Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 201-220 of 472
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Cancer proteomics : characterisation of protein expression in human epithelial tumours
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-05-14)Defining differences in protein expression between tumour cells of various degrees of malignancy is a first step in the development of markers for tumour diagnosis. In this thesis, the expression of multiple proteins in ... -
Clinical fluorescence cytometry : improvements to preparation methods and instrumentation
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-05-21)Fluorescence cytometry, which can be carried out by flow or image cytometry (FCM, ICM), provides a highly sensitive and specific tool for quantitative analysis of cell material. It is emerging from being a pure research ... -
Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-05-13)Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal ... -
Malignant melanoma of the vulva
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-05-14)From a consecutive, nationwide series of 219 females with primary vulvar malignant melanomas diagnosed in Sweden during 1960 to 1984 and followed up until 1994, we analyzed epidemiological, clinical, histopathological, ... -
Anabolic androgenic steroids and violence : a medicolegal and experimental study
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-05-07)Non-medical use of anabolic androgenic steroids (AAS) has been linked to various psychological and behavioural complications in case and survey reports. Judging from these reports, the symptoms most consistently associated ... -
Cell cycle control in G1 : restriction points for growth factors and anchorage dependence
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-05-07)Background: The eukaryotic cell cycle consists of four well-defined phases. During the S phase DNA is replicated and during the M phase the chromosomes are segregated to daughter cells. The time gap between completion of ... -
Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-04-30)Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four ... -
Oncogenes and tumour suppressor genes in human central nervous system tumours
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-04-29)Human central nervous system (CNS) tumours may arise from both developing and adult brain. Primitive neuroectodermal tumours (PNETs) are the most malignant tumours arising from developing brain, and constitute approximately ... -
On ionising radiation and breast cancer risk
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-01-01)Background: It is well known that exposure to ionising radiation increases the risk for breast cancer occurrence. However, better understanding of breast cancer risks in terms of dose-response relationships formulated ... -
Importance of insulin-like growth factor-1 receptor and EWS/FLI-1 fusion protein in growth and survival of two different types of neuroectodermal tumor cells
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1998-11-20)Treatment with comparatively low doses of the 3-hydroxy-3-metylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin caused growth arrest in both melanoma cells and Ewing's sarcoma (ES) cells. In melanoma cells ... -
Molecular aspects of cellular radiosensitivity in small cell lung carcinoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1998-11-13)To clarify some important molecular aspects of radiosensitivity (RS) in small cell (SCLC) compared with non small cell (NSCLC) lung carcinoma, five studies focusing on DNA damage repair, cell cycle checkpoints and apoptosis ... -
Cancer risks in Swedish pesticide applicators in agriculture, forestry and gardening : a toxicological and epidemiological approach
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1998-10-23)The aims of this thesis were (1) to study the cancer risks in Swedish pesticide applicators, which is one of the occupational groups that is most exposed to pesticides in Sweden. This could be done by utilizing a complete ... -
Predictors and consequences of loss of a child : nationalwide epidemiological studies from Sweden
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-11-24)In four different studies, we investigate loss of a child and aspects of care that influence mental health in bereaved parents. An underlying goal of these studies was to identify risk factors that can be influenced by ... -
Strategies to optimize T cell-based cancer immunotherapy
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-09-01)Remarkable progress has been made in the field of tumor immunology in the past decade but active immunotherapy is not yet an established treatment modality. Tumor associated antigens (TAAs) presented in the form of peptides ... -
Development of AIDS associated and endemic Kaposi sarcoma : HHV-8/KSHV viral load in cutaneous and oral tumor cells
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-09-05)Kaposi's sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion which usually presents as a cutaneous lesion and eventually progresses to systemic disease usually in the gastrointestinal (G1) tract, lungs, ... -
Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-08-25)Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult ... -
Hormones and breast cancer : aspects on receptor expression and metabolism
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-02-17)Breast cancer is the most common malignancy among women in the western world. Sex steroid hormones are implied as risk factors but endocrine regimens are also used in the therapy of breast cancer. Current knowledge about ... -
Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2006-01-20)A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for ... -
Immunotherapy with the anti-EpCAM monoclonal antibody and cytokines in patients with colorectal cancer : a clinical and experimental study
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-11-18)The tumor-associated antigen EpCAM (epithelial cell-adhesion molecule) (C017-1A) is over expressed by various human carcinomas, including colorectal carcinoma (CRC). This antigen can be used as a target structure for ... -
Genome instability, gene expression and prognosis in breast cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-02-18)Aneuploid cancers are regarded as being more malignant than tumors of other ploidy categories, and they are characterized by increased genomic instability. Our investigations resulted in the characterization of an aneuploid ...