Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 441-460 of 472
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Molecular profiling for predicting tumor prognosis, treatment outcome and progression of squamous cell carcinoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-05-20)Squamous cell carcinoma is the most common histological tumor type in the cervix uteri and oral tongue. Although both cancers are diagnosed at an early stage in the majority of cases, cervical cancer has a better prognosis ... -
The role of cyclin E in cell cycle regulation and genomic instability
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-04-23)Cyclin E, a positive regulatory subunit of Cdk2, normally accumulates periodically at the G1/S transition, where it promotes entry into S phase and other DNA replication-associated functions. However, in many types of human ... -
PDGFB and P53 in brain tumorigenesis
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-09-17)Glioblastoma is the most common, and malignant form of brain tumor. It is characterized by a rapid growth and diffuse spread to surrounding brain tissue. The cell of origin is still not known, but experimental data suggest ... -
Somatostatin effects on the proteome of human prostate cancer cells
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-01-09)The transition of prostate cancer from androgen dependent to the therapy resistant androgen independent state, is a large and persistent problem in the clinical management of prostate cancer. The aim of this thesis ... -
Functional characterization of the alternative reading frame protein p14ARF
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-05-06)A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ... -
Single cell analysis of checkpoints in G1
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-09-15)It is becoming evident that defective cell cycle regulation is an important property of the cancer cell. The restriction point (R), a G1 checkpoint after which cell cycle progression becomes independent of extracellular ... -
Nursing interventions in radiation therapy : studies on women with breast cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2000-02-11)The general aim of this thesis was to acquire knowledge to be used to improve the care of cancer patients during and after radiation therapy, in particular for women with breast cancer. The specific objectives were first ... -
Proteomic analysis of DNA damage induced stress signaling with focus on p53 : S100A6 regulation, function and potential as biomarker in lung cancer and as a novel therapeutic target
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-05-23)In this thesis powerful proteomics methods were used to reveal novel proteins involved in the cellular response to DNA damaging treatment. The goal was to find proteins with potential as biomarkers for prediction of cancer ... -
The many faces of p57Kip2 : acting in apoptosis, differentiation and cytoskeleton reorganisation
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-08-28)p57Kip2 is a known cyclin dependent kinase inhibitor, which has been suggested to be a tumor suppressor gene. Indeed various human cancers show a reduction in p57Kip2 expression, indicating that this protein might be of ... -
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-03-28)The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are ... -
IGF-1R inhibition : a tool for functional studies of insulin-like growth factor family in malignant cells
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-01-13)Cancer cells generally posses the capability of overusing normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. Major players in extracellular signaling ... -
HER2 and TP53 in human breast cancer : studies of methods and prognostic value
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-03-17)Prognostic and predictive factors are needed for tailored therapy strategies, aimed at reducing breast cancer relapse and improving survival. The present arsenal of such factors is insufficient. The aims of this ... -
The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-09-04)The tumor suppressor p53 is a critical regulator of life and death in cells. The p53 protein is present at very low levels in cells under normal conditions but accumulates in response to different stress stimuli, such ... -
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-09-21)Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ... -
Cutaneous malignant melanoma aspects of prognostic factors and time : trends in a Swedish population
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-11-01)One of the aims of this thesis was to assess the possible impact of primary and secondary preventive activities in the population of Stockholm-Gotland with the objective to reduce the incidence and mortality from cutaneous ... -
The epidemiology, biology and genetics of human astrocytic tumours
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-01-21)In Sweden > 1000 primary central nervous system (CNS) tumours are diagnosed each year. The majority are malignant and in adults astrocytic gliomas dominate. These are classified into four malignancy grades according to WHO ... -
Existential challenges and coping in palliative cancer care : experiences of patients and family members
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-08-25)The overall aim of this thesis was to gain knowledge about the existential crisis in patients and family members caused by an incurable cancer and how the crisis is managed. Two methodological approaches were used. ... -
Towards improved care and long-term well-being of men who lose a wife to cancer : a population based study
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-10-23)Background: Grief can be seen as the mirror of love. However, some persons suffer beyond what can be viewed as normal grief, experiencing long-lasting decline of both mental and physical health - and even death. Investigating ... -
Tissue biomarkers in prostate cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-09-25)Prostate cancer (PC) is the most common male cancer in the western world. Better biomarkers are needed to support diagnosis, prediction of prognosis and treatment decision Radical prostatectomy (RP) specimens are routinely ... -
Surviving cystectomy due to urinary bladder cancer with maintained quality of life
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-10-15)In 2008 1694 men and 626 women in Sweden were diagnosed as having bladder cancer. The character of bladder cancer is highly variable ranging from moderately serious development of superficial tumors to much more serious ...