Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 341-360 of 472
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End-of-life care and euthanasia : attitudes of medical students and dying cancer patients
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-05-03)Introduction: In end-of-life care, supporting the factors required for a good death is a goal. Core concepts in a good death are dignity, autonomy, and the relief of suffering. Paradoxically, these concepts are used both ... -
Pharmacological targeting of mutant p53 family members
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-04-18)The tumor suppressor p53 serves as a guardian of the genome and functions mainly as a transcription factor. In response to various stress signals p53 binds to specific DNA sequence motifs and regulates transcription of a ... -
Proteome profiling of human breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-04-11)Breast cancer (BC) takes thousands of woman’s lives yearly. Several factors have been found to influence initiation and development of breast cancer, and to affect prognosis and treatment of this disease. This thesis is ... -
Mechanisms determining efficacy of tyrosine kinase-targeting anti-cancer drugs
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-03-23)The expanding field of cancer research and the introduction of multiple molecular biology techniques have significantly improved cancer drug discovery, presented new drugs, including tyrosine kinase inhibitors, and thereby ... -
Interactions between neuroblastoma and the immune system : cellular pathways and mediators
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-03-04)Neuroblastoma (NB) is an embryonal tumor of early childhood arising in tissues of the sympathetic nervous system, such as the adrenal gland and paraspinal ganglia. It is the most common extra-cranial solid tumor of childhood, ... -
Using a 3-d model system to screen for drugs effective on solid tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-02-23)There is a large medical need for the development of effective anticancer agents with minimal side effects. The present thesis represents an attempt to identify potent drugs for treatment of solid tumors. We used a strategy ... -
WRAP53 unwrapped : roles in nuclear architecture and cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-01-13)WRAP53 is a gene of multiple functions; it encodes for a natural antisense transcript that regulates the actions of the tumour suppressor p53, and it gives rise to a protein with oncogenic properties that is important for ... -
Outcome of preoperative radiotherapy in the treatment of cervical cancer with focus on protein expression and dosimetry
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-01-12)Treatment with preoperative intracavitary radiotherapy (ICRT) is used in cervical cancer with the intention to reduce the tumour burden and sterilize microscopic disease in the paracervical tissues. Preoperative ICRT is, ... -
Towards new therapeutic targets : identification of novel tumor markers in chronic lymphocytic leukemia
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2010-11-02)Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the Western world and is caused by an abnormal accumulation of B lymphocytes in peripheral blood, bone marrow and lymphoid organs. It is a disease mainly ... -
Body site of cutaneous malignant melanoma : primary tumor location in relation to phenotypic and prognostic factors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-11-08)The main purpose of this thesis was to analyze the primary body site of cutaneous malignant melanoma (CMM) in relation to phenotypic traits and prognosis. It is clear that several characteristics of CMM are different, and ... -
Towards elimination of anal-sphincter and rectal dysfunction after radiation therapy for prostate cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-05-07)Background: External radiation therapy is one of the best management options available for localized prostate cancer. The higher the radiation therapy dose administered, the more likely local control will be obtained, but ... -
Translational studies of drug-induced tumor cell death
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-09-29)It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that ... -
Self-reported fecal incontinence and quality of life among gynecological cancer survivors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-05-07)Gastrointestinal symptoms following pelvic radiotherapy are common; however, selfreported descriptions of gastrointestinal symptoms and their impact on daily life among gynecological cancer survivors are rare in ... -
Corticosteroids in advanced cancer : epidemiology, symptom relief and patient experiences
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-04-06)Cortisol is the principal circulating glucocorticoid in man and has a wide variety of effects in the body. In advanced metastatic cancer, glucocorticoids are used to alleviate symptoms such as anorexia, poor strength ... -
On prognostic and treatment predictive factors in early stage breast cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-05-03)Breast cancer is the most common malignant tumor in Swedish women and the incidence is increasing with 1-2% per year in the Stockholm area. A subgroup of patients is women diagnosed with primary inoperable disease. This ... -
Sexual dysfunction and other distressful symptoms in cervical cancer survivors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-02-15)Background: The majority of cervical cancer survivors are young or middle-aged women who will live many years with their treatment-induced sequelae. The effects of preoperative brachytherapy are unclear and treatment ... -
Studies on polyomavirus virus-like particles : as vaccines and vectors for immune and gene therapy
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-03-10)Virus-like particles (VLPs) are similar to natural virus particles except that they lack viral genes. They have a similar cellular uptake to the natural virus from which they are derived but are non-infectious and can ... -
The role of 5'-nucleotidases and deoxynucleoside kinases in responses to nucleoside analogues
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2010-04-30)The efficacy of nucleoside analogues (NAs) in treating several hematological malignancies, solid tumors and viral infections is limited primarily by side-effects and the development of drug resistance. The aims of the ... -
T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) : an immunological study
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-02-16)There are several lines of evidence that T cells in patients with Multiple Myeloma (MM) and B-cell Chronic Lymphocytic Leukemia (B-CLL) are phenotypically aberrant. The overall aim of this thesis was to study T cells ... -
Molecular and cytogenic studies of oncogene alterations in human breast and cervical carcinomas
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-10-03)Characterization of human tumors with associated genetic changes is of importance for better understanding the tumor's basic biological behavior and of great value for clinical management of cancer patients. We therefore ...