Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 241-260 of 472
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On the pro-apoptotic mechanisms of the antitumor drugs doxorubicin and interferon-alpha
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-11-07)Anti-cancer drugs act primarily by inducing apoptosis. However, knowledge of how various substances induce apoptosis is still incomplete, and so is the basis for the great variation in cellular sensitivity to cytotoxic ... -
Genetic changes in lymphoid leukemia
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-09-26)It is today generally accepted that the vast majority of malignant tumors arise as a result of genetic changes in critical genes involved in the tightly regulated control of cell growth and cell death. Despite the remarkable ... -
Targets for immune mediated killing of tumor cells and T cell functions in B-CLL
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-08-22)There is a great need for developing and improving treatment alternatives in B-cell chronic lymphocytic leukemia (B-CLL). New therapeutical approaches based on the manipulation of the immune system enable establishment of ... -
Molecular factors relevant to the radiosensitivity of human tumours
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-05-16)Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been suggested to be determinants of cellular radiosensitivity (RS). Mutations and gene rearrangement of c-Ha-RAS and c-MYC ... -
Molecular genetic aspects of renal cell carcinoma development
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-04-25)Renal cell carcinoma (RCC) is the most common tumor of the renal parenchyma. The aim of this study was to further characterize known as well as new genetic abnormalities in a clinical material of RCC, as well as in established ... -
On the role of SAP kinase pathways in cellular responses to cancer treatment
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-03-21)Inherited or acquired resistance to therapy is a major clinical problem in the treatment of cancer. Defective apoptosis signalling is increasingly acknowledged as an important mechanism of resistance. Better understanding ... -
Vaccine strategies based on mycobacterial heat shock protein 65
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-02-07)Mycobacteria can infect macrophages and dendritic cells (DC), where they reside inside the endosomal compartment. The importance of CD4+ T cells in protective immunity against mycobacteria and other intracellular pathogens ... -
DNA-dependent protein kinase in normal and malignant cells : with special reference to anti-tumour agent sensitivity
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-01-03)The DNA-dependent protein kinase (DNA-PK) is a DNA double strand break (DSB) repair enzyme, essential for the cellular response to DNA damaging agents. DNA-PK is also of importance for lymphoid development, since it includes ... -
Targeted CD52 therapy in lymphoid malignancies : a clinical and immunological study
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-01-17)There is a great need for developing new treatment alternatives in low grade non Hodgkin's lymphoma (NHL) including chronic lymphocytic leukemia (CLL). The CD52 antigen, which is expressed on almost all lymphoid malignancies, ... -
Mortality and cancer incidence following cerebral angiography with thorotrast
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-08-30)Epidemiological studies are important tools in assessing radiation-related health effects in humans. The most common form of radiation exposure is low-dose alpha-radiation such as that from radon. However, the long-term ... -
Molecular markers and new techniques in the evaluation of colorectal cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-05-17)Colorectal cancer (CRC) is ranked in the Western world as the third leading cause of death from malignant tumors. Despite improvements in early detection of the disease, new surgical techniques and adjuvant and neoadjuvant ... -
Factors of importance for radiosensitivity of tonsillar carcinoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-05-24)Radiotherapy (RT) alone or in combination with surgery is the only curative treatment of tonsillar carcinoma (TC). As distant metastases are rare the loco-regional control is the most important factor determining survival. ... -
The biological role and clinical impact of SYT-SSX fusion gene and IGF-1R in synovial sarcoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-05-22)Synovial sarcoma, which is a highly malignant soft tissue tumour occurring mainly in young and middle-aged adults, is characterized by the translocation t(X; 18)(p 11.2; q 11.2). This translocation results in a fusion ... -
Sudden infant death syndrome : a medico-legal study of related cardiovascular, toxicological and genetic findings
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-05-03)The present medico-legal investigation of the deaths of infants less than one year of age was designed to enhance our understanding of the Sudden Infant Death Syndrome (SIDS). Special emphasis was placed on the significance ... -
Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-04-05)Breast cancer is the most common malignancy among women in the western world. Hormonal treatments for contraception and replacement after menopause have been associated with an increased risk of breast cancer. The basis ... -
Long term health-related quality of life among women with high-risk breast cancer receiving adjuvant high-dose chemotherapy : a comparison with the normal population
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2002-02-01)The aims of the thesis were 1) to provide reference values for the EORTC QLQ-C30 in the general Swedish population, 2) to investigate effects of adjuvant high-dose treatment on health-related quality of life (HRQoL) among ... -
Cloning and characterization of a p-53-inducible gene, WIG-1
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-11-27)Elucidating the mechanisms by which p53 inhibits tumor growth is a central issue in cancer research, as the TP53 gene is mutated in over half of all human cancers. Lack of functional p53 also contributes to the resistance ... -
Protein modification with hydrophobic prenyl groups in malignant cells
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-10-19)Mevalonate (MVA) is the key intermediate in the isoprene synthetic pathway leading to the formation of a number of biologically important lipid molecules. It is well known that inhibition of MVA synthesis blocks the cell ... -
Indicators of apoptosis and proliferation in haematological malignancies : with special reference to drug resistance and prognosis
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-09-07)Successful treatment of acute myeloid leukaemia (AML) and high-grade non-Hodgkin's lymphoma (HG- NHL) is hampered by development of drug resistance. A better understanding of mechanisms responsible for drug resistance ... -
Natural specific T cell immunity in patients with B-cell chronic lymphocytic leukaemia (B-CLL) : a clinical and immunological study
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2001-05-23)Analysis of TCRBV (T-cell receptor B variable) gene usage of the T cell repertoire in patients with B cell chronic lymphocytic leukaemia (B-CLL) and age-matched healthy control donors showed that major perturbations were ...