Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience: Recent submissions
Now showing items 101-120 of 773
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Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2021-07-01)The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ... -
Mechanisms of flavor perception : how odor and taste interact when we eat
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-06-02)Every time we eat, our brains are bombarded with sensory information from the olfactory and gustatory modalities. Through a binding process that is not fully understood, the odor and taste are then merged into flavor, a ... -
Detecting prolonged sitting bouts with the ActiGraph GT3X
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)The ActiGraph has a high ability to measure physical activity; however, it lacks an accurate posture classification to measure sedentary behavior. The aim of the present study was to develop an ActiGraph (waist-worn, 30 ... -
Post-migration stress and mental health among refugees : a population-based survey among refugees from Syria recently resettled in Sweden
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-31)Refugees are exposed to several risk factors for mental ill health before, during, and after the migration. While the impact of traumatic experiences on the mental health of refugees is well-known, the effect of adverse ... -
Exposure-based cognitive behavior therapy for atrial fibrillation : a novel treatment paradigm
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-28)Background: Atrial fibrillation (AF) is a prevalent arrhythmia associated with symptoms such as irregular heartbeat, palpitations, dyspnea, chest pain and fatigue. In many patients, AF symptoms are not alleviated by current ... -
An object's smell in the multisensory brain : how our senses interact during olfactory object processing
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-28)Object perception is a remarkable and fundamental cognitive ability that allows us to interpret and interact with the world we are living in. In our everyday life, we constantly perceive objects–mostly without being aware ... -
Novel measure of olfactory bulb function in health and disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-26)Present neuroimaging techniques are capable of recording the neural activity from all over the brain but the olfactory bulb (OB). The OB is the first olfactory processing stage of the central nervous system and the site ... -
Anti-CD20 therapy in multiple sclerosis : clinical and paraclinical outcomes
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-25)Multiple sclerosis is a chronic inflammatory disease of the central nervous system and the most common non-traumatic cause of neurological disability in young adults. Rituximab is a B-cell depleting drug targeting the CD20 ... -
Effects of child CBT and parent management training for children with disruptive behavioral disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-21)Background: An early identification and treatment of children with disruptive behavior disorders such as oppositional defiant disorder and conduct disorder is important to prevent further development of psychiatric disorders ... -
Serious and violent offending : psychological risk factors and treatment effectiveness
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-15)Background: Violent crime causes extensive suffering and costs to individuals and societies and is a major global health issue. Prevention of violence should occur at several levels, and effective psychological interventions ... -
Novel intervention approaches after recent exposure to trauma
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-12)Background: The life-time incidence of exposure to traumatic events is high and can have a profound negative impact on mental health. The majority of individuals exposed to trauma will go through a process of natural ... -
Emotion dysregulation, self-image, and eating disorders
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-12)Background: Eating disorders (EDs) are complex psychiatric disorders that entail great suffering, high prevalence of comorbid psychiatric and somatic conditions, and increased mortality. The understanding of how EDs develop ... -
Characterization and long-term follow-up of Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-05-07)Background: Pediatric acute-onset neuropsychiatric syndrome (PANS) is a cluster of psychiatric and somatic symptoms of proposed autoimmune etiology. It remains a descriptive entity, still of unclear validity and uncertain ... -
A neuroimaging perspective on regulation of emotion, reward, and attention
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-04-22)Emotional symptoms and non-emotional symptoms such as inattention often co-occur. Each of these symptom domains covers symptoms that are distributed along a continuum across the population; from non-clinical levels to ... -
Long-term aspects of stroke : survival, health-related quality of life and costs
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-04-15)Stroke, a disease that affects millions of people globally every year, is an emergency situation requiring fast and immediate action in hospital. Acute stroke treatments have rapidly improved and been developed over the ... -
Epiphora : impact on vision, outcome of lacrimal surgery and investigations with ultra-high-frequency ultrasound
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-04-08)Epiphora is a common condition that often receives little attention. Excessive tear production creates an irregular and ever-changing ocular surface, affecting refraction and reducing vision. However, in a standard test ... -
Recruitment to multicentre randomised controlled trials in stroke : lessons learnt from the effects trial
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-26)Randomised controlled trials are the gold standard for evaluation treatments. Nevertheless, recruitment into trials is still challenging and many trials fail to meet their recruitment goals within the predetermined time. ... -
Method development for [11C]carbon monoxide radiochemistry
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-25)Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found extensive utility in biomedical research and in drug development. A fundamental pre-requisite for PET is the tracer, which is ... -
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2021-02-24)Background and aims: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. We recently found enrichment of genes associated with calcification in carotid plaques ... -
Positron emission tomography studies of the D1-dopamine receptor in schizophrenia
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-02-19)This thesis is based on investigations of central D1-dopamine receptor (D1R) binding in vivo using positron emission tomography (PET). The aims were i) to examine the antipsychotic effect of a D1R antagonist in schizophrenia ...