on-metal total hip arthroplasty 

    Dahlstrand, Henrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-01-17)
    Background After the introduction of the Metasul system by Weber in 1988, total hip arthroplasty (THA) with metal-on-metal (MoM) bearings became increasingly popular in the 1990s. MoM bearings aimed to reduce the ...
  • Aspects of biliary tract cancer : incidence and reproductive risk factors 

    Kilander, Carl (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-21)
    Biliary tract cancer, including cancer of the extra-hepatic bile ducts, cancer of the Ampulla of Vater and gallbladder cancer, is a devastating disease with poor prognosis. The incidence of biliary tract cancer is ...
  • Preoperative local staging of prostate cancer : aspects on predictive models, magnetic resonance imaging and interdisciplinary teamwork 

    Jäderling, Fredrik (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-15)
    In prostate cancer surgery the two issues at stake are the removal of the tumour on one hand and functional outcome i.e. urinary continence and sexual function on the other. A nerve preserving procedure will optimise the ...
  • Interplay between mitochondria, primary cilium, diabetes and its complications 

    Moruzzi, Noah (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-12-12)
    Diabetes is one of the major health problems of the 21st century. Dysfunction of the insulin secreting pancreatic β-cell together with insulin resistance is central to the pathogenesis of type 2 diabetes mellitus (T2DM). ...
  • Estrogen : molecular mechanisms of antidiabetic action 

    Al-Qahtani, Saad Misfer (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-11-29)
    The pathogenesis of metabolic syndrome is multifactorial and hormones play an essential role in its development. Estrogen loss in postmenopausal women has been linked to several features of metabolic syndrome, while estrogen ...
  • Outcome and refinements of gender confirming surgery 

    Sigurjónsson, Hannes (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-11-28)
    Introduction Gender dysphoria is a state in which the individual shows strong and persistent identification with the opposite sex. After thorough diagnostic assessment, the treatment includes gender confirming surgery ...

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