Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 421-440 of 472
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Chemical, pharmacokinetic and biological aspects of platinum-based drugs
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-05-06)The use of cisplatin for the treatment of metastatic testicular cancer is a medical historical landmark given that, for the first time, patients could be cured with drug therapy. A third generation platinum-based drug, ... -
Transcription factors PROX1 and p53 in cancer development
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-05-14)The majority of malignant brain tumors in adults are astrocytic gliomas. These are classified into four malignancy grades according to the World Health Organization (WHO) criteria, including grade I pilocytic astrocytoma, ... -
Protein expression in prostate cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-01-06)The molecular pathology of prostate cancer (PCa) is complex and the pathways and the acquired molecular defects responsible for PCa initiation, development and progression are still largely unknown. Tumors of the prostate ... -
Germline CDKN2A/ARF alterations in human melanoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-03-01)Approximately 10% of cases of human cutaneous malignant melanoma (CMM) have been estimated to occur in individuals with a familial predisposition, frequently in association with dysplastic nevus syndrome (DNS). The genetics ... -
Analyses of Akt and PDGF receptor expression and activation in human tumors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-05-15)These studies aimed at developing methodology for detection of proteins involved in cancer and the evaluation of their prognostic significance in human tumors. Signal transduction profiling of tumors are becoming increasingly ... -
Immunological and molecular studies for the development of vaccine therapy for chronic lymphocytic leukemia
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-05-21)Chronic lymphocytic leukaemia (CLL) is a malignant lymphoproliferative disorder which typically affects elderly people. It is the commonest leukemia in the Western adults, accounting for 25-30% of all leukemias and for 10% ... -
DNA repair by HDR in experimental tumorigenesis
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-05-15)The aim of this thesis was to further understand how defects in the homology-directed repair (HDR) pathway affect tumor formation and development. To study proteins involved in HDR is challenging since most of its members ... -
Being in safe hands : the experiences of soft tissue massage as a complement in palliative care : intervention studies concerning patients, relatives and nursing staff
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-10-24)The overall aim of this thesis was to explore how patients, relatives and nursing staff experienced soft tissue massage in palliative care. In order to explicate the experiences of soft tissue massage two methodological ... -
Adjuvant tamoxifen in breast cancer : clinical and preclinical studies on the prediction value of estrogen receptor
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-09-17)Breast cancer (BC) exhibits great heterogeneity at histophatological, clinical and molecular levels. However, the different clinical outcomes in patients with seemingly similar breast cancer have led scientists to search ... -
Discovery and validation of protein biomarkers for lung cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-09-08)Lung cancer is a disease characterized by high incidence and mortality rates as well as by a remarkable resistance to common treatment strategies. Reliable and validated biomarkers could represent a possible breakthrough ... -
Elucidation of pro-apoptotic signaling induced by cisplatin
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-02-07)A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. ... -
Hsp70 in immunotherapy : a potential vector in cancer and viral vaccines
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2000-04-28)New efficient vaccines against cancers and infectious diseases are in demand. In 1993 heat shock protein 70 (hsp70) purified from tumour was shown to elicit tumour protection in mice. It was also shown that the protection ... -
Human papillomavirus in tonsillar cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-11-01)Human papillomviruses (HPVs) are known to be causative agents for the development of cervical carcinoma. To what extent HPV is associated with head and neck cancer remains to be clarified, but an association to tonsillar ... -
On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-04-13)Anticancer drug treatment gives rise to complex cellular responses in tumor cells. An improved understanding of the mechanisms underlying these responses is important in order to improve treatment. It is also of importance ... -
The prognostic significance of uPA, uPAR an d the cytokine IL-1-alpha in urinary bladder cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-03-22)Tumor invasion and metastasis are the major causes of cancer-related death. Proteases are important for the invasive and metastatic propensities of tumors. We have studied the mechanism underlying endogenous expression of ... -
IGF-1R : studies on the expression and role in transformation
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-05-08)Transformation is a complex nonlinear multistep process during which normal cell becomes cancerous. Main characteristics of transformed cells include uncontrolled growth, invasion and metastasis. Extensive research over ... -
The many faces of IGF-1R from cell surface to the nucleus
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-05-01)The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. ... -
Analysis of functional genetic polymorphisms in prostate cancer and type 2 diabetes : mucin 1 and growth hormone receptor
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-10-03)Prostate cancer and type 2 diabetes are complex diseases, the genetic and environmental basis of which are not well established. Epidimiology suggests a link between the two diseases, with type 2 diabetes redusing the ... -
Immunofluorescence studies on the cell cycle expression of cyclin A and cyclin E
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-04-07)Cell cycle progression is tightly regulated in normal eucaryotic cells. Cancer is caused by the transformation of cells, and is always associated with defects in the cell cycle regulatory machinery. An important result of ... -
Induction and repair of DNA double-strand breaks in human cells exposed to different radiation qualities
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-02-22)Radiation therapy is used in attempting to kill tumor cells by inducing DNA double- strand breaks (DSB), the most critical DNA lesions. Recent and planned radiation therapy strategies use high-linear energy transfer (LET) ...