Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 81-100 of 773
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Congenital cataract and contact lenses
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-03-29)Purpose: Having a child with congenital cataract is associated with a huge responsibility for the parents in terms of the outcome of their child’s visual development. If the cataract is not removed the condition will lead ... -
The role of pain modulation in non-suicidal self-injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-03-18)Individuals with non-suicidal self-injury (NSSI) behavior tend to report feeling little or no pain when they self-injure. Moreover, in laboratory studies the NSSI population tends to demonstrate reduced sensitivity to ... -
On mapping epilepsy : magneto- and electroencephalographic characterizations of epileptic activities
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-03-11)Epilepsy is one of the most common neurological disorder, affecting up to 10 individuals per 1000 persons. The disorder have been known for several thousand years, with the first clinical descriptions dating back to ancient ... -
Developing novel measures and treatments for gambling disorder
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-03-03)Background: While gambling is an activity that seems to have entertained humanity for millennia, it is less clear why problematic gambling behavior may persist despite obvious negative consequences, from a research and ... -
Quantitative MRI biomarkers of neurodegeneration in multiple sclerosis
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-02-28)Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease that targets myelin in the brain and spinal cord. The corpus callosum connects the cerebral hemispheres and is composed of ... -
Development of superselective endovascular tissue access and sampling
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-02-23)Endovascular techniques have revolutionized healthcare by allowing effective treatments of vascular diseases not possible through other surgical means. They have also largely supplanted some surgical treatments due to ... -
Interplay between blood-brain barrier disruption and neuroinflammation following severe traumatic brain injury
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2022-01-13)A severe traumatic brain injury (TBI) holds deleterious consequences for the afflicted, its next-of-kin and society. Still today, prognosis is semi-desolate. One explanation for this might be pathophysiological processes ... -
Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-12-14)Multiple sclerosis (MS) is a leading cause of incurable progressive disability in young adults caused by inflammation and neurodegeneration in the central nervous system (CNS). The capacity of microglia to clear tissue ... -
The impact of social information on emotional learning
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-11-24)Our survival is contingent on our ability to observe and interact with conspecifics. For example, by observing the facial expressions of others, we can vicariously learn to avoid potentially dangerous events without ... -
Immunogenicity of biological therapies : frequency, predictability and clinical relevance in chronic inflammatory diseases
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-11-12)Over the past three decades, biologic therapies have revolutionised the treatment of chronic inflammatory diseases such as multiple sclerosis (MS), systemic lupus erythematosus (SLE), and anti-neutrophil cytoplasmic antibody ... -
Suicidal behaviour and healthcare use among refugees
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-11-10)Background: Despite higher rates of mental disorders among refugees, there is limited evidence on their risk of suicidal behaviour (suicide attempt and suicide) and how such risk is influenced by differences in country-level ... -
Multisensory control of gaze stabilization : from brainstem to bedside
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-29)Without the continuous updates provided by the vestibular and visual systems, our world would appear blurry and unstable. In order to allow the retina to reliably record incoming light in a meaningful way, the vestibulo-ocular ... -
Self-harm among adolescents : correlates, treatment, and healthcare consumption
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-29)Background: Self-harm is common in adolescence and young adulthood, and it is associated with adverse outcomes, such as general psychopathology and suicide. We need a better understanding of self-harm and its correlates ... -
Treatment and logistics of acute ischemic stroke : safety and outcomes
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-22)Background: Stroke, both ischemic and hemorrhagic, accounts for over 20000 hospital admissions in Sweden yearly. The vast majority of patients (85%), suffer from ischemic stroke, an occlusion of a cerebral artery that can ... -
Bridging the gap : patients and professionals perspective on risk and recovery in forensic psychiatry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-10-08)Background: The aim of forensic psychiatry is to protect society and care for offenders with severe mental illness (SMI). People with severe mental illness show a certain increased risk of committing violent crimes, which ... -
Brief online interventions for concerned gamblers in a gambling helpline
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-09-23)Background: Problem gambling (PG) is common throughout the world and affects approximately 2% of the adult population in Sweden and most other western countries. Individuals who gamble in a problematic way experience ... -
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ... -
Subtypes of ischemic stroke : analysis of revascularization therapy, stroke etiology, and the role of blood pressure
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-09-01)Background: Treatment with intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT) improve outcomes for patients with acute ischemic stroke. The efficacy and safety of IVT and EVT may differ based on specific ... -
Tracking selective attention in a musical cocktail
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-08-18)The cocktail party effect refers to mankind’s ability to focus attention on a single sound within noisy or complex auditory environments, in order to extract the most behaviourally-relevant information present. To investigate ... -
Executive functions and successful behavior
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-07-28)Executive functions are the underlying mechanisms that drive top-down regulation of information processing. While suboptimal executive functions have been investigated in various groups of patients, their impact and ...