Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat)
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Recent submissions
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Radiation-induced toxicity and secondary malignant neoplasms in radiotherapy of intrathoracic tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-02-23)Radiation oncology is essential in the treatment of cancer, with approximately fifty percent of oncology patients undergoing radiotherapy (RT) at some stage of their disease management. Significant progress is being made ... -
The cellular thermal shift assay (CETSA) for elucidating drug mechanism of action and resistance in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-02-14)A complete understanding over drug mechanism of action (MoA) is important when attempting to predict treatment outcome or the presence of resistance in patients. Despite decades of scientific efforts, the MoAs of even some ... -
Exploring signaling pathways in endothelial mechanotransduction
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-01-19)Mechanotransduction, the process by which cells sense and convert mechanical forces from their surroundings, plays a pivotal role in cellular function. For vascular endothelial cells, coping with the continuous and significant ... -
How tumour cells hijack apical extrusion and how they can be targeted
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-11-22)Tissue development and cell behavior are influenced not only by chemical signals but also by physical ones. The responses of cells to mechanical forces can range from the immediate adjustment of cell morphology and motility ... -
Sarcoma ecosystems : spatial characterization and prognostic significance
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-11-14)Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies ... -
Art of tumor immunity : extricating hypoxia-driven immunosuppression in the solid tumor microenvironment
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-09-20)The fate of tumors, from initiation to in situ carcinoma and ultimately metastasis, is intricately tied to the balance between the immune system’s effector cytotoxic and tolerogenic immunosuppressive responses, collectively ... -
Targeting MTHFD1 and MTHFD2 as cancer treatment
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-09-18)One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and therefore plays a central role in DNA replication and repair. To sustain rapid proliferation, cancer cells often upregulate their 1C ... -
Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-09-15)The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation ... -
Long-term risk for fatal and distant metastatic disease in women with ER-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-08-24)Breast cancer is a major cause of mortality among women worldwide, with estrogen receptor (ER)-positive disease breast cancer being the most common type of breast cancer. A unique feature of ER-positive breast cancer ... -
Precision medicine of ovarian cancer for adults and children : molecular, hereditary and clinical aspects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-08-24)Ovarian cancer was 2018 ranked as the eighth most common cancer diagnosis and cause of death in women. Of these, the most common histological type is high-grade serous carcinoma. There is a diagnostic challenge in the early ... -
Discovering circulating protein biomarkers through in-depth plasma proteomics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-29)Plasma, i.e., the liquid component of blood, is one of the most clinically used samples for biomarker measurement. Despite that plasma proteins and metabolites are the most frequently analysed biomarkers in practice, ... -
Clonal structures and cell interactions in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-29)Despite sharing an identical genome, cells of higher order multicellular organisms display a large degree of phenotypic diversity. This diversity is maintained by a sophisticated regulatory machinery that integrates ... -
The odyssey of MYC transcript from the nucleus to the cytoplasm : the molecular mechanism of the gene gating in human cancer cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-22)Pathological expression of the MYC oncogene is a common denominator in a wide range of cancers and is linked with abnormal cell proliferation. To achieve this status, the MYC gene benefits from being embedded in a region ... -
Diagnostic and prognostic markers in primarily non-smoking related head and neck cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-05-16)Head and neck cancer (HNC) includes cancers of the oral cavity, the pharynx (i.e., the nasopharynx, the oropharynx, and the hypopharynx), the larynx, the nasal cavity, the paranasal sinuses, and the salivary glands. ... -
Deep learning algorithms for tumor detection in screening mammography
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-04-21)Population-wide mammography screening was fully implemented in Sweden in 1997. The implementation has helped to identify breast cancer at earlier stages and thereby lowered mortality by 30-40%. However, it still has its ... -
Telomerase related studies in thyroid cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-04-19)Follicular thyroid neoplasms are diagnostically challenging. On histologic evaluation, it can be difficult, resource-consuming, and observer-dependent to pinpoint the exact location of capsular or vascular invasion. In ... -
Heritable TP53-related cancer syndrome in Sweden : characterisation of genotype-phenotype correlation and surveillance
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-04-04)Around 25% of all cancers are considered as familial and are caused by an inherited susceptibility to develop certain tumours. But only 5-10% are hereditary and caused by known high risk cancer genes associated with specific ... -
Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-03-20)Rapid advancement in the field of immunotherapy has changed the treatment landscape of cancer, especially with the approval of immune checkpoint inhibitors for a wide range of cancer types. However, a large proportion of ... -
Radiotherapy in advanced head and neck cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-03-17)Head and neck cancer (HNC) is a group of malignant tumours located in the mucosa of the upper aero-digestive tract. The location of the tumour, close to several critical organs, can often result in great suffering for the ... -
Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-03-09)A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. Tumor suppressor ...