Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 301-320 of 472
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Production of high quality 11C beams for radiation treatment and accurate PET-CT dose delivery verification
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-08-19)Radiation therapy with external beams of positron emitter light ions offers the optimal solution for simultaneously treating and in vivo monitoring the delivery of the dose in 3D with Positron Emission Tomography (PET) or ... -
Towards better quality of life after radiation therapy by improved response modeling
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-05-27)Background: To improve the quality of life of radiotherapy cancer survivors we need to improve our knowledge of the dose, volume and time-response relations of radiotherapy induced late effects. Aims: The aim of the ... -
Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-05-23)Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, ... -
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-05-21)Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ... -
Studies on the influence of human papillomaviruses (HPV) and other biomarkers on the prevalence of oropharyngeal cancer and clinical outcome
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-04-25)Background: Oropharyngeal squamous cell carcinoma (OSCC), where tonsillar (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) dominate, is increasing and is now the most common head and neck squamous cell carcinoma ... -
Regulation of molecular processes in diffuse large B-cell lymphoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-04-25)The molecular understanding of diseases has advanced rapidly due to the use of gene expression profiling. However, these methods have been hampered by the limitation to use frozen tissue specimens. Formalin fixation and ... -
Transcriptional regulation of cell life and death decisions by p73
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-03-05)p73 is the second member to be identified within the p53 family and shares structure and functions with p53. P73 generates various isoforms, which include full-length transcriptionally active (TA) isoforms and amino-terminal ... -
Studies on the mechanisms of carcinogenesis and cancer cell death
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-02-05)Gastric cancer is the second most common cause of cancer-related mortality in the world. The mechanisms of gastric carcinogenesis are not fully elucidated. Telomerase and its catalytic subunit telomerase reverse transcriptase ... -
Studies on human papillomaviruses in head and neck cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-01-07)Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. The traditional risk factors for HNSCC are smoking and alcohol. However, recently IARC has also recognized human papillomaviruses ... -
Genetic and epigenetic mechanisms in primary hyperparathyroidism
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-12-10)Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by abnormally excessive secretion of parathyroid hormone (PTH) and elevated serum calcium. PHPT patients can develop a wide range of complications ... -
Clinical proteomics : quantitative analysis and biological interpretation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-10-11)The main expectations of applying proteomics technologies to clinical questions are the discovery of disease related biomarkers. Despite technological advancement to increase proteome coverage and depth to meet these ... -
Adjuvant tamoxifen and luteinizing hormone-releasing hormone agonists in premenopausal breast cancer : on long-term benefits and side effects in a randomised study
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-10-08)Adjuvant endocrine therapy improves breast cancer survival, unconditional of other treatment. In premenopausal breast cancer, tamoxifen for 5 years is the standard treatment, with or without the addition of ovarian ablative ... -
Stem cell signatures in glioma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-08-30)Gliomas are the most common tumors of the central nervous system in adults. Glioblastoma, the most aggressive form, has a median survival of 15 months regardless of the standard treatment with surgery and temozolomide-based ... -
Occurrence of human papillomaviruses (HPV) types in HPV related cancer and in the genital and oral tracts of young adults
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-08-24)Human papillomavirus (HPV) is associated to cancer of the uterine cervix, the third most common cancer among women, but also to head and neck squamous cell carcinoma (HNSCC), the sixth most common type of cancer in the ... -
Molecular function and targeting of β-arrestins in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-08-22)In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors. G Protein ... -
Making endothelial cells move : a study of angiomotin and binding partners
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-08-17)Angiogenesis is a process crucial for tumor growth and metastasis formation and encompasses the control of endothelial directional migration, anastomosis and lumen formation. We have previously shown that Angiomotin (Amot), ... -
Immunotherapy with the anti-EpCAM monoclonal antibody and cytokines in patients with colorectal cancer : a clinical and experimental study
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-06-20)The tumor-associated antigen EpCAM (epithelial cell-adhesion molecule) (C017-1A) is over expressed by various human carcinomas, including colorectal carcinoma (CRC). This antigen can be used as a target structure for ... -
Tumor radiosensitivity and proliferation as parameters for optimizing radiotherapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-06-01)Radiotherapy is a widely used method to treat malignant tumors. However, the sensitivity to the treatment varies between tumors, and local tumor control is not always achieved. The balance between treatment success and the ... -
MiRNAs in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-05-11)There are many layers of complexity involving the processes through which somatic cells transform into malignant cancers. Historically, cancer was considered to be a disease primarily caused by gene mutations, however it ... -
Molecular characterization of phenothiazines in experimental cancer therapy : new tricks of an old drug revealed
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2012-04-04)Cancer is characterized by uncontrolled malignant proliferation of cells that eventually interfere with tissue/organ functions. Traditionally, cancer is treated with chemo- and/or radiotherapy when surgery is not an option. ...