Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 381-400 of 472
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On the pro-apoptotic signaling induced by interferon-alpha
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-04-06)Interferon-alpha (IFNalpha) is a pleiotropic cytokine which has been used as an active drug in the treatment of malignant diseases for almost five decades. It has shown beneficial results in several hematological malignancies, ... -
Tumor-induced immune dysfunction : mechanism and therapeutic strategies
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-11-02)Cancer is one of the major causes of premature death in humans. Although standard treatments, such as surgery and chemotherapy, are successful in many cases, there are instances when their utility and efficacy are limited. ... -
Studies on the presence and influence of human papillomavirus (HPV) in head and neck tumors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-03-18)The aim of this thesis was to confirm the presence of human papillomavirus (HPV) in tonsillar cancer and the previous finding that presence of HPV in tonsillar cancer is prognostic favorable for patient survival. Furthermore, ... -
Improving the situation of urinary bladder cancer survivors treated with radical surgery or radical radiotherapy
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-10-18)In this thesis we investigated whether the situation of urinary bladder cancer survivors can be improved. To do this, it is necessary to acquire a more specific knowledge of longterm distressing symptoms, symptom characteristics ... -
The loss of a husband to cancer : additional and avoidable psychological traumata
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-05-07)Background: The loss of a loved partner is a stressful event and the long-term outcome of such a trauma may partly be determined by characteristics of the death. When death is the result of a chronic illness such as cancer, ... -
Stereotactic body radiotherapy in non-small cell lung cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2009-04-03)Patients with stage I non small cell lung cancer (NSCLC) are potentially curable. Eradication of the primary tumour is a prerequisite for cure with surgery as standard treatment. A large part of NSCLC patients, in parallel ... -
Molecular mechanisms underlying the oncogenic function of SS18 and SSX
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-01-04)The SS18 and SSX genes were initially identified based on their reoccurrence as fusion partners in synovial sarcoma. As a result of the specific chromosomal translocation t(X:18), the SS18 gene from chromosome 18 becomes ... -
On immunotherapy against prostate cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-02-12)Prostate cancer (PC) is the most frequently diagnosed cancer in Swedish men, with an incidence of around 9000 cases per year, and the main cause of cancer related death. Standard treatment includes surgery, radiotherapy ... -
The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-09-15)This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response ... -
Uveal melanoma : cytogenetics, molecular biology and tumor immunology
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-09-13)Uveal melanoma is the most common primary intraocular malignancy. The metastatic spread is hematogenous and exclusively to the liver. Although eye-sparing treatments are used more frequently the tumor-related mortality ... -
Studies of mutant p53-targeting small molecules
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-11-09)Multiple cellular stresses, such as DNA damage, oncogene activation, hypoxia, and telomere erosion induce p53 protein levels leading to an array of biological responses, including cell cycle arrest and apoptosis. p53 ... -
Malignancies associated with gynecological cancer : epidemiological and etiological aspects
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-10-26)The aims of this thesis were to analyze the incidence and risk of second primary malignancies (SPM) in a Swedish cohort of gynecological cancer patients, to explore suggested risk factors associated with second primary ... -
Mutant p53 reactivation by prima-1 : molecular mechanism and biological effects
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-11-14)Cancer has become one of the leading causes of death worldwide. It is now clear that tumors arise due to the malfunction of a number of genes, thus emphasising the importance of targeted therapies directed to crucial types ... -
Identifying molecular targets for cancer therapy
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-05-18)Within cancer research a molecular target is a specific molecular attribute in a cancer cell or tumor tissue that may play a role in promoting disease progression. There are many of these molecular attributes present ... -
Apoptotic signaling in lung carcinoma cells : with focus on mechanisms of radioresistance
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-05-02)In this thesis, IR-induced apoptotic signaling was studied in a panel of lung carcinoma cell lines. The goal was not only to achieve a better understanding of the process, but also to identify possible targets for ... -
Activating proto-oncogene mutations in human cutaneous melanoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-05-13)Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary ... -
Delivery of DNA vaccines against cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-10-06)DNA vaccines against cancer have shown promising results in animal models. Efficient antigenspecific T cell responses and tumor protection have been demonstrated after vaccination with DNA encoding tumor antigens in mice. ... -
Regulation of insulin-like growth factor-1 receptor expression and signaling
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-05-25)Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin receptor tyrosine kinase family is a broadly expressed transmembrane receptor that plays a key role in malignant cell growth. IGF-1R transmits information ... -
Growth factor pathways in human cancer : functional and therapeutic implications
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-10-04)The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric ... -
Skin cancer prevention : readiness to change sun-related behaviours
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-04-02)The general aim of this thesis was to collect data relevant for skin cancer prevention and to investigate the applicability of the Transtheoretical Model for sun-related behaviour. Also, to assess the readiness to change ...