Doktorsavhandlingar / Doctoral Theses - K7 (OnkPat): Recent submissions
Now showing items 181-200 of 472
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Genomic and functional analysis of microRNAs and PIWI-interacting RNAs in human cancers
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-05-13)Small non-coding RNAs, including microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs), play an important role in gene expression regulation and are involved in many biological and pathological processes. Study of small ... -
Molecular subclassification, stem cell markers and growth regulatory pathways in gliomas
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-05-11)Glioblastoma is the most common and aggressive primary brain tumor in adults. Median survival is no more than 15 months, even with combined treatment regimens. The lack of accurate pre-clinical model systems has limited ... -
Stereotactic body radiation therapy of primary lung cancer and metastases
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-05-08)Stereotactic body radiation therapy (SBRT) has been assessed by both retrospective and prospective studies showing excellent treatment outcome with acceptable toxicity and high grade of local control. However, late ... -
To kill two birds with one stone : targeting myeloid cells in cancers
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-05-08)Cancer progression is often accompanied by chronic inflammation and severe impairment of the immune system. In recent years, therapies eliciting tumor-specific immunity have resulted in striking tumor control and survival ... -
Development of therapeutic strategies for quiescent tumor cell populations
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-04-29)Phenotypic screening is an effective approach to the discovery of small-molecule drugs. In this thesis, I have used cancer cells grown as 3D microtissues (multicellular spheroids) to study the effect of anticancer drugs ... -
Targeting chronic lymphocytic leukemia cells using anti-ROR1 monoclonal antibodies and small molecules inhibitors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-04-29)Chronic lymphocytic leukemia (CLL) is characterized by accumulation of malignant B cells in blood, bone marrow, spleen and lymph nodes. It is the most common leukemia in the Western world. Major progress has been made ... -
The return of the nucleus : epigenetic regulation of autophagy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-04-07)Autophagy is an evolutionary conserved catabolic process activated in response to a variety of cellular stresses, for example nutrient deprivation or chemotherapy. During autophagy, cells engulf parts of their cytplasm ... -
Genetic and epigenetic alterations in melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-04-02)Malignant melanoma is a disease that may arise in several different parts of the body, preferentially the skin, rarely in the mucosal membranes or the choroidal tissues of the eye. The incidence of cutaneous melanoma (CMM) ... -
From membrane to nucleus : new roles and functions of SUMOylated IGF-1R and EGFR
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-03-19)Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated ... -
Studies on human papillomavirus and molecular markers in head-neck cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-03-03)Background: Oropharyngeal squamous cell carcinoma (OSCC), where tonsillar and base of tongue cancer (TSCC and BOTSCC) dominate, is associated with smoking and alcohol as well as human papillomavirus (HPV) infection. The ... -
Effect of ovarian surgery on ovarian reserve and fertility
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-03-02)The objective of this thesis was to investigate short- and long-term effects of ovarian surgery on the ovarian reserve of women of reproductive age. This research also considered their reproductive outcomes with regard ... -
Aspects of chemotherapy and photon and proton radiotherapy in patients with gastric cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-02-13)Gastric cancer remains a major health problem worldwide. The addition of chemotherapy alone or in combination with radiotherapy to surgery in local gastric cancer improves outcome. In more advanced stages, the optimal ... -
To unite or disconnect : AmotL2 in tubulogenesis and tumor invasion
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-01-16)For an epithelial- or endothelial cell sheet or ‐tissue to form, individual cells must come together unite and connect. Contacts to adjacent cells and underlying matrix must be initiated, and the junctional proteins mediating ... -
Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-12-16)Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, ... -
Molecular cytogenetic investigations of chromosomal abnormalities in prostate and urinary bladder cancers
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2000-08-25)Tumorigenesis is suggested to be caused by base pair mutations and chromosomal abnormalities leading to inactivation of tumor suppressor genes an activation of oncogenes. However, still it is not clear for the vast majority ... -
Cutaneous malignant melanoma : aspects on recurrence and mortality
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2000-04-21)The purpose of this thesis was to analyse patterns of recurrence and mortality from cutaneous malignant melanoma (CMM) in relation to clinical development and metastatic pathways. The basis of the study consists of patients ... -
Quantitative cellular methods in the evaluation of prostate cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-12-24)The distinction between those prostate cancers rapidly progressing and leading to death and those with little likelihood of causing death in cancer is a major goal in current prostate cancer research. Morphological tumor ... -
Genetic analysis of human astrocytic gliomas : xenografts as a research tool
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-11-26)Cancer is a genetic disorder of somatic cells. An accumulation of genetic changes is believed to result in neoplastic transformation and malignant progression. In humans, astrocytic gliomas are the most common primary ... -
Human papillomavirus infection, genetic instability and invasive properties of cervical lesions
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-08-27)Cancer of the uterine cervix is one of the most frequent malignancies in women worldwide. Approximately half a million new cases of cervical cancer are diagnosed each year, and about 200 000 women die from the disease. ... -
Tumor progression in melanocytic lesions : biological and diagnostic implications
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 1999-05-25)Cutaneous malignant melanoma has an annual incidence of 5% in Sweden, with about 1500 cases diagnosed yearly. In routine histopathology there are diagnostic difficulties in the analysis of pigmented lesions. In spite of ...