Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 361-380 of 472
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Determination and use of radiobiological response parameters in radiation therapy optimization
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-11-23)Optimization of radiation therapy is critically dependent on the use of patient related information. For this reason, radiobiological models describing the dependence of tumour and normal tissue responses on the irradiated ... -
TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2008-09-18)Transforming growth factor-beta (TGFbeta) is a key regulator of cell proliferation, death, migration and differentiation. One of the features of TGFbeta signaling is to inhibit tumor growth at the early stage of cancer but ... -
Enhancing T cell mediated immunity in DNA vaccination
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-11-21)For centuries infectious diseases have been one of the main causes of death in the world. With the invention of vaccine technology 200 years ago, we have been able to impede and even eradicate several dangerous pathogens. ... -
Thymidylate synthase expression and mismatch repair protein expression in colorectal cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-04-21)The tumour, node, metastasis (TNM) system, with the current staging and risk stratification methods for prognostication in colorectal cancer (CRC) has its limitations. The need for additional validated prognostic and ... -
Effect of genetic polymorphisms on urinary bladder neoplasms
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-01-19)Urinary bladder neoplasms (UBNs) are among the most common malignancies in the world and are mainly attributed to exogenous risk factors such as, smoking, exposure to industrial aromatic amines and certain medicinal drugs ... -
Immunological recognition and tumor escape mechanisms of ovarian carcinoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-09-22)Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment ... -
Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-05-03)In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ... -
Colorectal cancer : genome, transcriptone and proteome dynamics
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-05-27)Colorectal carcinomas are the third most common malignancies in the Western World. Despite screening programs about 70% of these tumors are detected at advanced stages. Late diagnosis, however, results in a significant ... -
Controlling angiogenesis : functional studies of angiomotin
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-12-28)The expansion of a blood circulatory network by the process of angiogenesis is essential for embryonic as well as postnatal growth. Deregulated blood vessel formation may also negatively contribute to the pathogenesis ... -
Toxicological studies of opiate-related death
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-04-25)This thesis comprises studies on opiate overdose death, and focuses on evaluation of toxicological characteristics including the possible influence of abstinence and polydrug use for the fatal outcome. In order to ... -
Analysis of stroma-derived factors with potential prognostic and therapeutic significance in prostate cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-09-10)Prostate cancer is the most common malignancy in Sweden with about 9000 new cases diagnosed every year. New markers are needed to improve diagnostic accuracy. The most commonly used tissue-biomarkers are basal cell markers ... -
Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-02-22)In spite of the promising results shown by new anti-myeloma agents, multiple myeloma (MM) remains incurable and additional therapy to overcome the inevitable disease recurrence is greatly needed. Immunotherapy is currently ... -
Neuroblastoma as a target for effector mechanisms of the immune system
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-05-24)Neuroblastoma (NB) is the most common solid extracranial tumor in children. Despite intensive multimodal treatment, the prognosis for high-risk NB patients remains poor and therefore new treatment modalities are needed. ... -
To catch a killer : on the mechanisms of interferon alpha induced apoptosis
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-01-28)A major clinical problem regarding treatment of malignant tumours is primary or secondary resistance to therapy. Anti-tumour drugs act primarily by induction of apoptosis. However, the knowledge of how various substances ... -
Studies on polyomaviruses in humans : in relation to haematopoietic stem cell transplantation and cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-02-05)The simultaneous discovery of two polyomaviruses in humans in 1971, BK and JC viruses (BKV and JCV), initiated the research on polyomaviruses in relation to human diseases. This has now been intensified with the consecutive ... -
The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-05-17)A key role of the p53 protein in tumor suppression is reflected by its frequent mutations in human tumors. p53 is activated by various types stress conditions such as DNA damage, hypoxia and oncogene activation that ... -
Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-02-25)Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ... -
Molecular determinants of glioma subsets with distinct histology or sensitivity to signal transduction inhibitors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-05-04)Gliomas are brain tumors that currently are treated with surgery, radiation and chemotherapy. Less than 7.5% of patients with GBM survive more than 2 years after diagnosis. The conclusion, from several decades of intense ... -
Mechanisms of immune escape : implications for immunotherapy against cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-01-17)Tumor cells can be recognized and killed by cytotoxic T cells specific for certain tumor antigens. Immune mediated selection pressure along with genetic instability of tumor cells result in a growth advantage of tumor cells ... -
AIDS and endemic Kaposi's sarcoma development : comparison by histopathology, virology (HHV8/KSHV) and cytogenetics
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-08-30)Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion with spindle cells (SC) affecting the skin, lymphnodes and viscera which is found in four different clinico-epidemiological forms as Classic KS ...