Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 281-300 of 472
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Imaging vascular development in zebrafish (Danio rerio)
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-05-15)Formation of a functional vascular network is a prerequisite for physiological organ function in vertebrates. Pathological vascularization furthermore plays a role in several human diseases, such as diabetic retinopathy, ... -
Natural killer cells in cancer : studies on migration and cytotoxicity
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-05-08)The role of natural killer (NK) cells in cancer development has been studied extensively over the last four decades and the increasing knowledge on NK cell regulation has improved both safety and efficacy of treatment. ... -
Molecular steps towards improving prognosis in ovarian cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-04-16)Epithelial ovarian cancer (EOC) is the most lethal of gynecological cancers, and cure rates have improved very little in the last 30 years. The most common histological subtypes are serous, endometrioid, clear cell and ... -
Protein tyrosine phosphatases : taking a 'redoxionist' look at PDGFR signaling
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-03-25)Protein Tyrosine Phosphatases (PTPs) are oxidized and inactivated by reactive oxygen species (ROS) upon stimulation of a wide range of cell surface receptors, including the platelet-derived growth factor (PDGF) receptor ... -
The destiny of natural killer cells in the tumor microenvironment : to be suppressed or activated?
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-03-07)In the mid-70s, the term “natural” was used based on the functional properties of NK cells where they recognize and lyse certain tumor cells without requirement of prior immunization. Although NK cells are “natural” in ... -
Vaccination in gastrointestinal cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-01-31)Advances in immunology have increased the possibility to develop therapeutic cancer vaccines (TCV), as a complementary approach to standard treatment. The goal of a successful cancer vaccine is to induce a potent long-lasting ... -
Identification and characterization of a proteasome deubiquitinase inhibitor
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-01-10)The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells. The FDA approval of bortezomib for the treatment of ... -
Epstein-Barr virus encoded deconjugases and AmotL2 in control of cell topology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-01-03)EPSTEIN-BARR VIRUS ENCODED DECONJUGASES: The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory ... -
Prognosis and predictive factors in human breast cancer during tumor progression
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-12-16)In 2010, 1.6 million women contracted breast cancer globally, almost three times the number in 1980, making breast cancer the most common malignancy among women. In Sweden, approximately one out of nine women is expected ... -
MicroRNA expression and function in virus-associated human cancers
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-12-13)microRNAs (miRNAs) are small non-coding RNAs that play important roles in gene regulation. It is now clear that miRNAs participate in tumor development and progression. Despite many studies have reported specific miRNA ... -
Molecular studies in different types of melanoma tumors : correlations to clinical data
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-11-12)Approximately 90% of melanomas arise from skin sites (known as cutaneous malignant melanoma; CMM), whereas the non-cutaneous melanoma (mucosal and ocular melanomas) are rare, accounting for about 10%. Familial melanoma ... -
Molecular characterization of the cancer susceptibility protein wrap53β in Cajal body formation and DNA repair
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-11-04)WRAP53β is a multifaceted protein involved in several biological processes including Cajal body maintenance, cancer cell survival and DNA damage repair. By directing factors to Cajal bodies and DNA double-strand breaks ... -
Cardiac and pulmonary side-effects of radiotherapy in early breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-10-31)The purpose of this thesis was to study early and late side-effects to lung and heart in adjuvant locoregionalradiation therapy (LRRT) of early breast cancer (BC). Papers I-III were intervention studies aiming to reduce ... -
Acute myeloid leukemia : apoptotic signalling and gene expression associated with treatment response
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-10-25)Acute myeloid leukemia (AML) is a severe, life threatening malignancy characterized by a clonal expansion of immature myeloid cells in the bone marrow, resulting in severe infections and bleedings. High dose chemotherapy ... -
Identification of novel tumor biomarkers for sensitivity to radio- and chemotherapy of lung cancer based on genomic analyses
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-10-01)Lung cancer (LC) is one of the most common human cancers and the leading cause of cancer-related deaths worldwide. Treatment of LC is by surgery if the tumor is resectable, otherwise chemo- and/or radiotherapy (CT/RT) is ... -
Endocrine signaling and molecular aberrations in primary hyperparathyroidism
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-09-27)Primary hyperparathyroidism is a common endocrine disorder, characterized by an inappropriate increase in serum parathyroid hormone (PTH) levels. It is most often caused by a single benign parathyroid tumor. The elevated ... -
Clinical and epidemiological studies on prognostic and predicitve factors in cutaneous melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-09-25)Background: Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in Sweden, as in many other western countries. In clinical practice, the histopathological evaluation has remained the basis for ... -
Teenagers losing a parent to cancer : experiences, modifiable risk-factors and long-term outcome
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-09-06)Background: We investigated the experiences of cancer-bereaved teenagers. The goal was to identify potentially modifiable risk-factors for long-term psychological consequences and thus be able to guide health-care providers ... -
From cell survival to dose response : modeling biological effects in radiation therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-09-06)The main goal in curative radiation therapy is to eradicate the tumor while minimizing radiation-induced damage to normal tissue. Ions, including protons and carbon ions, are increasingly being used for cancer treatment. ... -
Multivariate analysis of cancer proteomics data : towards a biological systems view and understanding
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-08-22)Important aims of cancer proteomics include gaining better understanding of cancer biology and identifying cancer biomarkers. Mass spectrometry (MS) based shotgun proteomics allow for identification and quantification of ...