Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions

Now showing items 461-472 of 472

    • Vaginal carcinoma : studies on etiology and prognostic factors 

      Hellman, Kristina (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-11-04)
      Primary carcinoma of the vagina (PCV) is a rare disease, with poor survival, mostly affecting elderly women. Due to its rarity the established knowledge originates from studies based on small materials, therefore little ...

    • Dendritic cells in immune and gene therapy against cancer 

      Lundqvist, Andreas (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-01-10)
      Dendritic cells (DC) are extensively used for vaccine therapy due to their superior T cell stimulatory capacity. However, the modest therapeutic effects reported by most clinical trials using DC, together with the rapid ...

    • Colorectal cancer treatment and early response evaluation : how do we best evaluate treatment response? 

      Byström, Per (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-02-05)
      Colorectal cancer (CRC) is common, being responsible for around 12% of new cancers in Sweden, and contributing heavily to the large numbers of cancer deaths yearly. CRC is the second most common cause of cancer death not ...

    • Vaccination against Her2/neu : expressing cancer using chimeric virus-like particles 

      Andreasson, Kalle (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-04-24)
      Thanks to the development of vaccines, children are these days protected against infectious diseases like polio, diphtheria and tetanus simply by receiving a few injections. Imagine a scenario where these injections would ...

    • Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects 

      Jerremalm, Elin (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-04-04)
      Oxaliplatin is a platinum-based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin for palliative and adjuvant treatment of metastatic colorectal cancer. The biotransformation of oxaliplatin ...

    • Studies on the occurence and effects of human papillomavirus in tumors of the head and neck 

      Lindquist, David (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-03-07)
      The presence of human papillomavirus (HPV) in squamous cell carcinoma of the head and neck (HNSCC) was first reported in 1985. Since then, this association has been studied intensively and today there is substantial evidence ...

    • Markers of differentiation and prognosis in prostate cancer : a morphological and immunohistochemical study 

      Glaessgen, Axel (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-03-28)
      Prostate cancer (PCa) is the most common malignancy in men worldwide. The disease shows a wide range of patient outcome between indolent and highly aggressive tumor behavior. Prognostic factors are needed to stratify ...

    • Prognostic markers in breast cancer associated with cell cycle control, proliferation and angiogenesis 

      Lindahl, Thomas (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-03-05)
      This thesis focuses on potential prognostic molecular breast cancer markers which are related to angiogenesis, proliferation or cell cycle control. A common denominator for all of the investigated markers in the thesis is ...

    • Wig-1 : a p53 target that regulates the mRNA of p53 and Myc – and more? 

      Vilborg, Anna (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-09-24)
      Wig-1 is a transcriptional target of the tumor suppressor p53. p53 is activated by cellular stress and can induce a wide variety of responses. Some like apoptosis follow upon severe damage, while milder damage results ...

    • On the mechanisms and consequences of cell to cell DNA transfer 

      Ehnfors, Jacob (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-11-23)
      Development of cancer is a multistep process where an accumulation of genetic alterations drives normal cells to malignancy. In most cancer cells genetic changes can be observed both at the level of point mutations and as ...

    • Molecular genetics of cutaneous malignant melanoma 

      Eskandarpour, Malihe (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-08-24)
      Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the skin with rapidly increasing incidence. Patients with advanced disease have a poor prognosis since the tumor is usually resistant to current therapies. ...

    • Induction of t-cell responses against PSA by plasmid DNA immunization 

      Pavlenko, Maxim (Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-05-20)
      This thesis is focused on using plasmid DNA encoding human prostate-specific antigen (PSA) for immunotherapy of prostate cancer. PSA is a secreted serine protease, which is produced almost exclusively by prostate epithelial ...