Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 401-420 of 472
-
Centrosome aberrations and tumor development
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-08-15)The transformation of a normal cell to a tumor cell is a result of a failure somewhere in a complicated system of coordination, checkpoints and control mechanisms of inhibitors and activators working as triggers and ... -
High dose rate brachytherapy boost for localized prostate cancer : clinical and patient-reported outcomes
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-11-17)Curative treatment of prostate cancer is controversial. The therapeutic effects of surgery and radiotherapy (RT) have hitherto proved to be similar, why other endpoints such as health related quality of life (HRQoL) stay ... -
The role of angiomotin in endothelial cell motility and cell-cell junction formation
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-08-26)Clinical as well as pre-clinical data show that tumor growth can be restrained by inhibiting angiogenesis. We have been investigating the mechanism of action of angiostatin, an inhibitor of angiogenesis, in order to design ... -
Fatigue in patients with advanced cancer : aspects of assessment and measurements
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-05-02)Symptoms are very common in patients with advanced cancer, with weakness, fatigue, anorexia, pain, and depression reported as the most common and distressing ones. A core issue in palliative care is to provide relief ... -
Mutations and molecular signatures in human melanoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-02-05)Cutaneous melanoma is a disease which results from a complex mixture of various extrinsic and intrinsic factors, with some major players still unknown. Although primary tumors are highly curable with surgical excision, ... -
Analytical strategies for identifying relevant phenotypes in microarray data
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-11-28)With microarray technology, the transcription thousands of genes can be determined simultaneously. The large number of genes, often assessed in a relatively small number of samples, presents a challenge. The risk of making ... -
Mitochondria and cellular energy metabolism in platinum chemotherapy
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-09-18)Chemotherapy is a major strategy in the treatment of cancer. Unfortunately, treatment of advanced cancers often fails due to tumor resistance to chemotherapeutic drugs. Studies of cell death signaling induced by chemotherapeutic ... -
Kaposi's sarcoma and malignant lymphomas in Tanzania during the AIDS epidemic
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-02-27)Kaposi s sarcoma (KS) studies Kaposi´s sarcoma (KS) is the most frequent AIDS tumor (AKS) and associated with HHV-8, but controversial whether a clonal tumor or mostly a reactive proliferation of endothelial spindle cells ... -
Identification and validation of therapeutic targets in sarcoma models
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-05-21)In spite of the low incidence of sarcomas, they are highly aggressive tumors, with high metastatic potential, and resistance to both chemotherapy and radiotherapy, leaving surgery as the only treatment option. There is ... -
Skin cancer prevention : behaviours related to sun exposure and early detection
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-09-05)Skin cancer is an emerging public health problem in Sweden. Even though the most important risk factor for the development of skin cancer - sun exposure - is known, the incidence of skin cancer is still increasing. Every ... -
Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-01-12)The goal of this thesis has been to elucidate the mechanisms underlying resistance to methotrexate (MTX), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), the antimetabolites widely used in treatment of childhood leukemia, ... -
The rehabilitation process after breast cancer diagnosis : factors of importance for return to work
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-10-24)The most common female cancer in Western countries is breast cancer and women diagnosed with this disease are often under 65 years old. With increasing prevalence of survivors it is important to shed light on problems ... -
Breast cancer survivors : information needs, attitudes towards illness and quality of life
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-03-26)Breast cancer (BC) is the most common female cancer. Only in Sweden about 7300 women are affected each year and 1500 die from the disease. Following progress in early detection and therapy there has been a marked improvement ... -
SUMO and ubiquitin : the yin and yang of IGF-1R function
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-10-04)Tumorigenesis is a multistep process involving genetic and epigenetic alterations that drive the progressive transformation of normal human cells into highly malignant derivatives. The insulin-like growth factor 1 receptor ... -
On the structure-function relationship of p73
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-10-02)The development of multicellular organisms requires a balance between the cellular processes of proliferation, differentiation and death. These processes are important throughout the whole life of the organism. Daily, the ... -
On 13q14 deletions in chronic lymphocytic leukemia
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-05-23)Malignant tumors arise as a consequence of a multistep process where an accumulation of genetic and epigenetic changes drives the transformation of normal cells into tumor cells. The identification and characterization of ... -
Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-01-05)Treatment of cancer is associated with challenges including the tumor development of resistance. By elucidating intracellular signal transduction pathways elicited by therapy it is possible to identify structures and ... -
Cancer proteomics : method development for mass spectrometry based analysis of clinical materials
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-11-06)To improve cancer treatment, biomarkers for diagnostics and therapeutic guidance are desperately needed. Mass spectrometry (MS) based proteomics is one of the most promising methods for biomarker discovery. Clinical materials ... -
Novel approaches for cancer immunotherapy
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-05-22)Cancer immunotherapy, i.e. activation of the patient s own immune system to combat cancer, represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy the current ... -
Targeting the GH/IGF-1 axis with novel, small molecule inhibitors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-10-05)The growth hormone (GH) / insulin-like growth factor (IGF) family of ligands, binding proteins and receptors play multiple roles in cell growth, metabolism and development. In addition, numerous studies have demonstrated ...