Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 221-240 of 472
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Identification, cloning and characterization of the p53 induced gene human Wig-1
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-11-26)The tumor suppressor p53 is a transcription factor that responds to various kinds of cellular stress. In respons to the sensed stress it is able to induces cell cycle arrest and apoptosis. In order to achieve these ... -
Colon cancer : disease related proteins in tumor tissue and serum
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-11-19)Despite the progress in surgical techniques and adjuvant therapies the mortality of around 60% within the group of colon cancer patients did not decrease significantly over the last decades. This determines a growing demand ... -
Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-11-12)Today, ample evidence demonstrates a clear role for the immune system in the battle against cancer. However, the relatively high rate of mutation and proliferation of tumor cells, in combination with the selective pressure ... -
Standardization and application of quantitative PCR methods in patients with hematological malignancies
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-10-29)Using modem combination chemotherapy regimens, it has been possible to increase the rate of complete remission (CR) in acute lymphoblastic (ALL) and acute myeloid leukemia (AML). The major reason for treatment failure in ... -
Targeting insulin-like growth factor-1 receptor in cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-09-24)Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. ... -
Endometrial carcinoma : prognostic factors and protein expression profiling
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-09-24)Endometrial carcinoma is the most common gynaecological cancer in the western world. It is usually diagnosed at an early stage since it presents with irregular vaginal bleeding when the tumour is still limited to the ... -
Synovial sarcoma : molecular, biological and clinical implications
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-08-13)Synovial sarcoma is a rare but mostly aggressive soft tissue tumor that mainly affects children and young adults. The tumor usually occurs in the vicinity of large joints, and may be subdivided into a classical biphasic ... -
Murine polyomavirus VP1 virus-like particles as vectors for gene therapy and as vaccines against polyomavirus infection and tumors
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-05-21)Murine polyomavirus (MPyV) is a double stranded DNA virus ubiquitous in mice. The virus genome encodes for three transforming antigens that interact with the host cell machinery in order to initiate viral production. The ... -
Molecular markers reflecting malignant transformation and tumor progression
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-05-06)The early detection of neoplastic lesions is most critical in the successful treatment of malignant disease. This thesis investigates molecular targets for an improved detection and diagnosis of cancer by exploring the ... -
Modulation of activity of the tumour suppressor p53 by small molecules and damaged DNA
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-04-16)The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p53 triggers a cell cycle arrest in GI or apoptosis, ensuring a suppression of a tumor development by the elimination of ... -
O6-methylguanine-DNA-methyltransferase and DNA mismatch repair in relation to drug resistance in malignant melanoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-03-26)Although the survival rate of patients with malignant melanoma has improved, treatment of the disease poses large problems since disseminated melanoma frequently shows primary resistance to chemotherapy. Resistance to ... -
Analyses of the expression and function of the aspartic protease napsin
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-04-02)Two-dimensional gel electrophoresis (2 DE) is one of the powerful tools for the expression profiling of proteins. Using 2 DE, two polypeptides which are expressed exclusively in primary lung adenocarcinomas have been ... -
Natural and induced idiotype immunity in patients with multiple myeloma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-02-20)There is a great need for development of new treatment alternatives for patients with multiple myeloma (MM). The idiotype (Id) immunoglobulin (Ig) expressed by the myeloma B cell clone might be regarded as a tumor specific ... -
Description and prediction of clinical radiosensitivity : emphasis on normal tissue reactions
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2004-02-27)There is a range in the severity of normal tissue reactions observed when cancer patients receive radiotherapy (RT). The limits of dosage in RT have empirically been set by doses that have caused severe reactions in the ... -
The role of angiomotin in angiogenesis
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-12-26)Angiogenesis plays key roles during embryonic development, female reproduction and wound repair. Angiogenesis, the formation of new blood vessels from of pre-existing capillaries, is a process tightly regulated by a balance ... -
Multiparameter flow cytometry and minimal residual disease in patients with acute leukemia
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-12-26)The investigation of minimal residual disease (MRD) with multiparameter flow cytometry (FC) immunophenotyping has proven to be a powerful approach for disease monitoring in patients with acute leukemia (AL). This technique ... -
Natural and induced immunity against the tumour-associated antigen, Ep-CAM
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-11-27)The tumour-associated antigen (TAA), Ep-CAM is overexpressed on various human carcinomas, including colorectal carcinoma (CRC). TAAs or their immunodominant epitopes that are spontaneously recognised by the immune system ... -
The p53-induced gene wig-1 : regulation of expression and role in embryonic development
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-11-21)The p53 tumor suppressor is a transcription factor that responds to various forms of cellular stress. Activated p53 induces growth arrest or apoptosis through transcriptional regulation of a wide range of target genes. ... -
Horizontal gene transfer by uptake of apoptotic bodies
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-11-14)In adults as well as during embryogenesis, apoptosis plays a key role in the elimination of cells in multicellular organisms. Apoptosis is important for the maintenance of tissue homeostasis. It is also of importance in ... -
Molecular studies of Wig-1, a p53-induced zinc finger protein
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2003-11-14)The fact that p53 is one of the most commonly mutated gene in human tumors indicates that it has a key role in tumor suppression. p53 accumulates after DNA-damage and other types of cellular stress, leading to the initiation ...