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  • Multimodality treatment of oesophageal cancer : effects and side effects 

    Alexandersson von Döbeln, Gabriella (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-10-22)
    Background: Oesophageal cancer is highly fatal and treatment with curative intent is beset with many side effects. Treatment options are (1) chemoradiotherapy, (2) chemotherapy with or without the addition of radiotherapy ...
  • Tumor-associated macrophages and microglia : double-edged sword in tumor evolvement and invasion 

    Wallmann, Tatjana (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-10-02)
    Tumor-associated macrophages (TAMs) are among the most abundant cell types in the tumor microenvironment. TAM infiltration is usually linked to tumor progression, metastasis and poor clinical outcome in most human cancers. ...
  • Towards transcriptome-wide studies of mRNA translation in tissues from cancer patients 

    Liang, Shuo (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-08-29)
    Gene expression consists of multiple strictly regulated steps, including transcription, RNA modification, splicing, messenger RNA (mRNA) transport, mRNA degradation, mRNA translation and protein degradation. mRNA translation, ...
  • The role of autophagy in anticancer therapy 

    Dyczynski, Matheus (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-08-24)
    Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject ...
  • A study of two major challenges in prostate cancer : effective chemo-prevention and overcoming resistance to hormonal and chemotherapy 

    Ma, Yuanjun (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-06-29)
    For men, over the course of a lifetime the risk of developing prostate cancer is 1 in 9. Both the illness itself and treatment affect quality of life in multiple aspects, including urinary problems, pain, and sexual ...
  • Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53 

    Zhang, Meiqiongzi (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-30)
    A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows ...
  • Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics 

    Crudden, Caitrin (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-25)
    Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors ...
  • Understanding p53 structure and targeting mutant p53 for improved cancer therapy 

    Zhang, Qiang (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-24)
    The p53 gene family consists of p53, p63 and p73. The three proteins share a high degree of structural similarity in their DNA-binding domains but have rather different functions. The tumor suppressor p53 acts as the ...
  • Mass spectrometry based proteomics : data analysis and applications 

    Zhu, Yafeng (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-08)
    Mass spectrometry (MS) based proteomics has become a widely used high throughput method to investigate protein expression and functional regulation. From being able to study only dozens of proteins, state-of-art MS ...
  • Exploring mechanisms regulating the heterogeneity of Tumor-Associated Macrophages 

    Wallerius, Majken (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-03)
    Accumulation of macrophages in the tumor microenvironment is associated to poor prognoses in most human cancers. Tumor-associated macrophages (TAMs) represent a heterogeneous and plastic population of cells that contribute ...
  • Human papillomavirus and other biomarkers in neck masses of unknown origin and in head and neck cancer 

    Sivars, Lars (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-04-13)
    Background. Human papillomavirus (HPV) is, in addition to smoking and alcohol, a risk factor for developing oropharyngeal squamous cell carcinoma (OPSCC), and more specifically tonsillar- and base of tongue squamous cell ...
  • Discovery and validation of prognostic markers for cutaneous melanoma 

    Falkenius, Johan (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-04-13)
    During the last years there has been an alarming increase in incidence of cutaneous melanoma (CMM) which is the deadliest form of skin cancer. There has been a paradigm shift in treatment of disseminated stage IV disease ...
  • WRAP53β and scaRNA2 on their journey to repair the DNA 

    Coucoravas, Christos (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-03-22)
    WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and ...
  • Fatal attraction : NK cell migration toward and activity in solid tumors 

    Kremer, Veronika (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-03-14)
    Natural killer (NK) cells play a key role in tumor immunosurveillance due to their ability to induce apoptosis of tumor cells and produce pro-inflammatory cytokines, without prior immune sensitization. In particular, NK ...
  • Vaginal morphological changes in cervical cancer survivors 

    Hofsjö, Alexandra (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-02-02)
    Background: Cervical cancer is globally the fourth most common cancer in women and has generally a good prognosis. Cervical cancer survivors report persistent changes in their sexual function, which result in considerable ...
  • Prognostic factors in breast cancer with a focus on the role of tumour proliferation 

    Falato, Claudette (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-01-26)
    Ki67 is the most commonly used marker of proliferation in breast cancer. The general aim of the thesis was to investigate the prognostic role of Ki67 and its interplay with other prognostic factors in breast cancer ...
  • MicroRNAs and their processing factors in Caenorhabditis elegans and human cancers 

    Chang, Roger Kae-Jia (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-01-04)
    MicroRNAs (miRNAs) are small noncoding RNAs approximately 20-22 nucleotides (nt) long. These small RNAs (sRNAs) was initially discovered in Caenorhabditis elegans (C. elegans), but is conserved in over 50 animal species. ...
  • Functional analysis of long non-coding RNAs in cancer 

    Vidarsdottir, Linda (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-11-24)
    For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives ...
  • Tumor microenvironment derived biomarkers in renal cell cancer 

    Frödin-Bolling, Magnus (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-11-16)
    Renal cell carcinoma (RCC) is the 13th most common malignancy worldwide, and constitutes around 2% of all malignant tumors. The entity renal cell carcinoma comprises a heterogenous group of malignant tumors that originates ...
  • Genetic studies in familial non-BRCA breast cancer 

    Wendt, Camilla (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-11-09)
    Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. ...

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