Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 321-340 of 472
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Prognostic and predictive factors in Vietnamese breast cancer : a comparison with Swedish patients and effect on survival
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-03-07)Breast cancer is a leading cause of cancer death among women in Western and Asian countries. Previous studies showed that Asian and African-American patients more often had poor tumor prognostic factors than Caucasian ... -
Cancer therapy using viral and bacterial proteins as vectors for vaccines or as carriers of cytostatics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-02-29)New cancer therapies are urgently needed, since available treatment options today have negative side effects, and cure only about half of the patients with invasive cancer. One, relatively new, option is to vaccinate against ... -
Proteomics of invasiveness of human breast epithelial cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-01-25)Mechanisms of malignant transformation and cancer invasion and factors controlling them in response to various stimuli remain elusive. We used proteomics and systems biology to explore these mechanisms in human breast ... -
The effects of breast cancer treatment on cognitive functions
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-01-13)Aims: Women with breast cancer have reported difficulties with memory, attention, and concentration during or after adjuvant treatment. Whether these symptoms are side effects of treatment has not been established. The aim ... -
Assessment of prognostic markers in benign and malignant melanocytic tumours
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-11-11)Cutaneous melanoma is a malignant tumour that arises from pigmented skin cells – melanocytes, represents the most rapidly increasing cancer worldwide which is causing significant public health problem. During the past ... -
Post-translational modifications of proteins in human breast cancer : proteomics studies of phosphorylation and nitration and implication of these PTMs in tumorigenesis
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-11-11)Breast cancer is the most common cancer in women. Even though improvements in diagnosis and treatment of breast cancer have been made, it is still the most common cause of cancer death in women. There is a great need to ... -
Towards prevention of pelvic radiation disease in gynecological cancer survivors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-11-09)Background: To improve the therapeutic ratio of radiation therapy, an increased knowledge of how dose distributions affect normal tissue outcomes is critically needed; however normal tissue outcomes in terms of self-reported ... -
The effect of spatial and temporal dose distributions on radiation-induced side effects in the lung
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-11-04)In radiotherapy (RT), the aim is to kill all malignant cells in a tumor or to render them incapable of further division and multiplication without producing damage to the normal tissues surrounding the tumor. To achieve ... -
Biopsies, diagnosis and prognosis in prostate cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-11-01)Prostate cancer is the third most common cancer in men worldwide, and poses a challenge both for patients and health care systems. Many aspects of prostate cancer are controversial, from screening for early detection to ... -
Tumor-mediated changes in the immune system of cancer patients : a balancing act between suppressors and effectors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-10-25)Tumors and immune cells interact in many ways: immune cells can recognize and even kill tumor cells, while the tumor on the other hand can induce cells of the immune system to participate in tumor-mediated immune ... -
External and intrinsic signatures in human teeth to assist forensic identification work
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-10-20)In forensic medicine, dead victim identification constitutes an important task for forensic professionals including forensic pathologists, anthropologists, and odontologists. If no clues are at hand regarding the identity ... -
ROR1 : a novel receptor tyrosine kinase with unique therapeutic potentials in chronic lymphocytic leukemia
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-10-13)Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of small B lymphocytes in blood, bone marrow, lymph nodes and other lymphoid tissues. CLL is the most common leukemia in the Western world. Despite ... -
Studies of targeted therapy in breast cancer using trastuzumab : HER2 testing and trastuzumab treatment, clinical and economic evaluation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-09-22)The incidence in breast cancer has more than tripled in Sweden since the 1960-ies. During the same time period the 5-year survival rate has increase from around 65% to almost 90%. The survival increase is mainly related ... -
F‐box proteins as regulators of oncogenic pathways by ubiquitylation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-09-21)F-box proteins are the substrate-recognition components of the SCF E3 ubiquitin ligases that catalyze the ubiquitylation of many key cell cycle regulators. Functional studies indicate that the ubiquitin-proteasome system ... -
Modeling PDGF-driven gliomagenesis in the mouse
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-09-07)Gliomas are the most common form of brain tumors, with glioblastoma being the most aggressive form. Glioblastoma is characterized by a number of genetic aberrations, among them amplification and overexpression of ... -
Customization of tamoxifen therapy : not only a dream
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-09-06)Breast cancer (BC) is the most common form of cancer in western women. The grand majority of the afflicted women are eligible for endocrine treatment. Tamoxifen has been the golden standard treatment for more than three ... -
Familial breast cancer : risk populations and their surveillance
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-05-24)Women carrying mutations in either BRCA 1 or BRCA2 have a lifetime risk of breast cancer of 80%. As little is known about the risk of other malignancies, apart from ovarian/tubal cancer in mutation carriers, the ... -
The role of the tumor suppressor gene, FBW7, and mechanisms of its inactivation in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-05-17)The F-box protein FBW7 is a tumor suppressor and SCF ubiquitin ligase targeting several key oncoproteins for proteasomal degradation. In this thesis we addressed whether the FBW7 gene is inactivated by mutations in various ... -
Signalomics : unsupervised and global strategies to explore mechanisms of radioresistence in lung cancer cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-05-11)To combat lung cancer (LC) which is the number one cancer associated killer, a combination of surgery, chemotherapy, radiotherapy and targeted agents are currently used. The main subtype of LC, Non small cell lung cancer ... -
PTPs : redox controlled regulators of cell signaling and transformation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2011-05-06)Protein tyrosine phosphatases (PTPs) are important redox regulated enzymes that control the tyrosine phosphorylation status in the cell. These studies aimed to increase the understanding on how PTPs are controlled by ...