Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 261-280 of 472
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Topoisomerase II and drug resistance in leukemic cells
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-05-21)Mechanisms for resistance to chemotherapy include among other, elevated p-glycoprotein (p-gp) level and/or altered topoisomerase II level (topo II). The present study focused on topo 11 expression, and the enzyme related ... -
Studies on persistent polyomavirus infection in relation to tumor development and options for vaccine and gene therapy
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-05-11)Polyomavirus is a small DNA virus capable of inducing tumors in mice with a defective or an immature immune system. The importance of T-cells in prevention of polyoma-induced tumor development has previously been shown. ... -
Genetic changes in childhood acute lymphoblastic leukaemia and other lymphoid malignancies
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-02-23)Malignant transformation of normal cells is the result of defects in cell growth control, differentiation and programmed cell death. It has been convincingly shown that malignant cells carry mutations in the genes controlling ... -
Cutaneous malignant melanoma : aspects on prevention
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2000-12-29)The general aims of the present thesis were to delineate factors of importance for prevention of cutaneous malignant melanoma (CMM). Three samples of patients with CMM, one sample of patients with dysplastic nevus syndrome ... -
Monoclonal antibodies and cytokines for therapy of patients with advanced colorectal carcinoma : a clinical and immunological study
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2000-11-23)There is a great need for developing and improving treatment alternatives in colorectal carcinoma (CRC). The tumour associated antigen (TAA) GA733/CO17-1A is expressed by more than 90% of all CRCs, on the majority of both ... -
Interactive antiproliferative mechanisms when 5-fluorouracil is combined with cisplatin or ionizing radiation : an in vivo and in vitro experimental study
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2000-11-03)Results from clinical studies and experimental investigations have given evidence of a synergistic effect when 5- fluorouracil (5-FU) has been combined with radiation or cisplatin (CDDP). From earlier experiments performed ... -
The tumor suppressor gene p53 : methods for determination and their implications
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2000-10-06)The tumor suppressor p53 plays a central part in the intracellular defense against malignant transformation and tumor progression. This, and the fact that mutations in the p53 gene are the most common genetic abnormalities ... -
Characterization of mitochondrial membrane proteins as novel components in mitochondrial dynamics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-11-14)Mitochondria are dynamic organelles that frequently change their shape by shifting the balance of fusion and fission in response to cellular metabolic needs. This process is termed mitochondrial dynamics. Dysregulation of ... -
Molecular signatures of progression and chemoresistance in epithelial ovarian carcinoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-11-07)Epithelial ovarian carcinoma (EOC) is a heterogeneous disease generally classified into five histopathological subtypes; low- and high-grade serous, endometrioid, clear cell and mucinous carcinomas. Although each subtype ... -
Targeted therapy and outcome in chronic lymphocytic leukemia
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-11-03)Despite major advances, chronic lymphocytic leukemia (CLL) is still considered incurable. Fludarabine refractory patients and those with TP53disruptions have a particularly poor prognosis. Alemtuzumab is an established ... -
The role of the RNA-binding protein Wig-1 in post-transcriptional regulation of gene expression
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-10-17)The p53 transcription factor is activated by cellular stress. This triggers transcriptional activation of a number of p53 target genes, leading to responses such as cell cycle arrest and/or induction of apoptosis. Wig-1 ... -
Malignant melanoma and other malignancies of the nasal cavity and the paranasal sinuses in Sweden
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-10-15)Background: Malignancies emerging in the nasal cavity and the paranasal sinuses are rare and accounts for 5% of all head and neck malignancies and 0.1% of all malignancies in Sweden. The incidence of sinonasal malignancy ... -
Studies of stem cell and adhesion proteins in breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-10-06)Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+. These cells constitute less than 5% ... -
The secret life of nuclear IGF-1R : functions beyond traditional signaling pathways
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-09-26)The implications of IGF-1R in normal development and disease are well established. IGF-1R plays pivotal roles in cell proliferation and cell survival and aberrant activation result in tumorigenesis and cancer progression. ... -
Getting in and out of shape : relevance for organ formation and cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-09-11)A central question during development is how single cells form functional multi-cellular organ structures. The high reproducibility indicates intricate synchronization of cellular behaviors such as migration, proliferation ... -
Different approaches to develop radio- and chemotherapy for treatment of human cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-09-03)Despite huge advancements in our knowledge and understanding of the molecular mechanisms of carcinogenesis, the prognoses of many malignant diseases have not improved dramatically. Improvements in the therapeutic efficacy ... -
Characterization of non-coding RNAs in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-08-25)While originally though to only code for proteins, it now stands clear that RNA is a multifunctional molecule involved in a great variety of molecular processes. Recent advances in genome-wide platforms have revealed ... -
Studies on the mechanisms of sorafenib-induced cell death
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-08-22)In 2008, 26% of all deaths were cancer-related, making this group of diseases the second leading cause of death in the EU countries. Derailment of tyrosine kinase signaling is one important pre-requisite towards tumorigenesis. ... -
Natural course and treatment outcome in hepatitis C recurrence after liver transplantation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-08-22)Hepatitis C virus (HCV) infection post-liver transplantation (post-LT) is associated with an increased rate of fibrosis progression compared to non-transplanted patients. Thus, 25% of the recipients will progress to cirrhosis ... -
Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-05-19)Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance ...